东吴证券发布研报称，维持康宁杰瑞制药-B(09966)"买入"评级，考虑到2025年公司有多款ADC新管线 完成临床前研发，该行提高了对研发费用的预测水平，相应影响归母净利润水平，2025-2026年归母净 利润分别下调为-1.15/-0.97亿元，原值为0.14/0.63亿元，新增2027年归母净利润预测为-0.26亿元。随着 公司后续产品KN026有望国内上市，JSKN003也即将申报上市，该行预计未来公司亏损将逐步缩小。同 时基于公司后备管线的逐步进入临床阶段，公司研发能力进入良性发展循环。 自研平台持续发力，多款新ADC分子即将进入临床 公司自研的技术平台持续产出新管线，在PD-L1靶点管线中，PD-L1/ITGB6/8多功能ADCJSKN022展现 出优于单抗ADC的内吞效率和体内外杀伤活性，该管线目前已经在2025年10月启动了I期临床。PD- L1/VEGFR2双抗ADCJSKN027整合了细胞毒杀伤、抗血管及免疫调节三重机制，公司在2025年12月已 经向中国药监局提交IND申请并获得受理，2026年有望开展针对JSKN027的I期临床研究。后续还有 EGFR/HER3双抗双载荷ADCJSKN ...

智通财经APP获悉，东吴证券发布研报称，维持康宁杰瑞制药-B(09966)"买入"评级，考虑到2025年公司 有多款ADC新管线完成临床前研发，该行提高了对研发费用的预测水平，相应影响归母净利润水平， 2025-2026年归母净利润分别下调为-1.15/-0.97亿元，原值为0.14/0.63亿元，新增2027年归母净利润预测 为-0.26亿元。随着公司后续产品KN026有望国内上市，JSKN003也即将申报上市，该行预计未来公司亏 损将逐步缩小。同时基于公司后备管线的逐步进入临床阶段，公司研发能力进入良性发展循环。 东吴证券主要观点如下： 多款核心管线催化剂密集，KN026已提交上市申请 KN026是公司开发的HER2双表位单抗，其核心适应症之一的联合化疗治疗2L及以上胃癌目前已经获得 NMPA受理，该行预计2026年年底或2027年有望获批上市。公司已经将该产品的国内权益授予石药集 团，未来上市后石药集团将负责相关商业化工作，公司将保留KN026的独家生产权，为石药集团提供产 品。除此之外KN026的乳腺癌1L治疗和新辅助治疗的方案也有望在2026年提交上市申请。 自研平台持续发力，多款新ADC分子即将进 ...

机构：东吴证券 研究员：朱国广/邹行健 考虑到2025 年公司有多款ADC 新管线完成临床前研发，我们提高了对研发费用的预测水平，相应影响 归母净利润水平，2025-2026 年归母净利润分别下调为-1.15/-0.97 亿元，原值为0.14/0.63 亿元，新增 2027年归母净利润预测为-0.26 亿元。随着公司后续产品KN026 有望国内上市，JSKN003 也即将申报上 市，我们预计未来公司亏损将逐步缩小。 多款核心管线催化剂密集，KN026 已提交上市申请：KN026 是公司开发的HER2 双表位单抗，其核心 适应症之一的联合化疗治疗2L 及以上胃癌目前已经获得NMPA 受理，我们预计2026 年年底或2027 年有 望获批上市。公司已经将该产品的国内权益授予石药集团，未来上市后石药集团将负责相关商业化工 作，公司将保留KN026 的独家生产权，为石药集团提供产品。除此之外KN026 的乳腺癌1L 治疗和新辅 助治疗的方案也有望在2026 年提交上市申请。JSKN003 是公司开发的首款ADC管线，其临床进展也较 为迅速，针对2L HER2 阳性乳腺癌的适应症预计有望在2026 年提交国内上市申请。 ...

Group 1 - The company is a pioneer in antibody technology in China, focusing on the research, production, and commercialization of innovative biopharmaceuticals for oncology, with a core technology platform that includes self-developed bispecific antibodies and ADC technology [2] - The global first PD-L1 subcutaneous injection KN035 was approved for market in November 2021, with expected sales and royalties of 130 million, 128 million, and 125 million yuan for 2025, 2026, and 2027 respectively [2] - The self-developed HER2 bispecific antibody KN026 has shown strong positive efficacy in treating 2L+ HER2-positive gastric cancer, with its application for market approval expected to be accepted by NMPA in September 2025, and anticipated approval in the second half of 2026 [2] Group 2 - JSKN003, a self-developed HER2 bispecific antibody ADC, is advancing in clinical trials for multiple indications in China, showing superior efficacy and safety compared to Enhertu, with data readout expected in 2027 [3] - The company plans to submit an NDA for 2L HER2-positive breast cancer in 2026 and will initiate a Phase III trial for HER2-positive metastatic colorectal cancer in October 2025, with projected sales of 0.05 million, 0.57 million, and 1.08 million yuan for 2027, 2028, and 2029 respectively [3] Group 3 - The company has established a diversified bispecific antibody ADC product matrix through its proprietary glycosylation site-specific conjugation technology platform and differentiated target layout strategy [4] - JSKN016 is the world's first TROP2/HER3 bispecific antibody ADC, currently enrolling over 400 patients for indications in lung and breast cancer, indicating a broad market potential [4] - JSKN022, a first-in-class targeted PD-L1/ITGB6 bispecific antibody ADC, initiated its first patient dosing in October, while JSKN027, which has a triple mechanism of action, is expected to file for IND soon [4]

