检查坚持"监管+普法"并重，现场解读《药品管理法》《医疗器械监督管理条例》等法规，发放相关宣 传资料60余份，增强经营者守法诚信意识并规范经营。下一步，新疆沙湾市市监局将持续加大巡查力 度，畅通投诉举报渠道，对违法违规行为保持"零容忍"高压态势，全力护航群众冬季用药用械安全。 （通讯员 韩剑报道）冬季是药品、医疗器械消费旺季，流感、呼吸道等疾病进入高发期，群众购药购 械需求激增，是药械质量安全风险防控关键期。新疆沙湾市市场监督管理局以专项检查为有力抓手，在 全市开展药品、医疗器械质量安全专项检查，筑牢民生安全防线。此次检查聚焦城乡结合部等风险易发 区域，覆盖零售药店、医疗机构、医疗器械专营企业等经营使用单位，实现高风险领域监管无死角。药 品监管领域，执法人员紧扣群众冬季用药需求，重点核查购进渠道、储存条件等关键环节，紧盯感冒退 热、慢性病及儿童用药等重点品种，严查处方药违规销售、哄抬物价等违法行为。医疗器械领域，以无 菌、植入性、冷链器械为监管重点，深入核查证照是否齐全，产品注册备案、购进验收及储存管理等情 况。 ...

Core Viewpoint - The Shanghai Municipal Government has issued measures to deepen the reform of drug and medical device regulation, aiming to promote high-quality development in the pharmaceutical industry, focusing on key areas such as cell and gene therapy, rare diseases, and pediatric medications [1] Group 1: Key Areas of Focus - The measures emphasize the importance of specific fields and products, including cell and gene therapy, rare diseases, pediatric medications, high-quality first generic drugs, artificial intelligence medical devices, medical robots, brain-machine interfaces, particle therapy equipment, and innovative traditional Chinese medicine diagnostic and treatment devices [1] Group 2: Regulatory Support - A service list for key varieties under research will be established, providing proactive guidance in clinical trials, registration and listing, inspections, and production licensing [1]

Group 1 - The article reports that 41 stocks were listed on the institutional trading leaderboard, with 18 stocks seeing net buying and 23 stocks experiencing net selling [1] - The top three stocks with the highest net buying by institutions were: Shikong Technology (208 million), Hailu Heavy Industry (141 million), and Kangzhi Pharmaceutical (118 million) [1] - Kangzhi Pharmaceutical, a local company in Hainan, specializes in children's medication and has a subsidiary focused on maternal and infant health care products [1] Group 2 - The article highlights notable stocks on the leaderboard, including Pingtan Development, the only listed company registered in Pingtan Island, which benefits from forestry carbon trading [1] - Three Wood Group operates a subsidiary that serves as a major operator for cross-border e-commerce public service platforms and logistics centers in Fuzhou [1] - Shouhua Gas, a company involved in natural gas exploration, development, production, and sales, is also mentioned on the leaderboard [1] Group 3 - The article notes that a cold wave is expected to hit in the second half of the year, with local temperatures dropping more than 12 degrees Celsius, potentially leading to new low temperatures for the year [1]

Core Viewpoint - The article emphasizes the growing focus on pediatric drug development in China, driven by regulatory incentives and the need to address unmet medical needs for children [3][5]. Group 1: Current State of Pediatric Drug Development - In the first five months of the year, China approved 57 pediatric drugs, significantly surpassing the previous year's figures, yet pediatric drugs still represent a small fraction of total drug approvals [3]. - Over 90% of pediatric medications are not specifically designed for children, with only about 60 out of over 3,500 approved chemical drug formulations being pediatric-specific [5][6]. - The pediatric drug supply system faces critical issues such as drug shortages, lack of evidence-based clinical use, and irrational clinical applications [5]. Group 2: Regulatory Support and Guidelines - The National Medical Products Administration (NMPA) has issued guidelines to encourage the development of modified new drugs for pediatric use, focusing on improving safety, efficacy, and adherence [3][6]. - The guidelines specify that pediatric drug development should prioritize the protection of children's rights and reduce unnecessary repetitive studies [7][11]. - The NMPA encourages the use of real-world evidence and extrapolation from adult data to address recruitment challenges in pediatric clinical trials [11][12][13]. Group 3: Challenges in Pediatric Drug Development - The development of pediatric drugs is complicated by difficulties in recruiting child participants for clinical trials, ethical considerations, high costs, and lengthy timelines [10]. - The NMPA emphasizes the importance of ensuring participant safety in pediatric clinical trials, advocating for the use of existing research evidence to minimize unnecessary studies [11]. - Ethical constraints often lead to reliance on adult data for pediatric drug trials, which may not accurately predict adverse reactions specific to children [12]. Group 4: Importance of Modified New Drugs - Modified new drugs are crucial for children due to their unique physiological characteristics and metabolic differences from adults, offering a lower-cost and shorter development cycle compared to innovative drugs [6][7]. - The NMPA's guidelines highlight the need for drug formulations that are suitable for children, including considerations for dosage, taste, and ease of administration [6][8].

