Core Viewpoint - The company reported strong financial performance in the first half of 2025, with significant growth in both revenue and net profit, driven by innovative products and a solid position in key therapeutic areas [1][2]. Financial Performance - In H1 2025, the company achieved revenue of 17.57 billion (CNY) (+10.7%) and a net profit attributable to shareholders of 3.39 billion (CNY) (+140.2%) [1]. - Adjusted net profit (non-HKFRS) reached 3.09 billion (CNY) (+101.1%), indicating a substantial increase in profitability [1]. Innovation and Product Development - The company launched two innovative products approved by NMPA in H1 2025, contributing to a revenue of 7.8 billion (CNY) from innovative products (+27.2%), which now account for 44.4% of total revenue (+5.8 percentage points) [1]. - The company has a broad pipeline of nearly 20 innovative products expected to be approved between 2025 and 2027, with over half projected to have peak sales exceeding 2 billion (CNY) [2]. Business Segments - The oncology segment generated revenue of 6.694 billion (CNY) (+24.9%), while the surgical/pain management segment achieved revenue of 3.105 billion (CNY) (+20.2%) in H1 2025 [1]. Future Outlook - The company anticipates that the proportion of revenue from innovative products will increase to 50% in 2025, 55% in 2026, and 60% in 2027, positioning innovation as the core driver of revenue growth [2]. - The acquisition of Lixin Pharmaceutical is expected to enhance the company's innovation pipeline and strengthen its core technology capabilities [2]. Profit Forecast - Revenue projections for 2025-2027 are 32.78 billion (CNY), 36.87 billion (CNY), and 41.14 billion (CNY), with year-on-year growth rates of 13.6%, 12.5%, and 11.6% respectively [3]. - Net profit forecasts for the same period are 4.81 billion (CNY), 4.88 billion (CNY), and 5.12 billion (CNY), with growth rates of 37.5%, 1.5%, and 4.8% respectively [3].

Core Insights - China Biopharmaceutical reported strong financial growth for H1 2025, with revenue of 17.57 billion yuan, a year-on-year increase of 10.7%, and a net profit of 3.39 billion yuan, up 140.2% [1] - The company has a robust pipeline in key therapeutic areas, including oncology, liver disease/metabolism, respiratory, and surgical/pain management, with several products in advanced clinical stages [2][3] Financial Performance - Revenue for H1 2025 reached 17.57 billion yuan, reflecting a 10.7% increase year-on-year [1] - Net profit from continuing operations was 3.39 billion yuan, showing a significant growth of 140.2% year-on-year [1] - Adjusted net profit was approximately 3.09 billion yuan, up 101.1% year-on-year [1] - Basic earnings per share (EPS) were 0.188 yuan, an increase of 145.7% year-on-year [1] - Cash reserves stood at 30.49 billion yuan, with 11.1 billion yuan in cash on hand [1] Innovation and Product Development - Revenue from innovative products reached 7.8 billion yuan, a year-on-year increase of 27.2%, accounting for 44.4% of total revenue [1] - The company has 18 innovative products, with expectations to exceed 35 by 2027 [1] - Recent approvals include the domestic recombinant human coagulation factor VIIa product and the long-acting analgesic NSAID injection [1] Pipeline Advancements - Key pipelines in oncology include TQB2922 and TQB6411 for lung cancer, and TQB3616 and TQB2102 for breast cancer, with multiple indications being pursued [2] - In gastrointestinal tumors, LM-108 has received breakthrough therapy designation, while TQB2868 is leading globally in development [2] - The respiratory/infection area features TQC3721, which is in the second position globally in development [2] - In liver disease/metabolism, Lanifibranor has completed patient enrollment for its Phase III trial, with expectations for a 2026 market application [2] Strategic Acquisitions - The company acquired Lixin Pharmaceutical for a net consideration of 500 million USD, enhancing its technology platform for antibody discovery and ADC development [3] - This acquisition is expected to accelerate the translation of Lixin's innovative pipeline, including several promising candidates [3] Profit Forecast - The company forecasts net profits of 3.454 billion yuan, 3.979 billion yuan, and 4.570 billion yuan for 2025-2027, with corresponding EPS of 0.18 yuan, 0.21 yuan, and 0.24 yuan [4]

