本报（chinatimes.net.cn）记者陶炜 南京报道 曾十几年都没有新药上市的抗失眠药领域，近两年陆续出现新产品获批，新药与新药之间、新药与老药 之间的竞争逐渐升温。 9月21日，先声药业神经与肿瘤药物研发全国重点实验室在2025年中国睡眠医学发展论坛上发布了"全重 求索计划"神经与失眠领域开放课题。实验室主任、先声药业执行董事唐任宏博士称，实验室计划未来 三年投入3000万元，积极拓展抗失眠新药达利雷生上市后新领域研究。 "这笔钱不是用于公司内部研发，而是对外界公开招募有意者共同参与新药研究。有意参与者可以来申 报开放课题，我们将根据不同情况资助相应的经费。"先声药业相关人士对《华夏时报》记者说。 公开数据显示，2021年，中国失眠药物市场规模为122.8亿元，预计2025年达151.2亿元，至2030年将达 到211.9亿元。这将是一个百亿级别的赛道。 一位医药行业资深人士告诉《华夏时报》记者，目前在我国失眠药治疗市场上，第二代咪达唑仑仍占据 首位，其次是第三代药物佐匹克隆和唑吡坦，而第四代药物的商业化还处于萌芽阶段。但是，第四代药 物已经被业内寄予厚望。"由于镇静催眠药物本身的特性，长期使用同一 ...

Core Insights - The Chinese innovative drug sector has become a hot area in the capital market this year, driven by the real demand for high-quality innovative drugs from domestic patients, which is seen as the core driver for industry recovery [1] Group 1: Market Performance - In the first half of this year, 21 innovative drug companies listed on A-shares achieved a revenue of 28.69 billion yuan, a year-on-year increase of approximately 42%, while 32 innovative drug companies listed on H-shares reported a revenue of 42.13 billion yuan, a year-on-year increase of about 10% [2] - Leading companies have shown particularly strong performance, with Heng Rui Medicine's innovative drug sales revenue reaching 7.57 billion yuan, a year-on-year increase of approximately 14.5% [2] - Innovative drugs from Bai Jie Shen Zhou, such as Bai Yue Ze and Bai Ze An, reported sales of 1.192 billion yuan and 2.643 billion yuan respectively, with year-on-year growth rates of 36.5% and 20.6% [2] Group 2: Policy and Market Dynamics - The Chinese innovative drug market is entering a dual development cycle with domestic medical insurance and overseas markets, leading to a gradual path to profitability for companies [2] - Since its establishment in 2018, the National Medical Insurance Bureau has included 149 innovative drugs in the medical insurance catalog through seven rounds of adjustments, significantly optimizing the clinical medication structure [3] - By May 2025, the medical insurance fund is expected to pay a cumulative 410 billion yuan for negotiated drugs, driving related drug sales to exceed 600 billion yuan [3] Group 3: Future Outlook - The innovative drug market in China is projected to reach a scale of 162 billion yuan by 2024, with medical insurance payments accounting for approximately 43.8% [4] - The commercial success of innovative drugs is seen as a starting point for higher-level research and development, with many companies increasing their R&D investments despite revenue growth [4] - China currently holds a 30% share in global drug research and development, with 1,775 first-in-class drug pipelines, representing 19% of the global total [4]

Investment Rating - The report maintains an "Accumulate" rating for the company [6][13]. Core Views - The company's Q2 2025 non-GAAP profit exceeded expectations, driven by the volume increase of Didasun and the gradual advancement of its innovative pipeline, indicating a positive outlook for its transformation into innovation [2][13]. Financial Summary - Total revenue for H1 2025 was 2.017 billion yuan, a decrease of 6.2% year-on-year, while net profit attributable to the parent company was 388 million yuan, down 3.5%. The non-GAAP net profit was 360 million yuan, an increase of 7.8%. The gross margin was 49.6%, down 2.0 percentage points [13]. - For Q2 2025, the single-quarter revenue was 1.06 billion yuan, a decrease of 2.6%, with a net profit of 225 million yuan, down 2.7%. The non-GAAP net profit was 214 million yuan, an increase of 20.4%, and the gross margin was 51.2%, down 0.03 percentage points [13]. - The company adjusted its EPS forecasts for 2025-2026 to 0.94 and 1.09 yuan respectively, with a new forecast for 2027 at 1.30 yuan. The target price was raised to 27.25 yuan based on a 25x PE for 2026 [13]. Business Performance - The main business remains stable, with the finished drug revenue for H1 2025 at 1.175 billion yuan, down 9.7%. However, foreign trade revenue grew over 30.1%. The innovative drug Didasun had its first year of insurance coverage, generating 55 million yuan in revenue during the reporting period [13]. - The raw material drug segment reported revenue of 453 million yuan, down 9.6%, while the medical device segment saw revenue of 349 million yuan, an increase of 12.0% [13]. Innovation Pipeline - The innovative pipeline is expected to continue catalyzing growth, with several drugs in various stages of clinical trials, including JX11502MA for schizophrenia and JX2201 for cardiovascular issues [13].

