Core Viewpoint - The approval of Liratinib tablets for first-line treatment marks a significant breakthrough for the company in the field of targeted therapy for lung cancer, expanding its innovative drug strategy [1][2][8] Company Developments - The company’s subsidiary, Jiangsu Aosaikang Pharmaceutical Co., Ltd., received approval from the National Medical Products Administration for Liratinib tablets, which are indicated for first-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with specific EGFR mutations [1][2] - Liratinib is a third-generation EGFR TKI developed collaboratively with the Chinese Academy of Sciences, featuring independent intellectual property rights and significant efficacy [1][2] Clinical Data and Efficacy - Clinical trials for Liratinib showed an objective response rate (ORR) of 68.8% and a disease control rate (DCR) of 92.4%, with a median duration of response (DoR) of 11.1 months and a median progression-free survival (PFS) of 11.0 months [4] - The drug demonstrated good efficacy in patients with central nervous system (CNS) metastases, with an ORR of 65.9% and a median PFS of 10.6 months [4] Market Potential and Commercialization - The domestic EGFR TKI market exceeds 20 billion yuan, and with the exclusive commercialization partnership with Innovent Biologics, Liratinib is expected to accelerate market penetration due to its efficacy and pricing advantages [5] - The company reported a net profit of 160 million yuan in 2024, indicating a turnaround and potential for stock price recovery and value reassessment [5] Research and Development Focus - The company has a robust pipeline with 42 ongoing projects, including 10 key innovative drugs in clinical research, and continues to invest heavily in R&D, with 354 million yuan allocated in 2024 [6][7] - The company aims to enhance its competitive edge by focusing on the development of small molecule targeted innovative drugs and tumor immunobiological innovative drugs [7][8]

Group 1 - The core viewpoint of the articles highlights the significant revenue growth and commercialization progress of DiZhe Pharmaceutical, with a reported revenue of 360 million yuan in 2024, marking a year-on-year increase of 294.24% [1] - The company has successfully launched two commercialized products, which have seen nearly doubled sales revenue, achieving a year-on-year growth of 96% in the first quarter of this year [1] - DiZhe Pharmaceutical has established a competitive product pipeline with seven products, including two that are in global clinical trials and have been approved for marketing in China [1][2] Group 2 - In 2024, the company invested 724 million yuan in R&D, accounting for 201.08% of its revenue, with an additional 210 million yuan spent in the first quarter [2] - The company plans to allocate nearly 1 billion yuan from its recent fundraising to the development of core pipeline drugs, including Shuwotini and DZD8586 [2] - DiZhe Pharmaceutical's innovative drug development is characterized by long cycles and high costs, with potential uncertainties in future sales revenue due to various market factors [3] Group 3 - The company is expected to remain unprofitable in the short term, with cumulative losses likely to increase due to ongoing investments in drug registration and market promotion [3] - Analysts believe that DiZhe Pharmaceutical's focus on oncology and innovative products will drive rapid growth in performance as commercialized products gain market traction [3]

刘闯 SAC：S1350524030002 liuchuang@huayuanstock.com 市场表现： | 基本数据 | 日 | | | | 2025 | 年 | | 29 | 04 | | | 月 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 收盘价（元） | | | | | | | | 103.09 | | | | | | | / 低 | | 最 | 高 | 最 | | | 年 | | | 内 | | | 一 | | （元） | | | | | | | | 109.89/49.00 | | | | | | | 总市值（百万元） | | | | | | | | 27,288.77 | | | | | | | 流通市值（百万元） | | | | | | | | 27,288.77 | | | | | | | 总股本（百万股） | | | | | | | | 264.71 | | | | | | | 资产负债率（%） | | | | | | | | 58.06 | | ...

Investment Rating - The report maintains a "Buy" rating for the company [1][8][14] Core Insights - The company's core products are experiencing steady growth, with significant advancements in clinical projects and new product launches [6][7][8] - In 2024, the company achieved a revenue of 658 million yuan, representing a year-on-year growth of 25.63%, while the net profit attributable to shareholders was a loss of 115 million yuan, a decline of 228.97% [5][10] - The company is expected to generate revenues of 789 million yuan, 981 million yuan, and 1.22 billion yuan in 2025, 2026, and 2027 respectively, with growth rates of 19.97%, 24.32%, and 24.30% [8][10] Revenue and Profitability - The company's revenue for Q1 2025 was 162 million yuan, showing a year-on-year increase of 24.24%, while the net profit attributable to shareholders was a loss of 19 million yuan, a decrease of 4.64% [5] - The core product, Sidaben, generated nearly 500 million yuan in revenue in 2024, marking a growth of 7.06% [6] - The new product, Sigle, achieved revenue of 140 million yuan in 2024, with a remarkable growth of 231.76% [6] Clinical Development - The company is advancing multiple innovative drug pipelines, including ongoing Phase III clinical trials for Sidaben in various cancer treatments [7] - The company has received approval for several clinical trials, including a Phase III trial for Sidaben in combination with other therapies for colorectal cancer [7] Financial Forecast - The report projects a net profit attributable to shareholders of -28 million yuan in 2025, followed by a profit of 58 million yuan in 2026 and 111 million yuan in 2027, with respective growth rates of 75.97%, 309.14%, and 92.48% [8][10]

