（文章来源：每日经济新闻） 相关机构表示，2025年前三季度，创新药板块营收达485.6亿元，同比增长21.41%，归母净利润虽仍 为-4.6亿元，但亏损幅度已大幅收窄。近年来国产原研药获批数量持续攀升，从肿瘤治疗到自身免疫疾 病领域，创新药凭借确切的临床价值迅速占领市场。与此同时，越来越多国产创新药通过"出海"实现价 值升级，海外授权交易金额屡创新高，为板块增长注入新动力。长期向好趋势已从业绩兑现延伸至BD 出海，创新药行业未来发展前景可期。 创业板医药ETF国泰（159377）跟踪的是创医药指数（399275），单日涨跌幅上限20%，该指数从A股 市场中选取涉及生物制药、化学制药、中药及医疗器械等研发与生产的上市公司证券作为指数样本，重 点关注高研发投入、成长性良好且具有较强创新能力的企业，以反映中国医药行业创新发展的整体趋 势。 ...

Core Insights - The 2025 China Medical Insurance negotiation has concluded, with the new commercial insurance innovative drug directory set to be implemented on January 1, 2026, featuring 24 out of 121 submitted innovative drugs [3][4]. - The launch of the commercial insurance innovative drug directory marks a significant milestone for China's innovative drug sector, accelerating clinical applications and laying a solid policy foundation for future national plans [3][4]. - The new round of major national projects aims to establish China as a global center for new drug creation and a hub for the biopharmaceutical industry by 2035 [4]. Industry Trends - 2025 is anticipated to be a landmark year for China's innovative drugs, with 50 innovative drugs approved in the first three quarters alone, surpassing the total for 2024 [5]. - Major licensing deals have been signed, including a $1.97 billion agreement between Heng Rui Medicine and Merck, and a $12.5 billion deal with GlaxoSmithKline [5]. - The A-share and Hong Kong stock markets have seen a surge in innovative drug listings and stock price increases, setting new records [5]. Policy and Regulatory Environment - The "14th Five-Year Plan" explicitly supports innovative drugs and medical devices, indicating a strong governmental push for the sector [5]. - The upcoming implementation of stricter regulations for traditional Chinese medicine is expected to drive high-quality development and improve the supply chain [13]. Market Dynamics - The medical device sector has not experienced the anticipated market performance despite new policies aimed at supporting high-end medical devices [11][14]. - The medical device market is under pressure due to factors such as inventory levels and centralized procurement policies, which have affected performance [11][14]. Future Outlook - The innovative drug sector is expected to remain at the forefront globally for the next 5-10 years, driven by strong R&D capabilities and competitive advantages [7][20]. - Emerging technologies, such as non-invasive brain-computer interfaces, are nearing commercialization, with significant developments expected in 2026 [18][19]. - High-value consumables are projected to see accelerated growth in 2026, benefiting from easing centralized procurement policies [16][17]. Investment Considerations - For innovative drug companies, key indicators to monitor include R&D progress, clinical data, and licensing agreements, which reflect global competitiveness [21][22]. - In the medical device sector, performance metrics such as sales revenue and procurement data will be crucial for assessing future growth potential [22].

Core Insights - The pharmaceutical and biotechnology industry is experiencing a peak in license-out transactions, with 103 deals totaling $92.03 billion in the first three quarters of 2025, representing a 77% increase compared to the total for 2024 [1] - Despite an 8.17% decline in the innovative drug index, external licensing remains a significant catalyst for industry growth, particularly in the dual antibody and ADC sectors, which have established a first-mover advantage [1] - Novo Nordisk and Eli Lilly announced plans to reduce the prices of GLP-1 products starting in 2026 to enhance accessibility and solidify their leading positions in the market [1] Industry Overview - The Vaccine ETF (159643) tracks the Vaccine Biotechnology Index (980015), which selects listed companies involved in bioproducts, life science tools, and services, focusing on vaccine research, production, and related services [1] - The constituent stocks of the index exhibit significant innovation and growth characteristics, reflecting the overall performance and technological development trends in the vaccine and biotechnology sectors [1]

Group 1 - The STAR Market is expected to nurture world-class technology companies, with a focus on creating a friendly and inclusive environment for hard-tech enterprises [1] - Since its establishment in 2019, the STAR Market has allowed unprofitable companies and those with special share structures to list, providing a dedicated financing channel for innovative enterprises [1] - The STAR Market has gathered 115 biopharmaceutical companies, making it the third-largest biopharmaceutical listing venue globally, contributing to China's goal of becoming a hub for biopharmaceutical innovation [1] Group 2 - Chinese innovative pharmaceutical companies need to achieve sales of $1 billion to $2 billion overseas to be considered world-class, indicating a growing capability in research and development [2] - Mergers and acquisitions are seen as a viable path for Chinese companies to become international players, with a focus on establishing core competencies and competitive barriers [2] - Achieving revenue of 10 billion yuan is viewed as a benchmark for demonstrating global competitiveness in the industry [2] Group 3 - Internationalization is a key factor in determining world-class status, with emphasis on intellectual property, product quality, and reputation rather than just sales figures [3] - The business development (BD) activities in China's biopharmaceutical sector have rapidly increased, with Chinese BD transactions accounting for 38% of global activity this year [3] - Companies are increasingly looking to license out their products to maximize the value of innovative drugs, with a focus on serving both domestic and global markets [3] Group 4 - The Chinese capital market is undergoing reforms to enhance transparency and efficiency, aiming to attract international investors and support the growth of innovative companies [4] - Key factors for becoming a world-class company include industry opportunities, international environment, continuous innovation capability, and an inclusive team [4] - There is a strong belief among industry participants that China will produce world-class companies in the future [4]

