以下文章来源于内分泌早知道 ，作者关注内分泌的 内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展，「每医健」旗下内容平台。 办公室一族注意了！每天久坐不动又管不住嘴的你，可能正在陷入"越胖越不想动"的恶性循环。最新一期Ce ll杂志带来突破性发现：餐 桌上常见的甜菜碱（be t a i ne），竟能模拟运动效果，让懒人们坐着也能获得运动带来的三大黄金效益——加速新陈代谢、抗击慢性炎 症、延缓衰老进程！ 这项研究犹如给"运动困难户"投下一剂强心针。甜菜碱作为纯天然营养素，能巧妙激活与运动相似的代谢通路。特别适合那些"办了健 身卡却总找借口"的拖延症患者，以及因体重过重导致运动受限的肥胖人群。现在起，不用汗流浃背也能享受部分运动红利，科学"躺 瘦"时代真的要来了！ ▍ 甜菜碱：科学界发现的"运动黑科技"，躺着也能享受健身效果？ 现代人总抱怨没时间运动，但科学告诉你：或许有一种方法，能让你"不运动"却享受运动的好处！最新研究发现，甜菜碱（be t a i ne） 可能是最接近"运动模拟物"的天然成分——它能在分子层面模拟运动效果，帮你改善代谢、抗炎、抗衰老，甚至保护心脑 ...

以下文章来源于内分泌早知道 ，作者关注内分泌的 内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展，「每医健」旗下内容平台。 现代职场人长期久坐引发的健康危机日益严重：没时间运动、懒得动、直到体重失控才追悔莫及。最新发表在顶级期刊《Ce ll》上的突 破性研究带来惊喜：天然营养素甜菜碱（be t a i ne）可能成为"运动替代品"，帮助久坐人群获得类似运动的代谢改善、抗炎和抗衰老等 健康益处。这究竟是天方夜谭还是科学突破？让我们揭开甜菜碱模拟运动的神秘面纱。 ▍ 甜菜碱：揭秘"懒人运动"的科学奇迹 你是否想过，有一天不流汗也能获得运动的健康效益？最新科学研究发现，甜菜碱——一种人体内天然存在的代谢物质，可能成为真正 的"运动黑科技"。 什么是"运动模拟物"？ " 运动模拟物" 指 的 是 一类 能 通 过生化途径模 拟运动 效果的活性 成 分 。 它 的 核 心 逻 辑在 于 ： 精 准 激 活 运 动 触发的 关键信 号通路 ，让身 体"误以为"在运动，从而带来类似的代谢优化、心血管改善和肌肉强化等益处。而寻找最理想的运动模拟物，最佳线索恰恰藏在运动时 人体自身 ...

Core Insights - The industrial sector in Zigong has shown significant growth, with a year-on-year increase of 16.6% in industrial added value for the first half of the year, ranking third in the province [7] - The city is focusing on four leading industries: energy conservation and environmental protection, new energy, new materials, and drones, while also pushing for breakthroughs in three potential advantageous industries: artificial intelligence, electronic information, and health care [7] Group 1: Industrial Growth and Investment - In the first half of the year, Zigong signed 119 new projects with investments exceeding 100 million yuan, totaling 445.2 billion yuan, including 23 projects over 1 billion yuan and 4 projects over 3 billion yuan [8][11] - The city aims to sign 6 projects exceeding 3 billion yuan by the end of the year [11] - The high-tech industry saw a remarkable increase of 34.4% in added value during the same period [7] Group 2: Technological Advancements - Companies in Zigong are adopting smart manufacturing practices, with significant investments in AI and robotics, leading to increased efficiency and reduced labor costs [12][13] - The implementation of smart supply chain logistics has improved operational efficiency by over 40% in some companies [12] - Zigong is promoting the transformation of manufacturing through digital upgrades, with a 63.5% increase in technical transformation investments [13] Group 3: Business Environment and Support - The local government has streamlined processes to facilitate rapid project implementation, exemplified by a chemical materials project that received land and permits in a short timeframe [14][15] - Zigong has restructured its investment promotion departments to enhance efficiency and focus on key industries, concentrating professional talent in relevant sectors [16] - The city has launched various support services for small and medium-sized enterprises, providing over 6,500 instances of assistance in areas like financing and talent training [16]

Core Insights - The research reveals the different responses of the human body to single and long-term exercise, identifying a key "exercise-mimicking molecule" called betaine [1][2] - The study establishes that exercise can delay aging by regulating rhythm factors, promoting vascular regeneration, and suppressing systemic inflammation [1] - A significant breakthrough is the identification of the kidneys as a core organ responding to the health benefits of exercise, with long-term exercise significantly increasing betaine levels in the kidneys [2] Group 1 - The research team conducted a study involving 13 healthy male volunteers and cross-species research between mice and humans to detail the body's response to exercise [1] - Single intense exercise is characterized as a "survival stress test," leading to metabolic storms and oxidative damage, while long-term regular exercise rebalances multiple body systems [1] - Long-term exercise improves metabolism, rejuvenates the immune system, reduces inflammation, enhances antioxidant capacity, and optimizes gut microbiota [1] Group 2 - Betaine, derived from choline in the kidneys, is synthesized through a key enzyme activated post-exercise, which is crucial for its health benefits [2] - In cellular studies, betaine treatment significantly improves the aging state of various human aging cells, while in animal studies, it extends the healthy lifespan of elderly mice and improves various health metrics [2] - Betaine acts on a natural immune kinase called TBK1, inhibiting its activity and blocking pro-inflammatory signaling pathways, thereby reducing inflammation levels in tissues [2]