Investment Rating - The report maintains a "Recommended" investment rating for Jingxin Pharmaceutical (002020.SZ) [1][8][10] Core Views - The company is expected to see continued growth in its innovative pipeline, particularly with the ongoing expansion of its first-class innovative drug, Didasinib [7][8] - The company reported a revenue of 2.017 billion yuan for H1 2025, a year-on-year decrease of 6.20%, while the net profit attributable to shareholders was 388 million yuan, down 3.54% year-on-year [4][7] - The report anticipates that the company will achieve revenues of 4.724 billion yuan, 5.357 billion yuan, and 6.092 billion yuan for the years 2025, 2026, and 2027, respectively, with year-on-year growth rates of 13.6%, 13.4%, and 13.7% [6][8] Financial Performance - In H1 2025, the company's revenue from finished drugs was 1.175 billion yuan, down 9.68% year-on-year, while revenue from medical devices increased by 12.01% to 349 million yuan [7] - The gross margin for H1 2025 was 49.57%, a decrease of 2.00 percentage points year-on-year, while the net margin increased by 0.57 percentage points to 19.45% [7] - The company expects to maintain its profit forecasts, projecting net profits of 829 million yuan, 947 million yuan, and 1.102 billion yuan for 2025, 2026, and 2027, respectively, with year-on-year growth rates of 16.4%, 14.3%, and 16.4% [8] Innovative Pipeline - The innovative drug Didasinib has seen significant growth, generating 55 million yuan in revenue in H1 2025, with over 1,500 hospitals now covered [7][8] - The company has a rich pipeline of drugs under development, including a first-class innovative drug for schizophrenia that has completed Phase II clinical trials and a new drug for cardiovascular diseases that is progressing through Phase I trials [7][8]

Core Insights - The company reported a revenue of 2.017 billion yuan for H1 2025, a decrease of 6.2% year-on-year, and a net profit attributable to shareholders of 388 million yuan, down 3.54% year-on-year [1] - The company experienced a decline in revenue from finished drugs and raw materials, while the medical device segment showed growth [2] - The innovative drug, Didasinib capsules, generated over 55 million yuan in revenue, indicating successful market penetration and collaboration with healthcare institutions [3] Financial Performance - H1 2025 finished drug revenue was 1.175 billion yuan (down 9.68% YoY), raw material drug revenue was 453 million yuan (down 9.59% YoY), and medical device revenue was 349 million yuan (up 12.01% YoY) [2] - The company's non-GAAP net profit increased by 7.78% YoY, driven by a reduction in sales and management expense ratios, leading to a non-GAAP net profit margin of approximately 17.87% [2] Innovation and Development - The company is focusing on the commercialization of its innovative drug Didasinib, having expanded its hospital coverage to over 1,500 institutions [3] - The company is advancing its pipeline in various therapeutic areas, including mental health, cardiovascular, and digestive diseases, with significant progress in clinical trials [4] Revenue Forecast - Projected revenues for 2025-2027 are 4.413 billion yuan, 4.849 billion yuan, and 5.361 billion yuan, with year-on-year growth rates of approximately 6%, 10%, and 11% respectively [4] - Expected net profits for the same period are 802 million yuan, 909 million yuan, and 1.045 billion yuan, with corresponding growth rates of about 13%, 13%, and 15% [4]

