香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容所產生或因依賴 該等內容而引致的任何損失承擔任何責任。 Jiangsu Hengrui Pharmaceuticals Co., Ltd. 江蘇恒瑞醫藥股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1276） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條刊發。 根據中華人民共和國的有關法例規定，江蘇恒瑞醫藥股份有限公司（「本公司」）在 上海證券交易所網站( www.sse.com.cn )刊發了以下公告。茲載列如下，僅供參閱。 承董事會命 江蘇恒瑞醫藥股份有限公司 董事長 孫飄揚先生 中國上海 2025年11月24日 於本公告日期，董事會成員包括(i)執行董事孫飄揚先生、戴洪斌先生、馮佶女 士、張連山先生、江寧軍先生及孫杰平先生；(ii)非執行董事郭叢照女士；及(iii) 獨立非執行董事董家鴻先生、曾慶生先生、孫金雲先生及周紀恩先生。 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容所產生或因依賴 該等內容而引致的任何損失承擔任何責任。 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條刊發。 根據中華人民共和國的有關法例規定，江蘇恒瑞醫藥股份有限公司（「本公司」）在 上海證券交易所網站( www.sse.com.cn )刊發了以下公告。茲載列如下，僅供參閱。 承董事會命 江蘇恒瑞醫藥股份有限公司 董事長 Jiangsu Hengrui Pharmaceuticals Co., Ltd. 江蘇恒瑞醫藥股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1276） 证券代码：600276 证券简称：恒瑞医药 公告编号：临 2025-186 江苏恒瑞医药股份有限公司 关于获得药品注册批准的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 近日，江苏恒瑞医药股份有限公司（以下简称"公司"）子公司成都盛迪医 药有限公 ...

Core Insights - The article highlights the top and bottom AH premium rates for various stocks, indicating significant discrepancies between H-shares and A-shares [1][2][3] Group 1: Top AH Premium Rates - Northeast Electric (00042) leads with a premium rate of 847.37%, followed by Sinopec Oilfield Service (01033) at 270.27% and Hongye Futures (03678) at 269.94% [1][2] - Zhejiang Shibao (01057) and Fudan Zhangjiang (01349) also show high premium rates of 263.16% and 250.00% respectively [2] Group 2: Bottom AH Premium Rates - The lowest premium rates are observed in CATL (03750) at -4.68%, China Merchants Bank (03968) at -1.05%, and Heng Rui Medicine (01276) at 4.32% [1][2] - Other companies like WuXi AppTec (02359) and Midea Group (00300) also show modest premium rates of 5.49% and 5.97% respectively [2] Group 3: Top AH Deviation Values - Guanghe Tong (00638) has the highest deviation value at 32.28%, followed by Beijing Jingcheng Machinery Electric (00187) at 21.40% and Fudan Zhangjiang (01349) at 17.42% [1][3] - Nanjing Panda Electronics (00553) also shows a significant deviation value of 17.34% [3] Group 4: Bottom AH Deviation Values - The lowest deviation values are recorded for Zhongwei New Materials (02579) at -23.92%, Longpan Technology (02465) at -15.25%, and Anhui Wanshan Expressway (00995) at -12.36% [1][3] - Other companies like Ganfeng Lithium (01772) and China Life (02628) also show negative deviation values of -11.85% and -9.94% respectively [3]

