Market Overview - The Hong Kong stock market opened lower on December 15, with the Hang Seng Index down 1% at 25,718.14 points, the Hang Seng Tech Index down 1.34% at 5,562.67 points, and the State-Owned Enterprises Index down 1.09% at 8,980.13 points [1] - Major tech stocks declined, including Alibaba down 2.14%, Tencent down 1.62%, and JD.com down 0.61% [1] - The innovative drug sector saw several stocks open lower, with Genscript Biotech down 5.92% and Zai Lab down 3.48% [1] - Chinese brokerage stocks collectively fell, with Everbright Securities dropping over 1% [1] - The automotive sector also experienced declines, with Li Auto down over 2% and XPeng down nearly 2% [1] - However, three-child policy concept stocks and photovoltaic stocks mostly rose, with star stock Jinxin Fertility rising about 3% [1] Company News - China Merchants Energy (01138.HK) signed shipbuilding contracts for one ethylene ship and eighteen oil tankers, totaling RMB 7.882 billion [2] - ZhongAn Online (06060.HK) reported cumulative original insurance premium income of approximately RMB 32.904 billion for the first eleven months [3] - R&F Properties (02777.HK) achieved total sales revenue of approximately RMB 12.7 billion in the first eleven months, a year-on-year increase of 24.63% [4] - Yida China (03639.HK) reported contract sales amounting to approximately RMB 681 million in the first eleven months, a year-on-year decrease of 23.22% [5] - Bole Technology (02592.HK) successfully held a meeting after the second phase of clinical trials for CBT-004 [6] - Junshi Biosciences (02696.HK) received acceptance for its marketing application for Hansizhuang® in combination with chemotherapy for gastric cancer [6] - CSPC Pharmaceutical Group (01093.HK) received approval for a new indication for its drug, Donyin® (liposomal irinotecan injection), for first-line treatment in metastatic pancreatic cancer patients [6] - Biyuan (00926.HK) increased its investment in ERX to maintain a 3% stake to support innovative research and development of non-GLP-1 weight loss therapies [7] - Hengrui Medicine (01276) received approval for clinical trials for HRS-1780 tablets [8] - AVIC Industry (02357.HK) plans to acquire a 59.1816% partnership interest in Hangtou Yuhua for a consideration of RMB 202 million [9] - China Environmental Resources (01130.HK) intends to acquire 90% equity in Sichuan Yuanlai Shun Recycling Resources Co., Ltd. for RMB 9 million [10] - AVIC Industry (02357.HK) proposed to implement full circulation of H-shares [11] - Yabo Technology Holdings (08279.HK) signed a framework agreement with Alipay (Hangzhou) [12] Institutional Insights - Guosen Securities indicated that the short-term adjustment in the Hong Kong stock market opens up space for a market rise in 2026, with net inflows from southbound funds exceeding RMB 110 billion in November [13] - CITIC Securities noted strong performance in gold and silver, while other risk assets were weak, predicting a segmented market for precious metals in 2025 [13] - CITIC Securities also emphasized the importance of resource self-sufficiency in the lithium industry, highlighting the need for low-cost quality resources to navigate market cycles [14]

重大事项： 复宏汉霖(02696)：汉斯状®联合化疗用于胃癌新辅助/辅助治疗的上市注册申请获国家药监局受理，并 已纳入优先审评 众安在线(06060)前11个月原保险保费收入总额约为329.04亿元 越秀地产(00123)前11个月累计合同销售金额约972.18亿元 诺诚健华(09969)：奥布替尼治疗系统性红斑狼疮的IIb期临床试验取得积极结果并启动III期临床试验 德林控股(01709)在选定海外矿场部署高效挖矿硬件 继续积极发展及扩展机构级比特币挖矿业务 粉笔(02469)与华图订立战略合作协议 巩固双方在行业的领导地位 经营业绩： 富力地产(02777)前11个月总销售收入约 127 亿元 同比增长24.63% 碧生源(00926)加码投资ERX维持3%持股 支持非GLP-1减肥疗法创新研发 石药集团(01093)：多恩益®(盐酸伊立替康脂质体注射液)的新适应症获上市批准 中远海能(01138)就建造一艘乙烯船和十八艘油轮订立造船合约，总代价78.82亿元 华润置地(01109)前11个月累计合同销售金额约1926亿元 同比减少15.9% ...

