香港联交所最新资料显示，11月21日，汇添富基金增持三生制药(01530)116.2万股，每股作价29.8174港 元，总金额约为3464.78万港元。增持后最新持股数目约为1.46亿股，最新持股比例6.01%。 ...

Core Insights - The ITP drug treatment market in China is projected to grow, reaching 2.4 billion yuan in 2024, an increase of 200 million yuan from 2023, and is expected to reach approximately 2.8 billion yuan in 2025 [1][3][4] - Eltrombopag, a novel oral small molecule TPO receptor agonist, has shown excellent efficacy in treating ITP, significantly expanding treatment options for patients [1][4][7] - The sales of Eltrombopag in hospitals reached 376 million yuan in 2023, with an estimated 430 million yuan for the entire year of 2024 [1][4] ITP Drug Treatment Industry Pathway - ITP, or Immune Thrombocytopenic Purpura, is primarily treated with corticosteroids as the first-line therapy, while second-line treatments include platelet-stimulating drugs [2][4] - The incidence of ITP in adults in China is estimated at 5 to 10 per 100,000, with a projected 130,400 patients in 2024 [2][3] ITP Drug Treatment Industry Development Status - The ITP drug treatment market has been expanding, with a notable increase in treatment options due to ongoing research into the disease's pathophysiology [4][6] - The market is characterized by a growing number of patients and an increasing demand for effective treatments [2][3] ITP Drug Treatment Industry Chain - The upstream of the ITP drug treatment industry includes active pharmaceutical ingredients (APIs), chemical raw materials, and related equipment, while the midstream focuses on drug manufacturing [4][6] ITP Drug Treatment Competitive Landscape - Major companies in the domestic ITP drug market include Jiangsu Aosaikang Pharmaceutical, Jiangsu Hengrui Medicine, and Shenyang Sanofi Pharmaceutical, among others [2][6] - Several companies have received approval for Eltrombopag, indicating a competitive environment for generic versions of the drug [6][7] ITP Drug Treatment Development Trends - The treatment of ITP is moving towards targeted and precision medicine, with new therapies showing potential in regulating key immune nodes [7] - Future research may explore the combination of Eltrombopag with existing therapies to enhance treatment outcomes and achieve long-term remission for patients [7]

来源：新浪基金 11月26日早盘，港股创新药板块领市大涨，龙头股再度领跑，三生制药、石药集团双双涨超6%，荣昌 生物涨超5%。 港股通创新药ETF（520880）基金经理丰晨成指出，创新药板块催化不断，重磅数据陆续读出，同时 11-12月也是BD交易较为活跃的时点，且今年国产创新药已落地较多总金额超过10亿美金规模的BD交 易。后续2025年创新药医保国谈结果与首版商保创新药目录预计将于12月上旬发布，ASH、SABCS、 ESMO ASIA等行业会议也将于12月上旬召开。创新药产业趋势不变，随着行业正向催化的陆续落地， 板块情绪有望逐步恢复。 把握创新药反攻机遇，配置首选同类最大港股通创新药ETF（520880）及其场外联接基金（025221）， 标的指数恒生港股通创新药精选指数具备三大独特优势： 1、纯粹，全面。不含CXO，纯正创新药！全面覆盖创新药研发类公司。 2、龙头占比大。前十大创新药龙头权重超71%，表征创新药硬核力量。 3、风险更可控。对流动性较差的成份股强制降权，有力管控尾部风险。 | | | 港股通创新药ETF (520880) 标的指数 | | | --- | --- | --- | -- ...