Group 1 - Hong Kong's Hang Seng Index rose by 1.42%, gaining 358 points to close at 25,578 points, while the Hang Seng Tech Index increased by 1.65% [1] - Alibaba-W (09988) surged over 4%, with its Qianwen App surpassing 10 million downloads in its first week of public testing [1] - Sinopharm (01801) rose over 3%, with plans to officially go blue starting December 8 [1] - Hengrui Medicine (01276) increased by over 5%, as nine drugs including SHR-9839 received approval for clinical trials [1] - Beijing Automotive (01958) gained over 3%, planning to sell 51% of its stake in Beiqi International for approximately 1.608 billion yuan to accelerate its international strategy [1] - WeRide (00800) jumped over 6%, having obtained Switzerland's first pure driverless license, with Q3 earnings report upcoming [1] - Rusal (00486) saw an intraday increase of over 4%, announcing plans to cease operations at the Krymni silicon plant by 2026 [1] - GAC Group (02238) surged over 12%, with its all-solid-state battery pilot production line officially completed and put into production [1] - Sino Biopharmaceutical-B (02591) rose over 20%, being included in the Hang Seng Composite Index effective December 8 [1] - 3SBio (01530) increased by over 4%, planning to spin off its subsidiary Mandi International for independent listing [1] Group 2 - Oil stocks continued to decline, with CNOOC (00883) dropping by 2.4% amid easing tensions in the Russia-Ukraine situation [2] - Semiconductor stocks faced significant declines, with Hua Hong Semiconductor (01347) falling over 9% and SMIC (00981) down over 5%, as reports indicated the Trump administration is considering approving exports of Nvidia's H200 AI chips to China [2] - Ganfeng Lithium (01772) dropped over 7%, facing potential downward risks in lithium spot prices, leading Goldman Sachs to downgrade the company to a "sell" rating [2]

Group 1 - The core viewpoint of the article highlights a significant rally in Hong Kong's innovative drug concept stocks on November 24, with notable gains among several companies [1] Group 2 - Three-Sixty Pharmaceutical (01530.HK) experienced an increase of over 6% [1] - Hengrui Medicine (01276.HK) saw a rise of more than 5% [1] - Innovent Biologics (01801.HK) and Hansoh Pharmaceutical (03692.HK) both rose by over 3% [1]

Core Viewpoint - Heng Rui Pharmaceutical (01276.HK) has seen a stock price increase of over 5%, currently trading at 69.3 HKD with a transaction volume of 141 million HKD [1] Group 1 - The stock price of Heng Rui Pharmaceutical rose by 5.08% [1] - The current trading price is 69.3 HKD [1] - The total transaction volume reached 1.41 billion HKD [1]

Core Viewpoint - Heng Rui Medicine (01276) experienced a stock price increase of over 5%, reaching HKD 69.3 with a trading volume of HKD 141 million following the announcement of new clinical trial approvals by the National Medical Products Administration [1] Group 1: Company Developments - On November 21, Heng Rui Medicine announced that it, along with its subsidiaries, received approval for clinical trials for multiple injectable drugs including SHR-9839(sc), SHR-A2009, SHR-1826, HRS-4642, and others [1] - The approved drugs include monoclonal antibodies and various formulations, indicating a broadening of the company's clinical pipeline [1]

Investment Rating - The report assigns a "Buy" rating for Jiangsu Hengrui Pharmaceuticals with a target price of Rmb123.000, indicating an expected share price return of 95.5% and an expected total return of 95.9% [4]. Core Insights - Jiangsu Hengrui Pharmaceuticals is positioned as a leading global biopharma, ranking No.2 in the size of its originated pipeline and No.3 in pipeline growth, benefiting from China's status as a significant source of global innovation [4][6]. - The report highlights that approximately 30% of global innovative drug trials originate from China, and about one-third of global innovative pipelines are from China-headquartered companies, indicating a robust growth trajectory for the industry [2][3]. - The Chinese pharmaceutical market shows significant potential for growth in innovative drugs, which currently account for only about 14% of total drug sales in hospitals, compared to much higher percentages in developed markets [3]. Summary by Sections Globalization and Innovation - Jiangsu Hengrui has made substantial progress in globalization, with over 20 global trials ongoing and a diversified portfolio across key therapeutic areas [6]. - The company leverages global partnerships and in-house capabilities to maximize innovation impact, with a strong record in out-licensing and strategic partnerships since 2018 [6]. Market Dynamics - The report notes that the demand for affordable innovation from China is expected to thrive due to increasing pricing pressures and the loss of exclusivity for leading multinational corporations [2]. - China's commitment to supporting innovative drugs is underscored by strong government backing for commercial health insurance, which is anticipated to improve coverage for innovative drugs in the future [3]. Financial Valuation - A discounted cash flow (DCF) approach is used to assess the fair value of Jiangsu Hengrui Pharmaceuticals, with a terminal growth rate of 4% and a weighted average cost of capital (WACC) of 8.3% [7].

