Group 1: Market Overview - The Hong Kong capital market is experiencing a significant recovery in 2025, with IPO financing reaching HKD 132.9 billion in the first eight months, a 50% increase compared to the total for 2024, marking a four-year high [1] - The secondary market for Hong Kong stocks is showing even stronger performance, with fundraising reaching HKD 190.5 billion, which is 3.8 times higher than the total for 2024, and an average fundraising size of HKD 1.1 billion per project [1] Group 2: Underwriting Market Characteristics - The underwriting market for Hong Kong stock issuances in 2025 is characterized by a concentration of top players, with foreign investment banks holding six of the top ten spots, including Goldman Sachs, UBS, and Morgan Stanley [2] - The top six underwriters have all surpassed HKD 15 billion in underwriting scale, collectively accounting for over 70% of the overall market [2] Group 3: Top Underwriters - Goldman Sachs leads the underwriting rankings with an underwriting scale of HKD 39.5 billion, holding a market share of approximately 21%, and is known for its focus on "head projects" [4][5] - CITIC Securities ranks second with HKD 24.8 billion in underwriting scale, but its performance is heavily reliant on a single large project, the HKD 43.5 billion issuance from BYD, which accounts for about 60% of its total underwriting [6] - UBS ranks third with HKD 24.1 billion, demonstrating a balanced approach by participating in both large and small projects, which enhances its structural resilience [7] Group 4: Performance Discrepancies - China International Capital Corporation (CICC) is the top underwriter for IPOs but has seen a significant drop in its performance in the secondary market, with only HKD 21.3 billion in underwriting scale, indicating a disconnect in core client cooperation [8][9] - Guotai Junan, despite having the highest number of projects at 27, ranks seventh in terms of underwriting scale at HKD 9.7 billion, primarily due to a lack of participation in large projects [10]

Group 1: Market Overview - The Hong Kong capital market is experiencing a significant recovery in 2025, with IPO financing reaching HKD 132.9 billion in the first eight months, marking a 50% increase compared to the total for 2024, which is the highest in nearly four years [1] - The secondary market for Hong Kong stocks is showing even stronger performance, with fundraising reaching HKD 190.5 billion, which is 3.8 times higher than the total for 2024, and the average fundraising per project is HKD 1.1 billion [1] Group 2: Underwriting Market Characteristics - The underwriting market for Hong Kong stock issuances in 2025 is characterized by a concentration of top players and a leading role of foreign investment banks, with six out of the top ten underwriters being foreign [3] - The top six underwriters have all surpassed HKD 15 billion in underwriting scale, collectively accounting for over 70% of the overall market [3] Group 3: Top Underwriters - Goldman Sachs leads the underwriting rankings with an underwriting scale of HKD 39.5 billion, holding a market share of approximately 21%, and has a strong focus on "top-tier projects" [5] - CITIC Securities ranks second with HKD 24.8 billion in underwriting scale, but its performance is heavily reliant on a single large project, which raises concerns about its ability to diversify its project coverage [6] - UBS ranks third with HKD 24.1 billion, demonstrating a balanced approach by participating in both large and small projects, which enhances its structural resilience [7] Group 4: Performance Discrepancies - China International Capital Corporation (CICC) is the top underwriter for IPOs but has seen a significant drop in its performance in the secondary market, with only HKD 21.3 billion in underwriting scale, indicating a disconnect in core client cooperation [8][9] - Guotai Junan, after its merger, has the highest number of projects at 27 but ranks seventh in underwriting scale at HKD 9.7 billion, highlighting its struggle to secure large projects [9]

