普瑞巴林
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“成瘾永远只是冰山一角”,为了“不用面对现实”,他们开始滥用普瑞巴林
Xin Jing Bao· 2025-12-26 00:12
新京报记者 李聪 编辑 陈晓舒 校对 李立军 在经历两次住院之后,林可决定戒断普瑞巴林。 这是一款原本用于治疗神经性疼痛的处方药。她曾一次性吞下二十多片普瑞巴林,试图用药物迅速压住体内的焦虑、恐惧和失控感——"让自己暂时不用 面对现实"。 随后,她被送进急诊。凌晨两点,林可躺在病房的床上,盯着天花板,已经七十多个小时没有合眼。这是林可今年夏天第二次因为滥用普瑞巴林住院,距 离上一次,只隔了一个月。第一次是在8月,她的心率飙升到每分钟150次,晕倒在路上被室友送进急诊,那次也吃了二十几片。 此前,林可还过量服用右美沙芬等多种药物。后来,右美沙芬被列管、购买变得困难,普瑞巴林成为"替代品"。 林可的经历并非个案。近段时间,我国陆续出现普瑞巴林滥用的病例报告。2025年3月,湖南省脑科医院在国际期刊《精神病学前沿》发表一则病例报 告,记录了一名患者在长期、大剂量滥用普瑞巴林后形成依赖。其中提到,此前,中国尚未报告过普瑞巴林依赖病例。 2025年4月,《中国药物依赖性杂志》发表一则由山东省药品不良反应监测中心报告的病例,一位既往有滥用右美沙芬病史的未成年患者,在右美沙芬列 管后,开始使用其他药物替代滥用,其中普瑞巴林 ...
右美沙芬被禁后 他们开始滥用普瑞巴林
Xin Lang Cai Jing· 2025-12-25 17:24
(来源:千龙网) 在经历两次住院之后,林可决定戒断普瑞巴林。 这是一款原本用于治疗神经性疼痛的处方药。她曾一次性吞下20多片普瑞巴林,试图用药物迅速压住体 内的焦虑、恐惧和失控感——"让自己暂时不用面对现实"。 随后,她被送进急诊。凌晨两点,林可躺在病房的床上,盯着天花板,已经70多个小时没有合眼。这是 林可今年夏天第二次因为滥用普瑞巴林住院,距离上一次,只隔了一个月。第一次是在8月,她的心率 飙升到每分钟150次,晕倒在路上被室友送进急诊,那次也吃了20几片。 此前,林可还过量服用右美沙芬等多种药物。后来,右美沙芬被列管,购买变得困难,普瑞巴林成 为"替代品"。 林可的经历并非个案。近段时间,我国陆续出现普瑞巴林滥用的病例报告。2025年3月,湖南省脑科医 院在国际期刊《精神病学前沿》发表一则病例报告,记录了一名患者在长期、大剂量滥用普瑞巴林后形 成依赖。其中提到,此前,中国尚未报告过普瑞巴林依赖病例。 2025年4月,《中国药物依赖性杂志》发表一则由山东省药品不良反应监测中心报告的病例,一位既往 有滥用右美沙芬病史的未成年患者,在右美沙芬列管后,开始使用其他药物替代滥用,其中普瑞巴林获 得最为便利,替代使 ...
用错或耽误病情!专家提醒:止痛药不能随意吃
Sou Hu Cai Jing· 2025-12-20 06:37
北京大学第三医院主任医师 李水清:要根据不同的病因使用相应的止痛药物,像肌肉关节来源的疼 痛,可以使用非甾体抗炎药,如塞来昔布。对于带状疱疹引起的神经痛,可以用普瑞巴林等这类治疗神 经痛的药物。 (央视财经《第一时间》)生活中,很多人在头痛、关节痛时,选择吃片止痛药来缓解。对此,专家发 出提醒:止痛药不能随意吃、长期吃。 专家介绍,常见止痛药的作用是控制疼痛症状,没办法消除引发疼痛的病因。如果长期乱吃止痛药,可 能会把身体的真实病情掩盖住,错过最佳的治疗时机。不过,针对癌痛患者,长期规范地使用止痛药, 是可以有效缓解疼痛、提升生活质量的。 北京大学第三医院主任医师 李水清:像突然出现的剧烈头痛,或者头痛的时候伴随发烧、恶心、呕 吐、意识不清、手脚麻木等这些情况,需要及时就医。另外,如果头痛的性质、部位和规律发生改变, 也一定要及时到医院就医,避免延误病情。 转载请注明央视财经 编辑:孙艺璇 很多人担心吃止痛药会上瘾,专家也对此进行了澄清:止痛药的成瘾性主要和阿片类止痛药的长期使用 有关,比如吗啡、羟考酮,这类药物国家有严格的管理规定,必须在医生指导下规范使用。而平时头 疼、关节痛常用的对乙酰氨基酚、布洛芬、塞 ...
