香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因倚賴該等內容而引致的任何損失承擔任何責任。 內幕消息 二零二六年度醫療健康大會簡報 本公告由WuXi Biologics (Cayman) Inc.藥明生物技術有限公司*（「本公司」）根據 香港聯合交易所有限公司證券上市規則（「上市規則」）第13.09條及香港法例第 571章《證券及期貨條例》第XIVA部項下內幕消息條文（定義見上市規則）而作出。 本公司將於二零二六年一月十四日（美國太平洋時間）出席第44屆年度摩根大 通醫療健康大會（「年度醫療健康大會」），會上將進行包含本公司業務營運的 若干資訊的簡報（「簡報」）。為確保本公司所有股東及潛在投資者能夠公平及 時地取得該等信息，本公司於本公告納入簡報全文。本公司股東及潛在投資者 務請注意，簡報可能包含前瞻性陳述，該等陳述就其性質而言存在風險及不確 定性，簡報中陳述的任何估計及未來建議均基於若干假設及估計以及管理層 僅根據當前可得資料作出的判斷。 – 1 – 誠如簡報中所披露，本集團業務及財務表現依 ...

进入12月，四川货物贸易进出口额达9343.8亿元，向全年万亿元目标冲刺；水电装机容量在全国率先 突破1亿千瓦，创造新纪录；13个高速公路项目（路段）元旦前10天内即将建成通车，新增3条出川大通 道……活力焕新的外贸合作、奔腾不息的清洁能源、川流畅达的交通大道，气贯长虹、气象万千。 创新争先的朝气、突破传统的锐气、战略支撑的底气——作为全国经济大省、西部经济龙头，在"十四 五"收官之年，四川一鼓作气、攻坚克难、顶压前行，推动经济运行稳中有进、量质齐升，前三季度地区生 产总值同比增长5.5%，经济总量全国排名第5。 回望"十四五"收官、面向"十五五"开局，着眼塑造发展新动能、形成竞争新优势，四川凝心聚气、乘 势而上，努力在全国高质量发展版图中力争上游、多作贡献。 在第三届民航科教创新成果展的亿航智能公司展区，参观者在参观展出的可应用于城市空中交通的无 人驾驶载人航空器。新华社记者鞠焕宗摄 朝气：新质新域显活力 下肢外骨骼机器人…… 从人工智能到商业航天，从生物医药到脑机接口，一系列"数得着""叫得响"的"首"字号创新成果，彰 显四川在新产业新赛道上的前沿探索。 今年前11个月，四川全省规模以上工业增加值同比增长 ...

Core Insights - The field of autoimmune diseases is rapidly evolving, with a competitive research pipeline reshaping market dynamics, drawing parallels from the advancements in hematologic oncology [1][2] - The significant breakthroughs in hematologic oncology over the past 15 years have led to unprecedented treatment options, which can serve as a model for the development of autoimmune therapies [1][4] Group 1: Treatment Innovations - The rapid expansion of diverse targets such as checkpoint inhibitors (e.g., PD-1), cell therapies (e.g., CD19, CD20), and targeted therapies (e.g., BTK, Bcl2) has provided multiple treatment options in hematologic oncology, emphasizing the need for biomarker-driven patient stratification [3] - The past decade has seen the introduction of several groundbreaking drugs in hematologic oncology, with a similar pace of innovation expected in the immunology field [8] - Multi-indication products like Bcl2 inhibitors and BTK inhibitors have significantly improved treatment outcomes in lymphoid cancers, showcasing the potential for similar advancements in autoimmune diseases [10] Group 2: Patient Outcomes and Quality of Life - The introduction of 15 new therapies from 2003 to 2021 has increased the five-year survival rate for multiple myeloma patients in the U.S. from 29% in the 1990s to 62% in 2021, highlighting the impact of modern treatments on patient outcomes [10] - In the realm of severe asthma, the introduction of biologics has led to a significant reduction in mortality rates, demonstrating the potential for improved patient outcomes in autoimmune diseases [12][13] Group 3: Strategic Insights for the Industry - The evolution of treatment strategies in hematologic oncology, from broad disease control to curative approaches, provides a blueprint for the next phase of autoimmune disease development [14][16] - The industry must learn from the successes and challenges faced in hematologic oncology to navigate the rapidly changing healthcare landscape for autoimmune diseases [18] - Key differences between autoimmune diseases and hematologic cancers include the chronic nature of autoimmune diseases, which require long-term management rather than immediate intervention, and the larger patient population affected [18] Group 4: Future Directions - The future of autoimmune disease treatment is likely to be driven by combination strategies, biomarker-based precision medicine, and sequential approaches rather than solely relying on single-agent efficacy [20] - The current technological environment, including AI-driven drug discovery and real-world evidence integration, presents new opportunities for accelerating innovation and improving patient outcomes [22]

