Summary of Chengdu XianDao Conference Call Company Overview - Chengdu XianDao operates four core technology platforms: drug discovery and development, nucleic acid platform, protein degradation mechanism, and chemical and biological technology services. Drug discovery and development accounts for nearly 50% of the business [2][4][5]. Industry Insights - The nucleic acid platform has seen rapid revenue growth, reaching 50 million, which constitutes over 10% of total revenue by 2024. The protein degradation mechanism has made breakthroughs in proprietary ligands and commercial conversion [2][5]. - The company has expanded its client base significantly, increasing from over 200 clients in 2022 to more than 500 in 2024, with over 2000 potential leads, indicating successful business development [2][7]. Financial Performance - In 2024, the company achieved a 15% year-over-year revenue growth, with domestic business up 7% and overseas markets growing between 10% to 17%. Net profit attributable to shareholders and non-recurring profit both improved significantly due to enhanced operational efficiency and government subsidies [3]. - The overall gross margin for sales business is maintained at around 75%, with the FBDD segment showing significant margin improvement [3][10]. Research and Development - R&D investment remains stable at 15% to 20% of revenue, influenced by the growth of the group's revenue scale and external environment [2][14]. - The company has transferred over 1,100 active compound entities and holds more than 110 IPs, covering 53 target categories and over 700 challenging global targets [2][15]. Clinical Projects - The HG146 solid tumor project has entered Phase II clinical trials, with nearly 10 patients enrolled, aiming for 40 patients within 12 months [2][16]. - The L17 inflammation project has progressed to the second generation exploration phase, confirming the PCC stage [2][17]. Technological Advancements - Chengdu XianDao is developing an AI and DMTA-based fully automated molecular optimization platform, with expectations for more feedback and applications by 2025 [2][18]. - The company has established a DEL technology platform combined with AI and machine learning for molecular discovery, launching the Halo platform [2][18]. Collaborations and Acquisitions - The acquisition of Haina Pharmaceutical aims to extend the industrial chain, increase domestic revenue, reduce geopolitical risks, and leverage rich data assets [4][30][31]. - The collaboration with BenevolentAI and Viralytics has shown significant synergy, leading to important breakthroughs in commercializing molecular delivery projects [6]. Market Dynamics - The company has diversified its client structure, with a resilient global revenue distribution: approximately 40% from the US, 34% growth in Europe, and 16% from domestic markets [3][2]. - The FDA's gradual elimination of animal testing is expected to enhance enthusiasm among overseas biotech companies for early drug development [27][28]. Future Outlook - The company anticipates continued growth in the AI application in drug discovery, with significant potential for cost reduction and time savings in drug development [18][19]. - The DEL technology library alliance has delivered several libraries, enhancing business growth and industry influence [42]. Conclusion - Chengdu XianDao is positioned for steady growth through its core and emerging business segments, leveraging technological advancements and strategic collaborations to enhance its market competitiveness and operational efficiency [45][46].

以下文章来源于RimeData 来觅数据 ，作者来觅研究院 RimeData 来觅数据 . 全面的一级市场数据平台 医疗服务概览 CXO领域中美"脱钩"风险阶段性告一段落。2024年12月07日,美国国会参 众两院军事委员会公布了2025财年国防授权法案（NDAA）最终协议文本, 《生物安全法案》未被列入其中,美国对生物科技领域的"制裁" 风波阶段性 落地。回顾来看,美国《生物安全法案》风波几乎贯穿全年,且在一二级市场 上造成了巨大的冲击,现在政策的不确定减少有望为相关CXO企业提供更稳定 的经营环境,有助于国内CXO企业继续在美国市场开展业务,减少因政策变化 带来的风险。 医疗服务一级市场投融热度回暖态势明显。据来觅PEVC数据统计，2024年四季度全国医疗服务领域合计发生融资案例45起，环比增加了36.36%，涉及已 披露融资金额18.19亿元，环比增加了75.75%。 从获投领域来看，2024年四季度医疗研发外包最受资本关注，合计发生融资案例17起，涉及融资金额11.92亿元，其中CXO领域合计发生融资案例12起， 涉及融资金额11.62亿元。从医疗信息化的细分领域来看四季度投融热度领域主要集中在数字医 ...