Summary of Key Points Core Viewpoint - As of August 26, a total of 135 stocks reached their 52-week highs, indicating a strong market performance with notable leaders in the sector [1]. Stock Performance Highlights - The top three stocks with the highest increase rates are: - 恒基发展 (Hengji Development) at 69.72% with a closing price of 0.335 and a peak of 0.370 [1] - 中国智能交通 (China Intelligent Transportation) at 68.89% with a closing price of 0.305 and a peak of 0.380 [1] - 桦欣控股 (Hua Xin Holdings) at 54.26% with a closing price of 17.000, reaching its peak at the same price [1] Additional Notable Stocks - Other significant performers include: - 绿色经济 (Green Economy) at 22.16% [1] - 米兰站 (Milan Station) at 21.83% [1] - 永义国际 (Yongyi International) at 21.21% [1] - 金界控股 (Golden Realm Holdings) at 18.11% [1] 52-Week Low Rankings - The stocks that reached their 52-week lows include: - 鸿盛昌资源股权 (Hongsheng Chang Resources) at a low of 0.010, down 37.50% [4] - 德商产投服务 (DeShang Investment Services) at a low of 0.830, down 17.00% [4] - 新华联合投资 (Xinhua United Investment) at a low of 0.092, down 15.60% [4]

证券研究报告 医药生物 | 化学制药 港股|公司点评报告 hyzqdatemark 2025 年 08 月 26 日 证券分析师 刘闯 SAC：S1350524030002 liuchuang@huayuanstock.com 联系人 市场表现： | 基本数据 | 2025 | 年 | | 日 | 月 | 25 | | 08 | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 收盘价（港元） | | | | 8.36 | | | | | | 一年内最高/最低（港 | | | 8.40/2.67 | | | | | | | 元） | | | | | | | | | | 总市值（百万港元） | | | | | | | 156,839.60 | | | 流通市值（百万港元） | | | | | | | 156,839.60 | | | 资产负债率（%） | | | | 38.88 | | | | | | 资料来源：聚源数据 | | | | | | | | | 中国生物制药(01177.HK) 投资评级： 买入（维持） ——创新业务加速，BD 出海在 ...

Group 1: Core Insights - The innovative drug business has become the main driver of revenue growth for several listed pharmaceutical companies, with some companies reporting that innovative drug revenue accounts for over 50% of total revenue [1][3] - Traditional pharmaceutical companies are increasingly transforming into innovative drug companies, but international expansion primarily relies on external licensing rather than establishing independent overseas sales systems [1][5] Group 2: Company Performance - Heng Rui Pharmaceutical reported a revenue of 15.762 billion yuan for the first half of 2025, a year-on-year increase of 15.88%, with innovative drug sales and licensing income reaching 9.561 billion yuan, accounting for 60.66% of total revenue [3] - Han Sen Pharmaceutical's innovative drug and cooperative product sales reached approximately 6.145 billion yuan, a year-on-year increase of 22.1%, making up 82.7% of total revenue [3] - Yuan Da Pharmaceutical achieved a record revenue of approximately 6.11 billion HKD, with innovative and barrier products accounting for about 51% of total revenue, a nearly 15 percentage point increase year-on-year [4] Group 3: R&D Investment - Heng Rui Pharmaceutical invested 3.871 billion yuan in R&D in the first half of 2025, with over 48 billion yuan cumulatively invested, and more than 100 innovative products in clinical development [4] - Xian Sheng Pharmaceutical's R&D investment rate reached 28.7%, with over 10 billion yuan cumulatively invested over the past decade [4] Group 4: Internationalization and Licensing - Despite the growth in innovative drug revenue, the primary market for domestic pharmaceutical companies remains within China, with only one domestic drug making it to the global top 100 sales list [5] - Companies like Heng Rui Pharmaceutical and Xian Sheng Pharmaceutical are focusing on external licensing as a primary path for internationalization, with Heng Rui having completed 15 external licensing agreements [5]

Group 1 - The acquisition involves Shuangrun Zheng'an Information Consulting (Beijing) Co., Ltd. making a partial tender offer for Jiangsu Haobio Pharmaceutical Co., Ltd. [1][2] - The tender offer includes 15,570,480 shares, representing 25.01% of the total shares after excluding repurchased shares, at a price of 33.74 CNY per share [2][3] - The tender offer period is set from December 24, 2024, to January 22, 2025, lasting for 30 calendar days [2] Group 2 - The financial advisor confirms that during the ongoing supervision period, Haobio and Shuangrun Zheng'an have complied with relevant regulations and operated in accordance with corporate governance standards [3][6] - Shuangrun Zheng'an and its concerted parties have committed to maintaining the operational independence of Haobio and ensuring no interference in its management [4][5] - There are no plans to change Haobio's main business or make significant adjustments within the next 12 months [7][8] Group 3 - The acquisition parties have committed to avoiding any competition with Haobio's main business and ensuring fair treatment in any necessary related transactions [5][6] - There are no plans for significant changes to the current board of directors or senior management of Haobio following the acquisition [9][10] - The financial advisor has verified that there are no plans for major changes to employee hiring or dividend policies within the next 12 months [11][12] Group 4 - The acquisition does not involve any guarantees or loans that could harm Haobio's interests [13] - The parties involved have fulfilled all other obligations stipulated in the acquisition agreement [13]