Core Viewpoint - 恒瑞医药 has received approval from the National Medical Products Administration for multiple clinical trial applications for new drug candidates, indicating a significant advancement in its oncology pipeline [1][2][3][4][5] Group 1: New Drug Approvals - The company has received clinical trial approval for SHR-9839, a humanized antibody drug targeting advanced solid tumors, with a cumulative R&D investment of approximately 72.31 million [1] - SHR-A2009, an antibody-drug conjugate targeting HER3, has a cumulative R&D investment of about 227 million [2] - SHR-1826, targeting c-MET, has a cumulative R&D investment of around 101 million [2] - HRS-4642, a KRAS G12D inhibitor, has a cumulative R&D investment of approximately 191 million [2] - 阿得贝利单抗, a humanized anti-PD-L1 monoclonal antibody, has been approved for use in extensive-stage small cell lung cancer, with a cumulative R&D investment of about 969 million [3] - 注射用瑞康曲妥珠单抗, targeting HER2, has been approved for use in non-small cell lung cancer, with a cumulative R&D investment of around 1.415 billion [4] - SHR-A2102, an ADC targeting Nectin-4, has a cumulative R&D investment of approximately 248 million [5] - HRS-7058, a selective small molecule inhibitor for KRAS G12C mutations, has a cumulative R&D investment of about 69.57 million [5] Group 2: Market Context and Competitors - SHR-9839 is the only drug in its class currently in development, with one similar drug already approved globally [1] - SHR-A2009 is the first of its kind, with no similar drugs approved globally [2] - SHR-1826 has a competitor, ABBV399, which received accelerated approval in the U.S. for specific lung cancer patients [2] - 阿得贝利单抗 has several competitors, including Atezolizumab and Durvalumab, which collectively generated approximately 9.648 billion in global sales in 2024 [3] - 注射用瑞康曲妥珠单抗 has competitors like Ado-trastuzumab emtansine and Fam-trastuzumab deruxtecan, with a combined global sales forecast of about 6.557 billion in 2024 [4] - SHR-A2102 has one competitor, Enfortumab vedotin, with a projected global sales of approximately 1.949 billion in 2024 [5] - HRS-7058 faces competition from Sotorasib and Adagrasib, which are expected to generate around 485 million in global sales in 2024 [5]

Core Viewpoint - 恒瑞医药 and its subsidiaries have received approval from the National Medical Products Administration for multiple clinical trials of new drug candidates, indicating a strong pipeline and ongoing investment in innovative therapies [1] Group 1: Clinical Trial Approvals - The company has received approval for clinical trials for several drugs, including SHR-9839, SHR-A2009, SHR-1826, HRS-4642, and others [1] - SHR-9839 is a humanized antibody drug aimed at treating advanced solid tumors, with a cumulative R&D investment of approximately 72.31 million yuan [1] - SHR-A2009 is a HER3-targeted antibody-drug conjugate, with no similar drugs approved globally, and a cumulative R&D investment of about 227 million yuan [1] Group 2: Market Potential and R&D Investments - SHR-1826 is a c-MET-targeted antibody-drug conjugate, with a cumulative R&D investment of around 101 million yuan [1] - HRS-4642 is a KRASG12D inhibitor, with a cumulative R&D investment of approximately 191 million yuan [1] - The approved drug, 阿得贝利单抗, is indicated for first-line treatment of extensive-stage small cell lung cancer, with a projected global sales of similar products totaling about 9.648 billion USD in 2024 and a cumulative R&D investment of approximately 969 million yuan [1] Group 3: Future Drug Approvals and Sales Projections - 注射用瑞康曲妥珠单抗 is expected to be approved in China by May 2025 for HER2-mutant non-small cell lung cancer, with projected global sales of similar products totaling around 6.557 billion USD in 2024 and a cumulative R&D investment of about 1.415 billion yuan [1] - SHR-A2102 is a Nectin-4-targeted antibody-drug conjugate, with projected global sales of about 1.949 billion USD in 2024 and a cumulative R&D investment of approximately 248 million yuan [1] - HRS-7058 is a KRASG12C inhibitor, with projected global sales of similar products totaling around 485 million USD in 2024 and a cumulative R&D investment of about 69.57 million yuan [1]