Core Viewpoint - The Hong Kong innovative drug sector is experiencing significant growth, with leading stocks such as 3SBio and CSPC Pharmaceutical rising over 6% and 8% respectively, driven by positive news and developments in the industry [1][2][3]. Group 1: Market Performance - The Hong Kong innovative drug ETF (520880) has over 70% of its portfolio invested in leading innovative drug stocks, showing a strong upward trend with a rise of over 3% in early trading [2][3]. - Major stocks in the innovative drug sector, including 3SBio and CSPC Pharmaceutical, have shown substantial gains, indicating a bullish sentiment in the market [1][2]. Group 2: Industry Developments - 3SBio plans to spin off its Minoxidil brand, Mandi International, for a listing on the Hong Kong Stock Exchange, which is expected to enhance its market position [1]. - CSPC Pharmaceutical has received approval for clinical trials of its ActRIIA/B antibody JMT206 injection for obesity treatment, marking a significant advancement in its product pipeline [1]. Group 3: ETF Insights - The Hong Kong innovative drug ETF (520880) is the largest in its category, with a total scale of 2.12 billion HKD and an average daily trading volume of 464 million HKD since its inception [4]. - The ETF's index, the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, has a high concentration of leading stocks, with the top ten holdings accounting for over 71% of the total weight, indicating a strong focus on major players in the innovative drug sector [4][3]. Group 4: Future Outlook - The innovative drug sector is expected to see continued positive catalysts, with significant data releases and active business development transactions anticipated in November and December [3]. - Upcoming industry conferences and the expected release of the first version of the commercial insurance innovative drug directory are likely to further boost market sentiment [3].

Core Insights - The core viewpoint of the article is that the power dynamics in China's anti-hair loss market have shifted from traditional daily chemical brands to pharmaceutical companies, driven by a growing consumer base and evolving market demands [4][5]. Market Dynamics - The anti-hair loss market in China has seen a significant transformation, with over 300 million people affected by hair loss, particularly among the 26-35 age group, indicating a shift from a minor issue to a widespread concern [4]. - Pharmaceutical companies, particularly those with OTC pipelines and dermatological resources, have emerged as the primary players in the market, leading to a dual oligopoly dominated by Sanofi's Mandi and Zhendong Pharmaceutical's Dafeixin [4][8]. - The market for anti-hair loss products has reached 5.247 billion yuan in sales within the first ten months of 2025, reflecting a year-on-year growth of over 47% [10][13]. Brand Strategies - Pharmaceutical companies are creating a new narrative of "anti-hair loss = medicine + consumer," leveraging high margins and professional barriers while extending their product lines into daily care categories [5][19]. - Brands like Mandi and Dafeixin are combining pharmaceutical and cosmetic products, promoting them through "scientific anti-hair loss salons" to capture consumer interest [6][9]. Competitive Landscape - Traditional daily chemical brands are struggling, with companies like Bawang reporting a significant decline in profits despite a slight revenue increase, highlighting a structural challenge in the market [8]. - The consumer focus has shifted from "shampoo for hair loss" to "medical treatment and scalp management," indicating a demand for more scientifically-backed solutions [9][10]. Emerging Trends - The average price of anti-hair loss products has risen to over 113 yuan, suggesting consumers are willing to invest more in effective scalp care solutions [13]. - New brands such as EHD and Off&Relax are gaining traction, with EHD leading in sales at 371 million yuan, showcasing a trend towards professional and functional care [16][18]. Future Directions - To compete effectively, beauty brands must transition from traditional narratives to scientific and medical language, focusing on the mechanisms behind hair loss and scalp health [19][23]. - The integration of devices with hair care products is emerging as a trend, with brands like Kérastase introducing scalp care devices that enhance treatment efficacy [25][27]. Conclusion - The anti-hair loss market is evolving into a sector characterized by scientific, medical, and long-term management approaches, with pharmaceutical companies redefining the rules and traditional brands being compelled to adapt [19].