Core Viewpoint - The article discusses the quarterly review changes of the FTSE China A50 index announced by FTSE Russell, highlighting the inclusion and exclusion of specific stocks and the implications for investment funds tracking the index [5][6]. Group 1: Index Changes - Four stocks, including BeiGene, NewEase, WuXi AppTec, and Zhongji Xuchuang, will be added to the FTSE China A50 index, while China Nuclear Power, China Unicom, Guodian NARI, and Wanhua Chemical will be removed [5]. - The newly added stocks belong to the innovative drug and CPO sectors, while the removed stocks are from traditional industries such as utilities and telecommunications [5]. - The newly included stocks have shown significant price increases this year, with NewEase and Zhongji Xuchuang rising over 200%, and BeiGene and WuXi AppTec around 90% [5]. Group 2: Market Impact - The estimated size of passive funds tracking the FTSE China A50 index exceeds $10 billion, indicating that changes in constituent stocks can lead to substantial capital flows, potentially in the hundreds of millions to billions [5]. - Investors have raised concerns about the inclusion of stocks perceived as overvalued and whether this adjustment is a strategy for foreign capital to take over high-priced stocks [6]. - The adjustment is based on market capitalization and liquidity criteria, with the review conducted quarterly, using data from the third Friday of February, May, August, and November [6].

致：香港交易及結算所有限公司 公司名稱: 無錫藥明康德新藥開發股份有限公司 呈交日期: 2025年9月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 02359 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 387,076,150 | RMB | | 1 RMB | | 387,076,150 | | 增加 / 減少 (-) | | | 91,150,340 | | | RMB | | 91,150,340 | | 本月底結存 | | | 478,226,490 | RMB | | 1 RMB | | 478,226,490 | | 2. 股份分類 | 普通股 | 股份類別 | A | | 於香港聯交所上市 (註1) | | 否 | | | --- | --- | --- | ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年8月31日 狀態: 重新提交 致：香港交易及結算所有限公司 公司名稱: 無錫藥明康德新藥開發股份有限公司 呈交日期: 2025年9月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 02359 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 387,076,150 | RMB | | 1 RMB | | 387,076,150 | | 增加 / 減少 (-) | | | 91,150,340 | | | RMB | | 91,150,340 | | 本月底結存 | | | 478,226,490 | RMB | | 1 RMB | | 478,226,490 | | 2. 股份分類 ...

Group 1 - The A-share innovative drug sector experienced a strong rebound, with the Biopharmaceutical ETF (159839) rising by 4.17% and a trading volume exceeding 44 million yuan [1] - The Biopharmaceutical ETF (159839) has seen a net inflow of over 15 million yuan for two consecutive days [1] - Several innovative drug companies reported significant stock price increases, with notable gains including 9.99% for Zhaoyan New Drug and 7.53% for Changchun High-tech [2] Group 2 - The pharmaceutical industry is experiencing structural differentiation, with a 0.7% decline in revenue and a 1.5% increase in net profit for listed companies in the first half of 2025 [3] - Leading innovative drug companies are achieving profitability, driven by strong sales of key products such as Zebutinib and Furmetinib [3] - The innovative drug sector is expected to benefit from improved policies and a downward trend in global central bank interest rates, which may enhance long-term valuations [4] Group 3 - The CXO industry is entering a recovery phase, with a resurgence in overseas demand expected by the end of 2023, leading to a recovery in domestic head companies' orders in 2024 [5] - The domestic innovative drug assets are progressing into late clinical stages, with increasing validation of clinical data and a clear trend towards internationalization [5]

Core Viewpoint - The medical services sector experienced a significant increase of 3.79% on September 5, with Zhaoyan New Drug leading the gains [1] Market Performance - The Shanghai Composite Index closed at 3812.51, up 1.24% - The Shenzhen Component Index closed at 12590.56, up 3.89% [1] Individual Stock Performance - Zhaoyan New Drug (603127) closed at 34.01, up 9.99% with a trading volume of 578,000 shares and a transaction value of 1.905 billion yuan - Tiger Medical (300347) closed at 66.58, up 6.66% with a trading volume of 146,300 shares and a transaction value of 950 million yuan - Kailaiying (002821) closed at 108.27, up 6.44% with a trading volume of 114,500 shares and a transaction value of 1.213 billion yuan - Posens (301257) closed at 49.20, up 5.81% with a trading volume of 84,700 shares and a transaction value of 407 million yuan - Kanglong Chemical (300759) closed at 31.30, up 5.56% with a trading volume of 615,400 shares and a transaction value of 1.887 billion yuan - WuXi AppTec (603259) closed at 107.40, up 5.36% with a trading volume of 802,300 shares and a transaction value of 8.39 billion yuan - Jiuzhou Pharmaceutical (603456) closed at 19.15, up 5.22% with a trading volume of 441,000 shares and a transaction value of 827 million yuan - ST Biological (000504) closed at 9.68, up 4.99% with a trading volume of 49,800 shares and a transaction value of 4.749 million yuan - Nossger (301333) closed at 58.02, up 4.94% with a trading volume of 56,100 shares and a transaction value of 32.2 million yuan - Boteng Co., Ltd. (300363) closed at 25.90, up 4.73% with a trading volume of 396,800 shares and a transaction value of 1.011 billion yuan [1] Capital Flow - The medical services sector saw a net inflow of 423 million yuan from institutional investors, while retail investors experienced a net outflow of 58.5864 million yuan [1]

