证券代码：300009 证券简称：安科生物 公告编号：2025-057 安徽安科生物工程（集团）股份有限公司 关于签署 PA3-17 注射液产品独家代理框架协议暨关联交易的公告 本公司及董事会全体成员保证公告内容真实、准确和完整，没有虚假记载、误 导性陈述或者重大遗漏。 特别提示： 1、本次事项构成关联交易，根据《深圳证券交易所创业板股票上市规则》《公 司章程》等规定，该事项已经公司第八届董事会第二十三次会议审议通过，无需提 交公司股东大会审议。 2、本协议不涉及具体金额，对公司当期经营业绩不会产生重大影响。 3、本协议为框架性协议，后续具体合作内容将以产品提交上市申请后签订的 正式协议为准。本次独家代理产品的上市时间存在不确定性，本次协议的履行及其 后续协议的履行存在一定不确定性，敬请广大投资者谨慎决策，注意投资风险。公 司将根据合作进展及时履行信息披露义务。 为推动参股公司博生吉医药科技（苏州）有限公司（以下简称"博生吉公司"） 旗下 PA3-17 注射液产品的销售与推广，安徽安科生物工程（集团）股份有限公司 （以下简称"公司"）与博生吉公司达成战略合作，于 2025 年 11 月 11 日签署《关 于 ...

证券代码：300009 证券简称：安科生物 公告编号：2025-059 为夯实公司创新药领域的战略布局，强化公司核心竞争力，同意公司拟以自 有资金 3,000 万元人民币对博生吉医药科技（苏州）有限公司（以下简称"博生 吉公司"）进行增资，认购博生吉公司新增注册资本 11.9062 万元，本次增资完 成后，公司持有博生吉公司 21.4121%的股权。根据《深圳证券交易所创业板股 票上市规则》规定，本次交易构成关联交易。具体内容详见同日披露于中国证监 会指定创业板信息披露网站巨潮资讯网（www.cninfo.com.cn）的相关公告。 本议案已经公司第八届董事会独立董事专门会议 2025 年第二次会议及第八 届董事会战略与投资委员会 2025 年第一次会议事前审议通过，一致同意将本议 案提交公司董事会审议。 本议案以12票同意、0票反对、0 票弃权获得通过。 2、审议通过《关于与博生吉医药科技（苏州）有限公司签署<产品独家代 安徽安科生物工程（集团）股份有限公司 关于第八届董事会第二十三次会议决议的公告 本公司及董事会全体成员保证公告内容真实、准确和完整，没有虚假记载、 误导性陈述或者重大遗漏。 安徽安科生物工 ...

Core Viewpoint - The biopharmaceutical sector experienced a decline of 0.37% on November 7, with He Yuan Bio leading the drop. The Shanghai Composite Index closed at 3997.56, down 0.25%, while the Shenzhen Component Index closed at 13404.06, down 0.36% [1]. Group 1: Stock Performance - Wan Ze Co. (000534) saw a significant increase in stock price, closing at 22.51 with an 8.80% rise and a trading volume of 754,200 shares, amounting to 1.681 billion yuan [1]. - Tibet Pharmaceutical (600211) closed at 46.05, up 2.74%, with a trading volume of 80,600 shares, totaling 371 million yuan [1]. - Anke Bio (300009) increased by 2.25%, closing at 10.93 with a trading volume of 442,300 shares, amounting to 482 million yuan [1]. - The overall biopharmaceutical sector saw a net outflow of 678 million yuan from institutional investors, while retail investors had a net inflow of 304 million yuan [2][3]. Group 2: Capital Flow - The main capital inflow was observed in Tibet Pharmaceutical, with a net inflow of 26.13 million yuan from institutional investors, while retail investors had a net outflow of 36.64 million yuan [3]. - Anke Bio also experienced a net inflow of 23.91 million yuan from institutional investors, with retail investors seeing a net outflow of 13.09 million yuan [3]. - The overall trend indicates a mixed sentiment in the biopharmaceutical sector, with institutional investors pulling back while retail investors showed some interest [2][3].

