12月21日，2025"人民好医生 金山茶花计划"总结交流在北京举行。现场汇集了肺癌、肝胆肿瘤、胃 癌、食管癌、乳腺癌、妇科肿瘤、泌尿肿瘤、淋巴瘤、鼻咽癌等领域专家，共同探讨癌症防控新进展， 助力推进癌症防控事业高质量发展。 中国科学院院士、复旦大学附属中山医院名誉院长樊嘉分享了肝胆肿瘤治疗进展。他说，当前肝胆肿瘤 治疗已迈入免疫主导阶段，免疫治疗与靶向、介入治疗的协同联动，显著延长了患者生存期，还为部分 不可切除肿瘤创造根治机会。2025年，国内外权威指南修订、国内多项专家共识出台，进一步推动肝胆 肿瘤诊疗从"经验型"向"循证型"转变。 "得益于精准诊疗的推广、靶向治疗和免疫治疗的应用等，肺癌患者的生存期和生活质量得到了有效延 长和提升。"广东省人民医院首席专家、广东省肺癌研究所名誉所长吴一龙介绍肺癌领域学术科研创新 进展："近年来，SCLC（小细胞肺癌）领域迎来突破性变革，全新的T细胞抗体激活类药物，在SCLC 二线治疗中效果显著，为临床提供了新的治疗范式；在NSCLC（非小细胞肺癌）早中期领域，相关研 究显示纳武利尤单抗联合化疗新辅助治疗能有效提升患者5年生存率，多款创新药物及治疗方案的出 现，推动非小 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因倚賴 該等內容而引致的任何損失承擔任何責任。 Shanghai Henlius Biotech, Inc. 上海復宏漢霖生物技術股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：2696） 自願公告 HLX18是本公司自主研發的納武利尤單抗生物類似藥，潛在適應症包括黑色 素瘤、非小細胞肺癌、惡性胸膜間皮瘤、腎細胞癌、經典型霍奇金淋巴瘤、 頭頸部鱗狀細胞癌、尿路上皮癌、胃癌、胃食管連接部癌或食管腺癌、食管 癌、結直腸癌、肝細胞癌等原研藥已獲批的適應症。T細胞中表達的PD-1受 體與其配體PD-L1和PD-L2結合，可以抑制T細胞增殖和細胞因子生成。部 分腫瘤細胞的PD-1配體上調，通過這個通路信號傳導可抑制激活的T細胞對 腫瘤的免疫監視。納武利尤單抗是一種人類免疫球蛋白G4(IgG4)單克隆抗體 (HuMAb)，可與PD-1受體結合，阻斷其與PD-L1和PD-L2之間的相互作用， 阻斷PD1通路介導的免疫抑制反應，包括抗腫瘤免疫反應 ...

来源：智通财经网 值得一提的是，在第67届美国血液学会(ASH)年会上，宜明昂科公布了阿沐瑞芙普α(IMM0306)联合来那 度胺治疗复发/难治性CD20阳性滤泡性淋巴瘤(R/R FL)的I/II期临床研究数据。数据显示，该联合方案在 既往接受过至少一线含抗CD20单抗治疗失败的患者中，取得91.2%的客观缓解率(ORR)和67.6%的完全 缓解率(CR)，安全性总体可控且无细胞因子风暴风险。该I/II期研究仍在进行中，为这一目前不可治愈 且复发后治疗选择有限的疾病提供了有前景的免疫治疗新策略。 宜明昂科-B(01541)涨近4%，截至发稿，涨2.98%，报6.23港元，成交额311.92万港元。 IMM0306S是基于宜明昂科核心产品阿沐瑞芙普α(IMM0306)开发的皮下制剂。阿沐瑞芙普 α(CD47xCD20, IMM0306)是基于宜明昂科"mAb-Trap"技术平台研发的全球首款进入临床阶段的 CD47xCD20双靶点特异性分子，宜明昂科目前已对这一产品进行了全面布局。 消息面上，据宜明昂科官微消息，12月18日，公司宣布，自主研发的、同时靶向CD47和CD20的双特异 性抗体-受体重组蛋白药物阿沐 ...

