Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [2] Core Views - The report highlights the release of the preliminary list of innovative drugs for commercial insurance, focusing on companies with leading clinical value and commercialization capabilities [4] - The pharmaceutical and biotechnology industry index increased by 2.21%, ranking 21st among 31 primary industries, underperforming the CSI 300 index which rose by 3.64% [5][16] - The report suggests a focus on companies in the oncology, metabolic diseases, and rare diseases treatment sectors, particularly those with strong clinical pipelines and commercialization capabilities [8] Industry Overview - The pharmaceutical and biotechnology industry PE (TTM, excluding negative values) as of August 15, 2025, is 31.38x, up from 30.97x in the previous period, indicating an upward valuation trend but still below the average [5][21] - The top three sub-industries by PE are vaccines (62.98x), hospitals (40.19x), and medical consumables (39.11x), while the lowest is pharmaceutical distribution (15.85x) [21] Important Industry News - The National Healthcare Security Administration (NHSA) has published the preliminary list of innovative drugs for commercial insurance, with over 100 innovative drugs included, covering areas such as oncology and rare diseases [8][26] - The NHSA is also advancing the reform of medical insurance payment methods, emphasizing a disease-based payment model to enhance the quality of healthcare services [30] Company Dynamics - Insmed's "Brensocatib" has received FDA approval for treating non-cystic fibrosis bronchiectasis, marking a significant advancement in targeted therapies for this condition [42][44] - Precigen's "Papzimeos" has been approved by the FDA as the first-in-class gene therapy for recurrent respiratory papillomatosis, providing a new treatment option for patients [48] - The approval of "博优平" (Dulaglutide injection) by 博安生物 marks it as the first domestically produced biosimilar of its kind, aiming to compete in the diabetes treatment market [49][50]

2025 年 8 月 15 日，公司通过中国证券登记结算有限责任公司系统查询获悉， 公司控股股东苏州吴中投资控股有限公司股份被轮候冻结，具体情况如下： 二、股东股份累计被冻结情况 证券代码：600200 证券简称：*ST 苏吴 公告编号：临 2025-086 江苏吴中医药发展股份有限公司 关于公司控股股东所持股份被轮候冻结的公告 本公司董事会及董事会全体成员保证公告内容不存在虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实、准确和完整承担法律责任。 重要内容提示： 三、其他情况说明 3、公司将进一步向控股股东核实上述事项相关情况，并将持续关注控股股 东持有的公司股票被司法冻结、标记以及债务风险化解情况，及时履行信息披露 义务。敬请广大投资者理性投资，注意投资风险。 截至本公告披露日，控股股东所持公司股份累计被冻结（包括司法冻结、司 股东名称 是否为 控股股 东 冻结股份数量 （股） 占其所持 股份比例 占公司总 股本比例 冻结股份 是否为限 售股 冻结起始日 冻结到期日 冻结申请 人 冻结原 因 苏州吴中 投资控股 有限公司 是 122,795,762 100.00% 17.27% 否 2025-08-1 ...

Summary of Key Points Core Viewpoint - The average stock price of A-shares is 12.79 yuan, with 39 stocks priced below 2 yuan, the lowest being *ST Suwu at 0.94 yuan [1] Group 1: Market Performance - As of August 15, the Shanghai Composite Index closed at 3696.77 points, with a total of 39 stocks trading below 2 yuan [1] - Among the low-priced stocks, 30 experienced price increases, with *ST Yunwang, ST Zhongzhu, and *ST Yangguang showing gains of 5.03%, 4.44%, and 3.37% respectively [1] - Conversely, 3 stocks declined, with *ST Suwu, *ST Gaohong, and Meike Home showing decreases of 5.05%, 4.97%, and 1.00% respectively [1] Group 2: Low-Priced Stocks Overview - The list of low-priced stocks includes *ST Suwu (0.94 yuan), *ST Jinke (1.41 yuan), and Rongsheng Development (1.42 yuan) [1] - A total of 13 out of the 39 stocks priced below 2 yuan are ST stocks, accounting for 33.33% of this group [1] - The highest daily turnover rates among low-priced stocks were observed in *ST Yunwang (3.96%) and ST Zhongzhu (3.99%) [2]

证券代码：600200 证券简称：*ST苏吴 公告编号：临2025-085 江苏吴中医药发展股份有限公司 股票交易异常波动的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 二、公司关注并核实的相关情况 （一）生产经营情况 经自查，除公司已披露的事项外，截至本公告披露日，公司日常生产经营及 外部环境未发生其他重大变化。 重要风险提示： 江苏吴中医药发展股份有限公司（以下简称"公司"）股票连续三个交 易日内收盘价格跌幅偏离值累计超过 12%，属于股票交易异常波动的情形。 2025 年 7 月 13 日，公司收到中国证券监督管理委员会（以下简称"中 国证监会"）下发的《行政处罚事先告知书》（处罚字〔2025〕58 号），具体 内容详见公司于 2025 年 7 月 14 日披露的《关于收到中国证券监督管理委员会< 行政处罚事先告知书>的公告》（公告编号：临 2025-064）。公司股票已于 2025 年 7 月 14 日起被叠加实施退市风险警示，如根据中国证监会正式的处罚决定书 结论，公司触及重大违法强制退市情形，公司股票将被终 ...