止痛药上瘾?国家卫健委答21:不能长期任意吃,以下药合理使用
2 1 Shi Ji Jing Ji Bao Dao· 2025-12-19 11:52
(原标题:止痛药上瘾?国家卫健委答21:不能长期任意吃,以下药合理使用) 北京大学第三医院主任医师李水清回应,止痛药不能长期任意吃。原因有以下几条:因为有一些止痛药 主要是控制症状,并不能消除病因,长期止痛药的使用,可能在某种程度上会掩盖病情,耽误治疗。当 然,对于一些癌痛的患者来讲,长期规范的药物使用可以缓解疼痛,提高他们的生活质量。另外,针对 不同的疼痛来讲,要根据不同的病因来使用相应止痛药物,像肌肉关节的疼痛,可以使用非甾体抗炎 药,像塞来昔布、双氯酚酸钠等。对于带状疱疹引起的神经痛,可以用普瑞巴林、克利加巴林等这类治 疗神经痛的药物。 另外,止痛药长期使用会不会上瘾。这主要是指一些阿片类的止痛药,像吗啡、羟考酮,长期使用可能 会有上瘾的问题。但是我们国家针对这一类型的药物有非常严格的管理制度,另外在医院里面,如果按 照医生的指导来规范使用的话,成瘾性就会大大降低。像日常用到的布洛芬、塞来昔布、对乙酰氨基酚 等这些非甾体抗炎药,一般没有成瘾的问题,但是剂量加大的话,疗效不会增加,副作用会增加,这方 面要引起重视。 关于头痛的问题,李水清举例说,像有些偏头痛如果反复发作,诱因比较明确的话,比如一些患者睡眠 ...
一头痛、关节痛就吃止痛药?专家建议
Ren Min Wang· 2025-12-19 10:33
止痛药长期使用会不会上瘾?李水清说,这主要是指一些阿片类的止痛药,像吗啡、羟考酮,长期 使用可能会有上瘾的问题。我国针对这一类型的药物有非常严格的管理制度,在医院,如果按照医生的 指导来规范使用的话,成瘾性就会大大降低。日常用到的布洛芬、塞来昔布、对乙酰氨基酚等这些非甾 体抗炎药,一般没有成瘾的问题,但是剂量加大的话,疗效不会增加,副作用会增加,这方面要引起重 视。 关于头痛的问题,李水清说,像有些偏头痛如果反复发作,诱因比较明确的话,比如一些患者睡眠 不足、睡眠过度,或者吃了一些特殊食物以后会诱发,找到并避开这些诱因可以减少偏头痛的发作。但 是有一些头痛不仅让人感到非常痛苦,而且它是身体发出的求救的信号,像突然出现的剧烈头痛,或者 头痛的时候伴随发烧、恶心、呕吐、意识不清、手脚麻木等等这些情况,就需要及时就医。另外,如果 头痛的性质、部位和频率发生改变,也一定要及时到医院来就医,避免延误病情。 人民网北京12月19日电 (记者乔业琼)生活中,不少人遇到过疼痛的困扰。有的人一头痛、关节 痛就吃止痛药。而有的人认为"头痛扛一扛就过去",也有人认为"经常吃止痛药会上瘾"。在国家卫生健 康委今日召开的新闻发布会上, ...
