Investment Rating - The industry investment rating is "Overweight" [1] Core Views - The biopharmaceutical investment and financing environment has shown significant recovery since the second half of 2025, with a total financing amount of USD 30.32 billion from July to November 2025, representing a year-on-year increase of 30.90% [4] - The number of new drug IND applications stabilized in 2025, with approximately 1,897 applications from January to November, reflecting a year-on-year growth of about 7.91% [4] - The demand for CRO services has shown a clear turning point, and the report continues to recommend opportunities in the innovative drug industry chain (CXO + research services) for 2026 [4] Summary by Sections Industry Performance - The biopharmaceutical sector experienced a decline of 0.14% in the third week of December 2025, outperforming the CSI 300 index by 0.14 percentage points, ranking 22nd among 31 sub-industries [7][14] - The offline pharmacy sector saw the highest increase, rising by 5.59%, while the chemical preparation sector had the largest decline at 2.1% [18][22] Investment Opportunities - The report highlights the strong performance of leading CXO and research service companies, with many exceeding earnings expectations. Companies like WuXi AppTec and Tigermed have raised their earnings guidance for 2025 [5] - The report recommends a valuation switch opportunity for leading CXO and research service companies, given the continuous improvement in demand [5] Clinical Research Organizations (CRO) - There has been a notable improvement in orders for preclinical and clinical CROs, with expectations for significant improvements in financial statements for 2026 [6] - The report anticipates that the market demand will continue to focus on leading companies as the capacity of clinical CROs is expected to be streamlined [6] Monthly and Weekly Recommendations - The report recommends a monthly investment portfolio including companies such as Sanofi, Innovent Biologics, and others, focusing on innovative drug opportunities and valuation switch [8]

10% 医药生物 沪深300 医药生物行业 -5% 0% 5% 10% 医药生物 沪深300 超配（维持） 医药生物行业双周报（2025/12/5-2025/12/18） 29 省耗材联盟集采启动 投资要点： 本报告的风险等级为中高风险。 本报告的信息均来自已公开信息，关于信息的准确性与完整性，建议投资者谨慎判断，据此入市，风险自担。 请务必阅读末页声明。 行 业 研 医药生物（申万）指数走势 -35% 资料来源：iFind，东莞证券研究所 -40% -20% 0% 20% 22-03 22-05 22-07 22-09 22-11 23-01 23-03 相关报告 -30% -25% -20% -15% -10% -5% 0% 5% 10% 医药生物 沪深300 -35% -30% -25% -20% -15% -10% 5% -35% -30% -25% -20% -15% -10% -5% 0% 医药生物 沪深300 -35% -30% -25% -20% -15% -10% -5% 0% 5% 10% 医药生物 沪深300 2025 年 12 月 19 日 分析师：谢雄雄 SAC 执业证书编号： S0 ...

泰格医药今年以来股价跌5.51%，近5个交易日涨2.09%，近20日涨3.51%，近60日跌13.66%。 资料显示，杭州泰格医药科技股份有限公司位于浙江省杭州市滨江区西兴街道聚工路19号盛大科技园A 座18层，成立日期2004年12月15日，上市日期2012年8月17日，公司主营业务涉及为国内外医药及健康 相关产品的研究开发提供专业临床研究服务,业务范围主要包括I至IV期临床试验技术服务、数据管理及 统计分析、注册申报、临床试验现场服务、SMO服务、医学检测服务、医学资料翻译、医学影像诊断 服务和培训服务。主营业务收入构成为：临床试验相关服务及实验室服务52.60%，临床试验技术服务 45.21%，其他(补充)2.19%。 12月19日，泰格医药盘中上涨2.03%，截至10:17，报51.33元/股，成交1.95亿元，换手率0.68%，总市值 441.96亿元。 资金流向方面，主力资金净流入594.29万元，特大单买入1725.09万元，占比8.83%，卖出2167.20万元， 占比11.10%；大单买入4843.08万元，占比24.80%，卖出3806.68万元，占比19.50%。 截至9月30日，泰格医 ...