Core Viewpoint - Recently, 3SBio announced the proposal to spin off its subsidiary Mandi International for independent listing on the Hong Kong Stock Exchange, with 3SBio holding 87.16% of Mandi's shares, and after the spin-off, 3SBio will not retain any interests in Mandi [1][5] Group 1: Company Overview - Mandi International was established in 1997 as Zhejiang Wansheng Pharmaceutical Co., Ltd., and launched China's first 5% minoxidil product in 2001, filling a gap in the domestic hair loss treatment market [1][2] - Mandi International's revenue is primarily dependent on the Mandi product series, which includes 5% minoxidil solutions and shampoos, contributing over 90% of its revenue [3][4] Group 2: Market Potential - The hair health management market in China has expanded from 19.8 billion yuan in 2018 to an estimated 52.7 billion yuan in 2024, with a projected compound annual growth rate (CAGR) of 11.3% from 2024 to 2035 [2] - Over 339 million people in China are affected by hair loss, with more than 60% of them under the age of 35 [2] Group 3: Financial Performance - Mandi International's revenue from 2022 to 2024 is projected to grow from 982 million yuan to 1.455 billion yuan, with a CAGR of 21.7%, and net profits are expected to rise from 202 million yuan to 390 million yuan [3] - In the first half of 2025, Mandi International achieved revenue of 743 million yuan, a year-on-year increase of approximately 20.2% [3] Group 4: Product Development - Mandi International launched the second-generation minoxidil product, Mandi 5% minoxidil foam, which saw rapid sales growth, generating 307 million yuan in 2024 and 283 million yuan in the first half of 2025 [4] - The company has a pipeline of products under development, including treatments for acne, obesity, and vitiligo, although these contribute less to current revenue [4] Group 5: Strategic Rationale for Spin-off - The spin-off is expected to provide multiple commercial benefits, including enhanced value transparency, independent financing platforms, and optimized management responsibilities, which will improve decision-making and market responsiveness [5]

Market Overview - The Hong Kong stock market showed a significant recovery on November 24, with all three major indices ending a streak of declines[9] - Large tech stocks performed strongly, with Kuaishou rising over 7%, and NetEase and Bilibili increasing over 5%[9] - The Hang Seng Tech Index closed at 5,546, up 2.78% for the day and 24.11% year-to-date[3] Sector Performance - Innovative pharmaceuticals and outsourcing concepts saw notable gains, with companies like Innovent Biologics rising over 6%[9] - Military stocks also performed well, with China Shipbuilding Defense up over 13%[9] - Oil stocks were weak, with China National Offshore Oil Corporation and China Oilfield Services both declining over 1%[9] U.S. Market Insights - On the same day, U.S. markets saw all three major indices close higher, driven by increased bets on a Federal Reserve rate cut[9] - The "Magnificent Seven" tech stocks, including Google and Nvidia, all rose, with Google gaining over 6%[9] - The S&P 500 index is projected to achieve double-digit annual growth according to HSBC strategists[14] Economic Indicators - The Federal Reserve is expected to cut rates in December, with market predictions showing a 70% probability[14] - The U.S. economy's third-quarter GDP report has been delayed due to a government shutdown, affecting economic analysis[14] Investment Trends - The Nasdaq Golden Dragon China Index rose by 2.82%, indicating a positive trend for Chinese concept stocks[13] - Significant inflows into semiconductor stocks were noted, with companies like Broadcom surging 11%[13]

【文/王力 编辑/周远方】 11月20日晚间，港股上市公司三生制药（01530.HK）发布公告，宣布将旗下消费医药业务板块蔓迪国 际分拆至港交所主板独立上市，华泰国际担任独家保荐人。这意味着，这家凭借米诺地尔产品连续十年 稳居中国脱发药物市场榜首的企业，即将以独立身份登陆资本市场。 蔓迪国际的背后，站着三生制药的灵魂人物——娄竞。1993年，娄竞的父亲、生物医学专家娄丹在沈阳 创立了三生制药。彼时正在美国福特汉姆大学攻读分子与细胞生物学博士学位的娄竞，于1995年学成归 国，加入父亲创办的公司担任研发主管，此后逐步接手公司管理，现任三生制药董事长兼首席执行官。 2015年，三生制药全资收购了拥有蔓迪品牌的浙江万晟药业，将其纳入集团化药发展平台。如今，这一 业务板块被推向独立上市，娄竞仍通过信托安排控制蔓迪国际的员工持股平台。 根据招股书披露，三生制药目前持有蔓迪国际约87.16%的股权，阿里健康等机构投资者亦在股东名单 之中。值得注意的是，公告明确指出分拆完成后三生制药将不会保留蔓迪国际的任何权益，这意味着蔓 迪将彻底脱离母公司，以独立个体在市场中搏杀。在集采降价、竞争加剧的行业背景下，这家"防脱神 药"制造 ...

