（原标题：数贸"引擎"与全链服务新机 驱动"武汉制造"货通全球） 11月21日下午，作为本届汉交会的重要配套活动，2025数字贸易暨跨境电商产业对接活动在汉成功举 办。本次活动以"数智赋能 助企出海"为主题，由武汉市商务局主办、武汉市跨境电子商务协会承办， 活动吸引30余家全球跨境电商知名平台、优质服务商及200余家企业参会交流。 武汉音石网络科技有限公司是一家员工平均年龄不到30岁的年轻公司，主要从事跨境高品质补剂的进 口。"来自美国、澳大利亚等地的蛋白粉、肌酸等，通过空运的方式直达湖北花湖机场，并依托武汉东 湖综保区保税仓储政策与区位优势，以更加实惠的价格送到国内消费者手中。"该公司新媒体运营总监 范倬良告诉记者，这次参加汉交会有助于帮助公司获得更大曝光量，让更多的消费者了解他们的产品。 武汉市商务局负责人介绍，下一步将坚持"线上线下"融合发展，打好"政策+平台+服务"组合拳，在优化 政策环境上持续加力，在提升服务效能上精准发力，在构建产业生态上协同聚力，为企业在汉发展提供 全方位服务保障，推动数字贸易、跨境电商高质量发展，为建设现代化大武汉、打造内陆开放高地提供 有力支撑。 今年10月，党的二十届四中全 ...

Core Insights - The U.S. is the largest consumer market globally, accounting for 24% of global retail sales in 2023, with stable growth in personal consumption expenditure and a rebound in consumer confidence [1][5][7] - E-commerce is thriving, with 255 million online shoppers in 2023, projected to reach 316 million by 2028, representing a 67.3% increase since 2019 [1][22] - Five key trends for the U.S. consumer market in 2024 include diverse demand scenarios, multi-channel shopping experiences, varied pricing strategies focusing on emotional value, rapid trend iterations, and diverse marketing opportunities [1][4][28] Group 1: Market Overview - The U.S. retail market remains robust, holding nearly a quarter of the global market share and continuing to grow steadily [5][7] - Personal consumption expenditure has shown consistent growth, supported by rising disposable income, indicating sustainable consumer power [7][8] - Consumer confidence is on the rise, with the University of Michigan's consumer confidence index reaching 79 in January 2024, a 13% increase from the previous year [9][11] Group 2: E-commerce Growth - The e-commerce market is experiencing significant growth, with 75% of the U.S. population shopping online in 2023 [1][22] - Social commerce is expected to see substantial growth, with 110 million users projected in 2024, making up 42% of internet users [1][22] - By 2025, U.S. social commerce retail sales are anticipated to exceed $100 billion, with per capita spending in social commerce expected to double from 2023 to 2027 [22] Group 3: Consumer Trends for 2024 - Demand scenarios are diversifying, with a rise in slow living, family activities, outdoor pursuits, and sports, driving new consumption needs [1][28][33] - Multi-channel shopping experiences are becoming essential, as consumers seek rich and varied shopping interactions [1][28][80] - Pricing strategies are evolving, with consumers placing greater emphasis on emotional value, allowing businesses to introduce high-margin products [1][28][29] Group 4: Marketing and Social Media Influence - TikTok is emerging as a key platform for global digital marketing, providing integrated solutions for businesses to tap into local markets and seize opportunities [1][28][59] - The marketing landscape is shifting towards diverse touchpoints, with brands needing to leverage various marketing moments effectively [1][28][29] - The rise of lifestyle marketing on platforms like TikTok is crucial for brands to connect with consumers and promote products in relatable contexts [1][28][63]

Core Viewpoint - Creatine plays a crucial role in energy metabolism within muscle and brain tissues, acting as an energy buffer, particularly during high-intensity neuronal activity. The genetic mutation of the creatine transporter protein (CRT) leads to X-linked creatine transporter deficiency (CTD), which currently lacks effective treatment options. A compound in phase II clinical trials, RGX-202, inhibits CRT's function, inducing apoptosis in tumor cells and suppressing colorectal cancer growth [2][6]. Group 1 - The study published in Cell Discovery details the cryo-electron microscopy structure of human CRT in various states, elucidating the molecular mechanisms of substrate and inhibitor recognition [3][6]. - The research team utilized molecular dynamics simulations and functional experiments to explore the impact of pathogenic mutations on CRT function and cellular localization [3][6]. - The findings provide a theoretical basis and structural foundation for the future development of therapeutic drugs targeting CTD [6]. Group 2 - The study reveals that creatine binds to CRT in an outward-open conformation, undergoing a conformational change in the presence of Na+ and Cl- to an inward-closed state, ultimately releasing creatine into the cytoplasm [5][6]. - RGX-202 inhibits CRT function by directly competing for the creatine binding site, highlighting its mechanism of action [5][6]. - The research was supported by various funding sources, including the Shanghai Municipal Basic Research and the Shanghai Aging Research Key Laboratory [6].