Investment Rating - The industry investment rating is "Positive" (maintained) [1] Core Insights - The report highlights the upcoming IPO of Ruibo Bio, which has passed the hearing for listing on the Hong Kong Stock Exchange. The company focuses on innovative siRNA technology platforms targeting various chronic diseases and tumors [4][14] - Ruibo Bio has established multiple technology platforms, including RiboGalSTAR for liver-targeted delivery and RiboOncoSTAR for tumor targeting, with a pipeline that includes over 20 clinical candidates [5][15] - The report emphasizes the potential of the siRNA sector and recommends investment in leading CXO and research service companies, particularly in the innovative drug space [8] Summary by Sections Industry Performance - In the fourth week of December 2025, the pharmaceutical and biotechnology sector declined by 0.18%, underperforming the CSI 300 index by 2.13 percentage points, ranking 25th among 31 sub-industries [7][11] - The raw material drug sector showed the highest increase, rising by 2.05%, while the hospital sector experienced the largest decline, falling by 2.82% [31] Company Developments - Ruibo Bio has seven siRNA pipelines in clinical research, with its core product RBD4059 being the first siRNA drug for treating thrombotic diseases currently in Phase 2 clinical trials [5][14] - The company plans to advance 2-4 new candidates into clinical stages annually, supported by significant partnerships with major pharmaceutical companies, reflecting recognition of its R&D capabilities [6][22] Investment Recommendations - The report recommends focusing on innovative drugs and their supply chains, particularly in the small nucleic acid space, and suggests a monthly investment portfolio including companies like Sangamo Therapeutics and Innovent Biologics [8]

Core Insights - The pharmaceutical and biotechnology sector experienced a decline of 0.14% this week, ranking 22nd among the 31 primary industries in the Shenwan index [2] - The medical services sub-sector showed a positive performance with a 0.55% increase, while the chemical pharmaceuticals sub-sector declined by 1.74% [2] Industry Performance - The medical services sector's PE (ttm) is 31.74X, and PB (lf) is 3.20X, with a slight increase in both metrics compared to the previous week [5] - Notable performers in the medical services sector include Meinian Health (+24.1%) and Baihua Medicine (+8.8%), while underperformers include Nanhua Biology (-6.5%) and Meidisi (-5.2%) [4] Legislative Impact - The U.S. 2026 National Defense Authorization Act (NDAA) has passed, incorporating the revised Biotech Safety Act, which limits federal contracts with certain biotechnology providers, potentially easing immediate impacts on the domestic biopharmaceutical industry [6][7] - The revised NDAA does not directly name specific companies, which may reduce the immediate shock to the industry [7] Investment Recommendations - The report maintains a "buy" rating for the medical services sector, highlighting high-growth opportunities in ADC CDMO and peptide CDMO companies like WuXi AppTec and Haoyuan Pharmaceutical [8] - It also suggests focusing on companies with expected improvements in profitability, such as Aier Eye Hospital and Dian Diagnostics [8]

■ 一、信息披露义务人及其一致行动人的基本信息 1.身份类别 ■ 2.信息披露义务人信息 登录新浪财经APP 搜索【信披】查看更多考评等级 股东舟山兰旦企业管理合伙企业(有限合伙)、舟山欣曦企业管理合伙企业(有限合伙)、吴波保证向本公 司提供的信息真实、准确、完整，没有虚假记载、误导性陈述或重大遗漏。 本公司董事会及全体董事保证公告内容与信息披露义务人提供的信息一致。 重要内容提示： 3、根据《中华人民共和国证券法》《上市公司收购管理办法》和《公开发行证券的公司信息披露内容 与格式准则第15号一一权益变动报告书》等法律、法规及规范性文件规定，本次权益变动涉及信息披露 义务人披露简式权益变动报告书，详见公司同日披露的《上海毕得医药科技股份有限公司简式权益变动 报告书》。 ■ 注：比例合计差异因小数点尾差所致。 三、其他说明 1、本次权益变动为信息披露义务人履行此前已披露的减持股份计划所致，不触及要约收购。本次减持 事项与信息披露义务人此前已披露的计划、承诺一致。 2、本次权益变动不会对公司治理结构及持续经营产生重大影响，亦不会导致公司控股股东、实际控制 人的变化。 ■ 注：舟山欣曦企业管理合伙企业（有限合伙）、 ...