Investment Rating - The investment rating for Jingxin Pharmaceutical (002020) is not explicitly stated in the provided content, but the report indicates a focus on growth and innovation in the pharmaceutical sector [1]. Core Insights - The report highlights that Jingxin Pharmaceutical's revenue for H1 2025 was 2.017 billion yuan, a decrease of 6.2% year-on-year, while the net profit attributable to the parent company was 388 million yuan, down 3.54% year-on-year. However, the net profit excluding non-recurring items increased by 7.78% to 360 million yuan [2][4]. - The company is experiencing short-term revenue pressure, particularly in finished drug sales, which fell by 9.68% to 1.175 billion yuan due to centralized procurement pressures. However, the medical device segment grew by 12.01% to 349 million yuan, indicating a robust performance in that area [4]. - The innovative drug, Didasini capsule, generated over 50 million yuan in revenue, demonstrating the company's ability to commercialize its innovative pipeline effectively [4]. Summary by Sections Financial Performance - In H1 2025, the company achieved total revenue of 2.017 billion yuan, with a net profit of 388 million yuan. The second quarter alone contributed 1.06 billion yuan in revenue, reflecting a 2.64% decline year-on-year [2][4]. - The gross profit margin for 2025 is projected to remain stable around 50%, with net profit growth expected to recover in the following years [6]. Revenue Breakdown - Finished drug revenue decreased to 1.175 billion yuan, raw material drug revenue fell to 453 million yuan, while medical device revenue increased to 349 million yuan [4]. - The company has expanded its market access significantly, with over 1,500 hospitals covered, enhancing the availability of its products [4]. Future Projections - Revenue is expected to grow to 4.413 billion yuan in 2025, with a compound annual growth rate (CAGR) of approximately 6% from 2025 to 2027. Net profit is projected to reach 802 million yuan in 2025, with a growth rate of 13% [7]. - The report emphasizes the potential of the JX2201 capsule in the cardiovascular disease treatment space, with ongoing clinical trials and significant market interest [5][7].

Core Viewpoint - The company reported a decline in revenue for the first half of 2025, with a focus on the commercialization progress of its core innovative drug, Didasinib, which has shown initial market penetration success [4][5]. Financial Performance - The company achieved a revenue of 2.017 billion yuan in the first half of 2025, a year-on-year decrease of 6.20% - Finished drug revenue was 1.175 billion yuan, down 9.68% - Raw material drug revenue was 453 million yuan, down 9.59% - Medical device revenue was 349 million yuan, up 12.01% - Net profit attributable to the parent company was 388 million yuan, down 3.54% - Deducted net profit attributable to the parent company was 360 million yuan, up 7.78% - Operating cash flow was 393 million yuan, down 17.48% - Basic EPS was 0.46 yuan [4]. Commercialization Progress - The core innovative drug Didasinib has made significant strides in commercialization, having been included in the National Basic Medical Insurance Drug List as of November 2024 - As of June 30, 2025, over 400 key medical institutions have been added to the access list, with a total of over 1,500 hospitals covered - The product generated revenue of 55 million yuan in the first half of 2025, indicating initial effects of insurance reimbursement [5]. R&D Pipeline Advancement - In the field of psychiatric disorders, the self-developed innovative drug JX11502 capsule has completed Phase II clinical trials, and the application for marketing authorization for Calirizine capsule has been submitted to the National Medical Products Administration - In cardiovascular disease, the pipeline continues to improve with ongoing Phase I clinical trials for a new drug targeting LP(a) mechanism and the submission of a marketing application for a drug treating high cholesterol - In digestive diseases, the modified traditional Chinese medicine for ulcerative colitis has completed Phase II clinical trials, supporting the design and implementation of Phase III trials [6].

Investment Rating - The report maintains a "Buy" rating for the company [4] Core Insights - The commercialization of the core innovative drug, Dazisini, has achieved significant progress, with over 1,500 hospitals covered and a revenue of 55 million yuan in H1 2025 [2][4] - The company has seen a decline in revenue due to price reductions from centralized procurement policies, leading to a downward adjustment in net profit forecasts for 2025-2027 [4] Financial Performance Summary - In H1 2025, the company reported total revenue of 2.017 billion yuan, a decrease of 6.20% year-on-year, with finished drug revenue at 1.175 billion yuan, down 9.68% [1] - The net profit attributable to the parent company was 388 million yuan, a decline of 3.54% year-on-year, while the non-recurring net profit increased by 7.78% to 360 million yuan [1] - The operating cash flow was 393 million yuan, down 17.48% year-on-year, with an EPS of 0.46 yuan [1] Revenue and Profit Forecast - The revenue forecast for 2025 is adjusted to 4.1 billion yuan, with net profit estimates revised to 788 million yuan, reflecting a decrease of 13% from previous estimates [4] - The company is expected to see a gradual recovery in revenue growth, with projections of 4.58 billion yuan in 2026 and 5.068 billion yuan in 2027 [10] R&D Pipeline Progress - The company is advancing its R&D pipeline in the fields of mental health, cardiovascular, and digestive diseases, with several products in various stages of clinical trials [3][9]