Group 1 - The core viewpoint of the news is that Yiming Anke-B (01541) has made significant progress in the development of innovative drugs for autoimmune diseases, with the acceptance of the clinical trial application for IMM0306S by the National Medical Products Administration (NMPA) [1] - IMM0306S is a subcutaneous formulation of the bispecific antibody targeting CD47 and CD20, developed based on the company's core product IMM0306, which is the world's first CD47xCD20 bispecific molecule to enter clinical stages [1] - The stock price of Yiming Anke-B increased by nearly 4%, with a trading volume of 3.1192 million Hong Kong dollars, reflecting positive market sentiment following the announcement [1] Group 2 - At the 67th American Society of Hematology (ASH) annual meeting, Yiming Anke presented data from the I/II clinical study of IMM0306 combined with lenalidomide for relapsed/refractory CD20-positive follicular lymphoma, showing an objective response rate (ORR) of 91.2% and a complete response (CR) rate of 67.6% [2] - The safety profile of the combination therapy was reported to be manageable, with no risk of cytokine release syndrome, indicating a promising new immunotherapy strategy for a currently incurable disease with limited treatment options [2] - The ongoing I/II phase study provides hope for patients who have failed at least one line of anti-CD20 monoclonal antibody treatment [2]

Core Viewpoint - Triple-negative breast cancer (TNBC) is characterized by high invasiveness and poor prognosis due to the lack of specific treatment targets and high rates of postoperative recurrence and metastasis. Current treatments primarily involve surgical resection followed by chemotherapy, but inherent chemotherapy resistance necessitates new effective treatment strategies. The study introduces a promising approach using nanozyme-based therapy for postoperative adjuvant treatment of TNBC [1][4][7]. Group 1: Research Background - TNBC is the most aggressive subtype of breast cancer, with high recurrence and mortality rates. It lacks expression of estrogen receptors, progesterone receptors, and HER2, leading to a lack of precise treatment targets. The main treatment methods are surgical resection and postoperative chemotherapy, but challenges such as residual metastatic lesions and chemotherapy resistance contribute to high recurrence and metastasis rates [4][5]. - Recent studies indicate that immune checkpoint blockade (ICB) therapy shows potential in TNBC treatment due to the high density of tumor-infiltrating lymphocytes. However, resistance to immune checkpoint inhibitors and low immune response limit treatment efficacy, highlighting the need for enhanced antitumor immunity [4][5]. Group 2: Study Findings - The research combines iron-based unit point nanozymes (MFCA) with a responsive hydrogel delivery system to address two key challenges in TNBC treatment: eliminating residual tumor satellite lesions and inhibiting postoperative metastasis. This hydrogel composite can be directly injected into the surgical cavity for sustained release of MFCA, inducing ferroptosis in TNBC cells and enhancing immunogenicity [2][6]. - The study developed a biodegradable unit point nanozyme-loaded hydrogel that effectively inhibits postoperative metastasis and systemic recurrence in TNBC, providing a direct, efficient, and safe adjuvant treatment method to improve patient prognosis [7].

Core Viewpoint - Recent cases of thyroid cancer among public figures have brought renewed attention to thyroid health issues, highlighting the increasing incidence of thyroid cancer globally and in China [1][2]. Group 1: Incidence and Characteristics of Thyroid Cancer - Thyroid cancer is the most common tumor in the endocrine system, with a significant rise in incidence. In China, the incidence rate increased 20 times from 2000 to 2016, with 466,000 new cases reported in 2022 [1][3]. - The overall development of thyroid cancer is slow, particularly for papillary thyroid cancer, which constitutes about 80% of cases. Many patients experience minimal changes over 5-10 years, and lymph node metastasis rates are low [1][2]. - The incidence rate of thyroid cancer among women in China is particularly high, with a rate of 49.4 per 100,000, making it one of the most common cancers among women [3]. Group 2: Treatment Approaches - Surgical intervention remains the primary treatment for thyroid cancer, with a trend towards preserving thyroid function rather than total thyroidectomy for low-risk patients. High-risk patients may require total thyroidectomy [2][4]. - There is ongoing debate regarding the appropriateness of ablation therapy for certain patients, and the decision-making process for surgery is complex, especially for small tumors [5][4]. Group 3: Emerging Therapies and Drug Approvals - Recent advancements in targeted therapies and immunotherapy for high-risk thyroid cancer have shown some promise, although overall efficacy remains suboptimal [6]. - Several new drugs for thyroid cancer have been approved in China since 2022, including broad-spectrum anti-cancer drugs and specific treatments for differentiated thyroid cancer [7][8]. Group 4: Public Perception and Awareness - The term "lazy cancer" is misleading, as it may downplay the seriousness of certain aggressive forms of thyroid cancer. High-risk cases account for 10-20% of all thyroid cancer cases, translating to thousands of new cases annually in China [9].

