Core Viewpoint - The chairman of Kelun Pharmaceutical, Liu Gexin, has become a spokesperson for the company's products, showcasing his physique in a recent advertisement, which has garnered significant attention on social media [4][5]. Financial Performance - In 2024, Kelun Pharmaceutical achieved a revenue of 21.812 billion yuan, representing a year-on-year growth of 1.67%, and a net profit of 2.936 billion yuan, up 19.53%, both hitting historical highs [1][7]. - From 2021 to 2023, the company's revenue grew from 17.277 billion yuan to 21.454 billion yuan, with respective year-on-year growth rates of 4.94%, 9.46%, and 12.69% [7]. - The sales expenses for Kelun Pharmaceutical have decreased for three consecutive years, from 4.728 billion yuan in 2022 to 3.493 billion yuan in 2024, with changes of -5.86%, -5.89%, and -21.51% respectively [1][10]. Research and Development - Kelun Pharmaceutical has invested nearly 14.5 billion yuan in R&D since 2013, with R&D expenses increasing from 1.795 billion yuan in 2022 to 2.171 billion yuan in 2024, reflecting growth rates of 3.37%, 8.27%, and 11.68% [2][8]. - The company has a diverse product portfolio, with 684 varieties and 1,073 specifications of pharmaceutical products, including 143 varieties of infusion products [9]. Market Position and Strategy - Kelun Pharmaceutical is recognized as one of the largest pharmaceutical enterprises in China, with a comprehensive industry system spanning R&D, manufacturing, and distribution [3]. - The company is focusing on optimizing its infusion product structure and expanding its market coverage, benefiting from national drug procurement policies [8][10]. - Analysts express optimism about Kelun Pharmaceutical's innovative drug business contributing significant revenue in 2025, despite short-term pressures on its infusion business [11]. Dividend Policy - For the fiscal year 2024, Kelun Pharmaceutical plans to distribute a total dividend of 1.214 billion yuan, which accounts for 41.34% of its net profit [10].

Core Viewpoint - The marketing strategy of Kelong Pharmaceutical, led by Chairman Liu Gexin, reflects the company's urgent need to explore new business avenues due to declining traditional business growth [5][8]. Group 1: Product and Marketing Strategy - Kelong Pharmaceutical's product, "Ergothioneine Capsules," is positioned in the high-end dietary supplement market, priced at 1499 yuan per bottle, with each capsule containing 30mg of high-activity ergothioneine [3]. - The product claims to have 10-30 times the antioxidant capacity compared to traditional Vitamin C and Coenzyme Q10, targeting health needs related to anti-aging and cell protection [3][9]. - The marketing campaign features Chairman Liu Gexin, who at 75 years old, promotes the product with a strong physical image, aiming to create a compelling narrative around health and vitality [5][9]. Group 2: Financial Performance and Challenges - Kelong Pharmaceutical reported a significant decline in revenue for Q1 2025, with a total revenue of 4.39 billion yuan, down 29.42% year-on-year, and a net profit of 584 million yuan, down 43.07% [5][7]. - The core business segment, particularly infusion products, has been adversely affected by centralized procurement policies, leading to an 11.85% revenue decline in 2024 [5][8]. - Another subsidiary, Chuaning Bio, also faced challenges with a 15% decrease in revenue and an 18.26% drop in net profit for Q1 2025, impacted by regulatory constraints on antibiotic production [8]. Group 3: Strategic Vision and Future Outlook - Liu Gexin's personal commitment to the product, having used it for three years, and his disciplined lifestyle are intended to enhance the credibility of the marketing campaign [8]. - The company aims to integrate treatment and preventive medicine over the next three to five years, indicating a strategic shift towards a dual focus on health and innovation [8][9]. - The health sector is viewed as a "blue ocean" market, but the oral product market for ergothioneine is still in its early stages, requiring further validation of its efficacy [9].

