凯盛（自贡）新能源有限公司太阳能材料生产车间内，机械手正将一张张光伏玻璃从输送辊道上取下。 自贡市沿 滩区委宣传部供图 优必选项目生产的智能教育类机器人。受访者供图 "4+3"重点产业 数读自贡工业"半年报" ●持续推进节能环保、新能源、新材料、无人机及通航4个主导产业形成明显支撑 ●努力推动人工智能、电子信息、大健康3个潜在优势产业实现明显突破 ●上半年，规模以上工业增加值同比增长16.6%，位列全省第三 ●规模以上高技术产业增加值同比增长34.4% ●1至6月，2025年纳入市级督办的项目履约率、开工率、投产率达93.4%、79.2%、46% ●上半年，新签约亿元以上项目119个，总投资445.2亿元。其中，10亿元以上项目23个，含30亿元以上项目4 个 数据来源：自贡市经济和信息化局、自贡市投资促进局 准备资料、打电话对接时间……8月11日上午，自贡市投资促进局投促二科科长赵军非常忙碌。"这个石墨烯 铝母料生产基地的线索，要赶紧联合相关部门研判。"赵军说，如果"看对眼"，市领导会立刻带队洽谈，"目前已 动态储备重点在谈项目24个。" "该项目能推动自贡人工智能产业链向高端延伸。"自贡高新区投资促进局副 ...

Core Insights - The research reveals the different responses of the human body to single and long-term exercise, identifying a key "exercise-mimicking molecule" called betaine [1][2] - The study establishes that exercise can delay aging by regulating rhythm factors, promoting vascular regeneration, and suppressing systemic inflammation [1] - A significant breakthrough is the identification of the kidneys as a core organ responding to the health benefits of exercise, with long-term exercise significantly increasing betaine levels in the kidneys [2] Group 1 - The research team conducted a study involving 13 healthy male volunteers and cross-species research between mice and humans to detail the body's response to exercise [1] - Single intense exercise is characterized as a "survival stress test," leading to metabolic storms and oxidative damage, while long-term regular exercise rebalances multiple body systems [1] - Long-term exercise improves metabolism, rejuvenates the immune system, reduces inflammation, enhances antioxidant capacity, and optimizes gut microbiota [1] Group 2 - Betaine, derived from choline in the kidneys, is synthesized through a key enzyme activated post-exercise, which is crucial for its health benefits [2] - In cellular studies, betaine treatment significantly improves the aging state of various human aging cells, while in animal studies, it extends the healthy lifespan of elderly mice and improves various health metrics [2] - Betaine acts on a natural immune kinase called TBK1, inhibiting its activity and blocking pro-inflammatory signaling pathways, thereby reducing inflammation levels in tissues [2]

本报北京电(耿令令)运动作为生命活动的生物学基础，是公认高效且低成本的健康促进与抗衰干预策 略。然而，其深层分子机制尚未完全阐明。6月25日，首都医科大学宣武医院王思研究员团队联合中国 科学院动物研究所刘光慧研究员、曲静研究员、宋默识研究员及国家生物信息中心张维绮研究员团队， 在Cell杂志上就此发表了研究论文。 研究团队历时6年，首次系统解析了人体对急性单次运动与长期规律运动的分子细胞动态响应谱，揭示 肾脏是运动效应的关键应答器官——其内源代谢物甜菜碱作为衰老延缓的核心分子信使，通过靶向抑制 天然免疫枢纽激酶TBK1，协同阻遏炎症并缓解多器官衰老进程。该发现不仅为"运动即青春之泉"的古 老认知提供分子注脚，更开创了基于"运动模拟药物"实现系统性抗衰干预的全新策略。 化学生物学研究揭示，天然免疫激酶TBK1是甜菜碱的直接作用靶点。甜菜碱特异性结合TBK1并抑制其 激酶活性，进而阻断下游IRF3/NF-κB信号通路激活，抑制促炎因子表达。在感染性炎症及自然衰老的 模型中，口服甜菜碱显著降低多组织TBK1磷酸化水平，有效减少免疫细胞浸润并抑制促炎因子释放。 该研究构建了多模态时空动态分析框架，系统地揭示了"运动悖 ...

