November 21, 2025 09:01 AM GMT China Healthcare - The WuXi Group | Asia Pacific At the Cutting Edge; Top Pick WuXi AppTec A The sector has sold off since mid-September, following a strong year-to-date rally, as investors take profit and await confirmatory signals for 2026 performance. Leading indicators for China's top CDMOs have offered an early look at project momentum and earnings for 2026. Key Takeaways In our sector, WuXi AppTec is the best proxy for a global R&D spending boom, increased reliance on Ch ...

Investment Rating - The report indicates a neutral investment rating for the pharmaceutical industry, suggesting it is expected to perform in line with the overall market [24]. Core Insights - The pharmaceutical sector experienced a decline of 6.9% this week, underperforming compared to the Shanghai Composite Index, which fell by 3.9% [3][5]. - The overall valuation of the pharmaceutical sector stands at 28.9 times earnings, ranking it 10th among 31 primary sectors [5][12]. - Key events include the acceptance of a new drug application for 百利天恒's drug iza-bren, which showed promising results in clinical trials for nasopharyngeal cancer [9]. - 泽璟制药's ZG006 received FDA orphan drug designation for treating neuroendocrine cancer, demonstrating significant efficacy and safety in clinical trials [10]. - 盟科药业 decided to terminate its stock issuance plan due to disagreements among major shareholders, which may impact its operational stability [11]. Market Performance Summary - The pharmaceutical index ranked 26th among 31 sub-industries this week, with various segments showing declines, including raw materials (-8.6%) and chemical preparations (-6.8%) [3][5]. - The report highlights a focus on innovative drug sectors and medical devices, recommending specific companies for investment [2].

第87名迈瑞医疗（证券代码300760）：三季报归母净利润75.70亿元（同比增长-28.83%），排名比半年报下降6名。 从2025年上市公司三季度归母净利润前100强看，尽管医药生物行业受到集采降价、医保控费等多重因素影响，整体业绩持续承压，但是药明康德、迈瑞医 疗依然能凭借强劲的盈利能力在市场中脱颖而出，跻身百强。 第55名药明康德（证券代码603259）：三季报归母净利润120.76亿元（同比增长84.84%），排名比半年报下降3名； 在行业整体低迷的背景下，创新药及其研发外包（CXO）产业链成为了少数高景气的子板块。药明康德作为CXO龙头，直接受益于这一趋势。而迈瑞医疗 所在的医疗器械领域，虽然短期受招标节奏影响，但其通过国际化和技术升级，展现出较强的抗风险能力。 ...

- The China Securities Biotechnology Theme Index was launched on August 26, 2015, by China Securities Index Co., Ltd. The index selects listed company securities involved in gene diagnosis, biopharmaceuticals, blood products, and other human biotechnology as index samples to reflect the overall performance of biotechnology listed company securities[3][38] - The index sample space is the same as the China Securities All Index sample space, consisting of A-shares and depository receipts issued by red-chip companies that meet the following conditions: "(1) Non-ST, *ST securities; (2) Other securities: listed for more than one quarter, unless the average daily market value ranks in the top 30 since listing; (3) STAR Market and Beijing Stock Exchange securities: listed for more than one year and two years, respectively"[39] - The index sample selection method includes: (1) Ranking the securities in the sample space by average daily turnover over the past year and removing the bottom 20%; (2) Selecting biotechnology-related companies from the remaining securities as biotechnology theme candidates; (3) Ranking the candidates by average daily market value over the past year and selecting the top 50 securities as index samples[39] - The index's top ten constituent stocks are highly concentrated, focusing on the pharmaceutical industry. As of November 19, 2025, the top ten constituent stocks accounted for 55.26% of the total weight, forming a "CXO + innovative drugs + medical devices" golden triangle combination[40][41] - The index constituent stocks are evenly distributed across different market value ranges, with weights of 35.79% for stocks with a market value of over 100 billion, 44.24% for stocks with a market value between 200-1000 billion, and the rest distributed among other ranges[42][43] - The index constituent stocks are mainly concentrated in the biological medicine III, medical services, chemical preparations, and medical devices industries, with weights of 42.33%, 20.99%, 17.33%, and 11.97%, respectively[44][46] - The index constituent stocks have high exposure to concepts such as industry leaders, comprehensive private enterprises, main trading forces, dual circulation, fund heavy positions, and innovative drugs, with exposure rates of 70.56%, 64.78%, 64.58%, 62.60%, 62.48%, and 62.16%, respectively[47][48] - The index's current style is characterized by small market value, high liquidity, and high momentum. As of October 31, 2025, the index's market value style is significantly negatively exposed compared to the China Securities 800 Index, with higher liquidity and trading activity[48][51][52] - The index's PE valuation is near the historical average, and the PB valuation is near the historical -1 standard deviation, indicating a high safety margin and potential for upward valuation[53][54] - The index's profitability is outstanding, with expected revenue growth rates of 6.54%, 6.00%, and 13.76% for 2025, 2026, and 2027, respectively, and expected net profit growth rates of 52.09%, 18.58%, and 24.11% for the same years[55][56][57][58]