12月19日，昭衍新药盘中下跌2.02%，截至10:04，报34.98元/股，成交3.59亿元，换手率1.61%，总市值 262.17亿元。 资料显示，北京昭衍新药研究中心股份有限公司位于北京市经济技术开发区荣京东街甲5号,香港铜锣湾 希慎道33号利园1期19楼1920室，成立日期1998年2月25日，上市日期2017年8月25日，公司主营业务涉 及以药物非临床安全性评价服务为主的药物临床前研究服务和实验动物及附属产品的销售业务。主营业 务收入构成为：药物非临床研究服务95.59%，临床服务4.34%，实验模型供应0.07%。 昭衍新药所属申万行业为：医药生物-医疗服务-医疗研发外包。所属概念板块包括：专精特新、H股、 MSCI中国、中盘、基金重仓等。 截至9月30日，昭衍新药股东户数9.65万，较上期增加57.61%；人均流通股0股，较上期增加0.00%。 2025年1月-9月，昭衍新药实现营业收入9.85亿元，同比减少26.23%；归母净利润8070.61万元，同比增 长214.79%。 分红方面，昭衍新药A股上市后累计派现7.03亿元。近三年，累计派现3.56亿元。 资金流向方面，主力资金净流入606. ...

Group 1 - The core viewpoint of the news is that BaiO Technology's stock has experienced a significant decline this year, with a drop of 21.72% and a recent 5-day decline of 11.54% [1] - As of December 19, BaiO Technology's stock price was 51.51 CNY per share, with a market capitalization of 23.02 billion CNY [1] - The company experienced a net outflow of main funds amounting to 6.38 million CNY, with large orders showing a buy of 22.73 million CNY and a sell of 28.98 million CNY [1] Group 2 - BaiO Technology, established on November 13, 2009, is located in the Daxing District of Beijing and specializes in antibody drug research and preclinical research services [2] - The company operates five divisions, including gene editing services, preclinical pharmacology and efficacy evaluation, model animal sales, antibody development, and innovative drug development focusing on oncology and autoimmune diseases [2] - BaiO Technology is categorized under the pharmaceutical and biological industry, specifically in medical services and medical research outsourcing, with concepts including innovative drugs, cell therapy, and CRO [2]

Core Viewpoint - The stock of Haoyuan Pharmaceutical has experienced a decline of 2.05% on December 18, 2023, despite a year-to-date increase of 100.54% [1] Group 1: Company Overview - Haoyuan Pharmaceutical, established on September 30, 2006, and listed on June 8, 2021, is located in Shanghai and specializes in the research and development of small molecule drug discovery, including molecular building blocks and tool compounds [2] - The company's main business revenue composition includes molecular building blocks and tool compounds (68.97%), with product sales contributing 63.42%, raw materials and intermediates 30.46%, and technical services 5.55% [2] - As of September 30, 2023, the number of shareholders is 12,000, a decrease of 6.34% from the previous period, with an average of 17,647 circulating shares per person, an increase of 6.77% [2] Group 2: Financial Performance - For the period from January to September 2023, Haoyuan Pharmaceutical achieved a revenue of 2.059 billion yuan, representing a year-on-year growth of 27.18%, and a net profit attributable to shareholders of 237 million yuan, up 65.09% year-on-year [2] - The company has distributed a total of 160 million yuan in dividends since its A-share listing, with 120 million yuan distributed over the past three years [3] Group 3: Stock Market Activity - On December 18, 2023, Haoyuan Pharmaceutical's stock price was reported at 71.13 yuan per share, with a trading volume of 111 million yuan and a turnover rate of 0.73%, resulting in a total market capitalization of 15.087 billion yuan [1] - The stock has seen a net outflow of 2.4429 million yuan from major funds, with significant buying and selling activities recorded [1] - The stock has appeared on the "Dragon and Tiger List" once this year, with the last occurrence on May 30, 2023, where it recorded a net purchase of 10.336 million yuan [1]

Company Overview - Yinos Bio is located in the China (Shanghai) Pilot Free Trade Zone and was established on May 12, 2010. The company specializes in providing non-clinical research services in the biopharmaceutical sector, primarily as a Contract Research Organization (CRO) [1] - The company's revenue composition is as follows: non-clinical services account for 96.31%, clinical services for 3.42%, and other services for 0.27% [1] Stock Performance - As of December 18, Yinos Bio's stock price increased by 2.03%, reaching 51.36 CNY per share, with a total market capitalization of 7.241 billion CNY [1] - Year-to-date, the stock price has risen by 45.95%, with a 19.16% increase over the last five trading days, a 10.64% increase over the last 20 days, and a 9.63% increase over the last 60 days [1] Financial Performance - For the period from January to September 2025, Yinos Bio reported a revenue of 571 million CNY, representing a year-on-year decrease of 35.33%. The net profit attributable to shareholders was -14.7881 million CNY, a decline of 111.14% compared to the previous year [2] Shareholder Information - As of September 30, the number of shareholders for Yinos Bio was 4,849, a decrease of 9.97% from the previous period. The average number of circulating shares per person increased by 257.28% to 18,703 shares [2] - The company has distributed a total of 45.1135 million CNY in dividends since its A-share listing [3] - Notable changes in institutional holdings include new entries from Huatai-PineBridge Healthcare Mixed Fund and Huaxia Stable Growth Mixed Fund among the top ten circulating shareholders [3]

