Business Overview & Highlights - 科伦博泰是一家致力于肿瘤学、免疫学和其他治疗领域新药的开发、制造和商业化的生物制药公司[14] - 公司有30多个在研药物，其中4个处于临床阶段，并且有超过1870名全职雇员[20] - 公司有3款产品上市，并且已经提交了5个新药申请(NDAs)[20] - 公司与默沙东就多个ADC资产展开合作，包括SKB410/MK-3120, SKB571/MK-2750, SKB535/MK-6204[30] Commercialization - 公司商业销售总额达3.098 亿元人民币，其中sac-TMT (佳泰莱®)销售占比为97.6%[53] - 公司已组建了一支人数超过350人的营销团队，覆盖30个省份和300多个城市，目标医院数超过2000家[57] - 佳泰莱®已完成29个省挂网，科泰莱®已完成25个省挂网，达泰莱®已完成15个省挂网[62] Financial Performance - 公司收入从2024年上半年的13.82791亿人民币减少到2025年上半年的9.50445亿人民币[85, 95] - 公司毛利从2024年上半年的10.7669亿人民币减少到2025年上半年的6.59988亿人民币[85, 95] - 公司研发费用从2024年上半年的6.52337亿人民币减少到2025年上半年的6.11539亿人民币[89, 95]

Core Viewpoint - The Hong Kong stock market's innovative pharmaceutical sector has seen a significant rebound this year, with net inflows of over 120 billion yuan into the pharmaceutical and biotechnology industry, highlighting a shift towards more reliable quality stocks [1] Group 1: Company Performance - Kelun-Biotech (06990) has emerged as a key target for market investment, achieving a historical high in stock price in August, with a market capitalization exceeding 100 billion HKD and a year-to-date increase of 192.40%, entering the "100 billion club" of Hong Kong's innovative pharmaceuticals [1] - The company's mid-2025 performance report indicates a transition from Biotech to Biopharma, with revenue driven by both business development (BD) collaborations and self-commercialization [3][4] - In the first half of 2025, Kelun-Biotech reported revenues of 950 million yuan, with cash reserves of 4.528 billion yuan, indicating strong cash flow and a shift in revenue structure from BD-driven to self-commercialization [4] Group 2: Commercialization Strategy - The company's core product, TROP2 ADC (Jiatailai), has shown strong commercial potential, generating sales of 51.698 million yuan in its first month post-launch and expanding its indications, which enhances market opportunities [5] - Kelun-Biotech has established a comprehensive commercialization capability, with a professional marketing team of 350 and a wide distribution network covering over 1,000 hospitals and partnerships with more than 60 distributors [8][9] - The company has successfully navigated market access, achieving broad coverage for its products across multiple provinces and actively pursuing inclusion in national insurance schemes to enhance drug accessibility [9] Group 3: Research and Development - Kelun-Biotech has increased its R&D investment, reaching 612 million yuan in the first half of 2025, and has developed three major technology platforms, ensuring a robust pipeline of over 30 candidate drugs [10][11] - The company's international collaborations with major pharmaceutical firms validate its technological capabilities and support the transformation of global innovative results into commercial value [11] - The dual strategy of BD collaborations and self-commercialization aligns with the trend of "true innovation + self-control" in the domestic pharmaceutical industry, positioning Kelun-Biotech as a key player in the Hong Kong pharmaceutical investment landscape [12]

