更多资料加入知识星球：水木调研纪要 关注公众号：水木纪要 China Healthcare Equities Takeaways on tariffs from clients and expert calls China We held joint marketing with HSBC global healthcare analysts Rajesh Kumar and Damayanti Kerai, as well an expert call, discussing the US tariff impact on China's and the global pharmaceutical supply chain. Below are our key takeaways: Tariff impact from highest to lowest: medical consumables, devices, drugs. The exact timeline and scope of tariffs remains unclear, but we expect tariffs on US pharm ...

Core Insights - Scorpius Holdings, Inc. is implementing a strategic restructuring initiative aimed at achieving over $6 million in annual cost savings through operational realignment and workforce reduction [1][2][3] - The company is exploring opportunities to establish a halal-certified biomanufacturing presence in Malaysia, targeting the underserved global Muslim population [4][5][6] - A new board member, Tan Sze Thuan, has been appointed to support the company's growth and global expansion strategy, particularly in Southeast Asia [7][8] Cost Optimization - The operational realignment includes a 28% reduction in headcount and the closing of North Carolina facilities to consolidate operations [2][4] - These measures are designed to improve capital efficiency while maintaining high-quality service delivery to clients [3][4] International Expansion - Scorpius is in preliminary discussions with Malaysian stakeholders to form a subsidiary focused on halal-compliant biomanufacturing [4][5] - The initiative aims to address the unmet need for halal-certified biopharmaceutical products within the 2 billion global Muslim population [5][6] Leadership and Governance - The appointment of Tan Sze Thuan is expected to enhance the company's ability to navigate partnerships and regulatory engagement in Southeast Asia [7][8] - This move aligns with the company's commitment to building a world-class board to guide its growth and international expansion [8]

Core Viewpoint - Scorpius Holdings, Inc. is navigating a challenging biotech funding environment by streamlining operations and refocusing on core CDMO capabilities to drive shareholder value [2][6]. Financial Performance - For the year ended December 31, 2024, Scorpius reported $6.0 million in contract revenue, a decrease from $6.6 million in 2023, primarily due to a client migrating to a larger CDMO [3]. - The company recognized $0.2 million in NIH grant revenue for 2024, down from $0.3 million in 2023 [3]. - Cost of revenues increased to $3.2 million in 2024 from $2.7 million in 2023, attributed to expanded biomanufacturing capabilities [4]. - Selling, general, and administrative expenses decreased to $21.6 million in 2024 from $26.2 million in 2023, driven by reductions in various operational costs [5]. - The net loss for 2024 was approximately $32.8 million, or ($13.04) per share, an improvement from a net loss of $45.2 million, or ($347.50) per share, in 2023 [6]. Operational Updates - The company has completed its Form 10-K filing, which was delayed due to necessary internal realignment for long-term success [2]. - Scorpius is focused on executing its business strategy and enhancing its operational efficiency to better serve clients and shareholders [2][6]. Company Overview - Scorpius Holdings, Inc. operates as an integrated CDMO, providing a range of services including analytical testing, process development, and manufacturing to pharmaceutical and biotech companies [8].

Group 1 - The company, King’s Ray Biotechnology, announced a share transfer agreement to acquire 300 million shares of Probio Cayman Class A preferred shares for approximately $225 million (around HKD 1.7 billion) [1] - Following the transaction, the company's direct and indirect ownership in Probio Cayman will increase from 71.72% to 85.09% [1] - Probio Cayman will continue to be an indirect non-wholly owned subsidiary of the company after the completion of the transaction [1] Group 2 - Probio Cayman and its subsidiaries provide comprehensive Contract Development and Manufacturing Organization (CDMO) services in the biotechnology and pharmaceutical sectors, including antibody drug discovery and clinical development [2] - The company has established Probio Cayman as a leading CDMO service provider, empowering innovators in antibody development, protein therapy, cell therapy, and gene therapy [2] - Probio Cayman is expected to generate cash inflows from a licensing agreement with Lixin Pharmaceutical Technology Co., Ltd. regarding the PD-1 VHH antibody, which will further enhance its future development prospects [2]

投资者关系活动记录表 编号：2025-001 投资者关系活动 类别 □特定对象调研 □分析师会议 □媒体采访 业绩说明会 □新闻发布会 □路演活动 □现场参观 □其他（请文字说明其他活动内容） 参与单位名称及 人员姓名 参加"金凯生科 2024 年度网上业绩说明会"的全体投资者 时间 2025 年 4 月 28 日(周一)下午 15:00-16:00 地点 公司通过全景网"投资者关系互动平台"（https://ir.p5w.net） 采用网络远程的方式召开业绩说明会 上市公司接待人 员姓名 1、金凯生科董事长兼总裁 FUMIN WANG（王富民）先生； 2、金凯生科董事会秘书兼财务总监王琦先生； 3、金凯生科独立董事郭玉坤先生； 4、保荐代表人逯金才先生。 投资者关系活动 主要内容介绍 投资者提出的问题及公司回复情况 公司就投资者在本次说明会中提出的问题进行了回复： 问题 1、公司 2025 年一季度业绩大增的主要原因是什么？ 回复：尊敬的投资者，您好！2024 年，受国际贸易政策环 境等因素的不利变化影响，公司迅速做出调整，通过强化全面服 务能力、综合协同能力、特色反应能力等能力建设，不断加大研 发投入、加 ...

