（文章来源：证券日报） 证券日报网讯科拓生物8月7日在互动平台回答投资者提问时表示，目前公司与深圳未知君生物科技有限 公司正有序推进研究开发益生菌新药项目工作，公司会根据进展情况及时进行信息披露。 ...

Group 1 - The article highlights the continuous attention on enterprises affiliated with Shanghai Jiao Tong University, driven by their "technical strength and alumni network collaboration" [1] - In July 2025, several alumni enterprises reported successful financing rounds, showcasing the innovative resilience of the Jiao Tong gene [1] - Notable alumni enterprises that completed financing include Xingnuoqi, Ouyun, and Weilizhibo [1] Group 2 - Xingnuoqi completed a Pre-IPO financing round led by Dingqing Fund, with participation from Caitong Capital and Deqing Industrial Investment, to support its smart production base in Deqing, Zhejiang [2] - Xingnuoqi is a leading domestic precision injection mold and component manufacturer, recognized as a national "specialized, refined, distinctive, and innovative" enterprise [2] - Major clients of Xingnuoqi include top international and domestic companies such as Bertly, Edex, Hitachi Astemo, BYD, Siemens, and Huaqing [2] Group 3 - Ouyun received C+ round financing from Haibang Investment in July 2025 [4] - Ouyun is a top provider of new retail, new circulation, and omnichannel digital solutions, established in 2015 and recognized as a "Shanghai Software Enterprise" and "Shanghai High-tech Enterprise" [4] - The chairman of Ouyun, Yi Jiawu, is an alumnus of Jiao Tong University and a co-founder of Yihaodian [4] Group 4 - Weilizhibo officially listed on the Hong Kong Stock Exchange on July 25, 2025, with a final IPO price of HKD 35 per share, raising a net amount of HKD 1.1793 billion [6] - On its first trading day, Weilizhibo's closing price was HKD 67.1, giving it a market capitalization of HKD 12.975 billion [6] - Weilizhibo focuses on discovering, developing, and commercializing new therapies for cancer, autoimmune diseases, and other major diseases, with 14 candidate drugs developed, 6 of which are in clinical stages [6] Group 5 - In July 2025, an additional 17 enterprises affiliated with Jiao Tong University secured financing, with amounts ranging from tens of millions to billions [12] - These enterprises span various fields, including biomedicine, artificial intelligence, advanced manufacturing, and new energy, reflecting both technological achievements and high recognition of their commercial potential [12] - Among these, 7 enterprises are part of the Jiao Tong University mother fund portfolio [12]

Market Overview - The Hong Kong stock market indices collectively rose, with the Hang Seng Index increasing by 0.68% to 24,902.53 points, the Hang Seng Tech Index up by 0.73%, and the State-Owned Enterprises Index rising by 0.65% [2] Biopharmaceutical Sector - The biopharmaceutical sector showed strong performance, with Junshi Biosciences rising over 33% following a report from CCTV on July 31, stating that the National Healthcare Security Administration supports the clinical application and pricing of new technologies like brain-computer interfaces [4] - Junshi Biosciences' stock price reached 32.180, reflecting a 33.75% increase [5] Steel Industry - The steel sector saw significant gains, with Maanshan Iron & Steel Co. rising over 15%. Despite challenges such as supply-demand imbalances, the industry is expected to maintain stable demand due to supportive policies and ongoing infrastructure investments [4] - Maanshan Iron & Steel Co.'s stock price was reported at 2.530, marking a 15.53% increase [6] Apple-Related Stocks - Apple-related stocks experienced an uptick, with BYD Electronics rising over 7%. Apple's third-quarter revenue growth was reported at 9.6%, reaching $94 billion, which is the fastest growth in nearly three years, exceeding Wall Street expectations [6] - BYD Electronics' stock price was noted at 35.420, with a 7.73% increase [7] Automotive Sector - The automotive sector faced a pullback, with NIO's stock declining over 6%. Recent sales data revealed that Leap Motor achieved over 50,000 monthly sales, while NIO delivered only 21,000 vehicles, placing it near the bottom of the sales rankings [8] - NIO's stock price was recorded at 35.700, reflecting a decrease of 6.54% [8]