Market Overview - The medical services sector experienced a decline of 2.71% on November 21, with Baihua Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3834.89, down 2.45%, while the Shenzhen Component Index closed at 12538.07, down 3.41% [1] Stock Performance - Notable gainers included Yangguang Nuohua, which rose by 4.47% to a closing price of 61.21, with a trading volume of 86,300 shares and a transaction value of 530 million [1] - Baihua Pharmaceutical saw a significant decline of 9.67%, closing at 9.06, with a trading volume of 292,400 shares and a transaction value of 275 million [2] - Other notable decliners included Chengda Pharmaceutical (-9.58%), Berry Genomics (-8.67%), and Guangzheng Eye Hospital (-7.26%) [2] Capital Flow - The medical services sector experienced a net outflow of 1.325 billion in institutional funds, while retail investors saw a net inflow of 1.332 billion [2] - The table of capital flow indicates that major stocks like Yangguang Nuohua had a net inflow of 10.986 million from institutional investors, while retail investors had a net inflow of 1.374 million [3]

Group 1 - The medical sector showed signs of recovery, with major player United Imaging Healthcare rising over 3%, while other stocks like WuXi AppTec and Aier Eye Hospital fell more than 1% [1] - The largest medical ETF in A-shares (512170) experienced a decline of over 2.8% in the morning but recovered slightly in the afternoon, ultimately dropping over 1%, marking a four-month low [1] - A-shares' three major indices collectively fell over 2% [1] Group 2 - The medical ETF (512170) fell below its six-month moving average and approached a critical yearly support level, with significant trading volume of over 874 million yuan, setting a new monthly high for daily trading [3] - In the first four trading days of the week, over 627 million yuan flowed into the ETF, indicating potential bottom-fishing activity despite the risk of larger sell-offs [3] - The medical ETF has a current scale exceeding 25.3 billion yuan, making it the largest medical-related ETF in the market, with a focus on "medical devices + medical services" [3][4] Group 3 - The ETF's composition includes a significant weighting of over 26% in CXO, along with leading companies in aesthetic medicine, private hospitals, and medical information technology [3] - The ETF is passively tracking the CSI Medical Index, which was established on December 31, 2004, and published on October 31, 2014 [4]

Core Insights - The oncology CRO (Contract Research Organization) services focus on specialized outsourcing for cancer drug development, addressing challenges such as long R&D cycles, high difficulty, and significant risks, thereby efficiently advancing drugs from preclinical stages to market [1][5][4] - The global oncology CRO services market is projected to grow from $7.2 billion in 2020 to $16.2 billion in 2024, with an expected increase to $18.6 billion by 2025 [1][5] - The oncology CRO sector is a highly specialized segment within the broader CRO market, providing comprehensive or partial outsourcing services for clinical trials of anti-cancer drugs [3][4] Industry Definition and Segmentation - CROs provide professional services to pharmaceutical companies and research institutions throughout the drug development process, covering drug discovery, preclinical research, clinical trials, data management, and regulatory submissions [2][4] - Oncology CRO services include preclinical, clinical, and post-marketing services, with preclinical services further divided into hematological cancers, solid tumors, and others [3][4] Current Industry Status - The CRO industry is experiencing significant growth, reflecting a revitalization of the entire pharmaceutical innovation ecosystem [4][5] - The global CRO services market is expected to expand from $62 billion in 2020 to $98.4 billion in 2024, with China's market growing from $7 billion to $10.5 billion in the same period [5] Industry Value Chain - The upstream of the oncology CRO service industry includes basic chemical raw materials, pharmaceutical intermediates, and various scientific instruments [6] - The midstream consists of oncology CRO service providers, which are the core of the industry chain, characterized by technology and talent intensity [6] - The downstream includes demand-side entities such as pharmaceutical and biotechnology companies, medical institutions, and clinical trial researchers [6] Competitive Landscape - The oncology CRO industry in China features a dynamic and layered competitive landscape, with significant differences in scale, service range, client base, and core competencies among companies [9][10] - Key players in the oncology CRO sector include WuXi AppTec, Kanglong Chemical, and others, with a focus on comprehensive services from target validation to new drug registration [10][11] Development Trends - The oncology CRO service industry reflects the pulse of China's pharmaceutical R&D, transitioning from a traditional labor-intensive service sector to a modern, technology-driven, data-intensive industry [13] - The trend towards intelligent systems in clinical CRO services is seen as an inevitable evolution [13]