证券代码：688073 证券简称：毕得医药 公告编号：2025-091 上海毕得医药科技股份有限公司 关于股东权益变动触及 5%整数倍的提示性公告 股东舟山兰旦企业管理合伙企业(有限合伙)、舟山欣曦企业管理合伙企业(有限合 伙)、吴波保证向本公司提供的信息真实、准确、完整，没有虚假记载、误导性陈述或 重大遗漏。 本公司董事会及全体董事保证公告内容与信息披露义务人提供的信息一致。 重要内容提示： | 权益变动方向 | 比例增加□ | | 比例减少☑ | | --- | --- | --- | --- | | 权益变动前合计比例 | 11.12% | | | | 权益变动后合计比例 | 10.00% | | | | 本次变动是否违反已作出的承 诺、意向、计划 | 是□ | 否☑ | | | 是否触发强制要约收购义务 | 是□ | 否☑ | | 一、 信息披露义务人及其一致行动人的基本信息 2.信息披露义务人信息 | 信息披露义务人名称 | | 投资者身份 | 统一社会信用代码 | | --- | --- | --- | --- | | 舟山兰旦企业管理合 | □ □ | 控股股东/实控人 控股股东/实控人的一致 ...

上海毕得医药科技股份有限公司 信息披露义务人 2：舟山欣曦企业管理合伙企业（有限合伙） 住所及通讯地址：中国（浙江）自由贸易试验区舟山市定海区北蝉乡（综保 区）舟山港综合保税区企业服务中心 305-114158 室 信息披露义务人 3：吴波 住所及通讯地址：浙江省三门县健跳镇琴江路 简式权益变动报告书 上市公司名称：上海毕得医药科技股份有限公司 股票上市地点：上海证券交易所 股票简称：毕得医药 股票代码：688073 信息披露义务人 1：舟山兰旦企业管理合伙企业（有限合伙） 住所及通讯地址：中国（浙江）自由贸易试验区舟山市定海区北蝉乡（综保 区）舟山港综合保税区企业服务中心 305-114175 室 三、依据《证券法》、《收购管理办法》、《准则 15 号》的规定，本报告书已 全面披露信息披露义务人在上海毕得医药科技股份有限公司中拥有权益的股份 变动情况。 截至本报告书签署之日，除本报告书披露的持股信息外，信息披露义务人没 有通过任何其他方式增加或减少其在上海毕得医药科技股份有限公司中拥有权 益的股份。 四、本次权益变动是根据本报告书所载明的资料进行的。信息披露义务人没 有委托或者授权其它任何人提供未在本报告书 ...

毕得医药公告称，2025年11月13日至12月19日，股东舟山兰旦企业管理合伙企业（有限合伙）及其一致 行动人吴波、舟山欣曦企业管理合伙企业（有限合伙）合计减持公司股份102.24万股，占总股本 1.12%。本次权益变动后，三者合计持股比例由11.12%降至10%，触及5%整数倍。本次减持系履行此前 计划，不触及要约收购，不会对公司治理及经营产生重大影响，减持计划尚未实施完毕。 ...

Investment Rating - The industry investment rating is "Overweight" [1] Core Views - The biopharmaceutical investment and financing environment has shown significant recovery since the second half of 2025, with a total financing amount of USD 30.32 billion from July to November 2025, representing a year-on-year increase of 30.90% [4] - The number of new drug IND applications stabilized in 2025, with approximately 1,897 applications from January to November, reflecting a year-on-year growth of about 7.91% [4] - The demand for CRO services has shown a clear turning point, and the report continues to recommend opportunities in the innovative drug industry chain (CXO + research services) for 2026 [4] Summary by Sections Industry Performance - The biopharmaceutical sector experienced a decline of 0.14% in the third week of December 2025, outperforming the CSI 300 index by 0.14 percentage points, ranking 22nd among 31 sub-industries [7][14] - The offline pharmacy sector saw the highest increase, rising by 5.59%, while the chemical preparation sector had the largest decline at 2.1% [18][22] Investment Opportunities - The report highlights the strong performance of leading CXO and research service companies, with many exceeding earnings expectations. Companies like WuXi AppTec and Tigermed have raised their earnings guidance for 2025 [5] - The report recommends a valuation switch opportunity for leading CXO and research service companies, given the continuous improvement in demand [5] Clinical Research Organizations (CRO) - There has been a notable improvement in orders for preclinical and clinical CROs, with expectations for significant improvements in financial statements for 2026 [6] - The report anticipates that the market demand will continue to focus on leading companies as the capacity of clinical CROs is expected to be streamlined [6] Monthly and Weekly Recommendations - The report recommends a monthly investment portfolio including companies such as Sanofi, Innovent Biologics, and others, focusing on innovative drug opportunities and valuation switch [8]

