FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 康方生物科技（開曼）有限公司 呈交日期： 2025年9月4日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | | 證券代號 (如上市) | 09926 | 說明 | | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | | 庫存股份變動 | | | | | 事件 | | 已發行股份（ ...

香 港 交 易 及 結 算 所 有 限 公 司 及 香 港 聯 合 交 易 所 有 限 公 司 對 本 公 告 的 內 容 概 不 負 責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部 或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 本公告僅作參考，並非收購、購買或認購本公司證券的邀請或要約。 本公告或其任何副本概不得直接或間接在美國，或在刊發或派發本公告屬違法的 任何其他司法權區內刊發或派發。 本公告並非在美國購買或認購任何證券之要約或招攬，亦不構成其一部分。本公 告所述證券並未且將不會根據《1933年美國證券法》（「美國證券法」）登記，亦不會 在美國提呈或出售，除非根據美國證券法作出登記或獲豁免或為毋須根據美國證 券 法 作 出 登 記 之 交 易 。 本 公 司 無 意 根 據 美 國 證 券 法 登 記 本 公 告 內 所 指 之 任 何 證 券，或在美國進行證券之公開發售。 Akeso, Inc. 完成根據一般授權配售一級新股及配售現有股份 董事會欣然宣佈，一級配售協議所有條件均已達成，一級配售的完成已於2025年 9 月 4 日 落 實 。 根 據 一級 ...

Group 1 - The A-share market is experiencing a correction, particularly in the pharmaceutical sector, with leading innovative drug companies like Huadong Medicine and BeiGene dropping over 5% [1] - The Hong Kong market's innovative drug ETF (520880) saw a significant decline of 3.32% after a previous rally, indicating a volatile trading environment [1][3] - The innovative drug ETF (520880) has accumulated over 6.2 billion yuan in net inflows over the past 60 days, reflecting strong investor interest despite recent market fluctuations [3][5] Group 2 - Upcoming major conferences, such as the World Lung Cancer Conference, are expected to catalyze a rebound in the innovative drug sector, with companies like CanSino Biologics and BeiGene presenting new research [5] - The innovative drug sector is anticipated to benefit from global competitiveness, overseas expansion, and supportive policies, which are expected to reshape valuations [5] - The Hong Kong innovative drug ETF (520880) is set to revise its index to focus solely on innovative drug research companies, enhancing its purity and potential performance [6] Group 3 - The innovative drug ETF (520880) has shown a remarkable year-to-date increase of 118.95%, outperforming other indices in the sector [8] - The medical ETF market is currently valued at 271.33 billion yuan, making it the largest in the pharmaceutical and medical category [10]

Core Insights - The AI Fund Ping An Medical Health Mixed A (003032) reported a profit of 352 million yuan for the first half of 2025, with a weighted average profit per fund share of 1.0034 yuan [2] - The fund's net value growth rate was 57.41% during the reporting period, with a total fund size of 966 million yuan as of the end of June [2] - The fund focuses on long-term investments in pharmaceutical and medical stocks, with a current unit net value of 3.103 yuan as of September 3 [2] Performance Metrics - As of September 3, the fund's one-year cumulative net value growth rate was 111.92%, ranking 5th out of 136 comparable funds [5] - The fund's three-month net value growth rate was 32.83%, ranking 29th out of 138 comparable funds [5] - The fund's three-year Sharpe ratio was 0.4698, ranking 15th out of 105 comparable funds [25] Investment Strategy - The fund manager emphasized the importance of sub-industry prosperity in investment strategy, focusing on companies with valuation advantages in the innovative drug sector [2] - The fund's top ten holdings include companies such as CloudTop New Medicine, Innovent Biologics, and BeiGene, indicating a concentrated investment approach [40] Valuation Metrics - As of June 30, 2025, the fund's weighted average price-to-earnings (P/E) ratio was approximately -202.85, compared to the industry average of 120.96 [9] - The weighted average price-to-book (P/B) ratio was about 7.89, while the industry average was 4.07 [9] - The weighted average price-to-sales (P/S) ratio was approximately 14.98, compared to the industry average of 6.52 [9] Growth Metrics - For the first half of 2025, the fund's weighted average revenue growth rate was 0.17%, while the weighted average net profit growth rate was -0.21% [16] - The fund's weighted annualized return on equity was -0.04% [16] Fund Composition - As of June 30, 2025, the fund had 24,900 holders, with a total of 395 million shares held [34] - Institutional investors held 64.36% of the fund's shares, while individual investors accounted for 35.64% [34] - The fund's turnover rate for the last six months was approximately 143.02%, consistently below the industry average [37]

