Core Viewpoint - The expectation for a rate cut by the Federal Reserve in December has increased, leading to a rise in Hong Kong stock indices, with the Hang Seng Index closing up 1.97% at 25,716.5 points, and a total trading volume of 302.64 billion HKD [1] Group 1: Market Performance - The three major indices in Hong Kong collectively rose, with the Hang Seng Index gaining over 2% at one point during the day [1] - The Hang Seng Technology Index increased by 2.78%, closing at 5,545.56 points [1] - The trading volume for the day reached 302.64 billion HKD [1] Group 2: Blue-Chip Stocks - Alibaba-W (09988) saw a significant increase of 4.67%, closing at 154.5 HKD, contributing 104.44 points to the Hang Seng Index [2] - Kuaishou-W (01024) rose by 7.11%, while NetEase-S (09999) increased by 5.87%, contributing 21.51 points and 26.03 points to the index respectively [2] Group 3: Sector Performance - Technology stocks rebounded, with Kuaishou rising over 7% and NetEase nearly 6% [3] - AI applications are gaining traction, with notable increases in stocks related to AI, such as Chuangmeng Tiandi (01119) up 9.38% and Innovation Qizhi (02121) up 8.83% [3] - Military stocks performed strongly, with China Shipbuilding Defense (00317) rising by 13.07% [4] Group 4: Automotive Sector - The automotive sector saw widespread gains, with GAC Group (02238) increasing by 12.03% and Beijing Automotive (01958) rising by 5.91% [5] - The Guangzhou Auto Show featured 93 new car launches, with nearly 60% being new energy vehicles [6] Group 5: Lithium and Semiconductor Stocks - Lithium stocks continued to decline, with Ganfeng Lithium (01772) down 5.66% [7] - Semiconductor stocks showed weakness, with Hua Hong Semiconductor (01347) falling by 4.91% [7] Group 6: Notable Stock Movements - Innovation Industry (02788) debuted with a significant increase of 32.76%, closing at 14.59 HKD [9] - Silver诺医药-B (02591) surged by 31.15% after being included in the Hang Seng Composite Index [10] - Miniso (09896) faced pressure post-earnings, with a decline of 4.84% despite a revenue increase of 28.2% [11]

Core Viewpoint - Silver诺医药-B (02591) has seen a nearly 10% increase in stock price following its inclusion in the Hang Seng Composite Index, effective December 8, 2025, which is expected to enhance its market visibility and support its research and commercialization efforts [1] Group 1: Stock Performance - As of the report, Silver诺医药-B's stock price rose by 9.81%, reaching 31.8 HKD, with a trading volume of 2.7693 million HKD [1] Group 2: Clinical Trials and Product Development - On November 21, it was announced that Silver诺医药 has completed the first patient dosing in a Phase III clinical trial for its core product, Isuparaglutide α, aimed at treating obesity and overweight conditions, with plans to recruit approximately 800 participants [1] - The company has demonstrated that Isuparaglutide α has good safety profiles and significant effects in reducing blood sugar and weight, showing advantages in treating chronic metabolic diseases such as diabetes, obesity, and fatty liver [1] Group 3: Market Outlook and Competition - The GLP-1 sector remains a focus, with ongoing competition intensifying; stakeholders are advised to monitor the expansion of indications, submission for market approval, and the commercialization process [1]