以下文章来源于每日经济新闻 ，作者每经记者 每日经济新闻 . 中国主流财经全媒体。互联网新闻信息服务许可证编号：51120190017 。 5月8日晚间，科伦药业（002422.SZ，股价34.14元，市值545.58亿元）董事长刘革新在科伦集团官方视频号发布的一则广告中赤膊上 阵，展示健硕肌肉，为 公司旗下抗衰老产品"麦角硫因胶囊"代言。 广告中，75岁的刘革新肌肉线条分明，配以" 刘先生75岁——'没有不可能！ '"的广告词， 迅速在社交媒体引发热议，相关话题一度冲上 微博热搜。据界面新闻报道，经记者核实，该视频中出现的男子确为科伦药业董事长刘革新。 对此，有网友意见不一，有网友怀疑视频真实性，也有网友认为"比请明星代言、网红带货靠谱"。 据了解，除了刘革新，科伦药业内部也有员工使用了一段时间这款产品。 这款麦角硫因胶囊由科伦药业全资子公司"科伦永年"销售，在售版本定价1499元/瓶（60粒），每粒含30mg（毫克）麦角硫因。产品宣 传称其"清除自由基效果远超传统成分VC与辅酶Q10的10至30倍"，并称"科伦集团携日本百年企业匠心打造"。 值得一提的是，据媒体报道，科伦药业子公司川宁生物负责提供原料，生 ...

Core Viewpoint - Kelong Pharmaceutical's chairman, Liu Gexin, promotes the company's anti-aging product, "Methylthioadenosine Capsules," in a striking advertisement, showcasing his fitness at the age of 75, which has generated significant social media buzz [1][2]. Company Overview - Kelong Pharmaceutical (002422.SZ) has a market capitalization of 54.558 billion yuan and a stock price of 34.14 yuan [1]. - The company is exploring the health and wellness sector as a potential growth avenue, especially after experiencing a decline in revenue and net profit in the first quarter of the year [6]. Product Details - The "Methylthioadenosine Capsules" are marketed at 1,499 yuan per bottle (60 capsules), with each capsule containing 30 mg of the active ingredient [3]. - The product claims to have antioxidant effects that are 10 to 30 times more effective than traditional ingredients like Vitamin C and Coenzyme Q10 [3]. - The capsules are sold through online platforms and Japanese physical stores, with plans for further online sales on JD Overseas and Tmall International [6]. Marketing Strategy - Liu Gexin has been using the product for three years and maintains a strict fitness regimen, which the company emphasizes in its marketing [2][6]. - The advertisement has sparked discussions on social media, indicating a successful initial marketing impact [2]. Industry Context - The high-end anti-aging health product market is competitive, and consumer acceptance of the product's efficacy will take time to establish [6]. - Methylthioadenosine is gaining attention in the skincare and health supplement sectors for its potential anti-aging properties, although large-scale human trial data is still limited [6][7].

长江证券承销保荐有限公司 关于四川科伦药业股份有限公司分拆所属子公司四川科伦 博泰生物医药股份有限公司境外上市 2024年持续督导核查意见暨持续督导总结报告 四川科伦药业股份有限公司（以下简称"公司""上市公司""科伦药业"） 将其所属子公司四川科伦博泰生物医药股份有限公司（以下简称"科伦博泰生物"） 分拆在境外上市（以下简称"本次分拆上市""本次分拆"），长江证券承销保 荐有限公司作为本次分拆上市的独立财务顾问，根据中国证监会《上市公司分拆 规则（试行）》（以下简称"《分拆规则》"），对本次分拆后上市公司核心资 产与业务的独立经营状况及持续经营能力、科伦博泰生物是否发生对上市公司权 益有重要影响的资产和财务状况变化、科伦博泰生物是否存在其他对上市公司股 票价格产生较大影响的重要信息以及上市公司是否依法履行相关信息披露义务 等持续督导事项进行了专项核查，发表核查意见如下： 一、本次分拆上市概况 2023 年 1 月 13 日，公司召开第七届董事会第二十三次会议、第七届监事会 第十五次会议，审议通过了《关于分拆所属子公司四川科伦博泰生物医药股份有 限公司至香港联合交易所有限公司主板上市符合相关法律、法规规定的议 ...