Core Viewpoint - The AI Fund Guotou UBS Innovative Medical Mixed A (005520) reported a profit of 9.4516 million yuan for the first half of 2025, with a net value growth rate of 20.2% and a fund size of 55.1318 million yuan as of the end of June 2025 [2][31]. Fund Performance - As of September 3, 2025, the fund's one-year cumulative net value growth rate reached 67.54%, ranking 58 out of 136 comparable funds [5]. - The fund's net value growth rates for the past three months and six months were 32.25% and 50.66%, respectively, ranking 34 out of 138 and 52 out of 138 among comparable funds [5]. Investment Strategy - The fund manager expressed optimism about the long-term potential of the innovative drug sector, focusing on companies with certainty and reasonable valuations for long-term holdings [2]. - The fund also maintains a positive outlook on the CXO/research service sector, anticipating continued demand improvement and favorable conditions for investment and financing as the Federal Reserve gradually lowers interest rates [2]. Valuation Metrics - As of June 30, 2025, the fund's weighted average price-to-earnings (P/E) ratio was approximately 44.55 times, significantly lower than the industry average of 120.96 times [10]. - The weighted average price-to-book (P/B) ratio was about 3.27 times, compared to the industry average of 4.07 times, and the weighted average price-to-sales (P/S) ratio was approximately 4.27 times, against an industry average of 6.52 times [10]. Growth Metrics - For the first half of 2025, the fund's weighted average revenue growth rate was 0.06%, and the weighted average net profit growth rate was 0.52% [17]. - The weighted annualized return on equity was recorded at 0.07% [17]. Fund Composition - As of June 30, 2025, the fund held a total of 4,131 investors, with a total of 58.9068 million units held [34]. - The top ten holdings included companies such as Heng Rui Pharmaceutical, Kelun-Botai Biological, and Innovent Biologics [39].

Group 1 - UBS maintains a "Buy" rating for Innovent Biologics, raising the target price to HKD 137.4, citing the promising product line and significant global R&D potential for IBI363 [1] - CMB (Hong Kong) maintains a "Buy" rating for China Life, increasing the target price to HKD 29, with a projected 7% YoY net profit growth in H1 2025 and a 20.3% increase in new business value [1] - CMB (Hong Kong) maintains a "Buy" rating for ZTE Corporation, raising the target price to HKD 42, with a 15% YoY revenue growth expected in H1 2025, driven by strong enterprise business performance [2] Group 2 - DBS reaffirms a "Buy" rating for China Merchants Bank, lowering the target price to HKD 53.5, with a projected CAGR of 2.5% for earnings from 2025 to 2027 [3] - Huatai Securities maintains a "Buy" rating for Li Auto, reducing the H-share target price to HKD 105.43, optimistic about the sales performance of the new i6 model [4] - CMB (Hong Kong) maintains an "Outperform" rating for Cha Bai Dao, with a target price of HKD 12, reporting a 4.3% YoY revenue growth and a 37.5% increase in net profit for H1 2025 [5] Group 3 - CMB (Hong Kong) maintains an "Outperform" rating for Chaoyun Group, setting a target price of HKD 3.65, with a 7.2% YoY revenue growth and a 101.4% increase in pet business revenue [6] - CMB (Hong Kong) maintains an "Outperform" rating for He Yu-B, raising the target price to HKD 20, highlighting the approval of a key clinical trial and strong financial position [7] - UBS gives a "Buy" rating to CanSino Biologics, setting a target price of HKD 224.3, anticipating updates on key data and potential collaborations [8]

