Core Viewpoint - The research led by Professor Zhang Rongzhen's team has successfully developed an efficient in vitro enzyme-catalyzed system for high-level bilirubin biosynthesis, achieving a yield of 1.7 g/L and a conversion rate of 95.8%, laying a solid foundation for industrial production [2][4]. Group 1: Enzyme Optimization - The study clarified the classical two-enzyme catalytic pathway from heme to bilirubin and identified the most efficient enzyme combinations through systematic evolutionary analysis [4]. - The combination of rat HO-1 and its specific cytochrome P450 reductase (CPR) showed the highest efficiency in converting heme to biliverdin, while the rat BVR-A subtype performed best in reducing biliverdin to bilirubin [4]. - Structural analysis of key enzymes led to the development of soluble truncated variants RnCPRΔ54 and RnHO-1Δ22, which maintained substrate affinity and catalytic efficiency while improving solubility [4][5]. Group 2: Addressing Inhibitory Factors - Initial one-pot reactions showed a heme conversion rate of 83.9%, but bilirubin yield was only 48.1%, indicating material loss due to bottlenecks in the first step of heme oxygenase catalysis [5]. - The study identified Fe²⁺ as a negative factor affecting product stability, as it formed complexes with deprotonated biliverdin or bilirubin, leading to degradation [7]. - The researchers developed a dual strategy to stabilize the reaction, using HEDP to chelate Fe²⁺ and lowering the reaction pH to suppress deprotonation, which together increased bilirubin yield to 80.1% [7][8]. Group 3: Integrated Multi-Enzyme System - The research revealed carbon monoxide (CO) as another inhibitory factor, as it formed stable complexes with heme, obstructing substrate binding and enzyme activity [8]. - To eliminate all inhibitory factors, the team constructed a fully integrated multi-enzyme system, incorporating a CO dehydrogenase and a formate dehydrogenase for in situ NADPH regeneration [8]. - This integrated system successfully converted 3 mM of heme to 2.87 mM of bilirubin in a 1-liter reaction, achieving a yield of 95.8%, confirmed as the bioactive bilirubin IXα isomer [8].

站在2025年岁末，回顾中国经济这一年的表现，即便面临总需求偏弱、房地产磨底等多重挑战，其展现 出的强大"韧性"依然超出了市场预期。这种韧性不仅源于对欧洲和东南亚出口的持续增长、制造业全产 业链优势的稳固，更源于上市公司业绩的转暖与内部结构调整带来的内生动力。长城证券首席经济学家 汪毅在近日接受《每日经济新闻》记者采访时指出，中国经济已通过结构优化和创新驱动实现了新的动 能转换，并非依赖传统增长模式。 展望2026年，"十五五"规划的开局之年，中国经济正迎来意义深远的转折点。汪毅认为，我们很可能正 在跨越两个重要周期的拐点：信用扩张逻辑正从债务驱动转向有效投资支撑，房地产支柱作用减弱，而 硬科技、绿色制造等新引擎正加速接棒。随着工业品需求回暖带动企业盈利修复，2026年的资本市场将 告别"被动防御"，迈向"主动进攻"。在明确产业趋势的前提下，聚焦国家战略主赛道，优选具备技术壁 垒、市场份额提升能力与真实业绩兑现的优质标的，将成为新一年的核心投资主线。 在消费端，汪毅认为不可忽视其修复潜力。通过"投资于人"、完善社会保障等措施激发内需，是实现经 济可持续发展的关键。政策在防风险与稳增长之间将更注重平衡，以适度宽 ...

一篇公告透露出软银集团的潜在接班人。 日本科技独角兽公司Spiber发布的一份公告显示，软银集团董事长孙正义的女儿亮相其中。 根据Spiber发布的公告，其已与川名麻耶（Maya Kawana）签署业务支持相关协议。待协议生效前提条件满足后，川名麻耶将于2026年上半年开展相关 支持工作。相关支持实施后，Spiber将继续借助与川名女士业务的协同效应，追求进一步的发展与价值创造。 在公告中，川名麻耶简介赫然写着：1981年4月，作为孙正义长女出生。其他经历报2004年加入高盛日本，2008年加入青羽BBT，2017年加入Afiniti日 本分公司，2019年12月：创立BOLD株式会社（BOLD Inc.），担任首席执行官；2025年先后担任Design Future Japan和Ai ROBOTICS的外部董事。 川名麻耶强调，她选择公开个人背景，旨在明确表明她与Spiber的合作基于长期视角，而非受首次公开募股（IPO）或企业并购（M&A）等短期资本收 益驱动。这使她能够全身心投入，助力Spiber成长为全球生物创业领域的领军企业，并为实现这一目标做出深思熟虑、及时有效的决策。 川名麻耶表示，吸引她关注S ...