太龙药业:拟向特定对象增发募资不超过约4.54亿元
Mei Ri Jing Ji Xin Wen· 2025-12-08 10:23
每经AI快讯,太龙药业(SH 600222,收盘价:8.58元)12月8日晚间发布公告称,本次向特定对象发行 A股股票相关事项已经公司第十届董事会第五次会议审议通过。本次向特定对象发行A股股票的发行对 象为江药控股,本次向特定对象发行A股股票的数量不超过约7461万股(含本数),占本次向特定对象 发行前公司总股本的13%,不超过本次发行前上市公司总股本的30%,最终发行数量在上交所审核、中 国证监会注册范围内,与本次发行的保荐机构(主承销商)在满足相关法律法规的前提下协商确定。发 行价格为6.09元/股。本次发行拟募集不超过约4.54亿元,扣除发行费用后,用于补充流动资金和偿还有 息负债。 2025年1至6月份,太龙药业的营业收入构成为:医药制造业占比70.59%,医药研发占比14.71%,医药 流通占比14.42%,其他业务占比0.28%。 截至发稿,太龙药业市值为49亿元。 每经头条(nbdtoutiao)——处方药变"瘾品":国内首次报告普瑞巴林滥用致成瘾病例,网络平台暴 露"无病历可购药"漏洞,列管与否尚需科学考量 (记者 王晓波) ...
处方药变“瘾品”:国内首次报告普瑞巴林滥用致成瘾病例,网络平台暴露“无病历可购药”漏洞,列管与否尚需科学考量
Mei Ri Jing Ji Xin Wen· 2025-12-08 07:51
每经记者|岳楚鹏 兰素英 每经编辑|高涵 一位20岁患者,因追求欣快感,每日服用80粒普瑞巴林。 一位30岁成瘾者,为改善睡眠和情绪,单次服用普瑞巴林剂量达4800毫克。 2025年3月和7月,湖南、上海分别报告了一例普瑞巴林滥用致成瘾病例,前者为国内首次。 但这并非个案。临床医生发现,越来越多的药物成瘾者,尤其是青少年,正通过网络购买普瑞巴林。而线上药店无需真实病历即可开处方,让这款处方药 轻易流入滥用群体手中。 《每日经济新闻》记者(以下简称每经记者)通过调查和多方采访,试图揭开普瑞巴林滥用的现状与风险。 0:00 / 4:33 国内首次报告普瑞巴林滥用致成瘾病例 普瑞巴林(原研药商品名乐瑞卡,Lyrica),是美国辉瑞研发的一款治疗癫痫、神经性疼痛和纤维肌痛的处方药,于2004年获得美国食品药品监督管理局 批准,并于2010年7月引入国内,现由晖致(辉瑞旗下Upjohn与仿制药企业Mylan合并而成)生产。 图片来源:视觉中国 2018年乐瑞卡专利到期后,国内多家厂商申请仿制。每经记者查询国家药品监督管理局官网发现,截至目前有超过50家国内厂商的普瑞巴林胶囊、缓释片 和口服液上市。 2025年3月,湖南 ...
处方药滥用亟须“踩刹车”
Zhong Guo Qing Nian Bao· 2025-11-25 01:47
Core Viewpoint - The article highlights the rising trend of prescription drug abuse among young people, particularly focusing on the misuse of Pregabalin (referred to as "Pr80") for recreational purposes, and the challenges in regulating its distribution and use [1][2]. Group 1: Drug Misuse and Experiences - Young individuals are increasingly sharing their experiences of abusing Pregabalin on social media, indicating a normalization of this behavior [1][3]. - Users report starting with small doses out of curiosity, but many quickly escalate their intake, leading to dependency and adverse effects [4][7]. - Some individuals have shared extreme cases of overdose, with one user claiming to have taken 47 capsules at once, showcasing the severity of the issue [9]. Group 2: Accessibility and Regulation - Pregabalin, although a prescription medication, is often obtained through online platforms without proper medical oversight, raising concerns about regulatory effectiveness [10][13]. - Despite regulations requiring prescriptions for purchase, users have found ways to circumvent these rules by misrepresenting their conditions [14][15]. - The article notes that while some pharmacies enforce prescription requirements, others do not, leading to inconsistent access to the drug [11][12]. Group 3: Health Risks and Consequences - Medical professionals warn that excessive use of Pregabalin can lead to serious health issues, including central nervous system reactions, addiction, and potentially life-threatening conditions [16]. - Symptoms of overdose can include drowsiness, dizziness, hallucinations, and in severe cases, coma or respiratory failure [16]. - The article emphasizes the importance of professional medical guidance when using such medications, particularly for non-therapeutic purposes [16]. Group 4: Prevention and Intervention Strategies - Experts suggest a shift in approach from merely prohibiting drug use to implementing comprehensive prevention, education, and support mechanisms [19][20]. - Recommendations include enhancing public awareness about the risks of drug misuse, improving mental health services, and optimizing prescription monitoring systems [20]. - The article calls for a collaborative effort among various sectors to address the issue of prescription drug abuse effectively [20].