Core Viewpoint - Anke Biological has shown a mixed performance in stock price and financial results, with a notable increase in stock price year-to-date but a decline in net profit for the recent period [1][2]. Financial Performance - As of October 31, Anke Biological reported a revenue of 1.963 billion yuan for the period from January to September 2025, representing a year-on-year growth of 2.15%. However, the net profit attributable to shareholders was 551 million yuan, which reflects a decrease of 6.48% compared to the previous year [2]. - The company has cumulatively distributed 2.662 billion yuan in dividends since its A-share listing, with 1.252 billion yuan distributed over the last three years [3]. Stock Market Activity - On November 7, Anke Biological's stock price increased by 2.06%, reaching 10.91 yuan per share, with a trading volume of approximately 90.89 million yuan and a turnover rate of 0.69%. The total market capitalization stood at 18.247 billion yuan [1]. - Year-to-date, the stock price has risen by 30.02%, with a slight increase of 5.72% over the past 20 trading days [1]. Shareholder Structure - As of September 30, 2025, Anke Biological had 76,900 shareholders, an increase of 4.63% from the previous period. The average number of circulating shares per shareholder decreased by 4.43% to 15,886 shares [2]. - The top ten circulating shareholders include significant institutional investors, with Hong Kong Central Clearing Limited holding 19.5226 million shares, a decrease of 1.269 million shares from the previous period [3].

Market Overview - The precision medicine sector experienced a decline of 1.77% on November 4, with TuoJing Life leading the drop [1][2] - The Shanghai Composite Index closed at 3960.19, down 0.41%, while the Shenzhen Component Index closed at 13175.22, down 1.71% [1] Stock Performance - Notable stock performances in the precision medicine sector included: - RenDu Bio (688193) closed at 52.90, up 1.05% with a trading volume of 7076.23 hands and a transaction value exceeding 36.99 million yuan [1] - TuoJing Life (300642) closed at 22.73, down 2.86% with a trading volume of 78,200 hands and a transaction value of 178 million yuan [2] - Other companies like DaAn Gene (002030) and Anke Bio (300009) showed minimal changes, with DaAn Gene remaining flat at 6.57 and Anke Bio down 0.55% to 10.84 [1][2] Capital Flow - The precision medicine sector saw a net outflow of 979 million yuan from institutional investors, while retail investors contributed a net inflow of 642 million yuan [2][3] - Specific stock capital flows indicated: - GuoMai Technology (002093) had a net inflow of 8.61 million yuan from institutional investors, while retail investors saw a net outflow of 15.98 million yuan [3] - TuoJing Life experienced minimal net inflow from institutional investors at 25,000 yuan, with retail investors also showing a slight outflow [3]

Core Insights - The Biotech Index (970038) closed at 2279.35 points, up 0.77%, with a trading volume of 28.709 billion yuan and a turnover rate of 1.85% [1] - Among the index constituents, 41 stocks rose, with Hualan Vaccine leading at a 17.88% increase, while 8 stocks fell, with Deep Technology leading the decline at 6.38% [1] Index Performance - The Biotech Index saw a net inflow of 140 million yuan from institutional investors, while retail investors contributed a net inflow of 210 million yuan, and there was a net outflow of 350 million yuan from speculative funds [1] Top Constituents - The top ten constituents of the Biotech Index include: - Mindray Medical (sz300760) with a weight of 13.81%, latest price at 215.04, and a decrease of 0.76% [1] - Changchun High-tech (sz000661) with a weight of 5.41%, latest price at 112.26, and a decrease of 2.55% [1] - Kanglong Chemical (sz300759) with a weight of 4.66%, latest price at 33.51, and an increase of 1.12% [1] - Other notable constituents include Muyuans (sz002714) and Aimeike (sz300896) with respective weights of 3.66% and 3.44% [1] Capital Flow Details - Detailed capital flow for key stocks includes: - Mindray Medical saw a net inflow of 26.2 million yuan from institutional investors [2] - Muyuans had a net inflow of 203 million yuan from institutional investors [2] - Hualan Vaccine experienced a net inflow of 74.8 million yuan from institutional investors [2]

Core Insights - The cell immunotherapy sector experienced a notable increase of 3.58%, ranking second among concept sectors, with 54 stocks rising, including Shutaishen which hit a 20% limit up [1] - Major inflows of capital were observed in the cell immunotherapy sector, with a net inflow of 831 million yuan, led by Shutaishen with a net inflow of 464 million yuan [1][2] Sector Performance - The top-performing sectors included: - Recombinant proteins: +3.72% - Cell immunotherapy: +3.58% - Sora concept (Wensheng video): +3.51% - AI corpus: +3.42% - Innovative drugs: +3.35% [1] Stock Performance - Key stocks in the cell immunotherapy sector with significant price increases: - Shutaishen: +19.99% - Rongchang Bio: +11.80% - Anke Bio: +6.75% - Zhaoyan New Drug: +4.58% [2][3] - Stocks with notable declines included: - ST Bailing: -3.04% - C Bait: -1.92% - Pruis: -1.37% [1][5] Capital Inflow Ratios - Leading stocks by net capital inflow ratios: - Shutaishen: 19.13% - Dongcheng Pharmaceutical: 11.95% - Rongchang Bio: 10.47% [2][3] Summary of Capital Flows - The cell immunotherapy sector saw significant capital flow, with 30 stocks receiving net inflows, and 8 stocks exceeding 30 million yuan in net inflows [1][2]