Core Insights - The Chinese innovative drug industry has reached a new watershed in 2025, characterized by significant transactions and a shift towards quality over quantity in drug development [5][7][8]. Group 1: Industry Evolution - The year 2025 marks the tenth anniversary of the Chinese innovative drug industry, described as a year of "frenzy" due to major transactions such as 60.5 billion USD partnership between 3SBio and Pfizer, 12.5 billion USD collaboration between Hengrui Medicine and GSK, and 11.4 billion USD deal between Innovent Biologics and Takeda [6][8]. - License-out upfront payments reached 4.55 billion USD in the first three quarters of 2025, surpassing the total financing amount of 3.19 billion USD in the primary market, indicating that BD transactions have become a crucial cash flow pillar during a capital winter [6][22]. - The approval speed of new drugs has accelerated, with 43 new drugs approved in the first half of 2025, a 59% increase year-on-year, and 26 innovative drugs approved by October [14][20]. Group 2: Market Dynamics - The total amount of BD transactions in the Chinese pharmaceutical sector exceeded 100 billion USD, with 103 license-out transactions totaling 92.03 billion USD in the first three quarters, a 77% year-on-year increase [16][20]. - The oncology field remains the core battlefield, with 63 projects going overseas in the first three quarters, while the endocrine and metabolic fields have also seen significant growth [16][22]. - The U.S. is the primary acquirer in license-out transactions, accounting for 49% of the total, followed by Germany, South Korea, and Switzerland [22]. Group 3: Financial Performance - The innovative drug sector achieved a revenue of 48.83 billion CNY in the first three quarters of 2025, a 22.1% year-on-year increase, with a notable profit turnaround for leading companies [41][43]. - Leading companies like BeiGene and Innovent Biologics reported significant profits, with BeiGene achieving a net profit of 1.139 billion CNY in the first three quarters [41][43]. - The financial performance of small biotech firms contrasts sharply, with many facing severe funding challenges and some, like NuoHui Health, being forced to delist due to financial misconduct [40][43]. Group 4: Challenges and Opportunities - Despite the industry's growth, deep-seated challenges remain, including insufficient late-stage clinical development capabilities and the phenomenon of "selling early-stage pipelines at a discount" [25][36]. - The gap in clinical trial capabilities between domestic companies and multinational corporations (MNCs) is evident, with MNCs leveraging their resources to dominate core clinical resources in China [30][33]. - The proportion of license-out transactions for late-stage projects has only slightly increased, indicating a continued reliance on early-stage assets [26][36].

Group 1 - Hong Kong's Hang Seng Index rose by 1.42%, gaining 358 points to close at 25,578 points, while the Hang Seng Tech Index increased by 1.65% [1] - Alibaba-W (09988) surged over 4%, with its Qianwen App surpassing 10 million downloads in its first week of public testing [1] - Sinopharm (01801) rose over 3%, with plans to officially go blue starting December 8 [1] - Hengrui Medicine (01276) increased by over 5%, as nine drugs including SHR-9839 received approval for clinical trials [1] - Beijing Automotive (01958) gained over 3%, planning to sell 51% of its stake in Beiqi International for approximately 1.608 billion yuan to accelerate its international strategy [1] - WeRide (00800) jumped over 6%, having obtained Switzerland's first pure driverless license, with Q3 earnings report upcoming [1] - Rusal (00486) saw an intraday increase of over 4%, announcing plans to cease operations at the Krymni silicon plant by 2026 [1] - GAC Group (02238) surged over 12%, with its all-solid-state battery pilot production line officially completed and put into production [1] - Sino Biopharmaceutical-B (02591) rose over 20%, being included in the Hang Seng Composite Index effective December 8 [1] - 3SBio (01530) increased by over 4%, planning to spin off its subsidiary Mandi International for independent listing [1] Group 2 - Oil stocks continued to decline, with CNOOC (00883) dropping by 2.4% amid easing tensions in the Russia-Ukraine situation [2] - Semiconductor stocks faced significant declines, with Hua Hong Semiconductor (01347) falling over 9% and SMIC (00981) down over 5%, as reports indicated the Trump administration is considering approving exports of Nvidia's H200 AI chips to China [2] - Ganfeng Lithium (01772) dropped over 7%, facing potential downward risks in lithium spot prices, leading Goldman Sachs to downgrade the company to a "sell" rating [2]