Group 1 - The core viewpoint of the report is that the company, Corning Jereh Pharmaceutical-B (09966), is projected to experience a significant decline in revenue in 2025, followed by a recovery in the subsequent years, with expected revenues of 4.43 billion, 4.86 billion, and 5.50 billion in 2025, 2026, and 2027 respectively, reflecting a year-on-year change of -30.87%, +9.78%, and +13.22% [1] - The company is recognized as a pioneer in domestic antibody technology, with its HER2 bispecific antibody expected to receive approval soon, focusing on the research, production, and commercialization of innovative biopharmaceuticals in the oncology field [1] - The company’s self-developed PD-L1 subcutaneous injection KN035 was approved for market in November 2021, with projected sales and royalties of 1.3 billion, 1.28 billion, and 1.25 billion for the years 2025, 2026, and 2027 respectively [1] Group 2 - JSKN003, a self-developed HER2 bispecific antibody ADC, is advancing through clinical trials in China, showing superior efficacy and safety compared to Enhertu in platinum-resistant ovarian cancer, with data readout expected in 2027 and NDA submission planned for 2026 for 2L HER2-positive breast cancer [2] - The company is leveraging its proprietary glycosylation site-specific conjugation technology platform and a differentiated target layout strategy to build a diverse product matrix of bispecific antibody ADCs, including JSKN016, the world's first TROP2/HER3 bispecific antibody ADC, which has enrolled over 400 patients in lung and breast cancer indications [3] - JSKN022, a first-in-class targeted PD-L1/ITGB6 bispecific antibody ADC, has initiated patient dosing, while JSKN027, which possesses cytotoxic, anti-angiogenic, and immune-regulatory mechanisms, is expected to file for IND soon [3]

Market Overview - The Hong Kong stock market opened lower but rebounded before closing down, with the Hang Seng Index falling by 0.44% to 25,357.69 points, the Hang Seng Tech Index down 1.26% to 5,389.3 points, and the National Enterprises Index down 0.6% to 8,790.55 points [1] - Major technology stocks experienced declines, including Alibaba down 1.58%, Tencent down 0.58%, and Xiaomi down 3.11% [1] - Airline stocks continued to rise, with Capital Airport increasing by over 7% [1] - Lithium battery stocks saw significant declines, with CATL down over 3% [1] - New consumption concept stocks weakened, with Pop Mart down over 2% [1] Corporate News - CICC (03908.HK) is planning a stock swap to absorb and merge with Dongxing Securities (601198.SH) and Cinda Securities (601059.SH), with resumption of trading on December 18 [2] - Ronshine China (03301.HK) reported a total contract sales of approximately 3.492 billion yuan for the first 11 months, a year-on-year decrease of 49.6% [3] - Wanbang Investment (00158.HK) reported revenue of 164 million HKD for the year ending September 30, 2025, a year-on-year increase of 1.6%, but a loss of 640 million HKD, widening by 309.61% [3] - Corning Jereh Pharmaceutical-B (09966.HK) had its IND application for JSKN027 officially accepted by the CDE [4] - China CNR (01766.HK) signed significant contracts totaling approximately 53.31 billion yuan over the past three months [5] - Bofull Property (00225.HK) reported a loss attributable to shareholders of 216 million HKD, a year-on-year decrease of 63.88% [6] - SenseTime (00020.HK) plans to issue shares at a discount of over 8% to raise approximately 3.15 billion HKD [7] - Minth Group (00425.HK) entered into a strategic cooperation agreement with a robotics company [8] - XunCe (03317.HK) is offering 22.5 million H-shares for subscription starting today until next Tuesday [9] - Budweiser APAC (01876.HK) appointed Bernardo Novick as CFO, effective April 1, 2026 [10] - China Metallurgical Group (01618.HK) plans to repurchase up to 2 billion A-shares and 500 million H-shares [11] - Kuaishou-W (01024.HK) repurchased 1.283 million shares for 83.037 million HKD at prices between 63.9 and 65.55 HKD [12] - Tencent Holdings (00700.HK) repurchased 1.057 million shares for 636 million HKD at prices between 595 and 605.5 HKD [13] - Techtronic Industries (00669.HK) repurchased 500,000 shares for 44.91 million HKD at prices between 89.35 and 90.50 HKD [14] - Country Garden Services (06098.HK) repurchased 3.697 million shares for 23.1748 million HKD at prices between 6.22 and 6.33 HKD [15] - Giga Bio (02367.HK) repurchased 400,000 shares for 13.9713 million HKD at prices between 34.62 and 35.22 HKD [16] Institutional Insights - According to CICC, the recent weakness in the Hong Kong market is attributed to southbound capital returning to A-shares due to new public fund benchmark regulations, concerns over IPO financing, and the upcoming peak of lock-up expirations [17] - Huatai Securities noted that while the market's downside is controllable, the upside potential remains limited, with sentiment indicators in a pessimistic range [18] - Ping An International expects the market to maintain a volatile trend in the short term, with investment strategies focusing on a "technology + dividend" barbell approach [18] - Jianyin International recommends buying on dips before the spring market in early 2025, focusing on high-yield stocks and sectors like technology, high-end manufacturing, and new energy [19]