Core Viewpoint - The article emphasizes the importance of key core technologies as national assets, crucial for promoting high-quality economic development and ensuring national security. It advocates for enhancing the capability to tackle key core technology challenges and maintaining control over technological development to provide robust support for high-quality growth [2][3]. Group 1: Importance of Key Core Technologies - Key core technologies are essential for national security and economic development, necessitating a focused effort to overcome challenges in critical areas such as integrated circuits, industrial mother machines, high-end instruments, basic software, advanced materials, and biomanufacturing [3][4]. - Recent advancements in key core technologies include breakthroughs in 5G, Beidou navigation, high-speed rail, and nuclear power, but significant gaps remain in several critical fields that require intensified efforts for decisive breakthroughs [3][4]. Group 2: Strategies for Overcoming Challenges - Accelerating the development of a strong technological nation and modernizing China requires addressing the "bottleneck" issues in key areas, which is vital for national security and competitive advantage [4][5]. - A systematic approach to deploying key core technology initiatives is necessary, including optimizing major technological innovation organizational mechanisms and enhancing the collaboration of innovation forces, resource allocation, and talent development [4][5]. Group 3: Innovation and Research Focus - The root of the "bottleneck" technology issues lies in the inadequacy of foundational theoretical research, highlighting the need for original theoretical proposals and mastery of underlying technical principles to strengthen the foundation of technological innovation and industrial development [5]. - To build a modern industrial system, innovation chains must be aligned with industrial chains, focusing on enhancing capabilities in key areas while avoiding mere imitative innovation [5]. Group 4: Collaborative Efforts and Policy Recommendations - Forming a collaborative framework for advancing key core technology initiatives requires leveraging the advantages of a new type of national system, effectively coordinating government, market, and societal resources [5]. - Implementing extraordinary measures to strengthen goal orientation and demand-driven approaches, while enhancing collaboration among enterprises, universities, and research institutions, is essential for achieving significant technological breakthroughs [5].

Core Insights - The official launch of the Hainan Free Trade Port's full island closure operation on December 18, 2025, marks a significant milestone in China's high-level opening-up strategy and the development of the Hainan Free Trade Port [1] Institutional Developments - The full island closure will implement a new institutional arrangement of "one line open, two lines controlled, and free flow within the island," enhancing the free movement of goods, capital, personnel, and information [1] - This arrangement aims to position Hainan as a high-level open gateway for international trade, investment, and talent flow, while also providing practical experience for domestic free trade port construction [1] Policy Enhancements - The "zero tariff" policy will expand significantly to cover approximately 6,600 tax items, accounting for 74% of all goods, thereby reducing operational costs for enterprises and facilitating industrial restructuring [2] - The policy will also lower market access thresholds for all eligible market entities on the island, creating a more free and convenient production and trading environment [2] - A comprehensive policy system characterized by "zero tariffs, low tax rates, and simplified tax systems" will be optimized, including tax reductions and simplified tax administration [2] Economic and Industrial Growth - Hainan Free Trade Port aims to enhance its policy system to align with high-level free trade standards, improving trade and investment liberalization and facilitating a globally leading business environment [3] - The port will focus on optimizing its economic structure, promoting the development of tourism, modern services, high-tech industries, and tropical agriculture towards clustering and high-end directions [3] Technological Innovation - Hainan will establish a multi-level technological innovation system, focusing on key areas such as seed industry, deep sea, and aerospace, to integrate technological innovation with industrial development [4] Regional Development - The port will integrate deeply with major national regional strategies, promoting urban coordination and balanced regional development, injecting new momentum into the comprehensive development of the island [4] Environmental and Social Progress - Hainan will advance green development and ecological civilization, aiming to become an international model for ecological protection and sustainable development [5] - The port will enhance public service systems to improve residents' income and quality of life, ensuring that all citizens benefit from the development of the free trade port [5] Security and Future Industries - Hainan will strengthen risk prevention and social governance to ensure a stable environment for the construction of the free trade port, which is essential for industrial upgrades and high-quality development [5] - The port will strategically position itself in emerging industries such as biomanufacturing, hydrogen energy, and brain-computer interfaces, aiming to secure a competitive edge in global markets [5]