Company Overview - WuXi AppTec Co., Ltd. is a leading global pharmaceutical and biotechnology company, providing comprehensive services in drug discovery, development, and manufacturing [1] - The company was established on December 1, 2000, and went public on May 8, 2018 [1] - The main business segments include small molecule chemistry (78.37%), testing services (12.93%), biological services (6.02%), and other services (1.90%) [1] Stock Performance - On September 5, the stock price of WuXi AppTec increased by 5.09%, reaching 107.13 CNY per share, with a trading volume of 7.877 billion CNY and a turnover rate of 3.05% [1] - The total market capitalization of the company is approximately 316.195 billion CNY [1] Fund Holdings - The Shangyin Fengyi Mixed A Fund (011504) holds a position in WuXi AppTec, having reduced its holdings by 2,000 shares in the second quarter, now holding 10,000 shares, which represents 1.26% of the fund's net value [2] - The fund has achieved a floating profit of approximately 51,900 CNY from its investment in WuXi AppTec [2] Fund Manager Information - The fund manager of Shangyin Fengyi Mixed A is Gao Yong, who has been in the position for 8 years and 255 days [3] - The total asset size of the fund is 55.1468 million CNY, with a best return of 23.78% during Gao Yong's tenure [3]

9月5日，药明康德涨5.09%，截至发稿，报107.13元/股，成交78.76亿元，换手率3.05%，总市值3161.95 亿元。 长安沪深300非周期指数A（740101）基金经理为肖洁。 截至发稿，肖洁累计任职时间3年211天，现任基金资产总规模5.16亿元，任职期间最佳基金回报 27.32%， 任职期间最差基金回报-26.3%。 风险提示：市场有风险，投资需谨慎。本文为AI大模型自动发布，任何在本文出现的信息（包括但不 限于个股、评论、预测、图表、指标、理论、任何形式的表述等）均只作为参考，不构成个人投资建 议。 责任编辑：小浪快报 资料显示，无锡药明康德新药开发股份有限公司位于上海浦东新区外高桥保税区富特中路288号,香港铜 锣湾希慎道33号利园1期19楼1910室，成立日期2000年12月1日，上市日期2018年5月8日，公司主营业务 涉及小分子化学药的发现、研发及生产全方位、一体化平台服务,以全产业链平台的形式面向全球制药 企业提供各类新药的研发、生产及配套服务。主营业务收入构成为：化学业务78.37%，测试业务 12.93%，生物学业务6.02%，其他(补充)1.90%，其他业务0.79%。 从 ...

Group 1 - The CRO (Contract Research Organization) concept stocks in the A-share market have shown strong performance, with notable gains in several companies [1] - Zhaoyan New Drug approached the daily limit increase with a rise of 9.12%, while other companies like Kailaiying, Nossger, and Kanglong Chemical also saw increases exceeding 5% [1][2] - The total market capitalization of Zhaoyan New Drug is 25.3 billion, and it has achieved a year-to-date increase of 103.06% [2] Group 2 - Kailaiying's stock rose by 5.48%, with a total market capitalization of 38.7 billion and a year-to-date increase of 42.84% [2] - Nossger and Kanglong Chemical experienced increases of 5.44% and 5.19%, respectively, with market capitalizations of 5.631 billion and 55.5 billion [2] - Other companies such as Sunshine Nuohuo and Boteng also reported gains of over 5%, with year-to-date increases of 109.05% and 64.55% respectively [2]