Core Viewpoint - Cancer is a significant global public health challenge, with the WHO reporting 10 million deaths in 2020, accounting for 1/6 of total deaths, and projections indicating that without urgent action, cancer deaths could exceed 18 million by 2050 [3][4]. Group 1: Current State of Cancer Research - China has emerged as a key player in global cancer research, with a record number of studies presented at major international oncology conferences, including 60 studies at the ESMO Asia Congress 2025 and 73 at the ASCO annual meeting [3]. - The National Healthcare Security Administration has added 36 cancer drugs to the 2025 basic medical insurance catalog, representing 31.58% of the new additions, thereby expanding treatment options for cancer patients [3]. Group 2: Future Outlook on Cancer Management - Experts predict that within the next 25 years, cancer will be recognized as a controllable chronic disease, with significant advancements in theoretical and technological innovations required to achieve this goal [4][5]. - The global burden of cancer is expected to rise, with an estimated 28.4 million new cases by 2040, a 47% increase from 19.3 million in 2020 [6]. Group 3: Factors Influencing Cancer Development - Five main factors contributing to cancer development have been identified: external triggers, infection-related factors, hormonal/receptor abnormalities, lifestyle-related factors, and psychological and immune-related triggers [7]. - The essence of cancer is a disruption in the body's regulatory mechanisms, leading to uncontrolled cell proliferation, which emphasizes the need for strategies that enhance the body's regulatory capabilities [7]. Group 4: Innovations in Cancer Treatment - The integration of advanced technologies such as AI, genomics, and precision medicine is expected to improve cancer survival rates significantly [8]. - A new classification standard for cancer is anticipated to revolutionize management and treatment, promoting a collaborative approach across multiple disciplines [8]. Group 5: Challenges Ahead - The transition from fragmented to integrated treatment poses challenges, including the urgent need for knowledge updates among healthcare professionals and the development of innovative diagnostic and treatment technologies [10]. - Early diagnosis is crucial for improving treatment success rates, with AI playing a role in enhancing the identification of high-risk populations and optimizing screening processes [10]. Group 6: Immunotherapy as a Growth Area - Immunotherapy has emerged as a significant growth area in cancer treatment, with a projected compound annual growth rate of 177.4% from 2017 to 2023, potentially reaching a global market size of $84.9 billion by 2030 [11]. - Despite its early development stage, immunotherapy shows great promise, but challenges remain in biomarker selection, toxicity management, and cost control [11].

Core Insights - Cancer remains a significant global public health challenge, with the WHO reporting 10 million deaths in 2020, accounting for 1 in 6 deaths globally. Without urgent action, cancer deaths could exceed 18 million by 2050 [1][2] - China has emerged as a key player in cancer research, with a record number of studies presented at major international oncology conferences, indicating its growing influence in the field [1][2] - The introduction of 114 new drugs in the 2025 National Basic Medical Insurance Directory, including 36 cancer drugs, expands treatment options for cancer patients [2] Group 1: Cancer Statistics and Projections - The global burden of cancer is expected to rise, with new cases projected to reach 28.4 million by 2040, a 47% increase from 19.3 million in 2020 [2] - The concept of "5-year survival rate" may evolve to "10-year survival rate," with predictions suggesting a 95% survival rate by 2040 and the potential for cancer to be managed as a chronic disease by 2050 [5] Group 2: Factors Influencing Cancer Development - Five main factors contributing to cancer include external triggers, infection-related factors, hormonal/receptor imbalances, lifestyle-related factors, and psychological/immune-related triggers [3] - The essence of cancer is a disruption in the body's regulatory mechanisms, leading to uncontrolled cell proliferation [3] Group 3: Innovations and Future Directions - Advances in technology, including digital communication, genomics, and artificial intelligence, are expected to enhance cancer survival rates and improve access to quality healthcare [4][7] - The establishment of new cancer classification standards and a focus on integrated treatment approaches are anticipated to transform cancer management and clinical outcomes [4] Group 4: Challenges in Cancer Treatment - The transition from fragmented to integrated treatment poses challenges, including the need for updated knowledge among healthcare professionals and the development of innovative diagnostic and treatment technologies [6][8] - Early diagnosis is critical for improving treatment success rates, with AI playing a role in enhancing the identification of high-risk populations [6] Group 5: Immunotherapy Growth - Immunotherapy has emerged as a significant growth area in cancer treatment, with a projected global market size of $84.9 billion by 2030, driven by advancements in CAR-T, TCR-T, and NK cell therapies [7] - Despite its potential, challenges remain in biomarker selection, toxicity management, and cost control, with breakthroughs expected within the next 25 years [7][8]