Group 1 - Hong Kong's Hang Seng Index rose by 1.42%, gaining 358 points to close at 25,578 points, while the Hang Seng Tech Index increased by 1.65% [1] - Alibaba-W (09988) surged over 4%, with its Qianwen App surpassing 10 million downloads in its first week of public testing [1] - Sinopharm (01801) rose over 3%, with plans to officially go blue starting December 8 [1] - Hengrui Medicine (01276) increased by over 5%, as nine drugs including SHR-9839 received approval for clinical trials [1] - Beijing Automotive (01958) gained over 3%, planning to sell 51% of its stake in Beiqi International for approximately 1.608 billion yuan to accelerate its international strategy [1] - WeRide (00800) jumped over 6%, having obtained Switzerland's first pure driverless license, with Q3 earnings report upcoming [1] - Rusal (00486) saw an intraday increase of over 4%, announcing plans to cease operations at the Krymni silicon plant by 2026 [1] - GAC Group (02238) surged over 12%, with its all-solid-state battery pilot production line officially completed and put into production [1] - Sino Biopharmaceutical-B (02591) rose over 20%, being included in the Hang Seng Composite Index effective December 8 [1] - 3SBio (01530) increased by over 4%, planning to spin off its subsidiary Mandi International for independent listing [1] Group 2 - Oil stocks continued to decline, with CNOOC (00883) dropping by 2.4% amid easing tensions in the Russia-Ukraine situation [2] - Semiconductor stocks faced significant declines, with Hua Hong Semiconductor (01347) falling over 9% and SMIC (00981) down over 5%, as reports indicated the Trump administration is considering approving exports of Nvidia's H200 AI chips to China [2] - Ganfeng Lithium (01772) dropped over 7%, facing potential downward risks in lithium spot prices, leading Goldman Sachs to downgrade the company to a "sell" rating [2]

Group 1: Market Movements - Sangfor Technologies (01530) rose over 5% following the news that Mandi International has submitted an application to list on the Hong Kong Stock Exchange, focusing on skin health and weight management solutions [1] - Yino Pharma (02591) surged over 22.5% after being included in the Hang Seng Composite Index, effective December 8, 2025 [1] - ASMPT (00522) fell over 2% as it was removed from the Hang Seng Tech Index [1] - Semiconductor stocks faced declines, with Hua Hong Semiconductor (01347) down 9.35% and SMIC (00981) down 5.38%, amid reports of potential U.S. chip exports to China [1] - Ganfeng Lithium (01772) dropped over 7% due to Goldman Sachs' report indicating that while the lithium market fundamentals have improved, extended inventory cycles in energy storage may offset this [1] Group 2: Company Earnings and Performance - Miniso (09896) fell over 6% despite reporting a 28.2% year-on-year revenue increase, as net profit dropped over 30% compared to the previous year [2] - NetEase (09999) rose over 5% after reporting a net income of RMB 28.4 billion (approximately $4 billion), an 8.2% year-on-year increase [2] - Alibaba (09988) increased over 4% as its AI assistant app surpassed 10 million downloads within a week of public testing [2] - CK Hutchison (00001) rose nearly 3% amid reports of plans for a dual listing of its Watsons brand, potentially raising up to $2 billion [2] Group 3: U.S. Market Highlights - Nvidia (NVDA.US) continued its downward trend, falling 0.97% despite a strong earnings report, with the founder expressing frustration over market perceptions [3] - Oracle (ORCL.US) dropped 5.66% after issuing $18 billion in investment-grade bonds to increase AI spending [4] - Retailer Ross Stores (ROST.US) saw an increase of over 8.41% after reporting third-quarter sales of $5.6 billion, exceeding market expectations [5] - Intuit (INTU.US) rose over 4.03% after reporting adjusted earnings per share of $3.34, surpassing Wall Street's expectations [5]