Investment Rating - The investment rating for the company is "Buy" (maintained) [1] Core Views - The company is experiencing continuous growth in innovative drugs, with a steady advancement in its pipeline [4] - For the first half of 2025, the company reported revenues of 2.017 billion yuan (down 6.20% year-on-year) and a net profit attributable to shareholders of 388 million yuan (down 3.54% year-on-year) [4] - The company maintains its profit forecast for 2025-2027, expecting net profits of 822 million yuan, 953 million yuan, and 1.106 billion yuan, respectively, with corresponding EPS of 0.95 yuan, 1.11 yuan, and 1.29 yuan [4] Financial Summary - In H1 2025, the company's gross margin was 49.57% (down 2.00 percentage points year-on-year), and the net margin was 19.45% (up 0.57 percentage points year-on-year) [4] - The sales expense ratio was 15.44% (down 2.41 percentage points year-on-year), while the management expense ratio was 4.49% (down 1.45 percentage points year-on-year) [4] - The R&D expense ratio was 9.17% (up 0.01 percentage points year-on-year) [4] Revenue Breakdown - In H1 2025, the company generated 1.175 billion yuan from finished drugs (down 9.68% year-on-year), 453 million yuan from raw materials (down 9.59% year-on-year), and 349 million yuan from medical devices (up 12.01% year-on-year) [5] - The innovative drug, Didasini, achieved revenue of 55 million yuan in H1 2025, with over 1,500 hospitals covered [5] Pipeline Development - The company has made significant progress in its R&D pipeline, with various innovative drugs in different stages of clinical trials [5] - In the field of mental and neurological disorders, the company has completed Phase II clinical trials for its innovative drug JX11502 [5] - In cardiovascular disease, the company is advancing its Phase I clinical trials for a new lipid-lowering drug targeting LP(a) mechanism [5]

Group 1: Company Overview - In the first half of 2025, the company achieved revenue of 2.017 billion CNY, a year-on-year decrease of 6.20% [3] - Finished drug revenue was 1.175 billion CNY, down 9.68% year-on-year [3] - Raw material drug revenue was 453 million CNY, a decline of 9.59% year-on-year [3] - Medical device revenue reached 349 million CNY, showing a growth of 12.01% year-on-year [3] - The net profit attributable to shareholders was 388 million CNY, down 3.54% year-on-year [3] - The net profit after deducting non-recurring gains and losses was 360 million CNY, an increase of 7.78% year-on-year [3] Group 2: Sales and Marketing Strategies - The company expanded the commercial layout of its product 京诺宁® (Didasyn) with over 400 new key medical institutions gaining access, totaling over 1,500 hospitals [3] - Revenue from Didasyn reached 55 million CNY in the first half of 2025 [3] - The company aims to enhance patient access to medications through a three-tier terminal network system [3] Group 3: Research and Development Progress - In the psychiatric field, the innovative drug JX11502 capsule completed Phase II clinical trials [4] - The NDA for the drug targeting the same indication was submitted to the National Medical Products Administration [4] - In the cardiovascular field, the Phase I clinical trial for a new LP(a) mechanism lipid-lowering drug is progressing [4] - The NDA for a drug treating high cholesterol was also submitted [4] - A modified traditional Chinese medicine for ulcerative colitis completed Phase II clinical trials [4] Group 4: Financial Management and Cost Control - Sales expenses amounted to 311 million CNY, with a sales expense ratio decrease of 2.41 percentage points [4] - The company has been reducing sales expenses for several years through improved sales efficiency and internal structure adjustments [4] - As of July 31, 2025, the company repurchased shares worth 610 million CNY, nearing the repurchase limit [4] Group 5: Business Segment Performance - The medical device segment achieved revenue of 349 million CNY, a year-on-year increase of 12.01% [4] - The raw material drug segment reported revenue of 453 million CNY, down 9.59% year-on-year, due to a client inventory destocking cycle [5] - The company is focusing on enhancing its supply chain and expanding its international market presence to stabilize growth in the raw material drug segment [5]