Core Viewpoint - Corning Jereh Pharmaceutical-B (09966) saw a significant increase of over 4%, currently trading at HKD 10.68 with a transaction volume of HKD 2.7829 million, following the announcement of its new drug clinical trial application acceptance by the National Medical Products Administration (NMPA) [1] Group 1: Company Developments - Corning Jereh announced that its self-developed PD-L1/VEGFR2 bispecific antibody drug conjugate (ADC) JSKN027 has received formal acceptance for clinical trial (IND) application by the NMPA [1] - The company is set to initiate Phase I clinical research for JSKN027, targeting advanced malignant solid tumors [1] - JSKN027 is the first PD-L1/VEGFR2 bispecific ADC to enter clinical research globally, with preclinical data showing significant tumor suppression activity in both in vitro and in vivo models [1] Group 2: Industry Context - Currently, there are no ADCs targeting VEGFR2 alone or simultaneously targeting both PD-L1 and VEGFR pathways in clinical research worldwide [1]

Core Viewpoint - Corning Jereh Pharmaceutical-B (09966) has seen a stock increase of over 4%, currently trading at 10.68 HKD with a transaction volume of 2.7829 million HKD, following the acceptance of its IND application for the dual-targeting ADC JSKN027 by the NMPA [1] Group 1: Company Developments - Corning Jereh has announced that its self-developed PD-L1/VEGFR2 dual-specific antibody conjugate drug (ADC) JSKN027 has received formal acceptance for clinical trial (IND) application by the National Medical Products Administration (NMPA) [1] - The company is set to initiate Phase I clinical research for JSKN027, aimed at treating advanced malignant solid tumors [1] - JSKN027 is the first ADC globally to enter clinical research that targets VEGFR2 alone or simultaneously targets both PD-L1 and VEGFR pathways [1] Group 2: Clinical Data - Preclinical data indicates that JSKN027 demonstrates significant tumor suppression activity in both in vitro and in vivo models [1]

Core Viewpoint - The company has received formal acceptance from the National Medical Products Administration (NMPA) for its Investigational New Drug (IND) application for JSKN027, a dual-targeting antibody-drug conjugate (ADC) aimed at treating advanced malignant solid tumors [1] Group 1: Drug Development - JSKN027 targets both Programmed Death Ligand 1 (PD-L1) and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), making it the first ADC to enter clinical research that specifically targets these pathways [1] - The planned Phase I clinical study will assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of JSKN027, as well as determine the maximum tolerated dose and/or recommended dose for Phase II [1] Group 2: Market Position - Currently, there are no ADCs targeting VEGFR2 alone or simultaneously targeting both PD-L1 and VEGFR2 in clinical research globally [1] - Preclinical data indicates that JSKN027 exhibits significant tumor suppression activity in both in vitro and in vivo models [1] Group 3: Safety and Efficacy - Good tolerability was observed in GLP toxicology studies at the highest dose [1] - JSKN027 is expected to provide new treatment options for various solid tumors due to its multiple mechanisms of action, including cytotoxicity, anti-angiogenesis, and immune modulation [1]

Core Viewpoint - Corning Jereh Pharmaceutical-B (09966) has received formal acceptance from the National Medical Products Administration (NMPA) for its Investigational New Drug (IND) application for JSKN027, a dual-specific antibody-drug conjugate (ADC) targeting PD-L1 and VEGFR2, aimed at treating advanced malignant solid tumors [1] Group 1: Clinical Trial Details - The company plans to conduct a Phase I clinical study of JSKN027 to evaluate its safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity in patients with advanced malignant solid tumors [1] - The study will also determine the maximum tolerated dose and/or recommended dose for Phase II trials [1] Group 2: Unique Positioning and Preclinical Data - JSKN027 is the first PD-L1/VEGFR2 dual-targeting ADC to enter clinical research globally, with no other ADCs targeting VEGFR2 alone or both pathways simultaneously currently in clinical studies [1] - Preclinical data shows that JSKN027 exhibits significant tumor suppression activity in both in vitro and in vivo models [1] - GLP toxicology studies indicate good tolerability of the drug at the highest doses [1] Group 3: Mechanism of Action and Potential Impact - JSKN027 is expected to provide new treatment options for various solid tumors due to its multiple mechanisms of action, including cytotoxicity, anti-angiogenesis, and immune modulation [1]