展望后市，创新药板块仍以交易BD预期为主，BD重新落地预计仍是刺激板块重新修复的关键。根据数 据统计每年四季度BD占比约占全年40%，此外大单品等仍具有预期。 科创创新药ETF国泰（589720）聚焦科创板创新药企业，跟踪汇聚30家代表性优质公司的上证科创板创 新药指数，以高成长biotech为主，产品20%涨跌幅限制使其更贴合板块波动。 （文章来源：每日经济新闻） 创新药指数盘中震荡下行，科创创新药ETF（589720）跌超3%，资金逢低买入，近10日净流入额超1.1 亿元，盘中溢价交易。 近两个月，创新药板块接连调整，经历大幅调整后，创新药板块的布局性价比逐渐显现。招银国际表 示，近期，医药板块略有回调，这将带来抄底机会：由于资本市场融资复苏、创新药出海交易规模上 涨，国内创新药研发需求出现回暖。叠加美国降息，CXO行业有望迎来业绩修复。 ...

每经编辑｜彭水萍 10月31日，A股震荡走低，前期强势的科技龙头股普遍回调，小盘股迎来反弹行情，市场逾3700股上涨。上证指数收跌0.81%报3954.79点，深证成指跌 1.14%，创业板指跌2.31%，北证50涨1.89%，科创50跌3.13%，万得全A跌0.52%，万得A500跌1.4%，中证A500跌1.24%。A股全天成交2.35万亿元，上日成 交2.46万亿元。 科创创新药ETF（589720）单日涨幅达7.27% 2.中期看临床里程碑：下一个关键节点将是这些进入全球后期临床的产品的数据读出，成功的"头对头"数据有望带动管线估值上修，或有望成为价值再次飞 跃的催化剂. 一、上涨驱动因素分析 消息面上，2025年10月31日，辉瑞正式登记启动三生制药旗下PD-1/VEGF双抗（代号：707）的两项全球多中心III期临床研究，针对非小细胞肺癌和结直肠 癌的一线治疗，并采用"头对头"设计直接挑战当前标准疗法（K药和贝伐珠单抗），本次两项III期是辉瑞为SSGJ707开启的首两个临床。本次事件的深远意 义在于，代表了中国创新药出海模式从"授权转让（License-out）"向"全球MNC巨头主导并投入重金 ...

Group 1 - The current hot topics in innovative drugs are bispecific antibodies (双抗) and antibody-drug conjugates (ADC), which are favored by overseas investors [1] - AI development, AI healthcare, and gene therapy are expected to gain popularity in the future, although they are still in early stages compared to ADC and bispecific antibodies [1] - The current leading companies in innovative drug licensing are primarily those focused on bispecific antibodies and ADCs [1] Group 2 - The performance of innovative drugs varies across different markets, with Hong Kong stocks performing well initially, followed by the STAR Market, while A-shares lagged behind [2] - A-shares' slower performance is attributed to many companies transitioning from traditional chemical drugs to innovative drug businesses, resulting in less elasticity compared to pure innovative drug companies [2] - Investors seeking stability can consider pure A-share innovative drugs or a combination of Shanghai, Shenzhen, and Hong Kong innovative drug ETFs [2] Group 3 - There is significant differentiation within the pharmaceutical sector, including biological drugs, chemical drugs, traditional Chinese medicine, medical devices, and medical services [3] - The innovative drug sector can be further divided into chemical innovative drugs and biological innovative drugs, with many investors lacking clarity on these distinctions [3] - For investors who recognize the trend in innovative drugs, it is recommended to invest through funds or ETFs to capture the development of this trend [3] Group 4 - Various indices related to innovative drugs have corresponding products, such as the STAR Market innovative drug ETF and the Shanghai-Shenzhen-Hong Kong innovative drug ETF [4] - Investors can choose based on their preferences, whether they prefer pure A-share innovative drugs or Hong Kong and STAR Market options [4] - It is important for investors to manage their risk tolerance and prepare psychologically for market fluctuations [4]

Core Viewpoint - The key driving factors for the innovative drug market this year can be summarized as "policy support + performance realization + risk appetite" [1] Performance Realization - The basic premise for performance realization is the surge in licensing transactions, known as BD, where innovative drug companies sell their intellectual property, creating significant potential for future performance release [1] - The supply-demand relationship is driven by the "patent cliff" faced by large pharmaceutical companies in the U.S., where the expiration of patents leads to a surge in generic drugs, causing a sharp decline in revenues for these companies [1][2] - Chinese biopharmaceutical companies have accumulated a wealth of innovative drug patents since 2016, which can be sold to U.S. companies, forming a complementary supply-demand relationship [2] - Many innovative drugs are not sold domestically due to high R&D costs and initial high prices, leading companies to sell their intellectual property to recover initial investments [2] Policy Support - Two significant policies are highlighted: the inclusion of 37 expensive innovative drugs into commercial insurance, which may eventually lead to inclusion in national insurance, and the expedited review and approval process for clinical trials, reducing the timeline to 30 working days [3] - These policies are expected to shorten the R&D cycle for pharmaceutical companies, allowing for quicker capital recovery and potentially extending the lifecycle of their products [3] Risk Appetite - The stock market has shown a "slow bull" trend since mid-June, which has positively influenced the risk appetite for the innovative drug sector [3][4] - The innovative drug index has seen a 98% increase this year, with the sustained risk appetite contributing to the continuation of this trend [4] Investment Opportunities - Current main areas for BD licensing include dual antibodies and ADC, while AI drug development and gene therapy are seen as potential hotspots [4] - Investors are advised to consider ETFs for exposure, with options for high elasticity or stable investments available [4]

Group 1 - The innovative drug sector is experiencing a strong surge, driven by the wave of BD (business development) going overseas, with the related ETF (589720) rising over 2% during trading [1] - The BD boom is a significant catalyst for the explosive growth of China's innovative drug market, with license-out transactions doubling year-on-year since 2025 [3] - Recently, major pharmaceutical companies have reached important licensing agreements, such as Heng Rui Pharma granting GSK exclusive global rights for PDE3/4 inhibitor HRS-9821, with an upfront payment of $500 million and potential milestone payments totaling around $12 billion [3] Group 2 - The application of AI in the pharmaceutical sector is igniting market sentiment, with expectations that AI will enhance the overall valuation of innovative drugs by improving R&D efficiency and reducing costs [4] - The innovative drug industry is poised for significant growth due to continuous breakthroughs in international markets, ongoing policy benefits, and the steady improvement of R&D capabilities among Chinese innovative drug companies [4] - Investors looking to capitalize on the high growth potential and internationalization opportunities in the innovative drug sector are encouraged to pay attention to the Guotai Innovative Drug ETF (589720) [4]