Investment Rating - The investment rating for the pharmaceutical industry is "Positive" (maintained) [4] Core Insights - The report highlights the promising data from CTLA-4 drugs, suggesting potential investment opportunities in related areas [3][5] - The pharmaceutical index experienced a slight decline of 0.14% from December 15 to December 19, 2025, but showed a relative outperformance of 0.14% against the CSI 300 index [5] - The report emphasizes the importance of innovative drugs as a key investment theme for 2026, with a focus on companies that are expected to show clear performance trends and potential reversals in operations [5][41] Summary by Sections 1. CTLA-4 Target - CTLA-4 is identified as a significant immune checkpoint that can inhibit T cell activation, presenting potential value in cancer immunotherapy [8][9] - The CTLA-4 monoclonal antibody Gotistobart shows promising clinical trial results for squamous non-small cell lung cancer (sqNSCLC) patients who are resistant to immunotherapy [14][15] - Gotistobart's innovative mechanism targets Treg cells in the tumor microenvironment, potentially leading to a new paradigm in tumor immunotherapy [20][24] 2. Industry Perspective - The report maintains that innovative drugs should be the main focus for the year, while also considering manufacturing exports and aging-related consumption as relatively undervalued assets [25][41] - The pharmaceutical index has shown a year-to-date increase of 14.49%, with a notable number of stocks experiencing significant gains [25][26] - The report suggests that the Chinese pharmaceutical industry has completed a transition from old to new growth drivers, with innovative drugs opening new growth avenues for companies [41][42] 3. Investment Recommendations - Recommended stocks include innovative drug companies such as Xinyi Tai, Zai Jian Pharmaceutical, and others, as well as companies in the medical device sector [5][45] - The report advises focusing on companies with strong performance trends and those expected to benefit from the aging population and outpatient consumption [42][44] - The report also highlights the potential of AI in the pharmaceutical sector, suggesting that related stocks may perform well in the coming years [42][44]

12月19日毕得医药大宗交易一览 证券时报·数据宝统计显示，毕得医药今日收盘价为64.50元，下跌0.29%，日换手率为1.91%，成交额为 5363.04万元，全天主力资金净流出73.98万元，近5日该股累计下跌4.43%，近5日资金合计净流出161.34 万元。 两融数据显示，该股最新融资余额为2827.16万元，近5日减少168.99万元，降幅为5.64%。 据天眼查APP显示，上海毕得医药科技股份有限公司成立于2007年04月27日，注册资本9088.2948万人 民币。（数据宝） 毕得医药12月19日大宗交易平台出现一笔成交，成交量8.66万股，成交金额519.75万元，大宗交易成交 价为60.00元，相对今日收盘价折价6.98%。该笔交易的买方营业部为中国银河证券股份有限公司金华证 券营业部，卖方营业部为浙商证券股份有限公司上海长乐路证券营业部。 进一步统计，近3个月内该股累计发生14笔大宗交易，合计成交金额为6574.76万元。 | 成交量 | 成交金额 | 成交价 | 相对当日收盘 | | | | --- | --- | --- | --- | --- | --- | | （万 | （万元） ...

Group 1: Pharmaceutical Sector - The innovation drug sector is expected to be the main focus, with particular attention on small nucleic acid technology and its accelerated development by 2026 [1][2] - The pharmaceutical industry is driven by supply creating demand, with significant trends observed from 2018 to 2024, including breakthroughs in PD-1, ADC technology, and new generation immunotherapy [2] - Key companies to watch in the pharmaceutical sector include Heng Rui Medicine, Hansoh Pharmaceutical, China National Pharmaceutical Group, and others involved in small nucleic acid and weight loss drug development [2] Group 2: CXO and Upstream Life Sciences - The CXO sector is expected to see continued improvement in fundamentals and valuation recovery, with a focus on companies like WuXi AppTec and Kanglong Chemical [3] - Upstream life sciences are benefiting from improved domestic research conditions, with companies like BGI Genomics and Bidu Pharmaceutical showing positive performance trends [3] - The raw material drug sector is entering a bottom price range, with companies that have quality clients and orders likely to see improved profit margins [3] Group 3: Medical Devices - The medical device sector is anticipated to benefit from improved hospital demand and inventory optimization, with a potential turning point in 2026 [4] - High-value consumables are expected to gain from collective procurement, enhancing domestic production capabilities [4] - Key players in the medical device sector include Mindray Medical, United Imaging Healthcare, and others [4] Group 4: Healthcare Consumption - The healthcare service sector is under pressure in 2025, but a mild recovery is expected in 2026, particularly in essential medical services and products [5] - Traditional Chinese medicine is projected to stabilize and grow, with a focus on OTC and prescription drug innovations [5] - The pharmacy sector is experiencing increased concentration due to regulatory changes, with companies like Yifeng Pharmacy and Dazhong Pharmacy showing improved performance [5]