Core Viewpoint - The article highlights the significant contributions of Chinese scholars in the field of research, particularly in the publication of papers in the prestigious journal Nature, with 13 out of 24 papers authored by Chinese researchers on July 2, 2025 [1][2][3][4][6][7][10][12][15][17][19][21][23]. Group 1 - On July 2, 2025, a total of 24 papers were published in Nature, with 13 authored by Chinese scholars [1][2][3][4][6][7][10][12][15][17][19][21][23]. - The paper titled "Boron-mediated modular assembly of tetrasubstituted alkenes" was authored by Liang Wei from the University of Bristol [1]. - The research "Stereodivergent transformation of a natural polyester to enantiopure PHAs" was led by Professor Chen Youxian from Colorado State University [2]. Group 2 - The paper "A mouse brain stereotaxic topographic atlas with isotropic 1 μm resolution" was co-authored by Academician Luo Qingming from Hainan University and Professor Gong Hui from Huazhong University of Science and Technology [2]. - The research titled "The mutagenic forces shaping the genomes of lung cancer in never smokers" was co-authored by Tongwu Zhang from the National Cancer Institute [3]. - The study "Mapping and engineering RNA-driven architecture of the multiphase nucleolus" was co-authored by Lifei Jiang from Princeton University [6]. Group 3 - The paper "Ancient DNA reveals the prehistory of the Uralic and Yeniseian peoples" was authored by Tian Chen Zeng from Harvard University [7]. - The research "Hybrid quantum network for sensing in the acoustic frequency range" was co-authored by Jun Jia from the University of Copenhagen [10]. - The study "Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery" was led by Amanda Xi Ying Chen from the University of Melbourne [12]. Group 4 - The paper "Inter-brain neural dynamics in biological and artificial intelligence systems" was authored by Professor Hong Weizhe from UCLA [15]. - The research "WSTF nuclear autophagy regulates chronic but not acute inflammation" was co-authored by Yu Wang from Harvard University [17]. - The study "PPP2R1A mutations portend improved survival after cancer immunotherapy" was co-authored by Professors Wang Linghua and Zhang Rugang from MD Anderson Cancer Center [19]. Group 5 - The paper "Discovering cognitive strategies with tiny recurrent neural networks" was authored by Li Ji-An from UC San Diego [21]. - The research "Ultrabroadband and band-selective thermal meta-emitters by machine learning" was co-authored by Professors Zhou Han from Shanghai Jiao Tong University and Qiu Chengwei from the National University of Singapore [23].

撰文丨王聪 编辑丨王多鱼 排版丨水成文 古埃及文明 曾繁荣了数千年，在其鼎盛时期，古埃及建造了众多叹为观止的 金字塔 ，此外，他们还曾流行制作 木乃伊 ，其中，许多数千年前的木乃伊保存至 今，科学家们一直希望从中提取古 DNA。然而，木乃伊的制作过程以及炎热的气候条件加速了 DNA 分解，导致其中的 DNA 保存状况不佳。 该研究从一个距今大约 4800 年的生活在最早期金字塔建造时期的木乃伊的牙齿中成功提取了完整 人类基因组，这也是 首个古埃及人类的完整基因组序列 。基 因组分析显示，这一木乃伊遗骸显示出与 北非新石器时代的祖先 以及 美索不达米亚 （现在的中东部分地区） 人群相似的血统。 该研究分析了一个发现于 1902 年的古埃及遗骸， 放射性碳测年显示，其生活在公元前 2855-公元前 2570 年左右， 这一时期与古埃及的早王朝时期末尾以及 古王国时期起始相重叠，此时古埃及尚未开始广泛的木乃伊制作。遗骸被埋葬于一个岩石墓穴的密封的陶罐中，这表明其社会地位较高 （但尚未达到精英统治阶 层） 。 研究团队从遗骸中提取了 7 组 DNA 样本，其中 2 组保存足够完好，可以进行基因组测序，并成功构建了完整 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 耳聋 是人类最常见的感官障碍，先天性耳聋影响了全世界大约 2600 万人，其中高达 60% 的病例是由基因突变引起。 常染色体隐性遗传耳聋9型 （ DFNB9 ） ，是由 编码 耳畸蛋白 （Otoferlin） 的 OTOF 基因突变导致的感音神经性耳聋，占 遗传性耳聋的 2%-8%。耳畸蛋白能使内耳毛细胞响应声音刺激而释放神经 递质，激活听觉神经元，当其功能受损时，声音信号将无法被传达到大脑，从而导致感音神经性耳聋。 此前， 复旦大学附属眼耳鼻喉科医院 舒易来 教授 、 东南大学 附属中大医院 柴人杰 教授等 已经在低龄儿童患者中证实了 AAV 基因治疗 能够安全且有效地恢 复 DFNB9 患者的听力，相关研究发表于《 柳叶刀 》、 Nature Medicine 、 Advanced Science 等期刊。但还有一些关键科学问题亟待解答—— 大龄 DFNB9 患者是否能够受益于 AAV 基因疗法？是否存在最佳治疗年龄窗口？ 2025 年 7 月 2 日 ， 东南大学 附属中大医院 柴人杰 教授联合加州大学欧文分校 曾凡钢 教授，山东省第二人民医院 （山东省耳鼻喉医 ...