Policy Developments - Qian'nan Prefecture's medical monitoring reported over 1,600 medical traceability rescues in the first half of the year, with 3.47 million residents insured, including 1.19 million special hardship groups [1] - Medical expenses for special hardship groups reached 282 million yuan, with reimbursements totaling 244 million yuan [1] Regulatory Changes - Tianjin's Medical Insurance Bureau proposed a new warning system for designated medical institutions, introducing yellow and red cards for non-compliance, which could lead to payment suspensions and contract terminations [2][3] Drug and Device Approvals - Qihuan Biotech's QT-019B CAR-T cell therapy received FDA approval for clinical trials, marking a significant milestone as the first universal CAR-T product developed by a Chinese company for autoimmune diseases [4] - Cloudtop's Acquimod NDA has been accepted in Taiwan, with peak sales potential estimated at 5 billion yuan, targeting moderate to severe ulcerative colitis [5] Financial Disclosures - China National Pharmaceutical Group reported a 10.43% decline in net profit for the first half of 2025, with revenues of 36.797 billion yuan [6] - Dongcheng Pharmaceutical's net profit fell by 20.7% to 88.65 million yuan, with revenues of 1.38 billion yuan [8] - Yangpu Medical reported a net profit of approximately 15.27 million yuan, with revenues down 21.22% to about 231 million yuan [9] Capital Market Activities - Hongxing Xianghe completed an A-round financing to enhance its innovative biopharmaceutical R&D efforts [10] - Silver诺药业-B saw a dark market surge of over 260%, with net proceeds from its global offering expected to reach approximately 610 million yuan [11] - Huaxi Biotech's controlling shareholder secured a loan commitment of up to 250 million yuan for share buybacks [12] - Nanmo Biotech's major shareholder increased its stake from 17.10% to 18.50% through market transactions [13] - WuXi AppTec repurchased 282,340 shares for approximately 27.99 million yuan as part of its buyback plan [14] Industry Developments - Wuxi City signed a strategic cooperation agreement with China National Pharmaceutical Group, emphasizing the importance of the biopharmaceutical industry for national security and economic development [15][16] Market Alerts - *ST Suwu's stock price fell below 1 yuan, risking delisting if it remains below this threshold for 20 consecutive trading days [17] - Aimeike's subsidiary REGEN Biotech Inc. is involved in a significant arbitration case with a claim of 1.6 billion yuan, affecting its financial outlook [18] - Sanyou Medical's actual controller plans to reduce their stake by up to 2% through block trades [19]

Core Viewpoint - A legal dispute has arisen over the exclusive distribution rights of the AestheFill product, with *ST Suwu's subsidiary, Datou Medical, seeking arbitration against Aimeike's subsidiary, Regen, for breach of contract and claiming damages of up to 1.6 billion yuan [2][3]. Group 1: Legal Dispute - Datou Medical has filed for arbitration with the Shenzhen International Arbitration Court, accusing Regen of breaching the exclusive distribution agreement for AestheFill [2][3]. - Regen's reasons for termination include alleged unauthorized transfer of distribution rights and violations of securities laws by *ST Suwu's executives, which they claim have harmed the product's reputation [3][4]. - *ST Suwu refutes these claims, asserting that no transfer of rights occurred and that the agreement does not allow for termination based on administrative penalties against its executives [3][4]. Group 2: Financial Performance - AestheFill has generated over 3 billion yuan in sales within just eight months, achieving an 82% gross margin, significantly contributing to *ST Suwu's turnaround from losses [2][6]. - In 2024, AestheFill's sales revenue reached 326 million yuan, accounting for 20.42% of *ST Suwu's total revenue, with a gross profit of 269 million yuan, representing 34.80% of the company's gross profit [6]. - The medical aesthetics segment of *ST Suwu reported a revenue increase of 4225.65% year-on-year, with a gross margin of 82.26% in 2024 [6]. Group 3: Market Context - AestheFill, known as the "童颜针" (youthful needle), is a high-margin product that has quickly gained market share in the aesthetic medicine sector, despite its higher price compared to similar products from Aimeike [6][7]. - Aimeike's revenue growth has slowed significantly, with a projected 2024 revenue of 3.026 billion yuan, reflecting a growth rate of only 5.45%, down from over 47% in 2023 [5]. - The overall medical aesthetics market in China is expected to grow at a rate of 10% to 15% in the coming years, indicating a competitive landscape for companies like Aimeike and *ST Suwu [5].

