Group 1: Core Insights - Guangzhou has become the third city in China to achieve a "double trillion" status in consumption and foreign trade during the 14th Five-Year Plan period, following Beijing and Shanghai [1][2] - By 2025, Guangzhou's airport is expected to handle over 83 million passengers, ranking among the top ten globally, while its port is projected to handle nearly 700 million tons of cargo, placing it in the top six worldwide [1] - The city aims to establish six advanced manufacturing clusters with outputs exceeding 100 billion yuan and ten service sectors with added value surpassing 100 billion yuan during the same period [1] Group 2: Economic Indicators - As of 2024, only seven cities in China have reached a consumption level of over one trillion yuan, including Guangzhou, which highlights the significance of its economic status [2] - The report indicates that Guangzhou's foreign trade volume also exceeds one trillion yuan, making it one of only seven cities to achieve this milestone [2] Group 3: Strategic Development - Guangzhou's government has outlined plans to enhance its role as a global supply chain innovation center, aiming to strengthen its core urban functions [3][4] - The city is leveraging its geographical advantages, including proximity to the Pearl River Delta manufacturing hub and its status as a major transportation and trade center, to transition from a trade hub to a supply chain management center [4] Group 4: Future Goals - The city has set ambitious goals for the 15th Five-Year Plan, focusing on increasing its visibility and resource allocation capabilities within the global resource network [3] - The government has previously articulated a vision to develop Guangzhou into a world-class city with both historical charm and modern vitality, as outlined in its urban planning documents [3]

1月20日，生成式人工智能驱动的临床阶段生物科技公司英矽智能(03696.HK)与深圳衡泰生物科技有限 公司(简称：衡泰生物)共同宣布，就ISM8969项目达成共同开发合作协议。基于这一战略伙伴关系，双 方将共同加速推进ISM8969的全球开发，这是一款口服且具备穿透血脑屏障性质的新型NLRP3抑制剂， 拟用于中枢神经系统疾病治疗。 为体现双方对该项目的共同承诺，英矽智能将主导ISM8969早期临床开发工作，包括完成新药临床试验 申报以及开展针对帕金森病适应症的I期临床试验。衡泰生物将牵头后续的全球临床研究、监管注册以 及商业化工作。 根据协议条款，英矽智能将授予衡泰生物对ISM8969在全球范围内进行研究、开发、注册、生产和商业 化的50%权利。与此同时，英矽智能有权获得总额最高逾5亿港元的预付款及里程碑付款，其中包括一 笔预计将在协议生效日起30日内支付的7800万港元预付款。 ...

Core Insights - The first month of operation under the Hainan Free Trade Port has shown strong performance in key metrics, indicating effective market activation and accelerated development momentum [2] Group 1: Trade and Economic Data - In the first month, Haikou imported "zero tariff" goods worth 29.94 million yuan, accounting for 3.97% of the province's total, primarily consisting of medical devices and production equipment [2] - The value of domestic sales of processed goods exempt from tariffs reached 41.42 million yuan, representing 48.2% of the province's total, with a tariff exemption of 1.32 million yuan, mainly in chemical products and food [2] - The total value of goods subject to relaxed trade management measures was 34.7 thousand yuan, accounting for 100% of the province's total, primarily including endoscopic equipment [2] - The first month saw the addition of 15,800 new business entities in Haikou, a year-on-year increase of 12.62%, representing 57.92% of the province's total [2] Group 2: Tourism and Passenger Traffic - Duty-free sales in the offshore market reached 2.24 billion yuan, a year-on-year increase of 44.4%, setting a new record for the same period [3] - Meilan Airport operated 39 international routes, with a total of 1,226 flights in the first month, a year-on-year increase of 28.5%, transporting 189,000 international and regional passengers, a 50% increase [3] - The international cargo transport on 5 operational routes amounted to 955 tons, reflecting a year-on-year growth of 9% [3] - The number of foreign visitors entering without a visa reached 7,681, a year-on-year increase of 31.3% [3] Group 3: Customs and Port Efficiency - Haikou was the first city in the province to complete the passage of "zero tariff," processed goods exempt from tariffs, and goods under relaxed trade management measures through regulatory channels [3] - In the first month, Haikou's four "second-line ports" processed 219 shipments of processed goods exempt from tariffs, covering 20 beneficiary enterprises in key sectors such as medical devices and food processing [3] - The average time for container trucks to pass through Haikou port has been reduced to 18 seconds, achieving "second-level customs clearance," significantly saving time and costs for businesses and logistics [4] - Approximately 80,399 domestic freight vehicles passed through the centralized inspection area in the first month, averaging about 2,590 vehicles per day, validating the port's capacity [4]