Core Viewpoint - The article discusses a groundbreaking study that presents a mouse brain stereotaxic topographic atlas with isotropic 1 μm resolution, which is expected to enhance multi-omics research at the single-cell level in neuroscience [3][6][8]. Group 1 - The research team, including academicians from Hainan University, Huazhong University of Science and Technology, and UCLA, published their findings in the journal Nature, detailing a 3D brain atlas for mice [3]. - The atlas, named STAM, provides a comprehensive dataset of 916 brain structures and allows for the generation of high-resolution images at any angle [6][8]. - The study utilizes continuous micro-optical sectioning imaging technology to create a dataset based on Nissl staining, achieving isotropic 1 μm resolution [6]. Group 2 - The STAM atlas is designed to support large-scale brain mapping projects by providing data analysis and visualization capabilities [8]. - It includes an informatics platform for visualizing and sharing atlas images, facilitating tasks such as brain slice registration and neuron circuit mapping [6]. - The atlas is compatible with widely used stereotaxic atlases, enabling cross-atlas navigation in both 2D and 3D spaces [6].

Core Viewpoint - Perovskite solar cells (PSC) are recognized as a key direction for next-generation photovoltaic technology due to their high efficiency, low cost, and solution processing capabilities. The development of self-assembled molecules (SAM) is crucial for enhancing the performance of PSCs [2]. Group 1: Research Breakthroughs - A significant breakthrough was achieved in the design of new organic self-assembled molecules, resulting in the first development of a highly efficient, stable, and well-dispersed self-assembled molecular material with dual radical characteristics [2][5]. - The research team successfully designed a dual radical self-assembled monolayer to facilitate hole transport within the monolayer [4]. Group 2: Performance Metrics - The small-area devices based on the new material achieved a power conversion efficiency of 26.3%, while micro-modules (10.05 cm²) reached an efficiency of 23.6%. The perovskite-silicon tandem cells (1 cm²) exceeded 34.2% efficiency, certified by the National Renewable Energy Laboratory (NREL) [7]. - The developed materials and devices exhibited excellent stability, maintaining over 97% performance retention after 2000 hours of operation at 45°C, significantly surpassing traditional materials and devices [8]. Group 3: Implications for Industry - This research provides a new molecular design paradigm to address the conductivity, stability, and large-area processing challenges in perovskite solar cells, injecting core driving forces for the industrialization of next-generation efficient and stable photovoltaic components [8].

Core Viewpoint - MD Anderson Cancer Center is recruiting postdoctoral researchers to advance cutting-edge single-cell multi-omics technologies and explore molecular regulatory networks in cancer development and drug resistance [3][8]. Group 1: Research Focus - The laboratory aims to develop single-cell multi-omics technologies, investigate the epigenetic regulatory mechanisms of cancer cell plasticity, and understand the epigenetic basis of individualized drug responses [3]. - The research group is led by Dr. Zhang Bingjie, who has a strong background in epigenomics and single-cell multi-omics [2]. Group 2: Institutional Overview - MD Anderson Cancer Center is a leading cancer treatment and research institution, consistently ranked as the top cancer specialty by U.S. News & World Report, located in Houston, Texas [8]. - The center has conducted over 1,680 clinical trials in 2024, with 22 drugs approved by the FDA and research funding amounting to $1.1 billion [8]. Group 3: Application Requirements - The position is for two postdoctoral researchers in genomics and tumor biology, requiring a Ph.D. in relevant biological fields [9][10]. - Candidates with backgrounds in tumor biology, genomics, and computational biology are preferred, along with strong communication and teamwork skills [10][11].

