FF301 第 1 頁 共 11 頁 v 1.1.1 | 2. 股份分類 | 普通股 | 股份類別 | A | | 於香港聯交所上市 (註1) | | 否 | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 688505 | 說明 | | A股（上海證券交易所科創板） | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 710,572,100 | RMB | | 0.1 | RMB | | 71,057,210 | | 增加 / 減少 (-) | | | | | | | RMB | | | | 本月底結存 | | | 710,572,100 | RMB | | 0.1 | RMB | | 71,057,210 | | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | -- ...

Core Viewpoint - The company is changing the use of part of its raised funds from the "Hemoporfin US Registration Project" to the "Photodynamic Drug Innovation R&D Sustainable Development Project" to enhance fund utilization efficiency and focus on advantageous R&D areas [1][8][20]. Summary by Sections 1. Overview of Fundraising Project Change - The original project name was "Hemoporfin US Registration Project," which is now changed to "Photodynamic Drug Innovation R&D Sustainable Development Project" [1]. - The amount of funds redirected is RMB 181.5461 million, which includes interest and investment income as of October 30, 2025 [1][7]. - The new project construction period is from the date of shareholder meeting approval until December 31, 2027 [1][9]. 2. Fundraising Basic Information - The company raised a total of RMB 1.074 billion by issuing 120 million shares at RMB 8.95 per share, with a net amount of RMB 974.3239 million after deducting issuance costs [2]. - The funds have been stored in a dedicated account, ensuring effective supervision [2]. 3. Reasons for Change - The change is due to slower-than-expected clinical research progress influenced by international environments and regulatory policies [8][20]. - The original project will continue as a sub-project under the new project, focusing on the ongoing Phase II clinical research in the US [9][20]. 4. New Project Details - The new project includes various initiatives such as expanding indications for the drug Ameluz, which is used for treating precancerous lesions and other conditions [12][14]. - The company plans to continue developing its photodynamic technology platform, which has shown significant clinical advantages [17][18]. 5. Market Outlook - The company is a leader in the photodynamic drug market, with a strong pipeline and a focus on expanding its product offerings [17][19]. - The photodynamic therapy market is growing due to its unique therapeutic value in treating various conditions [17][18]. 6. Approval Process - The board of directors and the supervisory board have approved the change, which will be submitted for shareholder approval [23][24].

Core Insights - Fudan Zhangjiang, established in 1996 and listed in 2020, focuses on the biopharmaceutical sector and is a leading company in photodynamic drug research in China [1] Financial Performance - For Q3 2025, Fudan Zhangjiang reported revenue of 551 million yuan, ranking 77th among 110 companies, with the industry leader, East China Pharmaceutical, generating 32.664 billion yuan [2] - The company recorded a net profit of -16.1327 million yuan, also ranking 77th, while the top performer, Hengrui Medicine, achieved a net profit of 5.76 billion yuan [2] Financial Ratios - As of Q3 2025, Fudan Zhangjiang's debt-to-asset ratio was 8.40%, down from 10.45% year-on-year and significantly lower than the industry average of 35.26%, indicating strong solvency [3] - The gross profit margin for the same period was 90.01%, slightly down from 91.79% year-on-year but still above the industry average of 57.17%, reflecting robust profitability [3] Management Compensation - The salary of General Manager Zhao Dajun decreased to 1.5446 million yuan in 2024 from 1.693 million yuan in 2023, a reduction of 148,400 yuan [4] Shareholder Information - As of September 30, 2025, the number of A-share shareholders increased by 6.42% to 21,000, while the average number of circulating A-shares held per shareholder decreased by 6.04% to 33,800 [5] - Among the top ten circulating shareholders, Hong Kong Central Clearing Limited ranked ninth, increasing its holdings by 682,500 shares to 3.6495 million shares [5]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責， 對其準確性或完整性亦不發表任何聲明，並明確表示概不因本公告全部或任何部份內 容而產生或因依賴該等內容而引致的任何損失承擔任何責任。 海外監管公告 本公告乃上海復旦張江生物醫藥股份有限公司（「本公司」）根據香港聯合交易所有 限公司證券上市規則第 13.10(B)條刊發。 茲載列本公司於上海證券交易所網站刊發的《國泰海通證券股份有限公司關於上海復 旦張江生物醫藥股份有限公司變更部分募集資金投資項目的專項核查意見》，僅供參 閱。該文件及其披露內容乃根據中國法律法規及境內相關監管要求而編制及刊發。 承董事會命 趙大君 主 席 国泰海通证券股份有限公司 关于上海复旦张江生物医药股份有限公司 变更部分募集资金投资项目的专项核查意见 国泰海通证券股份有限公司（以下简称"国泰海通" 或"保荐机构" ）作 为上海复旦张江生物医药股份有限公司（以下简称"复旦张江"、"公司"或"发 行人"） 首次公开发行股票并在科创板上市的保荐机构，根据《证券发行上市 保荐业务管理办法》《上市公司募集资金监管规则》《上海证券交易所科创板上 市公司自律监管指引第 1 号——规 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其 準確性或完整性亦不發表任何聲明，並明確表示概不因本公告全部或任何部份內容而產 生或因依賴該等內容而引致的任何損失承擔任何責任。 變更 A 股首次公開發行股票 所得款項用途 本公告乃由上海復旦張江生物醫藥股份有限公司（「本公司」）自願作出。 本公司董事會（「董事會」）於二零二五年十月三十日決議並提請公司臨時股東大會 （「臨時股東大會」）審議及批准本公司變更 A 股首次公開發行股票所得款項用途，詳 情如下： 兹提述本公司(i) 日期為二零一九年四月四日關於建議 A 股發行的股東通函; 及(ii) 本公司 日期為二零二零年六月十二日《上海復旦張江生物醫藥股份有限公司首次公開發行 A 股 股票並在科創板上市招股說明書》。 本公司於二零二零年六月十九日在上海證券交易所完成首次公開發行 A 股並於科創板上 市（「A 股發行」），募集資金總額為人民幣 107,400.00 萬元，扣除本次發行費用人民 幣 9,967.61 萬元，募集資金淨額為人民幣 97,432.39 萬元。截至二零二五年十月三十日， 本公司尚未使用的 A股發行募集資金約為人民幣 ...