Core Viewpoint - The article highlights the rapid rise of Guangzhou High-tech Zone in the biopharmaceutical industry, showcasing its significant growth and competitive advantages compared to other major biopharmaceutical hubs in China. Summary by Sections Industry Ranking and Growth - Guangzhou High-tech Zone ranked fifth in the national biopharmaceutical industry park competition, showing a remarkable improvement from twelfth place in 2021, climbing seven positions [4][5]. - The number of biopharmaceutical enterprises in Huangpu District has increased from 1,000 to 4,800 since 2017, a growth of 3.8 times, while revenue surged from 65 billion to 240 billion yuan, also a 2.7 times increase [6]. Leading Enterprises and Innovations - Huangpu District is home to 528 high-tech enterprises in the biopharmaceutical sector and 21 listed companies, accounting for 75% of Guangzhou's total [7]. - Notable companies include Kangfang Biotech, which has developed globally innovative dual-specific antibody drugs, and Hengrui Medicine, which has seen its innovative drug sales reach 9.561 billion yuan, making up 60.66% of its total revenue [9]. Competitive Advantages - The article identifies three key advantages for Huangpu's attractiveness to biopharmaceutical giants: top-tier location, superior medical resources, and a robust talent supply [10]. - The Guangdong-Hong Kong-Macao Greater Bay Area's economic scale reached 14.8 trillion yuan in 2024, making it a strategic development zone for pharmaceutical companies [10]. Policy Support and Ecosystem - Huangpu has implemented comprehensive policies to support the biopharmaceutical industry, including significant funding for innovative drug research and development [14]. - The district has established a "white list" system for the import of research materials, significantly reducing customs clearance times for biopharmaceutical companies [14]. Infrastructure and Development Model - Huangpu's industrial layout includes the Biopharmaceutical Island for R&D, the Science City for innovation, and the Knowledge City for production, creating a complete industrial chain [17][18]. - The integration of research, funding, clinical trials, and production within a short distance enhances operational efficiency for biopharmaceutical companies [18]. Future Outlook - Huangpu's development path reflects the broader transformation of China's biopharmaceutical industry, moving from generic drug production to innovative drug development [20].

Core Viewpoint - The Hong Kong Innovative Drug ETF (159567) experienced a decline of 3.38% on September 4, with a trading volume of 1.427 billion yuan. The fund has shown significant growth in both share volume and total assets since its inception in January 2024 [1][2]. Group 1: Fund Performance - The Hong Kong Innovative Drug ETF (159567) was established on January 3, 2024, with a management fee of 0.50% and a custody fee of 0.10% [1]. - As of September 3, 2024, the fund's latest share volume was 6.668 billion shares, and its total assets reached 6.724 billion yuan. This represents an increase of 1586.48% in share volume and 1679.83% in total assets compared to December 31, 2023, when the share volume was 395 million shares and total assets were 378 million yuan [1]. Group 2: Trading Activity - Over the past 20 trading days, the cumulative trading amount for the Hong Kong Innovative Drug ETF (159567) was 33.138 billion yuan, with an average daily trading amount of 1.657 billion yuan. Since the beginning of the year, the cumulative trading amount over 165 trading days was 185.061 billion yuan, averaging 1.122 billion yuan per day [1]. Group 3: Fund Holdings - The current fund manager of the Hong Kong Innovative Drug ETF (159567) is Ma Jun, who has managed the fund since its inception, achieving a return of 99.52% during this period [2]. - Key holdings in the fund include: - Innovent Biologics (9.52% holding, 2.60 billion yuan market value) - WuXi Biologics (9.47% holding, 2.58 billion yuan market value) - BeiGene (8.73% holding, 2.38 billion yuan market value) - CanSino Biologics (7.62% holding, 2.08 billion yuan market value) - China National Pharmaceutical Group (7.17% holding, 1.96 billion yuan market value) - CSPC Pharmaceutical Group (6.34% holding, 1.73 billion yuan market value) - 3SBio (5.83% holding, 1.59 billion yuan market value) - Hansoh Pharmaceutical (4.54% holding, 1.24 billion yuan market value) - Zai Lab (2.86% holding, 781.055 million yuan market value) [2].