世界镇痛日:“记忆痛”需要规范治疗
Xin Hua She· 2025-10-20 11:38
Core Insights - The article discusses "memory pain," a condition that can arise after the healing of shingles, known as postherpetic neuralgia (PHN) [1][2][3] Group 1: Understanding Memory Pain - Memory pain can begin 1 to 3 months after shingles has healed, despite the virus being cleared by the immune system [1] - The damage to the nerves caused by shingles leads the brain to misinterpret normal sensations as pain, resulting in various pain types such as sharp, burning, and allodynia [1] Group 2: Risk Factors and Prevention - Individuals over 60 years old, those with severe acute rashes, and those experiencing intense pain during the acute phase are at higher risk for developing PHN [1] - The optimal time to prevent PHN is during the acute phase of shingles, where early and adequate antiviral treatment within 72 hours is crucial [1][2] Group 3: Treatment Approaches - For chronic pain, a combination of oral medications like gabapentin and pregabalin, as well as topical treatments like lidocaine patches, can be effective [2] - If medication is insufficient, minimally invasive interventions such as nerve block therapy can be employed to directly target the damaged nerves [2]
美诺华: 宁波美诺华药业股份有限公司2025年半年度报告
Zheng Quan Zhi Xing· 2025-08-26 16:24
Core Viewpoint - The report highlights the financial performance and growth potential of Ningbo Menovo Pharmaceutical Co., Ltd. for the first half of 2025, showcasing significant increases in revenue and net profit, alongside strategic developments in the pharmaceutical industry [1][3]. Financial Performance - The company achieved a revenue of approximately 677.33 million yuan, representing an 11.42% increase compared to the same period last year [3]. - The total profit reached approximately 60.30 million yuan, marking a substantial increase of 117.00% year-on-year [3]. - The net profit attributable to shareholders was approximately 49.06 million yuan, reflecting a remarkable growth of 158.97% compared to the previous year [3]. - The net cash flow from operating activities was negative at approximately -6.93 million yuan, an improvement from -44.47 million yuan in the previous year [3]. Industry Overview - The global pharmaceutical market is projected to reach a size of 1.9 trillion USD by 2027, driven by economic growth, aging populations, and increasing health demands [5]. - The CDMO (Contract Development and Manufacturing Organization) market is expected to grow significantly, with a forecasted size of 124.3 billion USD by 2025 and 231 billion USD by 2030, reflecting a compound annual growth rate of 13.2% [5][6]. - The Chinese CDMO industry is anticipated to reach a market size of 104.88 billion yuan by 2024, with a continued growth trend into 2025 [6]. Business Strategy - The company focuses on a vertical integration strategy encompassing pharmaceutical intermediates, active pharmaceutical ingredients (APIs), and formulations, aiming to enhance its competitive edge in the market [11][20]. - The company has established long-term partnerships with renowned pharmaceutical firms, enhancing its market presence and operational stability [10][11]. - The company is actively expanding its CDMO services, aiming to create a comprehensive service platform to support future growth [11]. Innovation and Development - The company is committed to technological innovation, with ongoing projects in continuous flow, enzyme catalysis, and automation to improve efficiency and reduce costs [16][17]. - The company has a robust pipeline of over 50 formulation projects, with several products already approved for market entry [14]. - The company is also exploring new therapeutic areas, including weight management and metabolic health, to diversify its product offerings [13]. Regulatory Environment - The regulatory landscape is evolving, with policies aimed at enhancing drug quality and innovation, which is expected to benefit the pharmaceutical industry in the long term [9][8]. - The company has successfully passed multiple audits and inspections from international regulatory bodies, ensuring compliance with global quality standards [20]. Market Position - The company is recognized as one of the top pharmaceutical manufacturers in China, with a strong reputation for quality and reliability in the production of specialty APIs and formulations [11][20]. - The company is strategically positioned to leverage the growing demand for high-quality generic and innovative drugs in both domestic and international markets [11].