Core Viewpoint - Chengdu Zeling Biopharmaceutical Technology Co., Ltd. has successfully completed nearly 400 million RMB financing to advance multiple innovative drugs into critical Phase III clinical trials and expand its R&D pipeline [1][3]. Group 1: Company Overview - Founded in 2019, Zeling Biopharmaceutical focuses on unmet medical needs, particularly in oncology, autoimmune diseases, inflammation, and neurological disorders, aiming to discover and commercialize First-in-Class (FIC) and Best-in-Class (BIC) innovative drugs [3][4]. - The company has established a comprehensive innovation platform covering the entire lifecycle of drug development, including AI molecular design, structural biology, high-throughput screening based on organoids, PDX model construction, CMC research, clinical strategy formulation, and new drug registration [3][4]. Group 2: Product Pipeline - Zeling Biopharmaceutical has developed 7 innovative products with international competitiveness, with one indication entering critical Phase III and five indications in Phase II clinical trials [4][5]. - The core product, Purinostat Mesylate (PM), is the world's first single-agent high-selectivity HDAC inhibitor for relapsed/refractory lymphoma, achieving an objective response rate (ORR) of 69.0% in Phase IIa studies, comparable to existing combination therapies [4][6]. - Another significant product, Flonoltinib Maleate (FM), shows promising efficacy as a FIC potential JAK2/FLT3/CDK6 inhibitor in myelofibrosis, with over 80% of patients achieving a ≥35% reduction in spleen volume [5][6]. Group 3: Technological Advancements - Zeling Biopharmaceutical has obtained 34 invention patents, including 17 international patents, with an additional 45 patents pending [6]. - The integration of structural biology, AI drug design, and organoid-PDX dual-track validation has created a unique end-to-end innovation engine for drug development, facilitating the rapid transition of novel drugs into clinical development [6][7]. Group 4: Future Outlook - The company aims to accelerate its international expansion, with 2025 projected as a pivotal year for global growth, as it seeks to enter overseas markets and establish a presence on the global stage for innovative drugs [7]. - Investors have shown strong confidence in the company's development strategy and research outcomes, highlighting the potential for Zeling Biopharmaceutical to emerge as a significant player in the global innovative drug market [7].

Core Viewpoint - Baiaosaitu-B (02315) reported a significant increase in revenue and profitability for the first half of 2025, driven by innovation, market expansion, and optimized management strategies [1] Financial Performance - The company expects revenue for the first half of 2025 to reach between RMB 616 million and RMB 626 million, representing a year-on-year growth of approximately 50.1% to 52.5% [1] - Research and development expenses are projected to be between RMB 206.1 million and RMB 216.1 million, reflecting a year-on-year increase of about 27.5% to 33.6% [1] - The anticipated net profit is between RMB 42.7 million and RMB 52.7 million, indicating a turnaround from losses to profitability [1] Strategic Initiatives - The company has maintained a high level of R&D investment and dynamically adjusted its R&D focus based on business development needs [1] - Baiaosaitu has strengthened its overseas market presence by expanding its sales team and improving its sales system, leading to rapid growth in international business [1] - The release of R&D demand from domestic biopharmaceutical companies has created opportunities for Baiaosaitu, particularly in preclinical products and services [1] Market Performance - The stock price of Baiaosaitu has surged nearly 300% from a low of HKD 5.6 in late November last year to HKD 21.45 as of July 28, significantly outperforming the Hang Seng Index and Hang Seng Tech Index [2] Core Technology and Business Growth - Baiaosaitu has established a strong technological barrier with its unique gene editing technology and animal model platform, focusing on over 20 key disease areas [3] - The company has developed thousands of high-value target models, serving nearly 900 pharmaceutical and research institutions globally, completing over 5,300 drug evaluation projects [3] Revenue Diversification - The antibody licensing and development business is supported by the RenMice® platform, which has created a resource library of over one million fully human antibody molecules [4] - By the end of 2024, Baiaosaitu has established around 200 cooperation agreements with various domestic and international pharmaceutical companies, with over 50 licensed projects [4] - The ongoing expansion of clinical pre-service scale and growth in antibody licensing business is expected to enhance the company's value in the innovative drug industry chain [4]

公司董事会认为公司业绩保持良好增长，主要归因于以下因素： 格隆汇8月4日丨百奥赛图-B(02315.HK)发布业绩快报，截至2025年6月30日止六个月，预计集团营业收 入约为人民币6.16亿元至人民币6.26亿元，同比增加约50.1%至52.5%；预计净利润约为人民币4270万元 至人民币5270万元，同比扭亏为盈。预计研发费用约为人民币2.061亿元至人民币2.161亿元，同比增加 约27.5%至33.6%。 (III)公司持续推进精益管理，一方面伴随业务端的变化，调整和优化管理团队，提升运营效率，管理费 用率持续下降；另一方面，通过更合理地组织公司研发和生产活动，提高研发和生产条线的人力使用效 率，从而更加高效地实现从创新研发到商业生产的转化。这些举措的持续实施，使公司盈利能力显着提 升。 (I)公司始终围绕「以创新技术驱动新药研发」的战略目标，植根中国，面向全球市场，致力於成为全球 新药发源地。公司持续保持较高的研发力度，结合自身发展节奏和发展战略，不断调整研发投入总额及 重点研发方向，持续为国内外生物医药企业提供具备全球竞争力的高品质研发产品及服务，保持业务竞 争力的同时推动业务持续快速增长； (I ...

