该产品是本集团开发的全人源IgG1单克隆抗体药物，为司库奇尤单抗注射液(可善挺)的生物类似药。可 善挺在中国获批的适应症包括6岁及以上斑块状银屑病、银屑病关节炎、强直性脊柱炎及化脓性汗腺 炎，其疗效与安全性已获得广泛认可。 该项关键研究已达到预设主要终点，并取得积极的顶线结果。统计分析表明，该产品与可善挺具有临床 等效性，且安全性良好，未出现新的或非预期的安全性信号，有望能满足患者长期用药的安全性需求。 该研究的有关详细数据将于后续学术会议及期刊上发布。 智通财经APP获悉，石药集团(01093)再涨超4%，截至发稿，涨4.37%，报8.36港元，成交额5.79亿港 元。 消息面上，12月18日，石药集团发布公告，本公司附属公司石药集团巨石生物制药有限公司开发的司库 奇尤单抗注射液(该产品)在用于治疗中度至重度斑块状银屑病的等效性III期临床试验中获得顶线分析数 据。 ...

石药集团(01093)再涨超4%，截至发稿，涨4.37%，报8.36港元，成交额5.79亿港元。 消息面上，12月18日，石药集团发布公告，本公司附属公司石药集团巨石生物制药有限公司开发的司库 奇尤单抗注射液(该产品)在用于治疗中度至重度斑块状银屑病的等效性III期临床试验中获得顶线分析数 据。 该产品是本集团开发的全人源IgG1单克隆抗体药物，为司库奇尤单抗注射液(可善挺)的生物类似药。可 善挺在中国获批的适应症包括6岁及以上斑块状银屑病、银屑病关节炎、强直性脊柱炎及化脓性汗腺 炎，其疗效与安全性已获得广泛认可。 该项关键研究已达到预设主要终点，并取得积极的顶线结果。统计分析表明，该产品与可善挺具有临床 等效性，且安全性良好，未出现新的或非预期的安全性信号，有望能满足患者长期用药的安全性需求。 该研究的有关详细数据将于后续学术会议及期刊上发布。 ...

1. Report Industry Investment Rating - Not provided in the report 2. Core Viewpoints - On December 18, all four major stock index futures contracts for the current month declined. The overall trading volume of stock index futures decreased, indicating a cooling of investors' trading enthusiasm. The overall open interest of each index also decreased. The market is affected by factors such as A - share index differentiation, policy information at home and abroad, and central bank decisions [1][2] 3. Summary by Relevant Content 3.1 Stock Index Futures Data Tracking - **CSI 300 and Related Futures**: The CSI 300 index closed at 4552.8, down 0.59%. The IF2512 contract closed at 4550.4, down 0.73%, with a basis of - 2.39, and its trading volume decreased by 31440 and open interest decreased by 24245 [1] - **SSE 50 and Related Futures**: The SSE 50 index closed at 2998.5, up 0.23%. The IH2512 contract closed at 2995, down 0.02%, with a basis of - 3.52, and its trading volume decreased by 13480 and open interest decreased by 11717 [1] - **CSI 500 and Related Futures**: The CSI 500 index closed at 7100.8, down 0.52%. The IC2512 contract closed at 7101, down 0.71%, with a basis of 0.16, and its trading volume decreased by 29672 and open interest decreased by 22568 [1] - **CSI 1000 and Related Futures**: The CSI 1000 index closed at 7272.4, down 0.22%. The IM2512 contract closed at 7275.4, down 0.26%, with a basis of 3, and its trading volume decreased by 45179 and open interest decreased by 35409 [1] 3.2 Trading Volume and Open Interest Changes - **Trading Volume**: The total trading volume of IF decreased by 43587 lots, IH by 16253 lots, IC by 38325 lots, and IM by 65504 lots [2] - **Open Interest**: The total open interest of IF decreased by 7327 lots, IH by 8002 lots, IC by 8257 lots, and IM by 18274 lots [2] 3.3 Top 20 Member's Open Interest Changes in Stock Index Futures - For IF contracts, the long positions of IF2512 decreased by 16327, and the short positions decreased by 19569 with a net change of - 4749 in short positions [5] - For IH contracts, the long positions of IH2512 decreased by 8781, and the short positions decreased by 9176 with a net change of - 5721 in short positions [5] - For IC contracts, the long positions of IC2512 decreased by 16708, and the short positions decreased by 18402 with a net change of - 5523 in short positions [5] - For IM contracts, the long positions of IM2512 decreased by 25000, and the short positions decreased by 28272 [5] 3.4 Market Trends and Driving Factors - **Trend Intensity**: The trend intensity of IF and IH is 1, and that of IC and IM is also 1 [6] - **A - share Market**: A - share market showed differentiation. The Shanghai Composite Index rose 0.16% to 3876.37 points. The Shenzhen Component Index fell 1.29%, and the ChiNext Index fell 2.17%. The total trading volume of A - shares was 1.68 trillion yuan, down from 1.83 trillion yuan the previous day [6] - **Hong Kong Stock Market**: The Hang Seng Index rose 0.12% to 25498.13 points, the Hang Seng Tech Index fell 0.73% to 5418.29 points, and the Hang Seng China Enterprises Index fell 0.02% to 8841.51 points. The market trading volume was HK$1623.77 billion, down from HK$1831.41 billion the previous day [7] - **Policy Information**: The National Development and Reform Commission will take measures to expand effective investment. Trump said that the next Fed chair nominee will support "substantial" rate cuts [7] - **Central Bank Decisions**: The European Central Bank maintained the benchmark interest rate at 2% for the fourth consecutive time. The Bank of England cut interest rates by 25 basis points to 3.75% [7][8] - **US Stock Market**: The three major US stock indexes rose. The Dow Jones Industrial Average rose 0.14% to 47951.85 points, the S&P 500 Index rose 0.79% to 6774.76 points, and the Nasdaq Composite Index rose 1.38% to 23006.36 points [8]