Core Viewpoint - WuXi AppTec (02268) has seen a strong stock performance, with a recent increase of 4.89% to HKD 70.8, driven by positive market sentiment and favorable analyst reports [1] Group 1: Market Performance - The MSCI China Healthcare Index has risen 59.5% year-to-date, outperforming the MSCI China Index by 24% [1] - The pharmaceutical sector has experienced a correction, declining approximately 10% since early October [1] Group 2: Analyst Insights - CMB International's latest report highlights the attractiveness of undervalued pharmaceutical companies, including WuXi AppTec, amid a recovering capital market and increasing demand for innovative drug development in China [1] - Goldman Sachs reports that WuXi AppTec's order momentum remains strong, particularly from U.S. clients, with a target of 45% year-on-year revenue growth on track [1] Group 3: Future Prospects - The company is actively negotiating contracts for its Singapore facility, expecting to sign several agreements by year-end, although revenue contributions from this facility will be limited until 2027 due to capacity expansion timelines [1] - The clinical development of authorized innovative drug pipelines overseas is anticipated to be a significant catalyst for the innovative drug sector [1]

Core Viewpoint - WuXi AppTec (02268) has shown a strong performance with a stock price increase of 4.89% to HKD 70.8, amid a broader recovery in the healthcare sector, despite a recent pullback in the pharmaceutical market [1] Group 1: Market Performance - WuXi AppTec's stock rose over 5% in the morning session, with a trading volume of HKD 145 million [1] - The MSCI China Healthcare Index has increased by 59.5% year-to-date, outperforming the MSCI China Index by 24% [1] Group 2: Analyst Insights - CCB International's latest report highlights that despite a 10% pullback in the pharmaceutical sector since early October, undervalued pharmaceutical companies like WuXi AppTec remain attractive [1] - The firm anticipates a recovery in capital market financing activities and an expansion in the overseas trading scale of innovative drugs, alongside a rebound in domestic R&D demand for innovative drugs [1] Group 3: Company Performance and Prospects - Goldman Sachs reports that WuXi AppTec's order momentum remains strong, particularly from U.S. clients, with a target of 45% year-on-year revenue growth on track [1] - The company is actively negotiating contracts for its Singapore facility, expecting to sign several agreements by year-end, although revenue contributions from this facility will be limited until 2027 due to capacity expansion timelines [1]

Group 1 - The innovative drug sector continues to rise, with the Hang Seng Hong Kong Stock Connect Innovative Drug Index up by 3.7% and the CSI Innovative Drug Industry Index up by 1.1% as of 10:18 AM [1] - The Hang Seng Innovative Drug ETF (159316) has attracted a total of 1.4 billion yuan in the past month, indicating strong investor interest in related products [1] - The introduction of a "commercial insurance innovative drug catalog" in the 2025 national medical insurance negotiations is expected to create new payment channels for high-priced innovative drugs, significantly improving cash flow for pharmaceutical companies [1] Group 2 - In the first ten months of 2025, the total value of outbound licensing transactions for Chinese innovative drugs exceeded 100 billion USD, highlighting the global competitiveness of Chinese pharmaceutical companies [1] - Major leading pharmaceutical companies are expected to report strong performance in their Q3 2025 results, indicating a shift from the "R&D investment phase" to the "commercialization harvest phase" [1] - The trend of innovative drugs going global is clear, with ongoing benefits from drug review reforms and supportive policies, marking the entry of the Chinese innovative drug industry into its 2.0 era [1] Group 3 - The Hang Seng Hong Kong Stock Connect Innovative Drug Index consists of leading companies in the Hong Kong innovative drug sector, being the first ETF-tracked index with a "purity" of 100% in innovative drugs [2] - The CSI Innovative Drug Industry Index focuses on leading companies in the A-share innovative drug sector, comprising no more than 50 companies primarily engaged in innovative drug R&D [2] - The Hang Seng Innovative Drug ETF (159316) and the E Fund Innovative Drug ETF (516080) track the aforementioned indices, providing investors with convenient access to opportunities in the innovative drug industry [2]