Core Viewpoint - The inclusion of SINO Pharmaceutical-B (2591.HK) in the Hang Seng Composite Index marks a significant recognition of its investment value and lays the groundwork for its future inclusion in the Hong Kong Stock Connect program [1] Group 1: Market Performance and Recognition - SINO Pharmaceutical has demonstrated strong market performance since its listing, achieving a subscription rate of 5340 times during its IPO, making it the second most oversubscribed new stock of the year [2] - The company's stock price surged over 285% on its first trading day and maintained high interest, closing with a 206% increase, reflecting strong market recognition of its core value [2] - Despite experiencing short-term price adjustments due to market sentiment, the company's operational progress aligns with the broader trend of quality stocks in the innovative drug sector recovering in value [2] Group 2: R&D and Competitive Edge - SINO Pharmaceutical's R&D capabilities are a core competitive advantage, particularly in the efficiency of pipeline advancement and source innovation [4] - The company has positioned itself as a leader in the GLP-1 drug market with its product, Isu-Paglutide α, being the first GLP-1 drug approved in Asia and the third globally, showcasing its competitive edge [5] - The drug's long half-life allows for bi-weekly dosing, addressing patient compliance issues, which strengthens its market position [5] Group 3: Commercialization and Market Strategy - The rapid commercialization of Isu-Paglutide α, which generated revenue of 56.446 million yuan by June 30, demonstrates the company's effective commercialization capabilities [6] - The drug has successfully passed the formal review for inclusion in the National Medical Insurance Drug List, which could enhance its market penetration [6][7] - The company has established a robust commercialization team to support market entry and growth following the drug's inclusion in insurance [7] Group 4: Global Expansion and Market Positioning - SINO Pharmaceutical is leveraging its experience in the Greater Bay Area to create a replicable commercialization model for international markets [16] - The company is targeting emerging markets in Southeast Asia and Latin America, where there is a high demand for GLP-1 drugs due to insufficient supply [17][18] - SINO Pharmaceutical is also preparing to enter mainstream markets like Europe and the U.S. by accumulating necessary clinical data through ongoing trials [19] Group 5: Future Outlook and Investment Potential - The global market for anti-obesity drugs is projected to exceed $100 billion by 2030, positioning SINO Pharmaceutical favorably with its differentiated product offerings [21] - The company is expected to benefit from upcoming catalysts such as the results of insurance negotiations, BLA approvals in Southeast Asia, and the completion of clinical trials for obesity indications [21] - Current market conditions may present an opportune moment for investors to consider SINO Pharmaceutical as a key player in the valuation recovery of the Hong Kong pharmaceutical sector [21]

每经AI快讯，银诺医药-B(02591.HK)涨近10%，截至发稿，涨9.81%，报31.8港元，成交额276.93万港 元。 ...

Core Viewpoint - The inclusion of SINO Pharmaceutical-B (2591.HK) in the Hang Seng Composite Index marks a significant recognition of its investment value and lays the foundation for its future inclusion in the Hong Kong Stock Connect [1][2]. Company Performance - SINO Pharmaceutical has demonstrated strong market performance since its listing, achieving a subscription rate of 5340 times during its IPO, making it the second most oversubscribed new stock of the year [2]. - The company's stock price surged over 285% on its first trading day and closed up 206%, reflecting high market recognition of its core value [2]. - Despite experiencing short-term price adjustments due to market sentiment, the company's core operational actions have remained steady, aligning with the logic of prioritizing quality stocks for recovery [2]. Research and Development - SINO Pharmaceutical's R&D capabilities are a key competitive advantage, particularly in pipeline advancement and source innovation [4]. - The company has successfully launched its GLP-1 drug, Isu-Paglutide α, becoming the first in Asia to do so and the third globally, showcasing its leading clinical advancement efficiency [5]. - The drug's long half-life supports bi-weekly dosing, addressing patient compliance issues, which strengthens its competitive position in the market [5]. Market Strategy - The rapid commercialization of Isu-Paglutide α in China, with revenues of 56.446 million yuan by June 30, demonstrates the company's effective commercialization capabilities [6]. - The drug has passed the formal review for inclusion in the National Medical Insurance Drug List, which could enhance its market penetration [6][7]. - The company is expanding its indications for Isu-Paglutide α, with ongoing clinical trials for obesity and metabolic dysfunction-related fatty liver disease (MASH), which broadens its growth potential [7]. Innovation Pipeline - SINO Pharmaceutical has a robust pipeline with five preclinical candidates targeting various diseases, indicating its commitment to true innovation rather than following existing treatments [8][10]. - The company’s new targets are designed to address unmet clinical needs, positioning it for potential industry disruption [10][11]. Global Expansion - The company is building a global presence with a focus on emerging markets, leveraging its clinical data from China to gain regulatory approvals [15][17]. - SINO Pharmaceutical has achieved commercial success in Macau and is applying for BLA in Southeast Asia and Latin America, aiming to capture market share in regions with high unmet medical needs [16][18]. - The company is also preparing for entry into mainstream markets like Europe and the U.S. by accumulating necessary clinical data through ongoing trials [19]. Industry Outlook - The global market for GLP-1 drugs is expected to expand significantly, with projections indicating it could exceed $100 billion by 2030 [21]. - SINO Pharmaceutical's differentiated product offerings and global strategy align with institutional expectations for innovation value pricing [21]. - The company is positioned to benefit from upcoming catalysts, including insurance negotiations and clinical trial milestones, which could enhance its fundamental value [21].