来源：新浪证券-红岸工作室 11月20日，药明康德涨0.50%，成交额23.12亿元，换手率0.99%，总市值2794.89亿元。 异动分析 CRO概念+创新药+人民币贬值受益 1、公司是国际领先的开放式能力与技术平台,为全球生物医药行业提供全方位、一体化的新药研发和生 产服务。 2、国内医药外包行业龙头,是国内最早开始从事医药研发生产外包的CRO和CMO一体化公司,高层管理 团队共拥有超过200项的已授权和申请中的专利成果;其主营业务为小分子化学药的发现、研发及生产的 全方位、一体化平台服务,以全产业链平台的形式面向全球制药企业提供各类新药的研发、生产及配套 服务;公司还在境外提供医疗器械检测及境外精准医疗研发生产服务。 3、根据2024年年报，公司海外营收占比为78.67%，受益于人民币贬值。 (免责声明：分析内容来源于互联网，不构成投资建议，请投资者根据不同行情独立判断) 资金分析 今日主力净流入3320.88万，占比0.01%，行业排名1/51，连续2日被主力资金增仓；所属行业主力净流 入-10.45亿，连续3日被主力资金减仓。 区间今日近3日近5日近10日近20日主力净流入3320.88万-4.24 ...

Core Viewpoint - The domestic R&D demand is showing marginal improvement, driven by the overseas expansion of innovative drugs, leading to a recovery in R&D orders and stabilization of industry prices after a decline in 2023. The CRO sector is expected to see better performance growth by 2026, while the CDMO industry has also reached a bottom and is poised for continued strong growth due to robust demand for new molecules and new orders [1][2][3]. CRO Sector - The domestic R&D demand is recovering, with an increase in orders and stabilization of prices, indicating a clear upward trend for CRO companies. Clinical CROs like Tigermed, Nossan, and Prasis are expected to see revenue growth turning positive by 2025, with significant contributions from overseas business [2][3]. - The recognition of domestic CRO clinical data is improving, which is beneficial for companies like Tigermed [2]. CDMO Sector - The CDMO sector has seen a recovery in performance, with new orders continuing to improve quarterly. The global demand for innovative drug R&D is driving growth in new orders and backlog [3]. - The industry is benefiting from increased capacity utilization and profitability, with a strong certainty of performance and profit growth expected to continue into 2026 [3]. Life Sciences Sector - The life sciences upstream sector is experiencing a dual drive from domestic substitution and overseas expansion, with urgent demand for domestic alternatives in areas like cell culture media and biological reagents. Companies are expected to capture market share through new product categories and cost-effective offerings [4]. - The demand for specific segments such as drug efficacy, antibodies, and proteins is increasing, indicating a clear long-term growth logic for the industry [4]. API Sector - The raw material pharmaceutical industry is currently in a phase of price bottoming and supply surplus, with traditional product performance under pressure. However, companies are extending their business into generics, innovative drugs, and specialty APIs, which may lead to value reconstruction through business structure optimization [5]. - The valuation of raw material pharmaceutical companies is at a low point, presenting opportunities based on changes in new business layouts [5]. Investment Recommendations - For clinical and preclinical CROs, companies like Tigermed, Nossan, and Yinos are recommended due to the gradual recovery of the industry and expected improvement in order structure [6]. - In the CDMO sector, companies such as WuXi AppTec, WuXi Biologics, and others with strong fundamentals and capacity advantages are highlighted for their potential benefits from industry recovery and high demand for new molecules [6]. - In the life sciences upstream sector, companies like Baitai Biotechnology and others are recommended due to accelerated domestic substitution and strong overseas growth [6]. - Companies like Pro Pharma and Huahai Pharmaceutical are noted for their new business layouts that are expected to contribute significant value increments [6].

Core Insights - WuXi AppTec has been awarded the 2025 Global Company of the Year Award in the CRDMO industry by Frost & Sullivan, marking the ninth consecutive year of receiving this honor, which highlights the company's achievements in innovation and operational excellence [1][4] Company Overview - WuXi AppTec operates as a leading global pharmaceutical CRDMO, providing integrated, end-to-end services that drive scientific and technological advancement, enabling faster drug development and delivery of transformative therapies [2][5] - The company has established a robust foundation of scientific capability, quality, and customer-focused agility through a forward-looking growth strategy, which includes continuous investment in next-generation technologies such as complex peptides, oligonucleotides, and novel conjugates [3][5] Strategic Partnerships and Market Position - The integrated CRDMO model of WuXi AppTec eliminates handoffs between development stages, supporting continuity, quality, and compliance across the value chain, which helps clients reduce risk and improve efficiency [3][4] - The company serves a diverse range of clients, from emerging biotech firms to pharmaceutical multinationals, ensuring fast access to specialized expertise and a global infrastructure [3][5] Leadership and Future Focus - Dr. Ge Li, Chairman and CEO of WuXi AppTec, emphasized the commitment of the global teams to enable customers to advance medicines through the integrated CRDMO platform, with a focus on expanding global capabilities and capacity [4] - Frost & Sullivan's recognition is based on outstanding strategy development and implementation, resulting in measurable improvements in market share, customer satisfaction, and competitive positioning [4]