Group 1: Business Strategy and Market Position - The company plans to enhance its generic drug business by developing a multi-product matrix through rapid product development and cost reduction strategies [1][2][3] - The 11th batch of drug procurement is expected to favor companies with high R&D efficiency and strong market access capabilities [1][2] - The company aims to maintain a stable market share in the intravenous infusion market despite overall market decline [1][2][3] Group 2: Financial Performance and Projections - The company's R&D investment increased by 11.2% to CNY 2.171 billion, supporting future growth [1][2][3] - The revenue from the antibiotic intermediate business is projected to reach CNY 280 million in 2025, up from CNY 196 million in 2024 [20] - The company reported a 43% decline in Q1 performance, attributed to the impact of national procurement and reduced market demand [30][31] Group 3: Product Development and Innovation - The company has three innovative drugs approved for five indications in China, with ongoing commercialization efforts [10][11] - The ADC (Antibody-Drug Conjugate) development strategy focuses on optimizing payload-linker designs to achieve competitive advantages [15][17] - The company is actively exploring new therapeutic areas, including autoimmune diseases, with ongoing collaborations [18][19] Group 4: Market Expansion and International Strategy - The company plans to expand into Southeast Asia, starting with Singapore, and is exploring partnerships in the Middle East [27][28] - The company is preparing to enter the health supplement market, targeting the aging population, which is projected to grow significantly [24][25] - The company aims to leverage its strong R&D capabilities and resource advantages to enhance its international competitiveness [26][27] Group 5: Corporate Governance and Shareholder Relations - The company maintains a stable asset-liability ratio of 28% and plans to optimize its capital structure [31][32] - The board is committed to shareholder returns, with a focus on maintaining a dividend payout ratio of around 52% [32] - The company emphasizes transparency and fairness in information disclosure to ensure market integrity [34]

Investment Rating - The report rates the pharmaceutical industry as "Outperform" [1] - Sub-industry ratings include "Add" for pharmaceutical manufacturing and pharmaceutical services [1] Core Insights - The report is optimistic about innovative drugs, CXO, and strong consumer performance in Q1 2025 [5][27] - In April 2025, the pharmaceutical sector performed similarly to the market, with the SHCOMP index down 1.7% and SW Pharma Bio down 2.1%, ranking 11th among Shenwan primary industries [9][28] - The premium of the pharmaceutical sector over all A-Shares is currently at a normal level of 81.01% [18][28] Summary by Sections 1. Focus on Innovative Drugs and CXO - Key A-share stocks recommended include Jiangsu Heng Rui Medicine, Betta Pharmaceuticals, Shenzhen Salubris Pharmaceuticals, Sichuan Kelun Pharmaceutical, Remegen, Huadong Medicine, WuXi AppTec, APT Medical, and AIER EYE HOSPITAL GROUP [5][27] - H-share top picks include Wuxi Biologics Cayman, PATEO, Innovent Biologics, and Zai Lab, with beneficiaries being CSPC Pharmaceutical Group, Gushengtang, and Angelalign [27] 2. April 2025 Pharmaceutical Sector Performance - The pharmaceutical sector's performance was on par with the market, with notable sub-sectors being chemical preparations (+2.8%), pharmaceutical commerce (+1.5%), and chemical raw materials (+0.7%) [12][28] - Top gainers included Apichope Pharmaceutical (+56.2%), Qianjiang Yongan Pharmaceutical (+55.9%), and Kexing Biopharm Co., Ltd. (+55.2%), while top losers were Hainan Poly Pharm (-71.9%), Landfar Bio-Medicine Co., Ltd (-40.0%), and Jiangsu Wuzhong Industrial (-39.5%) [17][28] 3. Performance Disparities in 2024 and Q1 2025 - In 2024, the pharmaceutical sector's overall revenue fell by 1.5% YoY, and net profit decreased by 12.5% YoY, with medical consumables, chemical preparations, and blood products showing positive growth [22][28] - In Q1 2025, the sector's revenue fell by 6.1% YoY, and net profit fell by 9.7% YoY, with medical R&D outsourcing, consumables, and hospitals performing well [22][28] 4. Profitability Metrics - The gross profit margin (GPM) for the pharmaceutical sector fell by 0.5pp YoY in 2024, while the net profit margin (NPM) fell by 0.8pp YoY [24][28] - In Q1 2025, GPM decreased by 1.6pp YoY, and NPM decreased by 0.4pp YoY, with medical R&D outsourcing showing improvements in both GPM and NPM [24][28]