首个管线已进入II期临床阶段。 本文为IPO早知道原创 作者｜ C叔 微信公众号｜ipozaozhidao 据IPO早知道消息，近日，浙江德进生物医药科技有限公司（下称"德进生物"）完成数千万元A轮融 资，由弘晖基金领投，凯乘资本担任首席财务顾问并继续负责后续融资。融资金额将主要用于推进公 司核心产品——基于合成生物学平台开发的重组肉毒素的临床研究、产业化基地建设及国际化布局。 德进生物是一家专注于重组肉毒素研发、生产和销售的创新企业，致力于将合成生物学技术应用于药 学领域，研发和提供性价比卓越的肉毒素系列产品，最终成为该品类主要供应商之一。 在技术创新层面，基于公司自有专利技术，德进生物的首个管线"DJ-01注射剂"已进入II期临床阶 段，安全性和有效性良好；该产品基于基因工程菌株设计与构建技术平台开发，显著降低传统肉毒素 生产中突出的生物安全风险，在大幅提高产品纯度和质量的同时还能保持极具竞争力的成本，充分发 挥出工程菌株设计平台以及重组蛋白技术优势。 在产业化层面，德进生物核心团队成员工作时间均在十年以上，在重组蛋白研发、生物药开发、高活 性药厂建设、药品生产以及医美市场开拓领域拥有丰富经验。在公司建立 ...

1月19日，广州市第十六届人民代表大会第六次会议开幕，广州市市长孙志洋向大会作政府工作报告。 今年的市政府工作报告在延续"12218"现代化产业体系总体框架下，首次极为明确地提出聚焦人工智 能、海洋经济、生物医药三大产业，并将其分别定位为"制胜赛道""战略赛道"和"决胜赛道"。 这在往年政府工作报告中鲜有出现，背后则是广州经济发展进入新阶段的必然逻辑。过去五年，广州固 定资产投资稳居全省第一，社会消费品零售总额跨越1.1万亿元，商品出口增速领跑全省。自然指数科 研城市排名升至全球第六、GaWC世界城市名册跻身全球一线城市行列。 这些指标变化揭示了一个趋势：广州的竞争力，正在从传统要素驱动，加速转向科技创新与高端产业驱 动。6个产值超千亿元的先进制造业集群、48款备案人工智能大模型、超过2200亿元的生物医药产业营 收，是广州实力的一角；而报告提到的"动能转换接续还需提速""科技成果转化存在卡点"则指明了未来 还需发力的方向。 强调发展人工智能、海洋产业、生物医药三大产业，体现了广州在国家战略与自身优势交叉点上寻找增 长极的系统思维，也是城市对发展质量与动能的更深层次要求。在"十五五"开局之年2026年，广州将 ...

为贯彻落实创新驱动发展战略，武汉市政府日前发布《武汉市加快培育研发型企业推进研发产业化实施 方案(2025—2027年)》(下称《方案》)，通过5方面和18条举措推动科技创新和产业创新融合发展。目标 到2027年，武汉市研发服务基础进一步夯实，建成市级概念验证中心30家、中试平台200家。对企业牵 头承担的市级科技重大专项，给予单个项目最高2000万元支持。 两年建成市级概念验证中心30家 《方案》提出从引导企业加大研发投入、做大研发型企业规模、加强企业研发支撑服务、强化外资研发 中心引育、优化研发型企业发展生态等5方面18条举措出发，大力培育研发型企业，加速研发产业化， 引导企业推出新业态、新模式、新服务、新技术，为武汉建设具有全国影响力的科技创新中心提供支 撑。到2027年，研发服务基础进一步夯实，建成市级概念验证中心30家、中试平台200家，技术经理人 突破5000人；企业研发主体进一步壮大，市级企业研发中心突破1200家，研发型企业超过300家，外资 研发中心超过30家，在光电子信息、大健康和生物技术等产业领域形成3—5个研发产业集聚区。 为引导企业加大研发投入，《方案》提出深化高新技术企业培育、支持 ...

智通财经APP讯，英矽智能(03696)发布公告，英矽智能已与深圳衡泰生物科技有限公司(衡泰生物)，一 家由深圳市鹏复生物医药产业私募股权投资基金合伙企业(有限合伙)与复星医药联合孵化的企业，就英 矽智能的ISM8969项目达成独家许可与共同开发合作协议(该协议)(该合作)。 根据该协议的条款，英矽智能将授予衡泰生物对ISM8969于全球范围内进行研究、开发、注册、生产和 商业化的权利，双方各持有该项目50%的全球权益。与此同时，英矽智能有权获得总额最高达6600万美 元(等值于约5.148亿港元)的预付款及里程碑付款，当中包括一笔预计于该协议生效日起30日内支付的 1000万美元(等值于约7800万港元)预付款。 ISM8969作为一款潜在同类最佳(best-in-class)的NLRP3抑制剂，是透过英矽智能自主研发的生成式化学 引擎Chemistry42发现并优化。该分子于临床前研究中展现卓越疗效与良好安全性，且于多种疾病模型 中表现显著抗炎活性。值得注意的是，ISM8969具理想血脑屏障(BBB)渗透能力，使其能够穿过血脑屏 障，为神经炎症相关疾病治疗带来潜在受益。 基于具有前景的临床前数据，英矽智能 ...