Core Viewpoint - Tonghua Dongbao reported a significant decline in revenue and net profit for 2024, primarily due to adverse factors such as the impact of centralized procurement and the termination of R&D projects, but showed signs of recovery in early 2025 with a revenue increase [1][2]. Financial Performance - In 2024, the company achieved revenue of 2.01 billion yuan, a year-on-year decrease of 34.66% [1] - The net profit attributable to shareholders was a loss of 43 million yuan, with a non-recurring net profit loss of 9 million yuan [1] - For the first half of 2024, revenue was 740 million yuan, while the second half saw a revenue of 1.27 billion yuan, representing a quarter-on-quarter increase of 71.55% [1] - The first quarter of 2025 showed a revenue increase of 10.17% year-on-year [1] Market Expansion - The new round of centralized procurement accelerated the market entry and volume growth of Tonghua Dongbao's insulin products, with significant new hospital admissions: approximately 1,400 for glargine insulin, 3,000 for aspart insulin, and 5,000 for premixed aspart insulin [1][2] - The total signed volume for insulin products in the latest procurement round reached approximately 45 million units, marking a substantial increase compared to the previous round [2] R&D and Innovation - The company is advancing its core pipeline, with promising clinical data for its GLP-1/GIP dual-target receptor agonist (THDBH120) and successful completion of key clinical trials for other innovative products [3] - The R&D expenses accounted for 22.42% of revenue in 2024, indicating a continued commitment to high R&D investment [4] - The company is expanding its treatment areas beyond diabetes to include gout and hyperuricemia, while exploring products with multiple indications such as glucose reduction and weight loss [4] Future Outlook - The company is expected to experience a commercial explosion of several key products between 2025 and 2027, creating a positive growth pattern of stable growth from existing products and rapid breakthroughs from new products [3]

2025 年 04 月 30 日 公司点评 买入/维持 亿帆医药(002019) 目标价: 15 昨收盘:11.69 Q1 业绩基本符合市场预期，创新药产品收入实现高速增长 ◼ 走势比较 (30%) (20%) (10%) 0% 10% 20% 24/4/30 24/7/11 24/9/21 24/12/2 25/2/12 25/4/25 ◼ 股票数据 | 总股本/流通(亿股) | 12.16/8.41 | | --- | --- | | 总市值/流通(亿元) | 142.2/98.37 | | 12 个月内最高/最低价 | 14.4/9.94 | | (元) | | 电话： E-MAIL：zhouyua@tpyzq.com 分析师登记编号：S1190523060002 事件： 4 月 29 日晚，公司发布 2025 年一季度报告，2025 年第一季度公司实 现营业收入 13.27 亿元，同比增长 0.05%，归母净利润为 1.53 亿元，同 比增长 4.83%，扣非后归母净利润为 0.95 亿元，同比下滑 13.55%。 点评： Q1 髙基数下，收入和利润端均实现同比正增长。2025 年第一季度公 司实现营 ...

医药生物 | 化学制药 非金融|公司点评报告 hyzqdatemark 2025 年 04 月 30 日 证券分析师 刘闯 SAC：S1350524030002 liuchuang@huayuanstock.com 李强 SAC：S1350524040001 liqiang01@huayuanstock.com 市场表现： | 基本数据 | 2025 | | 年 | 04 | 月 | 日 | | 29 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 收盘价（元） | | | | | 20.33 | | | | | | 一 年 内 最 低 | | 高 | | | 21.99/11.92 | | / | | 最 | | （元） | | | | | | | | | | | 总市值（百万元） | | | | | 8,650.36 | | | | | | 流通市值（百万元） | | | | | 6,171.90 | | | | | | 总股本（百万股） | | | | | 425.50 | | | | | | 资产负债率（%） | ...