Core Points - The "2025 Global Top Ten Engineering Achievements" was recently announced, with the Taklamakan Desert Locking Project included as a significant accomplishment [2] - The project aims to create the world's longest ecological barrier around the desert, effectively controlling sand source expansion and protecting surrounding ecosystems [2] - The construction faced unprecedented challenges due to extreme environmental conditions, leading to innovative strategies for sand control [2] Summary by Category - **Project Overview** - The Taklamakan Desert Locking Project is recognized for its global impact and innovative engineering solutions [2][3] - It is part of a broader list that includes notable projects such as the Perseverance Mars Rover and the South-to-North Water Diversion Project [3] - **Engineering Challenges** - The project site in the Hotan region experiences over 60 days of strong winds annually, with sand dunes moving at rates of up to 100 meters per year [2] - A "three-in-one" comprehensive management strategy was implemented to enhance sand control efficiency and prolong the lifespan of sand barriers [2] - **Environmental Impact** - The project serves as a new model for desertification control and regional sustainable development, protecting oases, farmland, and grasslands [2]

Core Points - The 2025 World Engineering Organization General Assembly and Global Engineering Conference has commenced in Shanghai, focusing on the theme "Engineering Shapes a Green Future" and attracting representatives from over 60 countries and regions [1] - The conference announced the "2025 Global Top Ten Engineering Achievements" and will sign the "Shanghai Declaration - Proactive Action: Engineering Shapes a Green Future" [1] - The event is co-hosted by the World Engineering Organization, China Association for Science and Technology, Chinese Academy of Engineering, and the Shanghai Municipal Government [1] Summary of Engineering Achievements - The "2025 Global Top Ten Engineering Achievements" include: - Antibody-drug conjugates, which precisely target cancer cells and release potent anti-cancer agents, marking a new era in cancer treatment [2] - Blackwell GPU architecture, which supports trillion-parameter model training and inference through groundbreaking parallel computing design [2] - DeepSeek open-source large language model, recognized as one of the fastest-growing AI applications globally [2] - Human-shaped robots, which can assist or replace humans in various tasks across industrial manufacturing, rehabilitation, and special operations, potentially transforming future production and social structures [2] - The South-to-North Water Diversion Project in China, which optimizes water resource allocation and promotes ecological restoration along its route [2] - The Taklamakan Desert Locking Project, which constructs the world's longest ecological barrier to combat desertification and protect human living spaces [2]

Core Insights - The 2025 World Engineering Organization General Assembly and Global Engineering Conference was held in Shanghai, focusing on "Engineering Shapes a Green Future" [1] - The conference announced the "Top Ten Global Engineering Achievements of 2025," selected by the Chinese Academy of Engineering's journal "Engineering" [1] Group 1: Engineering Achievements - The ten engineering achievements include antibody-drug conjugates, Blackwell GPU architecture, DeepSeek open-source large language model, full ocean depth manned submersible, high-performance carbon fiber composites, humanoid robots, Perseverance Mars rover, Euclid space telescope, South-to-North Water Diversion Project, and Taklamakan Desert edge-locking project [1] - These achievements were selected from significant engineering technological innovations completed in the past five years, demonstrating global impact and effectiveness [1] Group 2: Characteristics of Engineering Achievements - The achievements reflect advanced technological levels and significant original breakthroughs in engineering science [2] - They showcase systematic innovation through technology integration, system optimization, and resource collaboration to achieve overall goals [2] - The achievements highlight the development direction of new productive forces, with potential to stimulate new industries and economic growth [2] - They emphasize the critical role of engineering in overcoming global challenges, exemplified by high-performance carbon fiber composites, which are widely used in aerospace, new energy, and high-end equipment sectors, driving innovation across the entire industry chain [2]