Core Viewpoint - The "15th Five-Year Plan" for Shanghai emphasizes enhancing the city's role as a global economic and financial center, focusing on high-quality development and the construction of a modern industrial system [2][4][6]. Group 1: Five Centers Development - The plan outlines the construction of "five centers" as a key strategy for Shanghai's modernization, which includes enhancing its international economic, financial, trade, shipping, and technological innovation centers [6][7]. - Specific initiatives include building a world-class high-end industrial cluster, establishing a global RMB asset allocation center, and enhancing the city's trade hub functions [6][9]. Group 2: Economic and Social Development Goals - The main goals for the "15th Five-Year" period include achieving significant high-quality development, elevating urban core functions, and enhancing social civilization levels [4][5]. - By 2035, Shanghai aims to double its per capita GDP compared to 2020 and fully upgrade the functions of the "five centers" to reach international leading levels [4][5]. Group 3: Modern Industrial System - The plan emphasizes the importance of maintaining a reasonable proportion of manufacturing within Shanghai's economy, identifying it as a foundation for the city's international economic status [8]. - It outlines a modern industrial system framework categorized into traditional, leading, emerging pillar, and future industries, aiming for a robust manufacturing backbone [8][10]. Group 4: High-End Service Industry - The development of high-end service industries is highlighted as crucial for enhancing Shanghai's international influence, with specific measures to strengthen the global supply chain and trade hub functions [9]. - The plan also includes fostering world-class enterprises as a dedicated task, providing guidance for the growth of large, medium, and small enterprises [9].

转自：成都日报锦观 签约重磅项目 发布机会清单 活动现场，成都与长三角迎来一系列合作落地。武侯区、郫都区、金堂县的3个产业园区分别与长三角 地区创新平台、研究院及行业协会签署合作协议，共建产业协同与人才共育平台；6个来自长三角地区 的重点产业项目集中签约，涵盖低空经济、人工智能、生物医药、先进能源等领域。 其中，中科长三角人工智能创新中心将与武侯区共建创新协同平台，支持跨区域联合研发与成果转化， 推动人才、技术、数据等要素有序流动。该中心主任赵安虎表示，成都与长三角在产业基础、创新资源 上的互补性极强，深化两地产业协同是顺应区域发展大势、实现1+1>2的关键举措。 此外，成都人才发展集团、成都人才发展促进会、成都市技术经理人协会与4家长三角专业人才服务机 构签订人才协同发展协议，构建起跨区域人才资源与技术资源双向流动的共享网络。 上午10点，现场已是人头攒动。来自长三角的求职者携带简历和满满的期许奔赴现场，其中不少人显然 提前做了功课，很快就精准锁定目标。 从事生物医药领域的周元直奔展位，一连投递了好几家企业。她说，"成都在生物医药领域发展势头强 劲，我的专业在成都定有用武之地。" 科技感与文化味的交融，成为 ...

Group 1 - The core viewpoint is that during the "14th Five-Year Plan" period, Xiamen's capital market has achieved significant development, characterized by scale expansion, innovation empowerment, and cross-strait integration, laying a solid foundation for the "15th Five-Year Plan" [1] Group 2 - By the end of 2025, the number of listed companies in Xiamen is expected to reach 70, accounting for nearly 40% of the province, with a total market value exceeding 903 billion yuan, representing a 43% increase from the end of 2020 [1] - The trading volume in securities and futures is projected to reach 15.05 trillion yuan and 16.17 trillion yuan respectively by 2025, indicating a significant increase in market activity [1] - The private equity fund scale has reached 214.4 billion yuan, and the scale of corporate bonds and asset securitization products has reached 220 billion yuan, showcasing a more complete multi-level capital service system [1] Group 3 - A total of 403.2 billion yuan has been raised during the "14th Five-Year Plan" period, primarily directed towards emerging industries such as software information and biomedicine [2] - The number of companies in the listing reserve has expanded to 597, and the first CVC mother fund in the country has been established, demonstrating significant progress in innovative bond issuance [2] - Research and development (R&D) spending by listed companies is expected to reach 11.25 billion yuan in 2024, with an average R&D intensity of 5.02% among 52 manufacturing and IT service companies [2] Group 4 - The construction of the first cross-strait capital market service base has shown remarkable results, with 7 Taiwan-funded listed companies in the region, accounting for 10.61% of the total number of Taiwan enterprises listed domestically [2] - The total amount of dividends during the "14th Five-Year Plan" period has increased 27 times, reflecting the strong performance of Taiwan-funded enterprises [2] - The Xiamen cross-strait equity trading center has showcased 1,124 enterprises on its "Taiwan-funded board," and the scale of Taiwan-funded private equity funds has reached 6.778 billion yuan [2] Group 5 - A comprehensive risk prevention system has been established, with 499 on-site inspections conducted and 28 administrative penalties issued during the "14th Five-Year Plan" period, amounting to 293 million yuan in fines [3] - Investor protection has been notably effective, with 1,308 investors receiving compensation of 224 million yuan through representative lawsuits [3] - Risks in key areas have been effectively mitigated, with issues such as fund occupation and illegal guarantees by listed companies being resolved, ensuring overall stability in the capital market [3]