Core Viewpoint - The commercial dispute over the exclusive distribution rights of the "AestheFill" product between Jiangsu Wuzhong and Regen Biotech has escalated, leading to significant implications for both companies and the medical aesthetics industry as a whole [2][3][4]. Group 1: Company Actions and Responses - Jiangsu Wuzhong announced that it would seek arbitration to confirm the validity of the exclusive distribution agreement and is claiming damages of 1.6 billion yuan, covering development costs and potential profits [8]. - Following the receipt of a termination letter from Regen, Jiangsu Wuzhong initiated a legal response, asserting that there was no transfer of exclusive rights and that the termination was unjustified [6][11]. - Aimeike, which has taken operational control of Regen, has been accused by Jiangsu Wuzhong of manipulating the situation to undermine its distribution rights [17]. Group 2: Financial Impact - Jiangsu Wuzhong's stock price has dropped over 40% since receiving the termination notice, with its market capitalization falling to 704 million yuan [3]. - The "AestheFill" product has been a significant revenue driver for Jiangsu Wuzhong, contributing 3.26 billion yuan in sales in its first year and 1.13 billion yuan in the first quarter of 2025 [9]. - The company reported a net profit of 70.48 million yuan in 2024, a 197.97% increase, largely attributed to the success of "AestheFill" [9]. Group 3: Industry Implications - The dispute has created uncertainty in the medical aesthetics industry, potentially causing anxiety among distributors and affecting market dynamics [3][12]. - The conflict highlights deeper issues within the industry regarding the balance of power between brand owners and distributors, with the latter often feeling insecure in their roles [17]. - Aimeike is also facing its own growth challenges, with a significant slowdown in revenue growth, indicating that the competitive landscape is becoming increasingly difficult for all players involved [13].

Core Viewpoint - Jiangsu Wuzhong Pharmaceutical Development Co., Ltd. is facing potential delisting due to significant violations of information disclosure regulations, as identified by the China Securities Regulatory Commission (CSRC) [2][4][10] Group 1: Investigation and Penalties - The company has been under investigation by the CSRC since February 26, 2025, for suspected violations of information disclosure laws [3] - On July 13, 2025, the CSRC issued a notice indicating that the company inflated revenue, costs, and profits from 2020 to 2023, leading to significant discrepancies in financial reporting [4] - The inflated figures included revenue increases of CNY 495.26 million, CNY 468.51 million, CNY 430.75 million, and CNY 376.66 million for the respective years, representing 26.46%, 26.39%, 21.26%, and 16.82% of reported revenues [4] Group 2: Potential Delisting Risks - If the formal penalty decision confirms the violations, the company may face mandatory delisting under the Shanghai Stock Exchange rules [2][5] - The company will apply for a trading suspension and disclose relevant information if it receives a formal penalty decision indicating delisting risks [7] - The stock price closed at CNY 0.99 on August 14, 2025, falling below the CNY 1 threshold, which could also lead to delisting if it remains below this price for 20 consecutive trading days [10][11] Group 3: Compliance and Future Actions - The company is committed to cooperating with the CSRC and will exercise its rights to defend against the allegations [2][5] - The company will continue to fulfill its information disclosure obligations as required by regulations [5][6]

罚字〔2025〕58 号），认定公司子公司江苏吴中进出口有限公司、中吴贸易发 展(杭州)有限公司、江苏吴中海利国际贸易有限公司通过与浙江优诺德贸易有限 公司等多家关联公司开展无商业实质的贸易业务，虚增营业收入、营业成本和利 润。上述行为导致*ST 苏吴在 2020 年至 2023 年年度报告中分别虚增营业收入 露营业收入的 26.46%、26.39%、21.26%、16.82%；分别虚增营业成本 48,068.05 万元、44,823.70 万元、41,082.09 万元、35,544.47 万元，占当期披露营业成 本的 37.08%、35.47%、28.40%、20.95%；分别虚增利润总额 1,458.27 万元、 强制退市。 证券代码：600200 证券简称：*ST 苏吴 公告编号：临 2025-083 江苏吴中医药发展股份有限公司关于公司股票 可能被实施重大违法强制退市的第六次风险提示公告 本公司董事会及董事会全体成员保证公告内容不存在虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实、准确和完整承担法律责任。 重要风险提示： 一、公司股票可能被实施重大违法强制退市风险暨立案调查进展情况 公司于 2 ...

公司指定信息披露媒体为《中国证券报》《上海证券报》以及上海证券交易 所网站（www.sse.com.cn），有关公司的信息均以上述指定媒体刊登的信息为准。 敬请投资者注意投资风险。 二、终止上市风险提示公告的披露情况 根据《股票上市规则》第 9.2.3 条第一款的规定：在上交所仅发行 A 股股票 或者 B 股股票的上市公司，首次出现股票收盘价低于 1 元的，应当在次一交易日 披露公司股票可能被终止上市的风险提示公告；出现连续 10 个交易日（不包含 公司股票停牌日）每日股票收盘价均低于 1 元的，应当在次一交易日披露公司股 票可能被终止上市的风险提示公告，其后每个交易日披露 1 次，直至公司股票收 盘价低于 1 元的情形消除或者出现终止上市情形之日止（以先达到的日期为准）。 根据《股票上市规则》第 9.6.1 条规定，交易类强制退市公司股票不进入退 市整理期交易。 三、其他事项 （处 罚字〔2025〕58 号），具体内容详见公司于 2025 年 7 月 14 日披露的《关于收 到中国证券监督管理委员会 <行政处罚事先告知书> 的公告》（公告编号：临 据中国证监会正式的处罚决定书结论，公司触及重大违法强制退市情 ...