Core Viewpoint - Biomanufacturing is recognized as a crucial driver of the fourth industrial revolution, with significant potential for economic growth and innovation in the manufacturing sector [1][3]. Group 1: Industry Development and Achievements - Since the start of the 14th Five-Year Plan, China's biomanufacturing industry has grown to a total scale of 1.1 trillion yuan, with bioproducts accounting for over 70% of global production [2]. - The production value of food and pharmaceutical biomanufacturing segments has each exceeded 400 billion yuan, showcasing a strong competitive advantage in traditional bioproducts like vitamins and antibiotics [2]. - China has established numerous national key laboratories and innovation platforms, contributing to over 20% of global research papers and patent applications in the biomanufacturing field [2]. Group 2: Future Economic Potential - Predictions indicate that by 2050, the biomanufacturing sector could generate an economic value of 30 trillion dollars, representing one-third of global manufacturing [3]. - The Chongqing government plans to implement various measures to accelerate the development of the biomanufacturing industry, including innovation actions and the establishment of verification platforms [3]. Group 3: Technological Challenges and Needs - Despite the current industry scale, there is a significant gap in technological supply, with a need for thousands of mature technologies to support a trillion-yuan industry [4]. - Experts emphasize the necessity of enhancing national strategic technological capabilities to provide a robust foundation for the biomanufacturing sector [4][5]. Group 4: Innovation and AI Integration - The integration of artificial intelligence with biomanufacturing is emerging as a trend, potentially enhancing research efficiency and process optimization [5][6]. - There is a pressing need to upgrade the research paradigm in biomanufacturing to leverage big data and AI, addressing challenges in data quality and model construction [6][7]. Group 5: Strategic Recommendations - The industry is encouraged to focus on original innovation and tackle engineering bottlenecks, fostering collaboration between academia and industry to drive technological advancements [7]. - The Ministry of Industry and Information Technology plans to release a development plan for biomanufacturing, outlining key products and AI applications to support the sector's growth [7].

主论坛会场。 主论坛会场，参会人员在做记录。 主论坛会场，参会人员在听会。 习近平总书记指出："企业既有经济责任、法律责任，也有社会责任、道德责任""只有积极承担社会责 任的企业才是最有竞争力和生命力的企业"。 12月19日，由人民日报社经济社会部主办的2025企业社会责任论坛在陕西西安举行。中央和国家机关有 关部委负责同志、地方政府主管部门代表、企业负责人和专家学者等200余位嘉宾共聚一堂，围绕"践行 社会责任 推动高质量发展"这一主题共话新时代企业社会责任，共商高质量发展之道。 与会嘉宾表示，要深入贯彻落实习近平经济思想，贯彻落实党的二十届四中全会精神和中央经济工作会 议精神，不断引导企业将履行社会责任内化为核心价值追求和自觉行动，实现企业价值与社会价值的统 一，为以高质量发展全面推进中国式现代化注入磅礴动力。 弘扬企业家精神，展现更大的担当与作为 企业是社会主义市场经济的主体，企业履行社会责任是中国特色社会主义市场经济的生动体现。与会嘉 宾认为，多年来中国企业积极履行社会责任，实践丰富、贡献突出，新时代新征程上责任重大、要求更 高，要更好弘扬企业家精神，实现企业价值与社会价值的统一。 "AI西安之夜"活 ...