Core Viewpoint - Silver诺医药-B (02591) has seen a nearly 10% increase in stock price following its inclusion in the Hang Seng Composite Index, effective December 8, 2025, which is expected to enhance its market visibility and support its research and commercialization efforts [1] Group 1: Company Developments - As of November 21, Silver诺医药's stock rose by 9.81%, reaching HKD 31.8, with a trading volume of HKD 2.7693 million [1] - The company announced the completion of the first patient dosing in a Phase III clinical trial for its core product, Isuparaglutide α, aimed at treating obesity and overweight, with plans to recruit approximately 800 participants [1] Group 2: Product and Market Insights - Shanghai Securities highlighted that Isuparaglutide α demonstrates good safety and efficacy in reducing blood sugar and weight, showing significant advantages in treating chronic metabolic diseases such as diabetes, obesity, and fatty liver [1] - The GLP-1 sector remains highly competitive, with ongoing attention on the expansion of indications, submission for market approval, and the commercialization process [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因倚賴 該等內容而引致的任何損失承擔任何責任。 關於董事會及監事會延期換屆的公告 廣州銀諾醫藥集團股份有限公司（「本公司」）第一屆董事（「董事」）會（「董事會」） 及監事會（「監事會」）的任期將於2025年11月22日屆滿。鑒於董事會換屆及監事 會換屆（「換屆」）籌備工作正在進行中，為保持董事會及監事會的連續運作，將延 期換屆，第一屆董事會及第一屆監事會的任期將順延至根據本公司組織章程細則 的規定於股東大會選舉產生新一屆董事會及監事會之日止。同時，本公司各董事 委員會的第一屆任期將相應順延。 於完成換屆之前，第一屆董事會、各董事委員會及第一屆監事會的成員將依照相 關法律、法規及本公司組織章程細則的規定繼續履行彼等之職責。 延期換屆將不會影響本公司的正常運營。本公司將積極推進換屆選舉工作並按照 香港聯合交易所有限公司證券上市規則的相關要求及時履行相應的披露義務。 承董事會命 廣州銀諾醫藥集團股份有限公司 董事長 WANG QINGHUA博士 中國，上海， ...

Summary of Key Points Core Viewpoint - As of November 21, 14 stocks reached their 52-week highs, with Hengfa Optical (01134), Chaowei Holdings (08059), and Cassava Resources (00841) leading the gains at 42.11%, 30.56%, and 22.49% respectively [1]. 52-Week Highs - Hengfa Optical (01134) closed at 0.375, with a peak price of 0.540, marking a 42.11% increase [1]. - Chaowei Holdings (08059) closed at 0.030, reaching a high of 0.047, reflecting a 30.56% rise [1]. - Cassava Resources (00841) closed at 0.200, with a maximum price of 0.207, indicating a 22.49% increase [1]. - Other notable stocks include Sibor Systems (08319) at 15.04%, MOS HOUSE (01653) at 11.46%, and Tianjin Jianfa (02515) at 5.19% [1]. 52-Week Lows - China Pengfei Group (03348) reached a low of 1.100, down 20.09% from its peak [1]. - China Information Technology (08178) closed at 0.285, reflecting a 19.35% decrease [1]. - XL Ernan Strategy - U (09799) saw a decline of 14.27% [1]. - Other significant declines include Hesai - W (02525) at -10.54% and MBC Bitcoin - U (03425) at -9.09% [1]. Additional Notable Stocks - Stocks like MBC Bitcoin (03430) and Tongyuan Kang Pharmaceutical - B (02410) also experienced declines of 6.64% and 6.62% respectively [2]. - The overall trend indicates a mix of significant gains in certain stocks while others are facing substantial losses, reflecting a volatile market environment [1][2].