Core Viewpoint - Anke Bio is a leading company in the domestic biopharmaceutical sector, focusing on cell engineering, gene engineering, and precision medicine, with strong R&D capabilities [1] Group 1: Business Performance - In Q3 2025, Anke Bio achieved a revenue of 1.963 billion yuan, ranking 7th among 34 companies in the industry, with the industry leader, Changchun High-tech, generating 9.807 billion yuan [2] - The net profit for the same period was 563 million yuan, also ranking 7th, with the top performer, Tonghua Dongbao, reporting a net profit of 1.188 billion yuan [2] Group 2: Financial Ratios - As of Q3 2025, Anke Bio's debt-to-asset ratio was 14.81%, lower than the previous year's 17.20% and below the industry average of 26.88%, indicating strong solvency [3] - The gross profit margin for Q3 2025 was 75.97%, slightly down from 77.75% year-on-year but still above the industry average of 70.17%, reflecting strong profitability [3] Group 3: Shareholder Information - As of September 30, 2025, the number of A-share shareholders increased by 11.15% to 73,000, while the average number of circulating A-shares held per shareholder decreased by 10.04% to 16,700 [5] Group 4: Business Highlights - The biopharmaceutical segment showed signs of recovery, with the first antibody drug, "Ansaiting," seeing a sales revenue increase of 298% [6] - Significant progress in business collaborations, including exclusive commercialization rights for recombinant human follicle-stimulating hormone-CTP fusion protein injection [6][7] - The company is advancing its innovation drug transformation with multiple projects making progress, such as the completion of Phase I clinical trials for "PA3-17 injection" [6][7]

Group 1: Market Performance - The biopharmaceutical sector increased by 3.42% compared to the previous trading day, with Sanofi leading the gains [1] - The Shanghai Composite Index closed at 3954.79, down 0.81%, while the Shenzhen Component Index closed at 13378.21, down 1.14% [1] Group 2: Stock Performance - Sanofi (688336) closed at 72.96, up 20.00% with a trading volume of 115,200 shares and a transaction value of 799 million [1] - Hualan Biological (301207) closed at 21.95, up 17.88% with a trading volume of 239,800 shares and a transaction value of 493 million [1] - Other notable stocks include Rongchang Bio (688331) up 11.80%, Jinke (688670) up 7.45%, and Kangchen Pharmaceutical (603590) up 7.38% [1] Group 3: Capital Flow - The biopharmaceutical sector saw a net inflow of 590 million from institutional investors, while retail investors experienced a net outflow of 268 million [2] - Major stocks like Rongchang Bio and Sanofi had significant net inflows from institutional investors, with 145 million and 14.1 million respectively [2] - Retail investors showed a net outflow in several stocks, including Sanofi and Hualan Biological, indicating a shift in investor sentiment [2]

Group 1 - The core point of the news is that Anke Bio's stock price increased by 5.09% to 10.74 CNY per share, with a trading volume of 334 million CNY and a turnover rate of 2.60%, resulting in a total market capitalization of 17.963 billion CNY [1] - Anke Bio, established on September 28, 2000, and listed on October 30, 2009, is primarily engaged in the research, development, production, and sales of biotechnological products, including cell engineering, gene engineering, gene testing, and precision medicine [1] - The company's main revenue sources are gene engineering drugs (88.24%), external patches (11.67%), and other supplementary products (0.09%) [1] Group 2 - Among Anke Bio's top ten circulating shareholders, a fund under Yinhua Fund has increased its holdings by 191,300 shares in the third quarter, now holding 11.2177 million shares, which accounts for 0.92% of the circulating shares [2] - The fund, named Innovation Medicine (159992), has a total scale of 12.005 billion CNY and has achieved a year-to-date return of 28.21%, ranking 2060 out of 4216 in its category [2] - The fund's performance over the past year shows a return of 23.93%, ranking 2220 out of 3889, while it has incurred a loss of 10.74% since its inception [2]