Group 1 - The core viewpoint of the news highlights the continuous rise of innovative drugs in the Hong Kong stock market, driven by strong performance from companies like BeiGene and 3SBio, leading to a significant increase in the Hang Seng Innovative Drug ETF [1] - BeiGene reported Q3 revenue of 10.077 billion yuan, a year-on-year increase of 41.1%, and a net profit of 689 million yuan, marking a turnaround from losses [1] - The innovative drug sector is experiencing fundamental improvements due to policy support, performance realization, and accelerated international expansion, indicating significant mid-to-long-term investment value [1] Group 2 - A breakthrough in policy is noted with the introduction of a "commercial insurance innovative drug catalog" in the 2025 national medical insurance negotiations, which is expected to improve cash flow for pharmaceutical companies and optimize the payment ecosystem for innovative drugs [1] - The performance of leading pharmaceutical companies in Q3 2025 shows a transition from a "research and development investment phase" to a "commercialization harvest phase," with significant reductions in losses or profitability being achieved [1] - The international expansion of Chinese innovative drugs is accelerating, with total foreign licensing transactions exceeding 100 billion USD in the first ten months of 2025, reflecting the growing recognition of Chinese drug pipelines by multinational corporations [1] Group 3 - The Hang Seng Innovative Drug ETF (159316) has seen significant capital inflow, with a net inflow of 1.298 billion yuan over the past 20 days, bringing its total size to 4.178 billion yuan [3] - This ETF is the only product tracking the Hang Seng Hong Kong Stock Connect Innovative Drug Index, focusing on core enterprises in the innovative drug industry, excluding CXO companies [3] - Key weighted stocks in the ETF include leading companies such as BeiGene, Innovent Biologics, WuXi Biologics, and CanSino Biologics, providing investors with a convenient tool for exposure to cutting-edge innovative drug companies in Hong Kong [3]

11月13日早盘，港股整体回调，"创新药一哥"百济神州继续领跑，带动创新药板块逆市走强！截至发 稿，百济神州涨超7%续创三年新高，信达生物、三生制药续涨超5%，创新药含量100%的港股通创新药 ETF（520880）逆市冲高3%！ | | | 分时 · 6日 1分 5分 15分 30分 · | | | | | | F9 盘航盘后 婴加 九弦 面述 工具 @ (2) > | | | | | 通販通创新的ETF (1) | 31. | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | | | | 520880(税配通省新商ET) 09:50 � 0.580 通跌 0.015(2.65%) 均价 0.575 服交量 1. .. | | | | 100 3,1096 | | 0.580 +0.015 +2.65% | | | × 520880 | | 0.577 [ VM P | | | | | | | | | 2.00% | | SSE CNY 9:50:28 交易中 | ...

Market Overview - The Hong Kong stock market showed mixed performance, with the Hang Seng Index rising by 0.85% to close at 26,922.73 points, with a total trading volume of HKD 236.395 billion [1] - The Hang Seng China Enterprises Index increased by 0.82%, while the Hang Seng Tech Index saw a slight rise of 0.16% [1] - Recent market fluctuations are attributed to external volatility and investors' desire to secure profits, but there are expectations for a market turnaround driven by positive catalysts [1] Key Catalysts - Positive developments in China's technology sector, easing US-China relations, the gradual implementation of the 14th Five-Year Plan, and anticipated interest rate cuts by the Federal Reserve are expected to support market recovery [1] Blue-Chip Stocks Performance - China Hongqiao (01378) reached a new high, closing up 5.06% at HKD 34.04, contributing 7.16 points to the Hang Seng Index [2] - Other notable blue-chip performers included China Resources Mixc Lifestyle (01209) up 6.32% and New World Development (00016) up 5.38% [2] - Xinyi Solar (00968) and Xinyi Glass (00868) faced declines of 4.85% and 3.51%, respectively, negatively impacting the index [2] Sector Performance Technology Sector - Major tech stocks exhibited mixed results, with Alibaba down 2.24% and Tencent up 1.08% [3] - The biotechnology sector showed strength, with BeiGene rising over 7% [3] Renewable Energy Sector - The solar sector faced a significant downturn, with stocks like Xinte Energy (01799) and Flat Glass Group (06865) dropping due to negative rumors regarding industry capacity [3] Real Estate Sector - Real estate stocks saw gains, with companies like Oceanwide Holdings (03377) and Shimao Group (00813) rising by 10.48% and 9.43%, respectively [4] Gaming and Leisure Sector - Gaming stocks collectively rose, driven by upcoming events in Macau, with companies like Melco International Development (00200) and Galaxy Entertainment (00027) seeing increases of 7.4% and 3.47% [5] Notable Stock Movements - Giant Star Legend (06683) surged by 7.79% following the announcement of a joint venture in consumer-grade IP robotics [6] - Hisense Home Appliances (00921) rose 6.99% amid reports of a potential merger of its electronics and home appliance businesses [7] - Conant Optical (02276) reached a new high, closing up 4.82% as it prepares for the launch of its AI glasses [8] - Yao Cai Securities (01428) faced pressure, dropping 5.28% due to uncertainties surrounding a potential investment deal [9]