变"外来者"为"自己人"，从"卖产品"到"输出方案" 济企出海：越过浅滩 驶入深港 2025年1—11月，济南市进出口总值2588.1亿元，同比增长24.9%，增幅列全省第一。在外部环境复 杂严峻、贸易保护主义抬头的背景下，这份成绩的"含金量"远超数字本身，折射出一场静水深流的深刻 变革。在全球化的深水区，中国企业如何从"路过者"变为"共建者"，从"走出去"变为"走进去"，从"卖产 品"到"输出现代化产业范式"？ 破壁 攻克标准壁垒输出中国方案 在济南企业出海的图谱中，龙头企业的轨迹，勾勒出产业升级的曲线。 "出口，对我们而言，是一个不断爬坡的过程。"回顾国际化之路，齐鲁制药集团副总裁张汉常说。 这条路径清晰但陡峭：从早期的非无菌原料药到无菌原料药，最终攻克技术、质量、注册的层层壁垒， 实现制剂成品药走向全球。 齐鲁制药有限公司副总经理王伟萍亲历了从"单舰破浪"到"舰队远征"的蜕变。"我们最早出口原料 药，处在价值链底端，拼的是成本和规模。"转折始于向制剂成品药的攻坚。2016年，齐鲁制药首个制 剂产品登陆美国，叩开全球监管最严、竞争最激烈市场的大门。至今，已有34个制剂产品出口美国，同 时向美、英、日、澳、 ...

Core Insights - Company Kexing Pharmaceutical has submitted its prospectus to the Hong Kong Stock Exchange, marking a significant step in its "A+H" dual-platform strategy following its listing on the STAR Market in December 2020 [3] - Kexing Pharmaceutical is distinct from Kexing Biotech, focusing on recombinant protein drugs and microbiome preparations, primarily in antiviral and oncology treatments, while Kexing Biotech specializes in preventive vaccines [3][4] - The company has faced declining growth momentum due to domestic price reductions and increased international competition, leading to a period of losses [3][10] - The actual controller, Deng Xueqin, has raised over 1 billion yuan through share reductions, raising market concerns about the company's stock price volatility [3][19] Company Background - Kexing Pharmaceutical and Kexing Biotech share a common origin dating back to 1989, but have since become completely independent entities with no substantial ties [4] - The company was established as a result of asset and business separations that began in 2001, with Kexing Pharmaceutical focusing on therapeutic biopharmaceuticals [4][5] Financial Performance - Kexing Pharmaceutical's revenue has fluctuated between 1.2 billion to 1.3 billion yuan from 2020 to 2023, with a net loss of 190 million yuan in 2023 [10][9] - The company expects revenue to recover to 1.4 billion yuan in 2024, with a net profit of 31 million yuan, and further growth in 2025 [9][10] - Approximately 90% of the company's revenue comes from four core products, all of which have been on the market for over 15 years, facing challenges such as price reductions and increased competition [10][11] Product Portfolio - The four main products contributing to revenue include Epoetin (依普定), Interferon (赛若金), Granulocyte Colony-Stimulating Factor (白特喜), and Clostridium Butyricum (常乐康), which collectively accounted for 89% of revenue in 2024 [10][11] - Despite strong historical performance, these products are now encountering growth ceilings, impacting overall revenue stability [10][12] Cost Management and Efficiency - The company has implemented cost-cutting measures, reducing R&D expenses by 51% and sales expenses by 13.4% in 2024 [15][14] - Employee numbers have decreased from 1,407 at the end of 2022 to 971 by mid-2025, indicating a significant reduction in workforce [15] Financial Health - Kexing Pharmaceutical's debt levels have increased, with a debt-to-asset ratio rising from 43% at the end of 2022 to 49% by mid-2025, alongside a significant increase in bank loans [17] - The company's liquidity position has also deteriorated, with the current ratio dropping from 2.6 in 2022 to 1.6 in mid-2025, indicating a tightening of short-term financial flexibility [17] Market Strategy - The submission for H-share listing aims to enhance the company's "innovation + internationalization" strategy and diversify financing channels [18] - The market is observing the implications of Deng Xueqin's share reductions, which may reflect either a lack of confidence or a strategic move to optimize the share structure ahead of the H-share issuance [19][22]