中国生物制药(01177)公布，集团开发的"TQC3721(PDE3/4抑制剂)"、"TQC2731(TSLP单 抗)"、"TQC3403(乌美溴铵维兰特罗吸入粉雾剂)"将于9月27日至10月1日举行的2025年欧洲呼吸学会年 会(ERS2025)公布4项研究成果。 ...

丨证券研究报告丨 港股研究丨公司点评丨中国生物制药（1177.HK） [Table_Title] 财务增长强劲，创新持续爆发 请阅读最后评级说明和重要声明 %% %% %% %% research.95579.com 1 报告要点 [Table_Summary] 2025H1 中国生物制药实现营收 175.7 亿元（同比+10.7%），持续经营业务归母净利润 33.9 亿 元翻倍大增（同比+140.2%）。创新产品收入及占比快速攀升，占总收入比例达 44.4%。公司以 5 亿美元全资收购礼新医药，整合其四大抗体与 ADC 技术平台，推进至少 6 项核心管线转化。 分析师及联系人 [Table_Author] 彭英骐 刘长洪 SAC：S0490524030005 SAC：S0490525070007 SFC：BUZ392 中国生物制药（1177.HK） cjzqdt11111 [Table_Title2] 财务增长强劲，创新持续爆发 [Table_Summary2] 事件描述 2025 年 8 月 18 日，中国生物制药发布 2025 年中期业绩公告：2025 年上半年实现营业收入 175.7 亿元，同比增长 ...

Investment Rating - The report maintains a "Buy" rating for China Biopharmaceutical (1177.HK) [6][3] Core Views - The company reported a revenue of 17.57 billion yuan (+10.7%) and a net profit attributable to shareholders of 3.39 billion yuan (+140.2%) for the first half of 2025, exceeding profit growth expectations [1][6] - The innovative product line is driving high growth, with two new innovative products approved by NMPA in the first half of 2025, contributing to an innovative product revenue of 7.8 billion yuan (+27.2%), accounting for 44.4% of total revenue [1][2] - The company expects nearly 20 innovative products to be approved from 2025 to 2027, with over half projected to have peak sales exceeding 2 billion yuan [2] Financial Performance - For 2025, the company forecasts revenues of 32.78 billion yuan, a growth of 13.6%, and a net profit of 4.81 billion yuan, a growth of 37.5% [3][4] - The projected earnings per share (EPS) for 2025 is 0.26 yuan, with a price-to-earnings (P/E) ratio of 29.08 [4][11] - The company anticipates that the proportion of revenue from innovative products will increase to 50% by 2027 [2][3] Business Segments - The oncology segment achieved a revenue of 6.694 billion yuan (+24.9%) in the first half of 2025, while the surgical/pain management segment generated 3.105 billion yuan (+20.2%) [1][2]

TQC3403是一款由长效抗胆硷能药物(LAMA)乌美溴铵与长效β受体激动剂(LABA)维兰特罗组成的吸入 粉雾剂，通过双重作用机制实现长效支气管扩张。其原研制剂于2018年在国内获批，目前国内尚无该药 物和同类药物的仿制药物获批。集团突破多项关键核心技术，在国内率先完成双支扩粉雾剂等效性研 究，有望在2026年上半年获批上市，实现乌美溴铵维兰特罗吸入粉雾剂的首仿上市。 TQC3721是一款全新机制的吸入性PDE3/4抑制剂，具有扩张支气管和抗炎的双重作用，从而减轻患者 症状并抑制炎症。目前，全球仅一款吸入性PDE3/4抑制剂获批上市。在Ⅱ期临床试验中，TQC3721展 现出良好的量效关系和安全性。基于该研究数据，TQC3721已经获得中国国家药品监督管理局药品审评 中心(CDE)突破性疗法认定，目前正在国内开展Ⅲ期临床试验。除吸入用混悬液外，TQC3721吸入粉雾 剂即将开展Ⅱ期临床试验，有望进一步提升疗效和患者的依从性。 TQC2731是一款抗TSLP的人源化单克隆抗体，通过靶向TSLP阻断其与受体结合、抑制下游通路，可以 减少哮喘急性发作。除哮喘外，TSLP与多种自身免疫性疾病、慢性炎症性疾病、过敏性疾 ...