Core Insights - A Chinese research team has revealed that the kidneys are a key organ in the effects of exercise, with the metabolite betaine acting as a core molecular messenger to delay aging by targeting and inhibiting the natural immune kinase TBK1, thereby alleviating inflammation and multi-organ aging processes [1][2] Group 1: Research Findings - The research, conducted over six years, provides a systematic analysis of the molecular and cellular responses to both acute single exercise and long-term regular exercise [1] - The findings offer cross-scale and cross-species scientific evidence for the positive effects of exercise on health, supporting active health interventions for aging [1] Group 2: Implications for Health and Aging - The study introduces a new paradigm of "endogenous metabolite-mediated exercise benefits," transforming complex physiological effects into quantifiable and operable chemical language [1] - This research lays the groundwork for developing "exercise-mimicking drugs" as a new strategy for systemic aging intervention [1][2]

Group 1 - The research reveals that the kidney is a key organ responding to exercise effects, with the metabolite betaine identified as a core molecular messenger for delaying aging [1][5] - The study systematically analyzes the physiological adaptations and mechanisms of acute single exercise versus long-term regular exercise, establishing a multi-dimensional adaptive system based on metabolic reprogramming, immune rejuvenation, epigenetic stability, and enhanced antioxidant capacity [4][5] - Long-term exercise significantly increases kidney betaine levels, and oral intervention with betaine in aged mice extends healthy lifespan and improves five major functional indicators: enhanced metabolic capacity, improved kidney function, better motor coordination, reduced depressive-like behavior, and improved cognitive function [5] Group 2 - The research provides important scientific evidence for promoting healthy aging, opening new pathways for scientific anti-aging research [5] - The study's findings were published in the international academic journal "Cell" on June 25 [1]

Core Viewpoint - The article discusses the molecular mechanisms underlying the health benefits of exercise and introduces betaine as a potential exercise mimetic for geroprotection, providing a new strategy for anti-aging interventions [1][3][22]. Group 1: Research Findings - The research team conducted a six-year study that systematically analyzed the molecular and cellular responses of the human body to acute and long-term exercise, identifying the kidneys as a key organ responding to exercise effects [2][11]. - Betaine was found to be a core molecular messenger for delaying aging, targeting and inhibiting the natural immune hub kinase TBK1, which helps to alleviate inflammation and slow down the aging process in multiple organs [2][15]. - The study established a multi-modal data coupling analysis framework, breaking down the complex biological responses to exercise into a quantifiable dynamic network [9][20]. Group 2: Mechanisms of Exercise-Induced Anti-Aging - The research revealed distinct effects of acute versus long-term exercise, with acute exercise triggering a "survival stress-type" metabolic storm, while long-term exercise promotes a health-oriented metabolic-immune homeostasis [11][12]. - Long-term exercise was shown to rejuvenate T lymphocytes by enhancing genomic and epigenetic stability, activating NRF2 pathways to suppress inflammatory factors, and promoting T cell survival and proliferation [12][14]. - The study demonstrated that long-term exercise significantly increases kidney betaine levels, with choline dehydrogenase (CHDH) identified as a key regulatory enzyme in this process [13][14]. Group 3: Implications of Betaine as an Exercise Mimetic - Betaine was shown to effectively simulate the benefits of long-term exercise, improving various aging-related cellular phenotypes in human diploid cells and extending healthy lifespan in aged mice [14][22]. - The study confirmed that betaine specifically binds to and inhibits TBK1 kinase activity, blocking downstream inflammatory signaling pathways, thus reducing immune cell infiltration and inflammatory factor release [15][20]. - The findings suggest that betaine could serve as a potential anti-aging alternative for elderly populations who cannot tolerate high-intensity exercise, marking a new paradigm in the development of exercise-mimicking drugs [20][22].