Company News - China COSCO Shipping Energy Transportation Co., Ltd. (中远海能) has signed shipbuilding contracts with Dalian COSCO Shipping Heavy Industry, Yangzhou COSCO Shipping Heavy Industry, and Guangdong COSCO Shipping Heavy Industry for the construction of one ethylene ship and eighteen oil tankers, with a total cost of RMB 7.882 billion [1] - ZhongAn Online P&C Insurance Co., Ltd. (众安在线) reported a total original insurance premium income of approximately RMB 32.904 billion for the first eleven months [2] - R&F Properties Co., Ltd. (富力地产) achieved total sales revenue of approximately RMB 12.7 billion in the first eleven months, representing a year-on-year increase of 24.63% [3] - Yida China Holdings Limited (亿达中国) reported a contracted sales amount of approximately RMB 681 million for the first eleven months, a year-on-year decrease of 23.22% [4] - Karsen International Holdings Limited (卡森国际) has entered into a steel structure procurement contract with suppliers, involving an investment of RMB 43.5366 million [4] Clinical and Regulatory Updates - Bolex Cloud-B (拨康视云-B) successfully held a meeting after the second phase of clinical trials for CBT-004 [5] - Innovent Biologics, Inc. (复宏汉霖) has had its application for the marketing registration of Hansizhuang® combined chemotherapy for gastric cancer accepted by the National Medical Products Administration, and it has been included in the priority review [5] - CSPC Pharmaceutical Group Limited (石药集团) received approval for a new indication for Donyi® (Irinotecan Liposome Injection) for first-line treatment in patients with metastatic pancreatic cancer [5] - Heng Rui Medicine (恒瑞医药) received a clinical trial approval notice for HRS-1780 tablets [7] Investment and Acquisition Activities - AVIC Aviation Industry Corporation (中航科工) plans to acquire a 59.1816% partnership interest in Hangtou Yuhua for a consideration of RMB 202 million [8] - China Environment Resources Holdings Limited (中国环境资源) intends to acquire 90% equity in Sichuan Yuanlai Shun Recycling Resources Co., Ltd. for RMB 9 million [9] - AVIC Aviation Industry Corporation (中航科工) has proposed to implement full circulation of H-shares [10] - Yabo Technology Holdings Limited (亚博科技控股) has entered into a framework agreement with Alipay (Hangzhou) [11] Financing and Buyback Activities - Yum China Holdings, Inc. (百胜中国) has entered into a share buyback agreement with a total repurchase amount of approximately USD 460 million, including about HKD 880 million under the Hong Kong plan, as part of a plan to return USD 1.5 billion to shareholders through dividends and share buybacks by 2026 [12] - Tencent Holdings Limited (腾讯控股) repurchased approximately 1.044 million shares for about HKD 636 million, with repurchase prices ranging from HKD 601.5 to HKD 616 [13] - Xuanwu Cloud (玄武云) repurchased 6,000 shares for a total of HKD 6,467.79, with prices between HKD 1.05 and HKD 1.07 [14] - China COSCO Shipping Holdings Co., Ltd. (中远海控) repurchased approximately 4.461 million shares for about HKD 60.8605 million, with prices ranging from HKD 13.38 to HKD 13.82 [15] - Geely Automobile Holdings Limited (吉利汽车) repurchased approximately 1.362 million shares for about HKD 23.9241 million, with prices between HKD 17.29 and HKD 17.82 [16] - China Anshun Energy (中国安储能源) plans to issue a total of 524 million shares at a discount of approximately 19.12%, aiming to raise about HKD 288.2 million [16]

Core Viewpoint - Fosun Pharma's subsidiary, Shanghai Fuhong Hanlin Biotechnology Co., Ltd., has received inclusion of its independently developed drug, Surulitinib Injection, in the breakthrough therapy program for the treatment of gastric cancer in China [1][2] Group 1: Drug Development and Approval - Surulitinib is an innovative anti-PD-1 monoclonal antibody developed by the group [2] - As of November 20, 2025, the drug has been approved for marketing in multiple countries/regions including China, the EU, the UK, Indonesia, Cambodia, Thailand, Malaysia, Singapore, and India [2] - In China, the approved indications include first-line treatment for squamous non-small cell lung cancer (sq-NSCLC), extensive-stage small cell lung cancer (ES-SCLC), esophageal squamous cell carcinoma (ESCC), and non-squamous non-small cell lung cancer (nsq-NSCLC) [2] Group 2: Regulatory Designations and Clinical Trials - The drug has received orphan drug designation from regulatory authorities in the US, EU, Switzerland, and South Korea [2] - Multiple combination therapies involving Surulitinib are currently undergoing clinical trials in various countries and regions, targeting indications such as lung cancer, esophageal cancer, head and neck squamous cell carcinoma, colorectal cancer, and gastric cancer [2]