浙江大学医学院姜东课题组诚聘专职研究员和博士后 浙江大学医学院 姜东 课题组，现公开招聘 专职研究员 和 博士后 ，欢迎相关背景的优秀申请者 加入 我们 的团队 ！ 实验室简介 姜东 ，浙江大学医学院 " 百人计划 " 研究员、博士生导师、浙江大学医学院附属第二医院 / 经血管植入器 械全国重点实验室研究员。 2014 年毕业于厦门大学获学士学位， 2019 年毕业于清华大学获博士学位， 并继续在清华大学完成博士后研究， 2025 年全职加入浙江大学 ，实验室位于浙江大学紫金港校区 。姜东 一直致力于 迁移体 （ migrasome ） 的生物学功能与机制研究，全程参与并系统推进了迁移体生物学的建 立与发展。博士 / 博后期间首次建立了迁移体研究的动物模型，开发了哺乳动物迁移体活体成像技术平台 等一系列体内迁移体研究的方法和系统，解析了迁移体在胚胎发育、凝血、肿瘤和免疫中的生理病理功 能，揭示了迁移体介导的时空特异性信号传递、信号梯度形成及细胞间通讯的新机制，开创了体内迁移体 研究的范式。相关研究工作 以第一（含共同）作者 发表在 Nature Cell Biology ( 2019 cover , 2024 ...

Group 1 - The article introduces Professor Song Zhenju, who holds multiple prestigious positions in emergency medicine and clinical research, including Director of the Emergency Department at Fudan University Zhongshan Hospital and Vice President of the same hospital [1] - Professor Song has led numerous national and provincial research projects, published extensively in high-impact journals, and holds multiple patents, indicating a strong research background and contributions to the field [1] Group 2 - The research directions focus on Acute Respiratory Distress Syndrome (ARDS) mechanisms and interventions, organ damage from sepsis, and mechanisms and interventions for acute poisoning [6] Group 3 - Recruitment is open for postdoctoral positions in fields such as Clinical Medicine, Life Sciences, Biology, Biomedical Engineering, and Pharmacy [3] - Candidates must be under 35 years old, have a strong academic background, and have published at least one SCI paper [5] Group 4 - Compensation will follow national and Fudan University standards, with additional rewards for outstanding performance during the contract period [7] Group 5 - Applicants are required to submit a detailed CV, proof of doctoral degree, and 1-3 representative papers [8] - Contact information for applications is provided, with specific instructions for email subject lines [9][10]

Core Viewpoint - The article discusses the advancements in in vivo CAR-T cell therapy, particularly focusing on a new type of lipid nanoparticle (LNP) that does not require antibody modification, which enhances the delivery of circRNA-based CAR-T cells for treating inflammatory aging diseases [1][2][3][5]. Group 1: In Vivo CAR-T Therapy Advantages - In vivo CAR-T therapy, based on mRNA, offers significant advantages over traditional ex vivo CAR-T therapy, especially in treating inflammatory aging diseases [6][14]. - The transient expression of in vivo CAR-T cells may be beneficial for inflammatory aging, contrasting with its potential drawbacks in solid tumor treatments [6][14]. Group 2: Research Innovations - The research team developed a novel type of LNP inspired by cardiolipin, which enhances T cell targeting without the need for antibody modification [8][15]. - The study demonstrated that the CAMP lipid increases the stiffness and phase separation of LNPs, improving T cell uptake [9][15]. Group 3: CircRNA Utilization - The research utilized circRNA to modify CAR mRNA, enhancing its stability and reducing cytotoxicity, which prolongs CAR protein expression in vivo [10][15]. - The encapsulation of CAR mRNA targeting uPAR in PL40-LNP provides a proof of concept for treating liver fibrosis and rheumatoid arthritis [11][12]. Group 4: Clinical Implications - The study highlights the potential of non-antibody targeting strategies in developing in vivo CAR-T therapies for clearing senescent cells associated with inflammatory aging diseases [17].

Core Viewpoint - The article announces the recruitment of postdoctoral researchers and PhD students by Dr. Ronghui Li's research group at the National University of Singapore, focusing on somatic reprogramming and stem cell development for drug screening and regenerative medicine [2][4]. Group 1: Research Focus - The main research directions include the simulation of organoid or embryonic development using stem cells to produce functional tissues or cells [3] - Editing and precise regulation of multicellular organoid or embryonic systems [3] - Cell reprogramming to restore and enhance engineered cell functions for improved therapeutic applications [3] Group 2: Recruitment Details - The group is open to recruiting postdoctoral researchers, PhD students, and outstanding undergraduate or intern candidates, including those funded by CSC [4] - Interested candidates are encouraged to send their resumes to the provided email address, with specific subject line instructions [4] - The article also mentions the establishment of professional communication groups to facilitate research dissemination and collaboration [7]