Core Viewpoint - Fudan Zhangjiang announced a change in its fundraising project, shifting from the "Heimofen American Registration Project" to the "Continuous Development Project for Innovative Photodynamic Drugs" [2] Group 1 - The eighth board meeting of the company will be held on October 30, 2025, to review the proposal for the change in fundraising projects [2] - The proposal requires approval from the company's shareholders' meeting [2]

上海复旦张江生物医药股份有限公司 股票代码：688505 股票简称：复旦张江 编号：临 2025-035 关于变更部分募集资金投资项目的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： 一、变更募集资金投资项目的概述 （一）募集资金基本情况 根据中国证券监督管理委员会于 2020 年 5 月 14 日出具的《关于同意上海复 旦张江生物医药股份有限公司首次公开发行股票注册的批复》（证监许可 [2020]912 号），同意公司公开发行股票的注册申请。公司公开发行人民币普通股 12,000 万股，发行价格为人民币 8.95 元/股，募集资金总额为人民币 107,400.00 万元，扣除本次发行费用人民币 9,967.61 万元，募集资金净额为人民币 97,432.39 万元。上述募集资金已于 2020 年 6 月 12 日全部到位，并由普华永道中天会计师 1 / 13 原项目名称：海姆泊芬美国注册项目； 新项目名称：光动力药物创新研发持续发展项目； 变更募集资金投向的金额：人民币 18,154.61 万元（该金额 ...

国泰海通证券股份有限公司 关于上海复旦张江生物医药股份有限公司 变更部分募集资金投资项目的专项核查意见 国泰海通证券股份有限公司（以下简称"国泰海通" 或"保荐机构" ）作 为上海复旦张江生物医药股份有限公司（以下简称"复旦张江"、"公司"或"发 行人"） 首次公开发行股票并在科创板上市的保荐机构，根据《证券发行上市 保荐业务管理办法》《上市公司募集资金监管规则》《上海证券交易所科创板上 市公司自律监管指引第 1 号——规范运作》等有关法律法规和规范性文件的相 关规定，对复旦张江变更部分募集资金投资项目事项进行了核查，核查情况如下： 一、变更募集资金投资项目的概述 （一）募集资金基本情况 根据中国证券监督管理委员会于 2020 年 5 月 14 日出具的《关于同意上海复 旦张江生物医药股份有限公司首次公开发行股票注册的批复》（证监许可 [2020]912 号），同意公司首次公开发行股票的注册申请。公司公开发行人民币 普通股 12,000 万股，发行价格为人民币 8.95 元/股，募集资金总额为人民币 107,400.00 万元，扣除本次发行费用人民币 9,967.61 万元，募集资金净额为人民 币 97,43 ...

Core Insights - The company reported a revenue of 161 million yuan for Q3 2025, representing a year-on-year growth of 14.40% [1] - R&D investment accounted for over 40% of revenue, reflecting the company's commitment to innovation and long-term growth [1] - The company has adjusted its marketing strategies in response to changes in the pharmaceutical industry, which has impacted short-term profits but is expected to benefit long-term market position [1] - The net cash flow from operating activities significantly improved to approximately 106 million yuan, reversing from negative to positive year-on-year [1] - Total R&D investment for the first three quarters reached 244 million yuan, an increase of 3.9% year-on-year, with the proportion of revenue dedicated to R&D rising by 1.49% [1] R&D Pipeline and Focus - The company's R&D pipeline is concentrated on competitive therapeutic areas, with several projects progressing well, indicating potential for long-term growth [2] - The company focuses on two main technology platforms: photodynamic therapy and ADC drug development, establishing a unique R&D system [2] - In the field of photodynamic therapy, the company has a comprehensive intellectual property layout and extensive R&D experience, expanding applications from treatment to innovative scenarios like surgical visualization [2] - The developed and in-development drug indications include conditions such as genital warts, port-wine stains, moderate to severe acne, actinic keratosis, and precancerous lesions of the cervix, as well as intraoperative visualization diagnostics for breast cancer, brain glioma, and bladder cancer [2] - The ADC platform has been built to support a complete capability from early R&D to industrialization, providing solid technical support for multiple ongoing projects [2]

Group 1 - The core viewpoint of the article highlights Fudan Zhangjiang's financial performance in Q3 2023, indicating a slight revenue increase but a net loss [1] - For the first three quarters of 2025, the company's revenue is approximately 551 million yuan, reflecting a year-on-year increase of 0.41% [1] - The net profit attributable to shareholders is a loss of approximately 15.94 million yuan, with basic earnings per share showing a loss of 0.02 yuan [1] Group 2 - As of the report, Fudan Zhangjiang's market capitalization stands at 9.5 billion yuan [1]