智通财经APP获悉，12月12日，复宏汉霖（02696）宣布公司自研创新型抗PD-1单抗H药 汉斯状®（斯 鲁利单抗，欧洲商品名：Hetronifly®）联合含铂化疗新辅助治疗，在手术后辅助治疗，用于PD-L1阳性 的、可手术切除的胃癌患者的上市注册申请（NDA）获国家药品监督管理局（NMPA）受理，并被纳入 优先审评审批程序。 此次被纳入优先审评意味着审评时限将大幅缩短至130个工作日，标志着H药胃癌围手术期治疗适应症 的上市进程全面提速，H药有望成为全球首个获批用于该领域的抗PD-1单抗。复宏汉霖执行董事、首席 执行官朱俊博士表示，此次获受理并被纳入优先审评，标志着H药胃癌围手术期适应症正式进入上 市"快车道"。 据了解，胃癌是全球高发恶性肿瘤，发病率和死亡率均居前列。当前，免疫治疗在晚期胃癌中已取得进 展，但在围手术期（手术前后）的应用仍属空白，中国尚无在该阶段获批的免疫疗法，临床需求迫切， 亟需能有效降低复发、提升治愈率的新方案。 本次上市申请主要基于该项关键性研究ASTRUM-006的积极结果。期中分析结果显示：该研究达到预设 的优效性标准，与安慰剂联合化疗相比，汉斯状®联合化疗显著改善无事件生存期 ...

Summary of Alpha Tau Medical Conference Call Company Overview - **Company**: Alpha Tau Medical (NasdaqCM:DRTS) - **Industry**: Medical Technology, specifically focused on cancer treatment using alpha particle radiation therapy Core Points and Arguments 1. **Unique Treatment Approach**: Alpha Tau Medical is pioneering the use of alpha particles for localized cancer treatment, allowing direct injection into tumors, which is a significant advancement over traditional gamma and beta radiation methods [2][3][4] 2. **Efficiency of Alpha Particles**: The company claims that alpha particles are more efficient in killing tumor cells, allowing for much lower doses of radiation, which can be administered in standard medical settings without the need for specialized nuclear facilities [4][5] 3. **Broad Applicability**: Alpha Tau is exploring treatment across various tumor types, having seen positive responses in over 20 different types in preclinical studies [5][6] 4. **Clinical Trials and Milestones**: The company is actively conducting pivotal studies for recurrent skin cancer and has recently treated its first patient with recurrent glioblastoma, achieving over 95% tumor coverage [6][7][38] 5. **Regulatory Approvals**: Alpha Tau has received approval for its treatment in Israel and is awaiting responses for submissions in Japan and the U.S. for various cancer indications [16][49][50] 6. **Market Potential**: The company targets difficult-to-treat cancer cases, estimating around 64,000 stubborn skin cancer cases annually in the U.S. that could benefit from their treatment [20] 7. **Combination Therapies**: Alpha Tau is investigating the potential of combining its treatment with checkpoint inhibitors like Merck's Keytruda, showing promising early results in enhancing systemic anti-tumor immunity [22][24][27] 8. **Financial Health**: As of Q3, Alpha Tau reported approximately $76 million in cash, with a burn rate of about $5 million per quarter, indicating a strong financial position to support ongoing trials and operations [40][41][47] Additional Important Information 1. **Manufacturing Expansion**: The company is expanding its manufacturing capabilities, having completed the first phase of a commercial-scale facility in New Hampshire, which is crucial for future production [40] 2. **Patient-Centric Focus**: Alpha Tau emphasizes the importance of minimizing side effects and improving patient quality of life, particularly in treating painful conditions like pancreatic cancer [35][36] 3. **Upcoming Data Releases**: The company anticipates significant data releases in the second half of the year, which could influence future approvals and market strategies [39][50][55] 4. **Investor Interest**: The stock has seen a 50% increase over the past six months, indicating growing investor interest and confidence in the company's potential [52] This summary encapsulates the key points discussed during the conference call, highlighting Alpha Tau Medical's innovative approach to cancer treatment, ongoing clinical trials, regulatory efforts, and financial stability.