Core Insights - The Hong Kong stock market's innovative pharmaceutical sector has seen a significant rebound this year, with net inflows of over 120 billion yuan into the pharmaceutical and biotechnology industry, driving funds towards more certain quality targets [1] - Kelun-Biotech (06990) has emerged as a key target for market investment, achieving a historical high in stock price and a market capitalization exceeding 100 billion HKD, with a year-to-date increase of 192.40%, entering the "100 billion club" of Hong Kong's innovative pharmaceuticals [1][3] Revenue Structure Transformation - Kelun-Biotech is transitioning from a biotech to a biopharma company, with its revenue structure evolving to be driven by both business development (BD) collaborations and self-commercialization [3][4] - In the first half of 2025, the company reported revenues of 950 million yuan, with cash reserves of 4.528 billion yuan, indicating a robust cash flow [4] - The sales revenue from its core product, Jiatailai® (TROP2 ADC), has shown strong market acceptance, contributing significantly to the company's revenue growth [5][6] Commercialization Strategy - The company has established a dual approach to commercialization, focusing on both licensing collaborations and self-sustaining revenue generation [4][5] - Kelun-Biotech has formed a professional marketing team of 350 people, achieving extensive coverage across 30 provinces and over 2,000 hospitals in China [7] - The company is actively pursuing national medical insurance access for its products, which could significantly enhance sales through payment leverage [7] R&D and Innovation - Kelun-Biotech has increased its R&D investment, reaching 612 million yuan in the first half of 2025, supporting its competitive edge in key therapeutic areas [8][9] - The company has developed three major technology platforms, enabling a pipeline of over 30 candidate drugs, with more than 10 in clinical stages [8] - International recognition of its R&D capabilities is reflected in its collaborations with various global partners, enhancing its innovation and market reach [9] Summary of Growth Path - Kelun-Biotech's mid-term performance illustrates a clear growth trajectory, with Jiatailai® providing cash flow and three technology platforms ensuring ongoing innovation [9] - The company's dual-driven model of BD collaboration and self-commercialization aligns with the core logic of pharmaceutical investment in Hong Kong, indicating its long-term potential for growth [9]

格隆汇8月18日｜科伦博泰生物(6990.HK)公布，截至6月底止中期业绩，收入9.5亿元，同比减少 31.27%；股东应占亏损1.45亿元，每股亏损0.64元，不派中期息。去年同期盈利为3.1亿元。 ...

收益减少乃主要由于许可及合作协议的里程碑付款较2024年上半年减少。同时，於2025年上半年，药品 销售贡献收入人民币309.8百万元。 格隆汇8月18日丨科伦博泰生物-B(06990.HK)公布中期业绩，截至2025年6月30日止六个月，公司收入为 人民币9.50亿元，同比减少31.3%；研发开支为人民币6.12亿元，同比减少6.3%，公司权益股东应占期 内亏损为人民币1.45亿元，去年同期则盈利人民币3.10亿元，每股亏损为人民币0.64元。截至2024年12 月31日及2025年6月30日，公司现金及现金等价物分别为人民币13.365亿元及人民币31.028亿元。 ...

2025年上半年商业销售总额达3.098亿元。其中，佳泰莱® 的销售占97.6%。同时，药品销售的所有应收 账款均于账期内收回，资金回笼高效稳健。 在三个具备ADC及新型偶联药物、大分子(单抗及双抗)以及小分子药物专有技术、内部开发的技术平台 的支援下，并经我们的临床阶段候选药物验证，我们的管线在药物模态、机制及适应症覆盖范围方面具 有多样性，并在这些方面发挥协同效应。值得注意的是，我们是开发ADC的先行者之一，在ADC开发 方面积累了超过十年的经验。我们是中国首批也是全球为数不多的建立内部开发ADC及新型偶联药物 平台OptiDCTM的生物制药公司之一。我们符合cGMP标准的端到端制造能力及全面的质量管理体系进 一步支援我们的药物开发能力。此外，凭藉我们控股股东科伦药业数十年的经验、行业关系及广泛的网 络，我们具备了扩充商业化基础设施及市场管道的良好条件。 智通财经APP讯，科伦博泰生物-B(06990)发布截至2025年6月30日止6个月的中期业绩，该集团取得收入 人民币9.5亿元(单位下同)，同比减少31.3%;研发开支6.12亿元，同比减少6.3%;公司权益股东应占亏损 1.45亿元;每股亏损0.64 ...