Core Viewpoint - The stock of Zhaoyan New Drug (06127) has risen over 8%, currently trading at HKD 22.14, with a transaction volume of HKD 39.86 million, driven by increasing demand for experimental monkeys used in preclinical safety evaluations [1] Group 1: Market Dynamics - Recent reports indicate a significant increase in the price of experimental monkeys, reaching approximately HKD 140,000 each as of December 9, 2025, due to rising demand and limited supply [1] - According to a report from Founder Securities, the demand for experimental monkeys is expected to rise as preclinical CRO orders recover, while supply-side expansion remains challenging [1] - Some monkey breeding facilities have indicated that their production capacity is already booked until the first quarter of 2026, suggesting a sustained tight supply situation [1] Group 2: Financial Implications - Founder Securities estimates that the fair value of experimental monkeys could increase from an average of HKD 84,900 per monkey in 2024 to HKD 140,000 by Q4 2025, with a projected output rate of 17% from breeding facilities [1] - Based on the known quantity of 23,200 monkeys, the estimated additional fair value for 2025 could reach approximately HKD 220 million, not accounting for new additions or the impact of juvenile and aging monkeys [1]

Core Viewpoint - The company, Jinkai (Liaoning) Life Science Technology Co., Ltd., specializes in providing custom development and production services for small molecule drug intermediates and a small amount of raw materials for global pharmaceutical companies, with a focus on fluorinated and non-fluorinated CDMO businesses [2][8]. Group 1: Business Overview - The main business involves providing small molecule drug intermediates and limited raw materials for new drug development projects for globally recognized pharmaceutical companies [2][8]. - The company has a significant focus on fluorinated CDMO services, including specialized fluorination agents and other fluorinated products [3][8]. - As of the 2024 annual report, overseas revenue accounts for 61.18% of total revenue, benefiting from the depreciation of the RMB [4]. Group 2: Financial Performance - For the period from January to September 2025, the company achieved a revenue of 488 million yuan, representing a year-on-year growth of 25.96%, and a net profit attributable to the parent company of 103 million yuan, reflecting a substantial increase of 163.24% [8]. - The company has distributed a total of 117 million yuan in dividends since its A-share listing [9]. Group 3: Market Activity - On December 16, the company's stock price fell by 2.50%, with a trading volume of 39.89 million yuan and a turnover rate of 2.15%, resulting in a total market capitalization of 3.896 billion yuan [1]. - The stock has shown no clear trend in major capital inflows, with a net outflow of 4.2829 million yuan today, ranking 27th out of 52 in its industry [5][6].

Investment Rating - The report maintains an "Overweight" rating for the CXO industry, indicating a positive outlook for investment opportunities in this sector [7]. Core Insights - The CXO industry is entering a new high prosperity cycle driven by external factors such as overseas interest rate cuts, domestic recovery, and industrial upgrades. The worst period for the industry is considered to be over, with a significant improvement in sentiment and operational conditions [1][2][17]. - The report emphasizes the competitive advantages of Chinese CXO companies, including efficiency, cost, quality, and rapid expansion capabilities, which are expected to maintain their global standing in the short to medium term [1][3][22]. - The emergence of new molecular drugs, such as peptides and oligonucleotides, is driving growth in the CRDMO sector, with Chinese suppliers positioned to lead globally due to their production capabilities and cost advantages [3][22][28]. Summary by Sections New Cycle - The CXO industry has transitioned from a prolonged adjustment period (2H21-1H24) to a new upward cycle, supported by recovering overseas financing and a favorable domestic IPO environment. The demand for CXO services is expected to increase significantly starting in 2026 [2][17]. New Molecules - New molecular CRDMO services are characterized by higher demand and technical barriers. Chinese companies are leading in areas like TIDES and ADC, achieving higher growth rates and maintaining robust profit margins [3][22][28]. New Landscape - The domestic CXO market is undergoing a restructuring, with market share increasingly concentrated among leading firms. The report highlights that smaller companies may struggle to survive due to heightened quality and sustainability demands from pharmaceutical clients [4][22][28]. Key Recommendations - The report recommends investing in leading companies with strong positions in the new molecular space, such as WuXi AppTec, WuXi Biologics, and others, which are expected to benefit from the ongoing industry upgrades and demand recovery [1][9][22].