2025年5月17日至23日是第十一届全民营养周，今年的主题定为："吃动平衡 健康体重 全民行动"。今年还将继续推进"体重管理年"专项行动， 进一步推广健康的生活方式。"国家喊你减肥"这一话题早已深入人心，凸显了我国肥胖问题的严重性。 国家卫生健康委面向社会发布的《体重管理指导原则（2024年版）》提到，有研究预测，如果不加以有效控制，到2030年我国成人超重和肥胖 率将高达70.5%，儿童超重和肥胖率也将达到31.8%。 许多人仍然认为肥胖只是"外形不美观"，但实际上，肥胖是一种隐匿的代谢危机。它不仅危害身体健康，还会带来经济负担、时间损耗，甚至 增加机会成本。 的肥胖率上升了1.8%，女孩则略有下降。研究还指出， 肥胖的儿童在成年后大多仍然肥胖，相关慢性疾病也呈现出年轻化的趋势 。 肥胖从来不是一个"单一的指标"，而是众多疾病的起点。只要BMI超过正常范围，高血压、糖尿病、脂肪肝、肿瘤等慢性病便会如多米诺骨牌 般接踵而至。这些健康问题不仅严重损害生活质量，更会直接影响健康寿命的长短。 ▍肥胖其实是"富贵病" 许多人把肥胖调侃为"富贵病"，觉得不过是"吃得好"带来的身材变化，甚至认为"胖点没什么大碍"。可当 ...

Group 1 - The theme of the 11th National Nutrition Week is "Balanced Eating and Exercise for Healthy Weight: A National Action" [1] - The National Health Commission predicts that by 2030, the adult overweight and obesity rate in China will reach 70.5%, and the rate for children will reach 31.8% [1] - Obesity is recognized as a chronic, recurrent metabolic disease that disrupts metabolic balance and damages multiple systems, including cardiovascular and endocrine systems [2][4] Group 2 - Obesity is a major driver of chronic diseases in China, with 34.8% of adults classified as overweight and 14.1% as obese [4] - Among obese individuals, 22.8% have three or more metabolic-related diseases, significantly higher than the 3.0% in normal-weight individuals [4] - Obesity is linked to various chronic diseases such as hypertension, diabetes, and fatty liver, which can reduce quality of life and lifespan [6] Group 3 - Overweight and obese individuals utilize medical services more frequently than those of normal weight, particularly in outpatient and examination settings [7] - The "time cost" of obesity affects both adults and children, with obese children showing lower self-esteem and reduced physical abilities, impacting their social and academic performance [9] - A weight loss of 5% to 10% can significantly reduce the risk of diseases like diabetes and hypertension [10] Group 4 - Improvements in health often do not require expensive medications or extreme surgeries but can be achieved through regular diet, moderate exercise, and early intervention [12]

Core Viewpoint - Recent studies reveal that taurine, a common ingredient in energy drinks, plays a significant role in leukemia progression by driving glycolysis in the tumor microenvironment, suggesting caution in its supplementation for leukemia patients [2][9]. Group 1: Taurine's Role in Leukemia - A study from the University of Rochester indicates that taurine from the tumor niche promotes glycolysis, facilitating leukemia development [2]. - The research utilized single-cell RNA sequencing to identify molecular interactions between the bone marrow microenvironment and leukemia stem cells (LSC), highlighting the importance of these interactions in leukemia progression [5]. - Taurine biosynthesis driven by cysteine dioxygenase-1 (CDO1) is limited to osteoblast lineage cells and increases during myeloid disease progression, with LSC relying on taurine transport proteins for their growth [5][6]. Group 2: Implications for Treatment - Inhibition of taurine transport proteins significantly suppresses the progression of acute myeloid leukemia (AML) in mouse models and human patient-derived cells [6]. - Elevated expression of taurine transport proteins in venetoclax-resistant AML patients suggests a potential therapeutic target, as inhibiting these proteins can enhance the efficacy of existing treatments [6]. - The study indicates that taurine uptake deficiency reduces leukemia stem cell capabilities by inhibiting mTOR activation and downstream glycolysis [6]. Group 3: Broader Research Context - Other studies have linked taurine deficiency to aging and its potential to extend healthspan in various organisms, indicating its multifaceted role in health and disease [9][11]. - Research has shown that taurine supplementation can reactivate exhausted CD8+ T cells, enhancing cancer treatment outcomes, further complicating the narrative around taurine's role in cancer [11]. - The discovery of a novel N-acetyltaurine hydrolase (PTER) suggests new avenues for obesity treatment, indicating taurine's relevance beyond oncology [14].

Core Viewpoint - The article discusses the alarming rise in obesity rates in China, predicting that by 2030, the adult overweight and obesity rate could reach 70.5%, approaching levels seen in developed countries like the United States [7][18]. Group 1: Obesity Trends in China - Over the past two decades, the percentage of overweight or obese adults in China has increased from 20% in 2000 to 41% in 2023 [4]. - The National Health Commission cites research predicting that if current trends continue, the adult obesity rate in China could reach 70.5% by 2030 [7][18]. - The article highlights that while China's obesity rates are rising, they still lag behind those of developed countries, where the rates are generally higher [6][8]. Group 2: Impact of Ultra-Processed Foods - The consumption of ultra-processed foods is linked to the rising obesity rates, with a 10% increase in their caloric contribution correlating to a 7% increase in the risk of becoming overweight [11]. - From 1990 to 2019, the caloric contribution of industrially processed foods in China rose from 1.5% to 28.7%, indicating a significant increase in the consumption of ultra-processed foods [12]. - In developed countries, ultra-processed foods account for a substantial portion of daily caloric intake, with the U.S., U.K., and Canada reporting figures of 57.9%, 56.8%, and 45.1% respectively [12]. Group 3: Nutritional Recommendations - To combat obesity, the article emphasizes the importance of reducing ultra-processed food intake and increasing the consumption of natural and minimally processed foods [21][38]. - The National Health Commission has launched a "Weight Management Year" initiative, promoting dietary guidelines that prioritize balanced nutrition while considering regional dietary preferences [34][35]. - The guidelines recommend increasing the intake of dairy products and vegetables, which are high in protein, calcium, and dietary fiber, to help manage weight effectively [39].