Core Insights - The company reported a revenue of RMB 950 million for the six months ending June 30, 2025, representing a year-on-year decrease of 31.3% [1] - Research and development expenses amounted to RMB 612 million, down 6.3% year-on-year [1] - The company incurred a loss attributable to equity shareholders of RMB 145 million, with a loss per share of RMB 0.64 [1] Financial Performance - Total commercial sales for the first half of 2025 reached RMB 309.8 million, with 97.6% of sales coming from the product "佳泰莱" [1] - All accounts receivable from drug sales were collected within the payment period, indicating efficient cash flow management [1] Product Development and Pipeline - The company has received marketing approvals for sac-TMT (佳泰莱), Tagolizumab (科泰莱), and Cetuximab N01 (达泰莱) and has commenced commercialization [1] - The company anticipates launching "博度曲妥珠单抗" (舒泰莱) in the Chinese market in the second half of 2025, pending regulatory communication and approval [1] - The company is a pioneer in developing ADCs and has over ten years of experience in this field, with a proprietary platform for ADC and novel conjugated drugs [2] Manufacturing and Quality Management - The company possesses end-to-end manufacturing capabilities that comply with cGMP standards and a comprehensive quality management system to support drug development [2] - The company benefits from the extensive experience, industry relationships, and network of its controlling shareholder, 科伦药业 (002422), which enhances its commercialization infrastructure and market pipeline [2]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內 容 概 不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不對因本公告全部或任何部份內容而產生或因倚賴該等內容而引致的 任 何 損 失 承 擔 任 何 責 任。 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. 四川科倫博泰生物醫藥股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6990） 截 至2025年6月30日止六個月 之 中期業績公告 董事會欣然宣佈本集團截至2025年6月30日止六個月的未經審計簡明綜 合 中 期 業 績，連 同 截 至2024年6月30日 止 六 個 月 的 比 較 數 字。本 公 司 獨 立 核數師已根據香港會計師公會頒佈的香港審閱工作準則第2410號「實 體 獨 立 核 數 師 審 閱 中 期 財 務 資 料」對 中 期 財 務 資 料 進 行 審 閱。除 本 公 告 另 有 界 定 外，本 公 告 所 用 詞 彙 與 招 股 章 程 所 界 定 者 ...

Group 1 - The core viewpoint of the news is the performance and holdings of the Huatai Fuhua Medical Active Growth One-Year Holding Mixed Fund A, which has shown significant returns in various time frames [1] - As of June 30, 2025, the fund's total assets amount to 1.922 billion yuan, with a recent net value of 0.8263 yuan, reflecting a growth of 1.04% [1] - The fund has achieved a return of 15.15% over the past month, 63.14% over the past six months, and 66.59% year-to-date, ranking 506 out of 4688, 60 out of 4532, and 84 out of 4490 respectively in its category [1] Group 2 - The top ten stock holdings of the fund account for a total of 61.79%, with significant positions in companies such as Sanofi (10.07%), Innovent Biologics (8.94%), and Kelun-Biotech (8.71%) [1] - The fund was established on August 21, 2020, and is managed by Zheng Lei, who has extensive experience in the medical and healthcare investment sector [2]

Core Viewpoint - The investment bank maintains a cautiously optimistic outlook on the Chinese pharmaceutical industry, noting a significant average increase of 137% in Hong Kong biotech stocks since early 2025, driven by cash returns from innovative drug licensing deals and unaffected by upcoming U.S. tariffs [1] Group 1: Market Performance - The biotech sector has recently experienced some pullback due to disappointing sales figures from major companies in the first half of 2025, including Hutchison China MediTech [1] - Concerns have arisen regarding Trump's phased implementation of drug tariffs, which could escalate to 150% within a year and ultimately reach 250% [1] Group 2: Company Recommendations - The bank's top pick is BeiGene (06160), with a target price set at HKD 230 and a rating of "Outperform," citing strong performance in the first half of 2025 and an improved gross margin guidance despite U.S. tariff impacts [1] - CanSino Biologics (09926) is expected to report adjusted earnings of RMB 23 million for the first half of 2025, benefiting from revenue growth from its drugs AK104 and AK112, also rated "Outperform" [1] - The target price for Innovent Biologics (01801) has been raised by 10% from HKD 100 to HKD 110, with a rating of "Outperform," reflecting confidence in the company's projected 37% year-on-year revenue growth [1] Group 3: Focus on Innovative Drugs - The bank continues to pay attention to licensing deals for Chinese innovative drugs, with expectations of increased subsidies for high-priced innovative drugs, which may drive sales growth for companies such as Kintor Pharmaceutical (02171), Fosun Pharma (02196), WuXi AppTec (02126), and Kelun-Biotech (06990) [2]