本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容 的真实性、准确性和完整性承担个别及连带责任。 一、交易概述 上海阿拉丁生化科技股份有限公司（以下简称"阿拉丁"或"公司"）拟以增资、认购老股方式对上海雅酶 生物医药科技有限公司（以下简称"目标公司"或"雅酶生物"）进行投资，认购目标公司一定的新增注册 资本及认购老股（"本次投资"）。本次投资分两步走，第一步由公司先按14,000万元的估值向目标公司 增资2,470万元，取得目标公司增资后15%的股权；第二步由公司按16,470万元的估值受让原股东持有的 目标公司（增资后）10%的股权，股权转让总对价为1,647万元。本次投资下投资方合计出资4,117万 元。本次投资完成后，公司将持有雅酶生物25%的股权。具体内容详见公司于2025年4月23日在上海证 券交易所网站(www.sse.com.cn)披露的《上海阿拉丁生化科技股份有限公司关于自愿披露对外投资上海 雅酶生物医药科技有限公司的公告》（公告编号：2025-025）。 二、交易进展 近日，雅酶生物已完成工商登记手续，工商登记信息如下： 公司名称：上海雅酶生物医药科技 ...

证券代码：688179 证券简称：阿拉丁 公告编号：2025-053 （公告编号：2025-025）。 二、交易进展 近日，雅酶生物已完成工商登记手续，工商登记信息如下： 公司名称：上海雅酶生物医药科技有限公司 转债代码：118006 转债简称：阿拉转债 上海阿拉丁生化科技股份有限公司 关于对外投资上海雅酶生物医药科技有限公司的进 展暨完成工商登记的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 一、交易概述 上海阿拉丁生化科技股份有限公司（以下简称"阿拉丁"或"公司"）拟以 增资、认购老股方式对上海雅酶生物医药科技有限公司（以下简称"目标公司" 或"雅酶生物"）进行投资，认购目标公司一定的新增注册资本及认购老股（"本 次投资"）。本次投资分两步走，第一步由公司先按 14,000 万元的估值向目标公 司增资 2,470 万元，取得目标公司增资后 15%的股权；第二步由公司按 16,470 万元的估值受让原股东持有的目标公司（增资后）10%的股权，股权转让总对价 为 1,647 万元。本次投资下投资方合计出资 4,1 ...

Market Overview - The Hong Kong stock market saw all three major indices decline, with the Hang Seng Index dropping by 1.36% and the Hang Seng Tech Index falling by 2.72%[3] - Southbound capital recorded a net inflow of HKD 11.714 billion into Hong Kong stocks[9] - Major tech stocks like Alibaba and JD.com experienced widespread declines, contributing to the overall market downturn[9] Sector Performance - The automotive sector faced challenges, with July retail sales of narrow passenger cars expected to decline by over 11% month-on-month, leading to a nearly 13% drop in Li Auto's stock price[9] - Semiconductor stocks remained sluggish, with SMIC's shares falling nearly 6% due to market sentiment affected by local industry chain concerns[9] - Biopharmaceutical stocks, which had been rising, saw a pullback, with notable declines in companies like CloudTop and Zai Lab, while CSPC Pharmaceutical rose over 2% after announcing a significant licensing agreement[9] Global Market Trends - In the U.S., the Federal Reserve maintained interest rates at 4.25%-4.50%, marking the fifth consecutive meeting without a change, which aligns with market expectations[12] - The Dow Jones Industrial Average closed down, while tech stocks showed mixed results, with Nvidia rising over 2% after a price target upgrade from Morgan Stanley[9] - Geopolitical tensions led to a rebound in international oil prices, with PetroChina and Sinopec stocks rising by nearly 4% and 3%, respectively[9] Economic Indicators - The U.S. ADP employment report indicated an increase of 104,000 jobs in July, while the second-quarter GDP growth rate was revised to an annualized 3%, both exceeding expectations[12] - Japan's Nikkei 225 index experienced a slight decline of 0.05%, with machinery stocks showing notable gains[12] - The IMF suggested that Japan's central bank may adopt a gradual interest rate hike path, reflecting a shift in economic policy outlook[12]

Market Overview - The Hong Kong stock market showed mixed results with the Hang Seng Index down by 1.07% to 24,906.39 points, while the Hang Seng Tech Index increased by 0.34% and the National Enterprises Index fell by 1.03% [2] Key Stock Movements - Kuaishou saw a significant increase of nearly 9%, while Bilibili rose over 2%. Conversely, Meituan and Xiaomi both dropped over 2%, and JD.com also experienced a decline [2] - AI-related stocks performed well, with Meitu rising over 15%. Oriental Securities expressed optimism about user growth and commercialization of vertical AI products in the second half of the year, particularly for companies with overseas AI applications [2] - Biopharmaceutical B-shares were active, with Lepu Biopharma increasing over 4%. The National Healthcare Security Administration discussed support for innovative drug development with Singapore's GIC [3][4] Gold and Real Estate Sector Performance - Gold stocks continued to decline, with Tongguan Gold dropping over 8%. Recent trends indicate a shift in investor sentiment away from gold towards stocks, as gold prices fell below $3,270 per ounce [4][5] - The real estate sector faced significant declines, with Country Garden falling over 6%. A recent meeting of the Central Political Bureau highlighted limited focus on real estate, emphasizing the need for high-quality urban renewal [6][7]