Company News - Emperor Capital (00717.HK) reported total revenue of approximately HKD 730 million for the year ending September 30, 2025, representing a year-on-year increase of 37.3%. Net profit reached approximately HKD 147 million, up 121.4% year-on-year [2] - New Special Energy (01799.HK) plans to sell a 79.92% stake in Xinjiang Wind Power New Energy Partnership for approximately HKD 1.337 billion to facilitate a REITs issuance [2] - Bay Area Development (00737.HK) signed a construction contract for the Shenzhen section with a contract value of RMB 1.448 billion [2] - Weichai Power (03393.HK) won a bid for the Brazil CPFL project with a contract amount exceeding HKD 80 million [3] - WuXi AppTec (02359.HK) invested approximately EUR 30 million to acquire a 3.22% stake in a French biopharmaceutical fund [3] - Joy Spreader Group (02473.HK) established a long-term strategic cooperation with New Stone Technology in areas such as autonomous vehicle procurement and market promotion [3] - Fosun Pharma (02196.HK) signed a cooperation and option agreement with Clavis Bio to jointly advance preclinical development of selected target compounds [3] - CSPC Pharmaceutical Group (01093.HK) reported top-line analysis data from the Phase III clinical trial of its drug, Truxima [3] - Yihai International (01662.HK) announced a strategic cooperation between Trio AI and HGC [4] Financing and Buyback Activities - Zhi Yuan Holdings (00990.HK) plans to issue a total of 515 million new shares at a discount of approximately 1.4%, aiming to raise about HKD 355.3 million [5] - Tencent Holdings (00700.HK) repurchased 1.055 million shares for HKD 636 million, with buyback prices ranging from HKD 599.5 to HKD 605.5 [5] - Xiaomi Group-W (01810.HK) repurchased 3.75 million shares for HKD 151 million, with buyback prices between HKD 40.12 and HKD 40.24 [6] - COSCO Shipping Holdings (01919.HK) repurchased 5.9 million shares for HKD 80.6 million, with buyback prices from HKD 13.52 to HKD 13.76 [7] - Kuaishou-W (01024.HK) repurchased 1.235 million shares for HKD 80.2 million, with buyback prices ranging from HKD 64.35 to HKD 65.60 [7] - Geely Automobile (00175.HK) repurchased 1.908 million shares for HKD 31.8 million, with buyback prices between HKD 16.26 and HKD 16.8 [8]