Core Viewpoint - The "Winter Investment Promotion" initiative in Keke Dara City has successfully signed 17 projects with investments exceeding 1 billion yuan, totaling 9.88 billion yuan, indicating a strong focus on attracting significant investments in various industries [1] Group 1: Investment Projects - A total of 17 projects have been signed, with 3 projects exceeding 1 billion yuan each, amounting to a total investment of 5.6 billion yuan [1] - The projects span various sectors including biomanufacturing, new energy materials, deep processing of agricultural products, and cultural tourism health [1] - Notable projects include the construction of storage tanks and a pilot research platform by Angel Yeast, boiler renovations and distillation tower construction by New Land New Materials, and a production line for 50,000 tons of rock wool [1] Group 2: Policy and Support Measures - Keke Dara City has implemented strict adherence to national "streamline administration and delegate power" reforms, expediting preliminary procedures such as energy assessments, environmental assessments, and safety evaluations [1] - A "green channel" has been established for the approval of key investment projects, optimizing processes and reducing approval times [1] - The city has enhanced its service mechanisms to create a practical and efficient investment environment, aiming to ensure the effectiveness of the "Winter Investment Promotion" [1] Group 3: Strategic Goals - The city is focused on the goals of attracting large and strong investments, promoting quality improvement and efficiency in investment attraction [1] - There is an active effort to conduct specialized promotions and comprehensively publicize the city's location advantages, resource endowments, and policy environment to attract more quality projects [1]

Core Insights - Linyi City is implementing a new "chain-based strategy" to transform its industrial landscape, focusing on 13 key industrial chains that have contributed over 95% of the city's industrial output growth from January to November this year [1][2]. Group 1: Industrial Structure and Strategy - Linyi's industrial base includes eight major sectors: food, wood, metallurgy, chemicals, machinery, pharmaceuticals, building materials, and textiles, which together account for over 80% of the city's industrial output, projected to reach 751.4 billion yuan in 2024 [2]. - The city is shifting from a traditional development model to a more precise and collaborative approach, addressing challenges such as insufficient cluster effects and low overall competitiveness [2][3]. Group 2: Organizational Mechanisms - An advanced manufacturing development command center has been established, led by top city officials, implementing a three-tiered mechanism of "chain leaders + special teams + counties" to enhance coordination and execution [3]. - The command center operates on a weekly schedule to identify issues, coordinate resources, and assess progress, fostering a strong collaborative environment for industrial development [3]. Group 3: Project and Policy Initiatives - Linyi has adopted a "three maps and six tables" approach to streamline decision-making and project management, resulting in 374 investment promotion trips and 272 signed industrial projects with a total investment of 81.62 billion yuan this year [4]. - The city is addressing key bottlenecks in the industrial chain through targeted reforms, such as reducing costs for steel and aluminum production, which collectively save companies significant amounts annually [4]. Group 4: Innovation and Branding - Linyi is establishing a "1+13+X" system of industrial technology research institutes to enhance innovation, with plans to complete four institutes by the end of the year [5]. - The city is implementing a brand-strengthening strategy, aiming to create regional and product brands, with 63 new product brands launched under the "Yimeng Good Goods" initiative [6]. Group 5: Future Outlook - The city aims to strengthen leading enterprises within the industrial chains, focusing on project execution, policy support, innovation, branding, and ecological foundations to drive future growth [7]. - Continued reforms and collaboration across financial and fiscal sectors are planned to support the development of key industrial chains, fostering a favorable industrial ecosystem [8].

中新网常州12月24日电 (记者 李雨昕)在数学里，原点是坐标轴的交汇处，是一切运算的起点。 在常州，"原点"被赋予了另一层含义：一杯咖啡、一场沙龙、一段对话……以及一座城市连接未来的方 式。 江山如画｜跨过万亿门槛，这座制造业城市再出发 一座制造业城市要向前走，往往是从一个具体的"点"开始。 常州是位于长三角核心区的一座紧凑型城市，万亿 GDP城市俱乐部中其人口规模和面积最小，也意味 着极高的产业密度与质量。 对于"万亿小城，信义常州"来说，这种"原点"显得更加重要。 当坐标原点更新，方向也随之改变。 从"+AI"到"AI+"，常州选择让人工智能(AI)向研发设计、生产制造、管理决策、运维服务等各环节延 伸，充分释放倍增效应。 位于江苏常州的新能源车辆智能制造基地生产车间内的忙碌景象。中新社记者 泱波 摄 为何常州如此迫切？ 和光战略研究院院长、焦裕禄干部学院特聘教授胡宇东指出，常州拥有不少全球"单项冠军"，但大多处 在产业链中游。它们在各自的细分领域做到极致，却往往依赖于产业链的上下游。 AI不仅仅是工具，更是一种颠覆性的改变和变革。胡宇东认为，常州正在探索一种"人工智能驱动下的 产业共同体"。通过AI打 ...