Core Viewpoint - Fosun Pharma's subsidiary Shanghai Fuhong Hanlin Biotech has received inclusion of its independently developed drug, Surulitinib Injection, in the breakthrough therapy designation for the treatment of gastric cancer, marking a significant advancement in the field of PD-1 monoclonal antibodies [1] Group 1: Company Developments - The drug Surulitinib Injection, marketed in China as Hanshuanzhuang®, is an innovative anti-PD-1 monoclonal antibody developed by the company [1] - The inclusion in the breakthrough therapy program indicates a potential expedited development and review process for the drug [1] Group 2: Industry Context - As of the announcement date, there are no approved PD-1 targeted monoclonal antibody drugs for neoadjuvant/adjuvant treatment of gastric cancer globally [1] - According to IQVIA MIDAS™ data, the global sales of PD-1 targeted monoclonal antibody drugs are projected to reach approximately $45.704 billion in 2024 [1]

Company Overview - Shanghai Fosun Pharmaceutical (Group) Co., Ltd. is a global healthcare industry group established in 1994, focusing on pharmaceuticals, medical devices, diagnostics, and healthcare services [1] - The company operates in major markets including the US, Europe, Africa, India, and Southeast Asia, with a strong emphasis on innovative drug development in oncology and immunology [1] Innovation and Product Development - Fosun Pharmaceutical employs an open innovation model through self-research, collaboration, licensing, and industrial investment, leading to the launch of innovative products in hematological malignancies, breast cancer, and lung cancer [2] - The company has introduced China's first biosimilar drug Hanlikang®, the first domestic trastuzumab biosimilar Hanquyou®, and the world's first approved anti-PD-1 monoclonal antibody for first-line treatment of small cell lung cancer, Hanshuang® [2] - As of July 2025, Fosun has five rare disease drugs on the market and ten additional indications under research, with its innovative drug Fumainin® approved for dual indications in May 2025 [2] Market Localization and Accessibility - Fosun Pharmaceutical aims to localize international technologies and products in China, enhancing the accessibility of quality medical resources [3] - The company's subsidiary, Fosun Kite, launched the first CAR-T cell therapy product Yikaida®, which is the first CAR-T therapy approved in China, benefiting over 800 lymphoma patients by the end of 2024 [3] - The first domestically produced Da Vinci surgical system was launched in October 2023, making China the only global production base outside the US, with over 670,000 patients treated by the Da Vinci surgical robot by the end of 2024 [3] Global Health Initiatives - Fosun Pharmaceutical is committed to improving the accessibility of medicines in developing countries, particularly in combating malaria in sub-Saharan Africa, where malaria claims a life every minute [4] - The company has developed artesunate for injection, a first-line treatment for severe malaria recommended by WHO, saving over 80 million patients by the end of 2024 [4] - The completion of the first phase of the Côte d'Ivoire park in May 2025 enhances the affordability and accessibility of pharmaceutical products in the region [4]

Shanghai Henlius Biotech, Inc. 上海復宏漢霖生物技術股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：2696） 自願公告 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因倚賴 該等內容而引致的任何損失承擔任何責任。 | 產品/聯合療法 | 適應症 | 最新進展 | | --- | --- | --- | | HLX43 | 晚期/轉移性 | 於中國境內處於1期臨床試驗中 | | | 實體瘤 | （其中胸腺癌(TC)隊列為國際多 | | | | 中心試驗） | | | | 於美國、日本獲許可開展1期臨 | | | | 床試驗 | | HLX43 | 晚期非小細胞肺癌 | 於中國境內、美國、澳大利亞處 | | | (NSCLC) | 於2期臨床試驗中（國際多中心 | | | | 試驗） | | | | 於日本獲許可開展2期臨床試驗 | | HLX43單藥或 | 晚期/轉移性 | 轉移性結直腸癌(mCRC)、宮頸 | | 聯合治療 | 實體瘤 | 癌( ...