Group 1 - Institutions ranked 335 stocks today, with a net purchase of 21 stocks and a net sale of 14 stocks. The top three stocks with the highest net purchases were Lu'an Environmental Energy (397 million), Boyun New Materials (153 million), and Tianqi Lithium (126 million) [1] - Lu'an Environmental Energy saw a price increase of 7.34% with 4 buyers and no sellers, while Boyun New Materials decreased by 6.65% with 3 buyers and no sellers. Tianqi Lithium increased by 9.99% with 2 buyers and 1 seller [2] - Tianqi Lithium is recognized as the fourth largest global supplier of lithium chemical products and the second largest in China and Asia, having turned a profit year-on-year in the first quarter [2] Group 2 - The Hainan Free Trade Zone is set to implement a customs supervision special area by December 18, 2025, characterized by a policy of "opening up on one line, controlling on another line, and free movement within the island" [2] - The three-year action plan to boost and expand consumption in Hainan aims to increase the variety and quantity of "immediate purchase and immediate delivery" goods, with a projected sales figure exceeding 60 billion by 2027 for duty-free operations [3] - The "Yaxia" hydropower project has an estimated investment of approximately 705.6 billion, with an average annual investment of about 47 billion over a 15-year construction period, which is expected to significantly increase demand for construction materials and explosives [5]

Group 1: Administrative Law Enforcement - The provincial government is advancing a special action to standardize administrative law enforcement related to enterprises, focusing on addressing prominent issues raised by businesses to optimize the business environment and support high-quality development in Shaanxi [1] - The approach emphasizes a cycle of "rectification - standardization - enhancement," increasing efforts to investigate and rectify previously identified issues, while ensuring effective implementation of various tasks [1] - The government aims to create a coordinated "one chess game" framework, enhancing responsibility and guidance across all levels to ensure the special action is effectively implemented [1] Group 2: Food and Drug Safety - The meeting underscores the political and public significance of food and drug safety, advocating for the strictest standards, regulations, penalties, and accountability to ensure consumer safety [2] - A problem-oriented approach is emphasized, with a focus on enhancing local management responsibilities and supervision in key areas such as school canteens, farmers' markets, and emerging sectors like live-streaming sales [2] - Continuous improvement of local food and drug safety standards is encouraged to facilitate the transformation and upgrading of the province's specialty food and drug industries, thereby enhancing overall safety levels [2]

Core Points - The meeting emphasized the importance of food and drug safety as a critical issue for the public, highlighting the need for strict standards, regulations, and accountability in the industry [1][2] - The provincial government aims to enhance the quality and safety of food and drugs through comprehensive regulatory measures and the use of advanced technologies [2][3] Group 1 - The provincial government is committed to implementing the directives from the central government regarding food and drug safety, focusing on rigorous standards and strict enforcement [1][2] - There is a strong emphasis on enhancing supervision across all stages of food and drug production, distribution, storage, and sales, with clear responsibilities assigned to various stakeholders [2] - The meeting discussed the approval of key work arrangements for food and drug safety for the year 2025 [3] Group 2 - The government plans to address specific issues such as campus food safety, online food delivery, and the regulation of new food business models [2] - There is a focus on preventing issues through improved regulations and the integration of traditional inspection methods with new technologies like big data and AI [2] - The meeting highlighted the importance of community involvement in food safety oversight, encouraging public reporting and the use of delivery personnel as safety monitors [2]