Group 1 - The article promotes a weekly newsletter focused on stocks in the biotech, pharma, and healthcare industries, aimed at both novice and experienced investors [1] - The newsletter provides insights on key trends, catalysts, product sales forecasts, and integrated financial statements for major pharmaceutical companies [1] - The author, Edmund Ingham, has over 5 years of experience in the biotech sector and has compiled detailed reports on more than 1,000 companies [1]

Lilly Falls as Weight-Loss Pill Data Overshadows Sales Beat. Listen for more on Bloomberg Intelligence. https://t.co/xnkPTNhImP ...

Core Insights - Eli Lilly and Company (LLY) reported strong second-quarter 2025 results, with adjusted earnings per share (EPS) of $6.31, exceeding the Zacks Consensus Estimate of $5.61, and a 61% year-over-year increase in earnings [1] - Revenues reached $15.56 billion, a 38% year-over-year increase, driven by sales of tirzepatide medicines, including diabetes drug Mounjaro and weight loss medicine Zepbound, surpassing the Zacks Consensus Estimate of $14.749 billion [1][2] Revenue Breakdown - U.S. revenues increased by 38% to $10.81 billion, while ex-U.S. revenues rose by 37% to $4.74 billion [2] - Mounjaro sales were $5.2 billion, up 68% year over year, exceeding estimates [3] - Zepbound sales reached $3.38 billion, a 172% increase year over year, also beating estimates [4] Competitive Landscape - Mounjaro and Zepbound face competition from Novo Nordisk's semaglutide medicines, Ozempic and Wegovy, which have seen lowered sales expectations due to competitive pressures [5] - Other companies like Amgen and Viking Therapeutics are developing more potent GLP-1-based candidates [6] Key Drug Performance - Trulicity generated $1.09 billion in revenue, down 12% year over year, but still beat estimates [7] - Jardiance sales declined by 10% to $690 million, surpassing estimates [7] - Taltz brought in $847.6 million, up 3% year over year, but missed estimates [8] - Verzenio generated $1.49 billion, up 12% year over year, but also missed estimates [8] - New drugs like Jaypirca, Omvoh, and Ebglyss contributed to sales growth [9][10] Guidance Update - Lilly raised its 2025 revenue guidance to $60.0 billion to $62.0 billion, up from $58.0 billion to $61.0 billion, and increased EPS guidance to $21.75 to $23.00 [11] Orforglipron Study Results - The oral obesity pill orforglipron showed a weight loss of 12.4%, which was below investor expectations, leading to a decline in shares [14][19] - Despite meeting primary endpoints, the weight loss results were disappointing compared to competitors [14][19] - Lilly plans to submit regulatory applications for orforglipron by the end of the year [15] Market Reaction - Following the earnings report, shares fell approximately 12% in pre-market trading due to the underwhelming results of orforglipron [19][20] - Lilly's stock has declined 3% year-to-date, compared to a 4.2% decrease in the industry [20]

back. Eli Lily be beating estimates and raising guidance for its latest quarter, but the stock tumbling to its lowest level since January 2024 after trial data for its obesity pill came in below Wall Street's expectations. Eli Liy CEO David Ricks was on Squapbox earlier today to discuss the results.Take a listen. The goal was to create an oral pill that was convenient and could be made at huge scale um really for for the mass market and had weight loss that was competitive with other single acting GLP1s and ...

Economic Overview - U.S. pre-market futures are at peak highs, with the Dow up 185 points, S&P 500 up 35 points, and Nasdaq up 120 points, indicating a healthy market environment [1] - The small-cap Russell index is up 20 points, showing recovery from a previous selloff, with Q2 earnings season exceeding expectations across various industries [2] Productivity and Labor Costs - U.S. Productivity in Q2 increased by 2.4%, surpassing the expected 1.9%, marking a significant recovery from the previous quarter's -1.8% [3] - Unit Labor Costs rose by 1.6%, slightly above the estimated 1.3%, and down from a revised 6.9% in Q1, indicating improved economic conditions [4] Employment Data - Initial Jobless Claims rose to 226K, 5K higher than estimated, but still below the near-term high of 250K reported in early June [5] - Continuing Jobless Claims reached 1.974 million, the highest since November 2021, but still below the psychologically significant 2 million mark [6] Company Earnings Reports - Eli Lilly reported Q2 earnings of $6.31 per share, exceeding the $5.61 estimate, with revenues of $15.56 billion, up 5.5% [7] - Despite strong earnings, Eli Lilly's shares fell 7% due to disappointing performance of its new obesity pill, which had a 12% weight loss rate [8] - Warner Bros. Discovery reported earnings of $0.63 per share, significantly better than the expected -$0.16, with revenues of $9.81 billion [9] - Ralph Lauren's fiscal Q1 earnings were $3.77 per share, beating the $3.48 estimate, with revenues of $1.7 billion, up 14% year over year [10] Upcoming Economic Data - Wholesale Inventories for June and Consumer Credit data will be released later today, following a previous Consumer Credit increase of $5.1 billion [11]

And then Eli Lilly losing 14%. Katie, I just can't believe how bad the market is taking this. I mean, just because the pill only gives you 11% weight loss, 11% is a lot of percent of your entire body.Right. Is a lot of percent. And you're right.That is Eli Lilly's biggest decline since October. You have at least one sell side analysts saying that this is an overreaction. Gerard hails from Mizuho, saying that the magnitude is high given what we learned this morning.So let's wrap it all together with Bloomber ...