Core Insights - The successful shipment of the first batch of Bevacizumab biosimilar to Colombia marks a significant milestone for the company in deepening its presence in the Latin American market [1] Group 1: Overseas Commercialization Strategy - The company has been actively advancing the overseas registration of its collaborative products, receiving industry acclaim for its "multi-country registration" commercial efficiency [2] - The innovative "global selection + global coverage" outbound platform model has led to partnerships with several well-known pharmaceutical companies, securing over twenty key products for overseas commercialization across diverse therapeutic areas [2] - Colombia, as the fourth largest pharmaceutical market in Latin America, has seen a notable increase in the export of Chinese pharmaceutical products, with a 10.4% year-on-year growth in the first quarter of 2025 [2] Group 2: Regulatory and Market Entry - The Colombian pharmaceutical market is a key focus for the company, with the local regulatory body INVIMA's standards closely aligned with international authorities like the FDA and EMA, indicating a high level of market entry rigor [2] - The INVIMA certification is expected to facilitate the introduction of Bevacizumab in other Latin American markets, enhancing the company's overall market penetration strategy [2] Group 3: Collaborative Efforts and Future Plans - The successful commercialization of Bevacizumab overseas is attributed to the deep collaboration between the company and its partner, which ensures stringent production compliance and high product quality [3] - The company plans to continue advancing the registration of Bevacizumab in Latin America and other key markets, while also enhancing its local operational capabilities for other products [3] - The ongoing efforts aim to expand the company's international footprint and provide hope for more patients through access to essential medications [3]

Core Viewpoint - The company, Kexing Pharmaceutical, announced plans to issue H-shares for a Hong Kong listing, joining a wave of A-share companies pursuing dual listings to enhance internationalization and diversify financing channels [1][5] Group 1: Company Developments - Kexing Pharmaceutical's revenue for the first half of 2025 was 700 million yuan, a year-on-year decrease of 7.82%, while net profit attributable to shareholders reached 80.34 million yuan, a significant increase of 576.45% [1] - The company reported a net cash flow from operating activities of 30 million yuan, a year-on-year increase of approximately 188%, attributed to increased sales collections and reduced operating expenses [2] - The company has made significant progress in innovative drug research, with its interferon α1b inhalation solution being included in the list of breakthrough therapies by the National Medical Products Administration [2][3] Group 2: Market Position and Strategy - Kexing Pharmaceutical's overseas commercialization platform has expanded to over 40 countries, covering emerging markets with populations over 100 million and GDP rankings within the top thirty [4] - The company aims to build a dual financing platform through the A+H listing, facilitating coordinated development in domestic and international markets and accelerating its internationalization process [5] - The company focuses on various therapeutic areas, including antiviral, oncology, and immunology, with a research and development investment of approximately 95.97 million yuan in the first half of 2025, representing 13.70% of its revenue [3]

Core Viewpoint - The company Kexing Pharmaceutical (688136.SH) announced plans to issue H-shares for a Hong Kong listing, joining a wave of A-share companies pursuing dual listings in Hong Kong, with 25 companies announcing similar plans in September 2023 [1]. Group 1: Company Developments - Kexing Pharmaceutical aims to deepen its "innovation + internationalization" strategy and accelerate overseas business development through the Hong Kong listing [1]. - The company reported a revenue of 700 million yuan in the first half of 2023, a year-on-year decrease of 7.82%, while net profit attributable to shareholders increased significantly by 576.45% to 80.34 million yuan [1]. - The net cash flow from operating activities reached 30 million yuan, a year-on-year increase of approximately 188%, attributed to increased sales collections and reduced operating expenses [2]. Group 2: Research and Development - Kexing Pharmaceutical's innovative drug pipeline has made significant progress, with its interferon α1b inhalation solution included in the list of breakthrough therapies by the National Medical Products Administration [2]. - The company focuses on antiviral, oncology, and immunology research, with R&D investment in the first half of 2023 amounting to approximately 95.97 million yuan, representing 13.70% of total revenue, an increase from 11.52% in the previous year [3]. Group 3: Market Position and Future Outlook - Kexing Pharmaceutical's overseas commercialization platform has expanded to over 40 countries, covering emerging markets with populations over 100 million and GDP rankings in the top thirty [4]. - The company’s product, albumin-bound paclitaxel, has shown significant growth in the European market, with a quarter-on-quarter revenue increase of 35.84% in Q2 2023 [3][4]. - The upcoming Hong Kong listing is expected to help Kexing Pharmaceutical build a dual financing platform, facilitating coordinated development in domestic and international markets [4].

Group 1 - The forum "Emerging Market Development Forum for China's Pharmaceutical Industry" was successfully held during the 2025 CPHI & PMEC Pharmaceutical Industry Exhibition in Shenzhen, focusing on opportunities and challenges in emerging markets [1] - The Shenzhen Pharmaceutical and Medical Device Industry Outbound Union aims to create a collaborative ecosystem for companies to expand internationally, involving major enterprises and professional service institutions [1] - The forum featured industry leaders discussing the evolution of the global pharmaceutical landscape and innovative practices for internationalization, highlighting the growing interest in emerging markets [1] Group 2 - IQVIA's analysis indicates that the global biopharmaceutical market is undergoing significant restructuring, with China accounting for one-third of global innovation in drug development [2] - The report emphasizes that Chinese pharmaceutical companies are entering a new era of internationalization, with opportunities arising from technological advancements and innovative business models [2] - The "API+ANDA," "NewCo," and "JV" outbound models were discussed, outlining their characteristics and advantages [2] Group 3 - The MENA and South Asia regions are identified as key markets, with a pharmaceutical market size of approximately $35 billion and an annual growth rate of 6.3%, projected to increase by 35% to 55% over the next five years [3] - Kexing Pharmaceutical's localized marketing strategies in Algeria, Egypt, and Saudi Arabia demonstrate the potential for Chinese pharmaceutical companies in the MENA region [3] - In South America, regulatory compliance and local partnerships are crucial for market entry, with Brazil being the largest contributor to growth in the region [3] Group 4 - The roundtable discussion highlighted the role of new productive forces in the pharmaceutical sector, focusing on biotechnological innovation, digital R&D, and intelligent management [4] - Chinese pharmaceutical companies are encouraged to collaborate with trustworthy partners to enhance their international competitiveness through innovation and ecological synergy [4] - The successful forum aims to provide strategic guidance for Chinese pharmaceutical companies looking to enter emerging markets, with Kexing Pharmaceutical committed to building high-level international exchange platforms [4]