事件： 单季度收入和利润端均实现正增长，在公司感冒类和部分集采医药产品、维生素业务同比营收出现较大 波动背景下，公司核心产品实现了快速增长，其中创新药产品实现收入同比增长327.73%。 毛利率略有下降，净利率同比提升1.55pct。2025 年Q1 公司整体毛利6.16 亿元，毛利率达46.39%，比去 年同期下降0.98pct；因政府补助增加，Q1 净利率为10.42%，比去年同期提升1.55pct。公司期间费用率 基本保持稳定，其中销售费用率为23.64%，比去年同期下降0.10%；管理费用率为6.56%，比去年同期 下降0.19%；研发费用率为4.79%，比去年同期增长0.27%。 在研创新药产品有序进行，亿立舒商业化有望加速。去年底公司已实现亿立舒在中国、美国、欧盟和巴 西等34 个国家获准上市销售，今年商业化有望加速。同时，公司在F-652 治疗慢加急性肝衰竭 （ACLF）IIb 临床试验设计及AH 适应症II 期临床方案与中国监管机构达成了共识或得到认可；AH 适 应症II 期临床方案获得FDA 默示许可和境外资助用于开展二期临床试验。另外，公司也在不断推进创 新药N-3C01 和EY-SF-0 ...

Core Viewpoint - The company is facing significant pressure on its performance due to rising costs and declining revenues in certain segments, particularly in the two-sex health medication category, while showing potential growth in gastrointestinal medications [1][2]. Financial Performance - In 2024, the company achieved revenue of 721 million yuan, a year-on-year decrease of 5.23%, with a net profit attributable to shareholders of 108 million yuan, down 32.45% year-on-year [1]. - For Q1 2025, the company reported revenue of 185 million yuan, a decline of 2.35%, and a net profit of 32 million yuan, down 30.62% year-on-year [1]. - The decline in profits is attributed to rapid growth in expenses, including management expenses of 75 million yuan (up 12.64% year-on-year) and R&D expenses of 86 million yuan (up 37.42% year-on-year) in 2024 [1]. Segment Performance - Revenue from two-sex health medications fell to 178 million yuan, a decrease of 20.87%, primarily due to intensified market competition [2]. - Revenue from gastrointestinal medications remained stable at 206 million yuan, with a slight increase of 1.04% year-on-year [1][2]. - The company is optimistic about the potential of its gastrointestinal medication, Hewei Zhengchang Wan, which has received acceptance for its production registration application and is expected to be approved within the year [2]. R&D Progress - The company has made significant progress in R&D, with several key developments: - The CKBA ointment for vitiligo has completed Phase II enrollment, with data expected in mid-2025 [2]. - The NDA for compound sodium sulfate tablets was accepted in November 2024, marking the first application in the country, with approval anticipated within the year [2]. - The company is also advancing in ophthalmic medications, with the sodium dichloride eye drops expected to be approved this year [2]. - In the two-sex health segment, the lidocaine and prilocaine aerosol has completed its first enrollment and is expected to submit an NDA within the year [2]. Earnings Forecast - Based on the 2024 annual report, the company has revised its revenue forecasts, projecting earnings per share of 0.33, 0.61, and 1.01 yuan for 2025-2027, respectively [3]. - The target price for the company is set at 22.77 yuan, based on a 69 times price-to-earnings ratio for 2025 [3].

Core Viewpoint - The company demonstrated steady growth in Q1 2025, with revenue and net profit increasing, while maintaining a focus on core products and optimizing its industrial structure [1][3]. Financial Performance - In Q1 2025, the company achieved operating revenue of 10.841 billion yuan, a year-on-year increase of 0.62% [1] - The net profit attributable to shareholders was 1.935 billion yuan, up 13.67% year-on-year [1] - The net profit after deducting non-recurring items was 1.887 billion yuan, reflecting an 11.65% year-on-year growth [1] - Industrial revenue reached 4.470 billion yuan, with a year-on-year growth of 7.63% and an industrial gross margin of 68.34%, up 1.76 percentage points [1] Operational Efficiency - The net cash flow from operating activities was 714 million yuan, a significant increase of 35.39% year-on-year, driven by strong cash receipts from sales [1] - The sales expense ratio decreased by 1.6 percentage points to 9.9%, while the management expense ratio fell by 0.3 percentage points to 1.4% [1] - Inventory decreased by 5% year-on-year, indicating improved inventory management efficiency [1] Product Development Strategy - The company is focusing on short, medium, and long-term product development, particularly in traditional Chinese medicine and innovative drugs [2] - Currently, there are 11 major traditional Chinese medicine products undergoing secondary development, with 25 projects in progress [2] - The company is advancing innovative traditional Chinese medicine products, including the Yunnan Baiyao transdermal preparation, with various clinical trials underway [2] Investment Outlook - The company is recognized as a leading player in the traditional Chinese medicine sector, with a clear strategic layout for the short, medium, and long term [3] - Revenue projections for 2025-2027 are 42.7 billion, 45.4 billion, and 48.1 billion yuan, with year-on-year growth rates of 7%, 6%, and 6% respectively [3] - Expected net profits for the same period are 5.2 billion, 5.7 billion, and 6.2 billion yuan, with corresponding growth rates of 9.9%, 9.4%, and 8.5% [3]