Industry Rating - The report rates the pharmaceutical industry as "Leading" [1] Core Insights - The report highlights a concentrated trend of domestic innovative drug collaborations and transactions as the year ends, with expectations for value recovery in 2026 [1][4] - The overall market performance shows a decline, with the Hang Seng Index down 0.8% and the Hang Seng Healthcare Index down 4.3% during the week [4][7] - The report emphasizes the importance of stock selection logic returning to fundamentals and valuations, focusing on stocks that are currently undervalued with expected fundamental improvements [4] Valuation Summary - The report provides a detailed valuation overview of various companies, indicating target prices and earnings per share estimates for FY25E and FY26E, along with their respective price-to-earnings ratios [3] - Notable companies with "Buy" ratings include AstraZeneca, BeiGene, and Hansoh Pharmaceutical, with target prices significantly above current trading prices [3] Market Trends - The report notes a slight decrease in domestic institutional holdings through the Hong Kong Stock Connect, while foreign holdings remain stable [33] - The report identifies a trend of increasing positions in leading innovative pharmaceutical companies by domestic investors, particularly in companies like Heng Rui Medicine and Rongchang Bio [36] Investment Insights - The report mentions several significant business development (BD) transactions exceeding $1 billion, indicating a robust pipeline for innovative drugs [4][5] - It recommends focusing on specific segments such as innovative drugs and CXO companies that are expected to benefit from downstream recovery and high market demand [4]

石药集团(01093)发布公告，本公司附属公司石药集团巨石生物製药有限公司开发的司库奇尤单抗注射 液(该产品)在用于治疗中度至重度斑块状银屑病的等效性III期临床试验中获得顶线分析数据。 银屑病是一种免疫相关的慢性、炎症性、系统性疾病。目前，中国约有超700万银屑病患者。全人源白 介素(IL)-17A(IL-17A)主要由活化T细胞产生，是银屑病发病机制中的关键分子。司库奇尤单抗可特异性 结合IL-17A，阻断IL-17受体的信号传导，从而抑制银屑病炎症。 该产品是本集团开发的全人源IgG1单克隆抗体药物，为司库奇尤单抗注射液(可善挺)的生物类似药。可 善挺在中国获批的适应症包括6岁及以上斑块状银屑病、银屑病关节炎、强直性脊柱炎及化脓性汗腺 炎，其疗效与安全性已获得广泛认可。 本集团遵循生物类似药的研究指导原则开展该产品的研发，并与可善挺进行了"头对头"等效性研究。该 研究是一项多中心、随机、双盲、平行、阳性对照等效性Ⅲ期临床试验，旨在验证该产品与可善挺治疗 中度至重度斑块状银屑病患者疗效的一致性。该研究的入组人群为中度至重度斑块状银屑病患者，按照 1:1比例随机分配至试验组(该产品)和对照组(可善挺)，其主 ...

该产品是本集团开发的全人源IgG1单克隆抗体药物，为司库奇尤单抗注射液(可善挺®)的生物类似药。 可善挺®在中国获批的适应症包括6岁及以上斑块状银屑病、银屑病关节炎、强直性脊柱炎及化脓性汗 腺炎，其疗效与安全性已获得广泛认可。 智通财经APP讯，石药集团(01093)发布公告，本公司附属公司石药集团巨石生物製药有限公司开发的司 库奇尤单抗注射液(该产品)在用于治疗中度至重度斑块状银屑病的等效性III期临床试验中获得顶线分析 数据。 银屑病是一种免疫相关的慢性、炎症性、系统性疾病。目前，中国约有超700万银屑病患者。全人源白 介素(IL)-17A(IL-17A)主要由活化T细胞产生，是银屑病发病机制中的关键分子。司库奇尤单抗可特异性 结合IL-17A，阻断IL-17受体的信号传导，从而抑制银屑病炎症。 本集团遵循生物类似药的研究指导原则开展该产品的研发，并与可善挺®进行了"头对头"等效性研究。 该研究是一项多中心、随机、双盲、平行、阳性对照等效性Ⅲ期临床试验，旨在验证该产品与可善挺® 治疗中度至重度斑块状银屑病患者疗效的一致性。该研究的入组人群为中度至重度斑块状银屑病患者， 按照1:1比例随机分配至试验组(该产 ...