本报北京电(耿令令)运动作为生命活动的生物学基础，是公认高效且低成本的健康促进与抗衰干预策 略。然而，其深层分子机制尚未完全阐明。6月25日，首都医科大学宣武医院王思研究员团队联合中国 科学院动物研究所刘光慧研究员、曲静研究员、宋默识研究员及国家生物信息中心张维绮研究员团队， 在Cell杂志上就此发表了研究论文。 研究团队历时6年，首次系统解析了人体对急性单次运动与长期规律运动的分子细胞动态响应谱，揭示 肾脏是运动效应的关键应答器官——其内源代谢物甜菜碱作为衰老延缓的核心分子信使，通过靶向抑制 天然免疫枢纽激酶TBK1，协同阻遏炎症并缓解多器官衰老进程。该发现不仅为"运动即青春之泉"的古 老认知提供分子注脚，更开创了基于"运动模拟药物"实现系统性抗衰干预的全新策略。 化学生物学研究揭示，天然免疫激酶TBK1是甜菜碱的直接作用靶点。甜菜碱特异性结合TBK1并抑制其 激酶活性，进而阻断下游IRF3/NF-κB信号通路激活，抑制促炎因子表达。在感染性炎症及自然衰老的 模型中，口服甜菜碱显著降低多组织TBK1磷酸化水平，有效减少免疫细胞浸润并抑制促炎因子释放。 该研究构建了多模态时空动态分析框架，系统地揭示了"运动悖 ...

Core Insights - A Chinese research team has revealed that the kidneys are a key organ in the effects of exercise, with the metabolite betaine acting as a core molecular messenger to delay aging by targeting and inhibiting the natural immune kinase TBK1, thereby alleviating inflammation and multi-organ aging processes [1][2] Group 1: Research Findings - The research, conducted over six years, provides a systematic analysis of the molecular and cellular responses to both acute single exercise and long-term regular exercise [1] - The findings offer cross-scale and cross-species scientific evidence for the positive effects of exercise on health, supporting active health interventions for aging [1] Group 2: Implications for Health and Aging - The study introduces a new paradigm of "endogenous metabolite-mediated exercise benefits," transforming complex physiological effects into quantifiable and operable chemical language [1] - This research lays the groundwork for developing "exercise-mimicking drugs" as a new strategy for systemic aging intervention [1][2]

Group 1 - The research reveals that the kidney is a key organ responding to exercise effects, with the metabolite betaine identified as a core molecular messenger for delaying aging [1][5] - The study systematically analyzes the physiological adaptations and mechanisms of acute single exercise versus long-term regular exercise, establishing a multi-dimensional adaptive system based on metabolic reprogramming, immune rejuvenation, epigenetic stability, and enhanced antioxidant capacity [4][5] - Long-term exercise significantly increases kidney betaine levels, and oral intervention with betaine in aged mice extends healthy lifespan and improves five major functional indicators: enhanced metabolic capacity, improved kidney function, better motor coordination, reduced depressive-like behavior, and improved cognitive function [5] Group 2 - The research provides important scientific evidence for promoting healthy aging, opening new pathways for scientific anti-aging research [5] - The study's findings were published in the international academic journal "Cell" on June 25 [1]

Core Viewpoint - The article discusses the molecular mechanisms underlying the health benefits of exercise and introduces betaine as a potential exercise mimetic for geroprotection, providing a new strategy for anti-aging interventions [1][3][22]. Group 1: Research Findings - The research team conducted a six-year study that systematically analyzed the molecular and cellular responses of the human body to acute and long-term exercise, identifying the kidneys as a key organ responding to exercise effects [2][11]. - Betaine was found to be a core molecular messenger for delaying aging, targeting and inhibiting the natural immune hub kinase TBK1, which helps to alleviate inflammation and slow down the aging process in multiple organs [2][15]. - The study established a multi-modal data coupling analysis framework, breaking down the complex biological responses to exercise into a quantifiable dynamic network [9][20]. Group 2: Mechanisms of Exercise-Induced Anti-Aging - The research revealed distinct effects of acute versus long-term exercise, with acute exercise triggering a "survival stress-type" metabolic storm, while long-term exercise promotes a health-oriented metabolic-immune homeostasis [11][12]. - Long-term exercise was shown to rejuvenate T lymphocytes by enhancing genomic and epigenetic stability, activating NRF2 pathways to suppress inflammatory factors, and promoting T cell survival and proliferation [12][14]. - The study demonstrated that long-term exercise significantly increases kidney betaine levels, with choline dehydrogenase (CHDH) identified as a key regulatory enzyme in this process [13][14]. Group 3: Implications of Betaine as an Exercise Mimetic - Betaine was shown to effectively simulate the benefits of long-term exercise, improving various aging-related cellular phenotypes in human diploid cells and extending healthy lifespan in aged mice [14][22]. - The study confirmed that betaine specifically binds to and inhibits TBK1 kinase activity, blocking downstream inflammatory signaling pathways, thus reducing immune cell infiltration and inflammatory factor release [15][20]. - The findings suggest that betaine could serve as a potential anti-aging alternative for elderly populations who cannot tolerate high-intensity exercise, marking a new paradigm in the development of exercise-mimicking drugs [20][22].