Core Viewpoint - The article highlights the announcement of the "2025 Global Top Ten Engineering Achievements," showcasing significant engineering innovations that have been completed in the last five years and have a global impact [3][5]. Group 1: Overview of the Achievements - The "2025 Global Top Ten Engineering Achievements" includes antibody-drug conjugates, Blackwell GPU architecture, DeepSeek open-source large language model, full ocean depth manned submersible, high-performance carbon fiber composites, humanoid robots, Perseverance Mars rover, Euclid space telescope, South-to-North Water Diversion Middle Route Project, and the Taklamakan Desert Locking Project [5][28]. Group 2: Detailed Descriptions of Selected Achievements - The Perseverance Mars rover, which landed on Mars on February 19, 2021, utilizes advanced technologies for autonomous navigation and sample collection, marking a significant step in the exploration of extraterrestrial life [7]. - The Euclid space telescope, launched on July 1, 2023, is designed to explore dark matter and dark energy, providing crucial insights into the early universe and cosmic evolution [9]. - The full ocean depth manned submersible "Limiting Factor" reached the Mariana Trench's Challenger Deep, demonstrating advancements in deep-sea exploration technology [12]. - The South-to-North Water Diversion Middle Route Project, operational since August 25, 2022, is a major cross-basin water diversion project in China, optimizing water resource allocation and promoting ecological restoration [14]. - The Taklamakan Desert Locking Project, completed on November 28, 2024, aims to combat desertification and protect surrounding ecosystems through innovative engineering solutions [17]. Group 3: Technological Innovations - The Blackwell GPU architecture, released in March 2024, significantly enhances AI computational efficiency and energy efficiency, supporting the training and inference of trillion-parameter models [19]. - The DeepSeek open-source large language model, launched between December 2024 and January 2025, aims to democratize AI technology and accelerate its integration across various industries [21]. - High-performance carbon fiber composites are revolutionizing manufacturing with their lightweight and high-strength properties, impacting sectors such as aerospace and renewable energy [28]. Group 4: Characteristics of the Achievements - The achievements reflect advanced technological levels and significant breakthroughs in engineering, showcasing innovations that push the boundaries of current capabilities [28]. - They demonstrate systemic innovation through technology integration and resource collaboration, as seen in the Perseverance rover and humanoid robots [28]. - The projects highlight the potential to drive new industries and economic growth, particularly in materials science and AI applications [29].

Core Viewpoint - The 2025 World Engineering Organization General Assembly and Global Engineering Conference opened in Shanghai, highlighting significant engineering achievements that have global impact and practical validation over the past five years [1] Group 1: Engineering Achievements - The "2025 Global Top Ten Engineering Achievements" were announced, showcasing major innovations in engineering technology, including antibody-drug conjugates, Blackwell GPU architecture, DeepSeek open-source large language model, deep-sea manned submersible, high-performance carbon fiber composites, humanoid robots, Perseverance Mars rover, Euclid space telescope, South-to-North Water Diversion Project, and Taklamakan Desert edge-locking project [1] Group 2: Characteristics of Achievements - The engineering achievements reflect four key characteristics: 1. They represent the most advanced technological levels or significant original breakthroughs in engineering technology [1] 2. They demonstrate systematic innovation through technology integration, system optimization, and resource collaboration to achieve overall goals [1] 3. They highlight the development direction of new productive forces, with potential to stimulate new industries and economic growth [1] 4. They emphasize the critical role of engineering in overcoming global challenges through continuous breakthroughs [1]

Core Insights - The 2025 World Federation of Engineering Organizations General Assembly opened in Shanghai, announcing the "Top Ten Global Engineering Achievements of 2025" [1][2] - The achievements reflect advanced technological levels and significant breakthroughs in engineering science, showcasing innovations that address global challenges and promote sustainable development [1] Group 1: Top Ten Global Engineering Achievements - The ten achievements include: antibody-drug conjugates, Blackwell GPU architecture, DeepSeek open-source large language model, deep-sea manned submersible, high-performance carbon fiber composites, humanoid robots, Perseverance Mars rover, Euclid space telescope, South-to-North Water Diversion Project, and Taklamakan Desert edge-locking project [1][2] - Antibody-drug conjugates are recognized as "precision missiles" in cancer treatment, highlighting their impact on healthcare [1] - The Perseverance Mars rover integrates multiple cutting-edge technologies such as autonomous navigation and sample collection, demonstrating systemic innovation through technology integration [1] Group 2: Evaluation Process - The selection of the top ten achievements involved global nominations, expert recommendations, public surveys, and review by a selection committee [2] - The achievements are defined as significant engineering innovations completed in the last five years that have been practically validated and have a global impact [2]

Core Insights - The article discusses the announcement of the "2025 Global Top Ten Engineering Achievements" by the Chinese Academy of Engineering, highlighting significant engineering innovations completed in the last five years that have global impact [3][5]. Group 1: Overview of Achievements - The ten engineering achievements include: antibody-drug conjugates, Blackwell GPU architecture, DeepSeek open-source large language model, full ocean depth manned submersible, high-performance carbon fiber composites, humanoid robots, Perseverance Mars rover, Euclid space telescope, South-to-North Water Diversion Project, and the Taklamakan Desert edge-locking project [5][6]. Group 2: Key Features of Achievements - The achievements reflect advanced technological levels and significant original breakthroughs, such as antibody-drug conjugates that precisely target cancer cells, marking a new era in cancer treatment [8]. - They demonstrate systemic innovation through technology integration and resource collaboration, exemplified by the Perseverance Mars rover's advanced autonomous navigation and sample collection capabilities [8][9]. - The achievements highlight the development direction of new productive forces, with potential to drive new industries and economic growth, such as high-performance carbon fiber composites leading to innovation in the new materials industry [9]. - They also emphasize the role of engineering in addressing global challenges, as seen in the South-to-North Water Diversion Project, which optimizes water resource allocation and promotes ecological sustainability [9].