Investment Rating - The report maintains an "Outperform" rating for the industry [1] Core Insights - There is an unmet clinical need in HR+/HER2- breast cancer (BC), which accounts for approximately 60-70% of all breast cancer cases globally [2][8] - New mechanism drugs are expected to extend chemotherapy-free survival for HR+/HER2- BC patients, with a focus on overcoming resistance to endocrine therapy (ET) and enhancing the efficacy of CDK4/6 inhibitors [2][40] - The report highlights the potential of various new target molecules and mechanisms to improve patient outcomes and expand market size [2][40] Summary by Sections 1. Unmet Clinical Needs in HR+/HER2- BC - HR+/HER2- BC is the most common subtype of breast cancer, with significant unmet clinical needs, especially for patients with specific mutations [2][8] - Current treatment options, including ET and CDK4/6 inhibitors, are limited for patients who progress after first-line therapy [2][40] 2. Endocrine Therapy: New Mechanism Molecules to Overcome Resistance - New generation oral SERDs and ER PROTACs are promising in overcoming resistance caused by ESR1 mutations [2][40] - The estrogen signaling pathway plays a critical role in breast cancer, and targeting this pathway is essential for effective treatment [13][48] 3. CDK Inhibitors: Partners in ET to Extend Treatment Duration - CDK4/6 inhibitors significantly improve progression-free survival (PFS) when combined with ET in first-line treatment [14][25] - There is a need for new mechanism molecules targeting the CDK-cyclin pathway to address resistance after first-line therapy [2][40] 4. Other New Target Molecules: Potential to Extend Chemotherapy-Free Survival - Activation of the PI3K/AKT/mTOR pathway is a common resistance mechanism in HR+/HER2- BC, with several products already approved for treatment [2][40] - New targets such as KAT6i and ADCs are expected to show advantages over chemotherapy and occupy significant positions in treatment sequences [2][40] 5. Company Analysis - Companies leading in the development of new mechanism drugs include BeiGene, Hansoh Pharmaceutical, Kelun-Botai Biopharmaceutical, and China National Pharmaceutical Group [2][40]

Shares of Eli Liy are now down over 14 plus%. That is uh well more than where uh the stock opened this morning. This follows what is being seen as disappointing data for its upcoming pill to treat obesity.Let's get to Angelica Peebles for more. Angelica, this is uh this is getting pretty serious in terms of a market cap loss now. Yeah, David, quite a big reaction today and that's because of the data like you talked about.So, let's get into the numbers. people lost about 12% of their body weight after a litt ...

Group 1 - Novo Nordisk (NVO.US) shares rose nearly 6%, reaching $47.99 as of the report [1] - Eli Lilly (LLY.US) competitor's first small molecule oral GLP-1 drug, Orforglipron, achieved an average weight loss of 11.2%, which is below the expected range of 13% to 15% or more [1]

Summary of Eli Lilly's Q2 2025 Earnings Call Company Overview - **Company**: Eli Lilly - **Date**: Q2 2025 Earnings Call Key Financial Performance - Gross margin reached **85%**, up **3%** year-over-year, driven by lower production costs and optimized product mix, partially offset by price declines [2][3] - Non-GAAP operating margin at **40.5%**, an increase of over **6 percentage points** year-over-year [4] - Earnings per share (EPS) increased by **61%** to **$6.31**, including a negative impact of **$0.14** from the acquisition of IPR and depreciation [4] - Revenue growth of **38%** in the U.S., primarily due to strong sales of **Mounjaro**, despite an **8%** price decline [3][5] - European revenue grew by **77%**, reflecting strong performance from the Montana business [5] - Revenue in China increased by **19%**, mainly due to increased sales from the Montana business [5] - Total revenue expected to be between **$60 billion** and **$62 billion** for 2025, with non-GAAP operating margin projected between **43%** and **45.5%** [3][13] Market Performance - U.S. market revenue growth driven by **Mounjaro**, **Bydureon**, and **Trulicity** sales [3] - International sales growth of **12%** in oncology, with U.S. prescriptions up **454%** [3][10] - Montana product line achieved **$5.2 billion** in global sales, becoming a leader in the type 2 diabetes prescription market [12] Research and Development Highlights - Multiple new clinical projects initiated, with increased R&D investment [6] - Acquisition of **Site One Therapeutics** and **Verb Therapeutics** to expand non-opioid pain and cardiovascular gene therapy portfolios [6] - FDA approval for new dosing schedule of **Casirol** and positive results from **Surpass CDOT** and **Brewing CLL 314** Phase III trials [7] - **Atern** Phase I trial showed significant weight loss in obese patients, with safety comparable to injectable GLP-1 drugs [8] Addressing Global Health Challenges - Eli Lilly is actively addressing the global obesity challenge with new drug submissions planned [8] - The company supports government reforms to share the costs of medical research more equitably and reduce consumer costs in the U.S. pharmaceutical market [9] Pricing and Cost Management - Eli Lilly's **Lily Direct** model offers affordable medications, with weight loss drugs priced over **50%** lower than previous prices and insulin prices reduced by **70%** [9] - The company emphasizes the need for urgent reforms in the U.S. pharmaceutical market to lower consumer costs [9] Future Expectations - Anticipated production capacity in the second half of 2025 expected to be at least **1.8 times** that of the second half of 2024 [14] - Continued focus on expanding market share in the obesity and diabetes sectors, with new product launches planned [12][20] Conclusion Eli Lilly's Q2 2025 performance reflects strong revenue growth across multiple markets, significant advancements in R&D, and a commitment to addressing global health challenges while managing costs effectively. The company is well-positioned for future growth with a robust pipeline and strategic acquisitions.