Core Viewpoint - The company has demonstrated strong international growth and operational resilience, with recent regulatory issues not impacting its current business or future prospects [1][5]. Group 1: Regulatory and Compliance - The Hong Kong Stock Exchange issued a disciplinary statement regarding a historical investment management agreement from 2019, which has been fully rectified by the company in 2023 [1]. - The company has upgraded its internal control systems and established a "Financing Management Committee" to enhance risk management [1]. - The incident is viewed as a historical procedural flaw, with no penalties imposed and no impact on the current management or business operations [1]. Group 2: Financial Performance - For the first half of 2025, the company reported total revenue of 2.8195 billion yuan, a 10.5% year-on-year increase, with a net profit of 390.1 million yuan [2]. - Operating cash flow surged to 770.9 million yuan, reflecting a dramatic increase of 206.8% year-on-year [2]. - Global product revenue exceeded 2.55 billion yuan, with overseas product profits soaring over 200% [2]. Group 3: Product Development and Market Expansion - The company's core product, Hanquyou®, has achieved significant sales of 1.44 billion yuan and has been approved in over 50 global markets [3]. - HLX14 has received recent approvals in the U.S. for multiple indications, with expectations for simultaneous approvals in the EU and Canada by the second half of 2025 [3]. - The company is advancing its innovative drug pipeline, including HLX43 and HLX22, which are positioned to address significant market needs and have shown promising clinical results [7][9]. Group 4: Strategic Collaborations - The company has formed strategic partnerships with global giants like Abbott and Organon, enhancing its market presence and operational efficiency [4]. - These collaborations are part of a broader strategy to embed itself within the global value chain and optimize revenue generation [4]. Group 5: Market Sentiment and Stock Performance - Since 2025, the company's stock price has surged over 450%, with a market capitalization exceeding 45 billion HKD, indicating strong investor confidence [6]. - Major financial institutions have raised their target prices for the company, reflecting a consensus on its growth potential and successful internationalization strategy [6]. Group 6: Innovation and R&D Capabilities - The company is focused on continuous innovation, with a robust pipeline of differentiated products and advanced technology platforms [10][11]. - The development of HLX43 and HLX22 showcases the company's commitment to addressing unmet medical needs and enhancing treatment efficacy [8][9]. - The integrated R&D system allows the company to maintain a competitive edge in the global biopharmaceutical landscape [11]. Group 7: Market Trends and Future Outlook - The company is positioned to benefit from a favorable market environment, with multiple catalysts for growth and a clear path for revenue enhancement [12]. - The combination of improved operational performance, strong product pipeline, and positive market sentiment suggests a promising trajectory for the company's future [12].

Core Viewpoint - The stock of Fuhong Hanlin (2696.HK) reached a new high of 85.95 HKD, with a year-to-date increase exceeding 250% [1] Group 1: Company Performance - The latest report from CICC initiates coverage of the company with an "outperform" rating and sets a target price of 102.91 HKD [1] - Citigroup previously raised the company's target price to 95 HKD, indicating strong market confidence in the company's international progress and core product expansion [1] Group 2: Product Portfolio - The company has established a competitive advantage through its core innovative drugs, including HLX43 (PD-L1 ADC), HLX22, and Hanshu® [1] - The contribution from biosimilars like Hanquyou® provides stable cash flow, supporting the company's dual-driven model of "innovation + commercialization" [1]

Core Insights - The company reported a revenue of 2.82 billion RMB for the six months ending June 30, 2025, representing a year-on-year increase of 2.67% [1] - Gross profit reached 2.199 billion RMB, up 10.47% year-on-year, while net profit attributable to shareholders was 390 million RMB, a 0.99% increase [1] - The company invested approximately 995 million RMB in R&D, an increase of about 170 million RMB compared to the same period last year, focusing on innovative R&D projects to accelerate transformation [1] Group Performance - The overseas product sales revenue was approximately 40.6 million RMB, with profits from overseas products more than doubling compared to the same period last year, driven by the company's international strategy and increased sales in the U.S. market [1] - As of August 22, 2025, the company has successfully launched six products (covering 25 indications) in multiple countries, including China, the U.S., Europe, and others, benefiting over 850,000 patients globally [2] - The product "Hanshu" for extensive-stage small cell lung cancer was approved for first-line treatment in the EU in February 2025, marking the company's second product approved in the EU [2] - The biosimilar HLX14 received a positive opinion from the European Medicines Agency (EMA) in July 2025, paving the way for its market entry in broader overseas markets [2]