Core Insights - The latest net value of ICBC Frontier Medical Stock A (001717) is 2.8300 yuan, reflecting a decrease of 1.77% [1] - The fund has shown a one-month return of 5.28%, ranking 400 out of 471 in its category; a three-month return of 8.06%, ranking 71 out of 471; and a year-to-date return of 7.56%, ranking 113 out of 469 [1] Fund Holdings - The top ten holdings of ICBC Frontier Medical Stock A account for a total of 59.05%, with the largest positions being: - Heng Rui Medicine (10.11%) - Kelun Pharmaceutical (8.01%) - WuXi AppTec (7.72%) - BeiGene (6.85%) - Xinlitai (4.90%) - Zai Lab (4.77%) - Yuyue Medical (4.60%) - New Horizon Health (4.36%) - East China Pharmaceutical (4.20%) - Haizhi Pharmaceutical (3.53%) [1] Fund Overview - ICBC Frontier Medical Stock A was established on February 3, 2016, and as of March 31, 2025, it has a total scale of 9.081 billion yuan [1] - The fund manager is Zhao Bei, who has extensive experience in the healthcare sector [2]

Group 1 - The core point of the news is the performance and holdings of the China Europe Medical Health Mixed A Fund, which has seen a recent decline in net value and varying returns over different time frames [1] - As of May 7, 2025, the latest net value of the fund is 1.5753 yuan, reflecting a decrease of 1.28%. The fund's return over the past month is -2.61%, ranking 4118 out of 4649 in its category. Over the past three months, the return is 4.24%, ranking 1179 out of 4597, and since the beginning of the year, the return is 1.73%, ranking 2415 out of 4556 [1] - The top ten stock holdings of the fund account for a total of 55.30%, with significant positions in companies such as Heng Rui Pharmaceutical (10.60%), WuXi AppTec (9.95%), and Kanglong Chemical (6.24%) [1] Group 2 - The China Europe Medical Health Mixed A Fund was established on September 29, 2016, and as of March 31, 2025, it has a total scale of 15.613 billion yuan. The fund manager is Ms. Ge Lan [1] - Ms. Ge Lan has a background in biomedical engineering with a Ph.D. from Northwestern University in the United States. She has held various research and fund management positions before becoming the manager of the China Europe Medical Health Mixed Fund [2]

Group 1: Business Segments Overview - The company expects stable performance in the infusion segment for 2025 compared to 2024, with growth anticipated in parenteral nutrition and powder-liquid dual-chamber bag products [2] - The company aims to expand its market share in specialty drugs, particularly in antibiotics, with effective market access achieved in 2024 [1] - The company plans to focus on expanding its diabetes medication portfolio, with products like Ertugliflozin and Sitagliptin expected to drive growth in the next 2-3 years [1] Group 2: International Expansion Strategy - The company is initiating its overseas strategy by targeting the preventive medicine sector in Singapore, with plans to expand into Southeast Asia [1] - Ongoing discussions with major pharmaceutical companies in the Middle East are part of the company's international market exploration [1] Group 3: Innovation Pipeline and Commercialization - The company has several important meetings planned for the second half of the year to discuss its innovation pipeline, particularly focusing on TROP2-ADC and other ADC products [3] - Three products across five indications have been approved since November last year, with a strong focus on major cancer types such as breast cancer and lung cancer [4] Group 4: Market Challenges and Responses - The tenth batch of centralized procurement has significantly impacted the company's potassium chloride injection segment, affecting both unit prices and market share [5] - The company plans to compensate for the decline in potassium chloride sales by increasing the volume of other plastic injection products [5] Group 5: Financial Performance and Cost Management - The gross margin for the infusion segment has slightly decreased in recent years, with the company implementing cost-reduction measures through new high-speed production lines [9] - The overall gross margin for Chuan Ning Bio is projected to be around 36% in 2024, reflecting a 4% increase compared to the previous year [9] - The company has seen a steady decline in sales expense ratios due to effective marketing management reforms [9] Group 6: Raw Material and Export Considerations - The company is currently exempt from U.S. tariffs on antibiotic intermediates, with most overseas sales directed to India [12] - Should tariffs be imposed, the company is prepared to take proactive measures to minimize the impact [12]