Core Viewpoint - The company announced that its subsidiary, Stone Pharma, has achieved positive topline results in a Phase III clinical trial for its biosimilar drug, Secukinumab injection, aimed at treating moderate to severe plaque psoriasis [1][2] Group 1: Product Development and Clinical Trials - The product, Secukinumab injection, is a fully human IgG1 monoclonal antibody that specifically binds to IL-17A, a key molecule in the pathogenesis of psoriasis [1] - The Phase III clinical trial was a multicenter, randomized, double-blind, parallel, positive-controlled equivalence study designed to verify the consistency of efficacy between the product and Cosentyx in treating moderate to severe plaque psoriasis patients [2] - The primary endpoint of the study was the proportion of patients achieving a 75% improvement in the Psoriasis Area and Severity Index (PASI-75) score from baseline at week 12, which the study successfully met [2] Group 2: Market Context and Patient Impact - There are over 7 million psoriasis patients in China, highlighting a significant market opportunity for effective treatments [1] - The safety profile of the product was found to be good, with no new or unexpected safety signals, indicating it may meet the long-term safety needs of patients [2] - The detailed data from the study will be published in upcoming academic conferences and journals, which may further validate the product's efficacy and safety [2]

該產品是本集團開發的全人源Ig G1單克隆抗體藥物，為司庫奇尤單抗注射液（ 可善挺® ）的 生物類似藥。可善挺®在中國獲批的適應症包括6歲及以上斑塊狀銀屑病、銀屑病關節炎、 強直性脊柱炎及化膿性汗腺炎，其療效與安全性已獲得廣泛認可。 CSPC PHARMACEUTICAL GROUP LIMITED 石 藥 集 團 有 限 公 司 （股份代號：1093） （於香港註冊成立之有限公司） 自願公告 司庫奇尤單抗注射液III期臨床試驗獲得頂線分析數據 石 藥 集 團 有 限 公 司（「 本 公 司 」， 連 同 其 附 屬 公 司 統 稱「 本 集 團 」）董 事 會（「 董 事 會 」）欣 然 宣 布 ， 本 公 司 附 屬 公 司 石 藥 集 團 巨 石 生 物 製 藥 有 限 公 司 開 發 的 司 庫 奇 尤 單 抗 注 射 液（「 該 產 品」）在用於治療中度至重度斑塊狀銀屑病的等效性III期臨床試驗中獲得頂線分析數據。 銀 屑 病 是 一 種 免 疫 相 關 的 慢 性 、 炎 症 性 、 系 統 性 疾 病 。 目 前 ， 中 國 約 有 超 700 萬 銀 屑 病 患 者。全人源白介素(IL) -1 ...

Market Overview - The Hong Kong stock market showed mixed performance, with the Hang Seng Index closing up 0.12% at 25,498.13 points, while the Hang Seng Tech Index fell 0.73% to 5,418.29 points. The total trading volume was HKD 162.38 billion [1] - Huatai Securities noted that the market's downside is manageable, but the upside potential remains limited. Market sentiment indicators are still in a pessimistic range, indicating a bottoming phase [1] Blue-Chip Stocks Performance - Hang Lung Properties (00101) led the blue-chip decline, falling 2.91% to HKD 8.68, contributing to a 0.74-point drop in the Hang Seng Index. The company announced the retirement of CEO Lu Weibao by August 31, 2026 [2] - Other notable blue-chip movements included CSPC Pharmaceutical (01093) rising 6.52% to HKD 8.01, contributing 6.31 points to the index, and Sinopec (00386) increasing 3.37% to HKD 4.6, adding 5.49 points [2] Sector Highlights - The aviation sector saw significant gains, with China Eastern Airlines (00670) up 8.08% to HKD 5.35, driven by improved passenger load factors and ticket prices. The overall industry supply-demand relationship is favorable [3][4] - Coal stocks generally rose, with China Shenhua (01088) increasing 2.29% to HKD 39.34, supported by new government guidelines tightening coal consumption standards [4][5] - Pharmaceutical stocks were active, with CSPC Pharmaceutical (01093) up 6.52% and CanSino Biologics (09966) rising 4.3% after receiving breakthrough therapy designation from the FDA for a new treatment [5][11] Notable Stock Movements - MicroPort Scientific (00853) surged 7.5% to HKD 10.9 following the approval of a strategic merger aimed at enhancing its capabilities in cardiac care [8] - Zhaojin Mining (01818) rose 6.21% to HKD 31.12, benefiting from the discovery of a significant underwater gold mine in Shandong province [9] - CICC (03908) resumed trading with a 2.53% increase to HKD 19.44, following its merger with Dongxing Securities and Xinda Securities, which is expected to significantly boost its asset scale [10]