Core Viewpoint - Kangfang Biopharma, a promising Chinese innovative drug company, is facing challenges as it reports increased losses despite revenue growth, leading to investor concerns about its financial health and stock performance [3][5]. Financial Performance - For the first half of 2025, Kangfang Biopharma reported total revenue of 1.412 billion yuan, a year-on-year increase of 37.75%, while losses expanded from 249 million yuan in the same period last year to 588 million yuan, an increase of over 135% [3][4]. - The company's product sales revenue reached 1.402 billion yuan, a significant year-on-year growth of 49.20%, driven primarily by two key products: PD-1/CTLA-4 dual antibody Cardunili and PD-1/VEGF dual antibody Yiwosi [6][7]. Stock Market Activity - Following the earnings report, the company's stock price dropped by 7.1% the next day and continued to decline by 3.18% on August 28, reflecting negative investor sentiment [3][5]. - On August 28, Kangfang Biopharma announced a new share issuance to raise 3.522 billion yuan, with a significant stock sale by its founders totaling approximately 450 million yuan, raising concerns about the timing and implications of these actions [4][5]. Research and Development - The company has increased its R&D spending to 731 million yuan, a year-on-year increase of 23.02%, accounting for 51.8% of total revenue, due to the initiation of multiple Phase III clinical trials and the development of new platforms and product pipelines [7]. - Kangfang Biopharma's recent announcement of statistically significant results in overall survival (OS) from a key clinical trial for Yiwosi highlights the potential of its product pipeline [7]. Market Valuation - Despite the current financial challenges, Kangfang Biopharma's market valuation remains high, with a price-to-sales ratio of approximately 45 times, compared to 13 times for another recognized Chinese biopharma company, Innovent Biologics [7].

Core Viewpoint - The Hong Kong stock market for innovative drugs is experiencing a low-level operation, but there are signs of increased buying interest, particularly in the Hong Kong Stock Connect Innovative Drug ETF (520880), which has seen significant trading volume and price fluctuations [1][3]. Group 1: Market Performance - As of September 3, 2023, the Hong Kong Stock Connect Innovative Drug ETF (520880) has achieved a year-to-date increase of 118.95%, outperforming other innovative drug indices [4]. - The ETF has attracted nearly 73 million yuan in capital over the past two trading days, indicating strong investor interest [3]. Group 2: Upcoming Events and Opportunities - The 2025 World Lung Cancer Conference (WCLC) is set to take place from September 6 to 9 in Barcelona, where Chinese pharmaceutical companies will showcase their innovative drug developments [3]. - The current market adjustment may present a strategic opportunity for investors to enter the innovative drug sector, especially with the upcoming conference acting as a potential catalyst for recovery [3]. Group 3: Industry Trends - From January to July 2023, the amount of License out (patent authorization) transactions by Chinese innovative drug companies reached nearly 80 billion USD, reflecting a year-on-year growth of over 160% [3]. - The trend of Chinese innovative drug companies expanding internationally is expected to continue, with potential benefits from a favorable global investment environment if a new round of interest rate cuts occurs overseas [3]. Group 4: Index Adjustments - The Hong Kong Stock Connect Innovative Drug ETF (520880) will undergo a revision of its index compilation scheme on September 8, 2023, focusing exclusively on companies engaged in innovative drug research and development [6].