April 22, 2025 09:00 PM GMT China Healthcare | Asia Pacific SMID-Cap CRO/CDMOs: Impacts from Potential Tariffs and FDA Animal Testing Rules Direct CMO tariff exposure of major China CRO/CDMO names is no more than 10%, while increasing macro uncertainties beyond tariffs could dampen funding beta. FDA proposal to phase out animal testing has limited impact on our covered pre-clinical CROs in 2025. Key Takeaways Higher tariffs + Increasing uncertainty = Softer funding beta + more cautious R&D budget: The direc ...

Core Points - Scorpius Holdings, Inc. has received notice from NYSE American regarding the commencement of delisting proceedings due to the low selling price of its common stock [1] - The company is also noncompliant with NYSE American's continued listing standards due to the failure to timely file its Form 10-K for the year ended December 31, 2024 [2] - Scorpius plans to appeal the delisting decision and request a review from the Exchange's Listings Qualifications Panel [3] - The CEO of Scorpius emphasized the company's commitment to regulatory compliance and transparency while working towards maximizing long-term shareholder value [4] Company Overview - Scorpius Holdings, Inc. is an integrated contract development and manufacturing organization (CDMO) focused on advancing biologic and cell therapy programs [4] - The company provides a range of analytical testing, process development, and manufacturing services to pharmaceutical and biotech companies from its facilities in San Antonio, TX [4]

Investment Rating - The report maintains a "Buy" rating for Weigao, AK Medical, and AngelAlign, while holding a "Neutral" rating for Jinxin and Tigermed [2][3][13]. Core Insights - The report indicates a cautious optimism regarding the recovery of surgical volumes in 2025, with expectations of manageable impacts from recent regulatory changes and tariff adjustments [1][4]. - The focus is shifting towards internal operational management and shareholder returns, with companies emphasizing cash flow management and reducing capital expenditures [8][11]. Summary by Sections Surgical Volume and Regulatory Environment - Surgical volume is expected to trend positively in 2025, with many companies reporting improved sentiment at the start of the year [4]. - The impact of the Value-Based Pricing (VBP) is seen as manageable, with major players focusing on market share gains [4][7]. Company-Specific Developments - Weigao anticipates a revenue growth of 10-15% year-on-year in FY25, driven by new product ramp-ups [9]. - AK Medical's market share in Tier 1 hospitals has increased significantly, and the company expects continued growth in overseas markets [4][9]. - AngelAlign is focusing on overseas expansion, particularly in Europe, with a projected 50% year-on-year increase in overseas case volumes [9][19]. Financial Guidance and Earnings Revisions - The report revises sales estimates downwards for several companies, with average changes of -1.6% to -2.2% for 2025-2027 and earnings estimates down by -13.3% to -16.7% [1][14]. - Gushengtang expects revenue growth to exceed 25% year-on-year in FY25, while Jinxin did not provide specific revenue guidance due to uncertainties [8][19]. Target Price Changes - Target prices have been adjusted for several companies, with Hygeia's target price set at HK$27.60, AngelAlign at HK$76.20, and Gushengtang at HK$46.00 [13][17][18].

本报记者张文湘见习记者金婉霞 4月17日晚间，和元生物披露2024年年报。数据显示，2024年，和元生物营业收入达2.48亿元，同比增 长21.16%。其中，公司合同定制研发生产（即CDMO，是一种新兴的研发生产外包组织）业务的销售 收入达1.35亿元，同比增长26.12%。这一数字引起市场关注，被认为是"超预期"。 4月18日开盘，和元生物技术（上海）股份有限公司（下称"和元生物"）股价直线拉升，涨幅一度逾 5%。一位行业人士向《证券日报》记者解释称："和元生物是A股市场细胞与基因治疗CDMO第一股。 它所服务的客户对象并非传统的药品，而是细胞药品、基因药品，后者是最前沿的医药科技产品，也在 一定程度上体现了生命科技前沿产品的市场景气度。" 在年报中，和元生物表示，2024年，公司在溶瘤病毒、AAV基因治疗、CAR-T/NK、干细胞等细胞治疗 以及mRNA、外泌体等多个细分领域开拓新客户，并已取得较好的订单进展，年内新增CDMO业务订单 额超过2.7亿元，全年协助客户获得12项新药临床研究申请（IND）批件。"截至2024年末，公司累计协 助客户获得国内外IND批件44项，累计承接各类细胞和基因治疗CDMO ...

中证报中证网讯(记者李梦扬)4月17日晚间，和元生物发布的2024年年报显示，公司2024年实现营业收 入2.48亿元，同比增长21.16%。和元生物表示，公司核心业务稳健增长的同时，再生医学领域实现"从0 到1"的突破，为未来业务发展增长注入新可能。据介绍，2024年9月，公司全资子公司和元和美"再生医 学中心"正式成立，进一步将公司技术服务的应用领域从基础研究、新药研发扩展至再生医学，标志着 公司在细胞治疗的战略布局上迈出了坚实的一步，有望成为业务发展的新亮点。 同时，公司募投项目临港产业基地一期全面投产成为公司年报亮点之一。和元生物介绍，临港产业基地 约7.7万平方米，配备13条GMP载体生产线与20条细胞生产线，具备5L-500L质粒发酵规模和50L-2000L 悬浮细胞培养规模，产线数量与产能规模位居国际行业前列，是国内为数不多能够为细胞和基因治疗产 品开发提供从DNA到NDA一站式服务的企业，能够帮助客户在一个场地内完成从药物开发、临床试验 到商业化生产服务。 和元生物表示，2024年，公司继续发挥业务全面性、技术多样化、项目经验丰富等优势，在溶瘤病毒、 AAV基因治疗、CAR-T/NK、干细胞等 ...