Investment Rating - The report maintains a "Buy" rating for the company [10] Core Views - The company reported a revenue of 700 million yuan in the first half of 2025, reflecting a year-on-year decrease of 7.82%, while the net profit attributable to the parent company was 80 million yuan, showing a significant increase of 576.45% [6][10] - The growth in net profit outpaced revenue growth, attributed to improved operational quality and rapid growth in overseas sales, with export revenue reaching 188 million yuan, doubling year-on-year [7][10] - The company is advancing its "global selection and coverage" strategy, with 19 products having obtained overseas commercialization rights and approximately 150 registration applications submitted in over 70 countries/regions [8] - The company has laid out multiple innovative drug pipelines, with 10 innovative drugs disclosed, most of which are global firsts, potentially providing a second growth engine [8] Financial Summary - Total revenue for 2025 is projected at 1.615 billion yuan, with a year-on-year growth rate of 14.8% [5] - The net profit attributable to the parent company is expected to be 108 million yuan in 2025, with a significant year-on-year growth of 244.2% [5] - The company’s gross margin is projected to be 65.3% in 2025, with a return on equity (ROE) of 6.1% [5]

Group 1 - Since August, nearly 20 A-share listed companies have announced plans to list in Hong Kong, with companies like Luxshare Precision and Victory Technology formally submitting H-share listing applications [1][6] - The main motivations for these companies to pursue a Hong Kong listing include expanding international strategies, optimizing overseas business layouts, enhancing brand recognition, and improving overseas financing capabilities [1][5] Group 2 - The recent A-share companies planning to list in Hong Kong span various industries, including electronics, machinery, pharmaceuticals, food and beverage, chemicals, and media, with the electronics sector being the most concentrated [5][6] - Notable companies in the electronics sector include Huajin Technology, Chipsea Technologies, and Luxshare Precision, while the pharmaceutical sector features companies like Sinovac Biotech and Kefu Medical [5][6] Group 3 - Industry analysts suggest that sectors with strong global attributes, such as resource energy, equipment manufacturing, and pharmaceutical innovation, are more likely to benefit from the "A+H" listing strategy [5][7] - For instance, Sinovac Biotech aims to deepen its "innovation + internationalization" strategy through its Hong Kong listing, which will accelerate overseas business development and enhance its international brand image [5][6] Group 4 - Companies in the electronics industry, such as Jinghe Integration and Huajin Technology, believe that listing in Hong Kong will help them expand overseas customer bases and optimize investment layouts [6][7] - Leading companies like Luxshare Precision, with a market value exceeding 300 billion, plan to use the funds raised from their IPO for capacity expansion and technological research [6][7] Group 5 - Market analysts indicate that large state-owned enterprises and industry leaders prefer the "A+H" model to support long-term international financing needs, while mid-sized growth companies can enhance international investor recognition through this model [7] - The new regulations effective from August 4 at the Hong Kong Stock Exchange have improved the pricing and public market rules for initial public offerings, which is expected to further encourage A-share companies to list in Hong Kong [7]

Core Insights - The company reported a significant increase in revenue and net profit for the first half of the year, with revenue reaching 700.46 million yuan and net profit at 80.34 million yuan, marking a year-on-year growth of 576.45% [1] - The company is positioning itself as an innovative multinational pharmaceutical enterprise through its focus on research and development and international expansion [1] Innovation and R&D - The company has established a robust innovation pipeline based on its recombinant protein drug technology platform, focusing on high-value clinical pipelines and antibody drug development technology [2] - The company is developing several new drugs, including GB05 for respiratory syncytial virus (RSV) and GB18 for cancer cachexia, with promising clinical trial results [2][3] - The GB12 project targets specific dermatitis with a dual-blocking mechanism, showing significant advantages over existing treatments, indicating a favorable competitive landscape [3] - The company is also advancing the GB24 project, which addresses intestinal fibrosis in inflammatory bowel disease (IBD) patients, enhancing its competitive edge in gastrointestinal diseases [4] International Expansion - The company has made significant strides in its international commercialization strategy, establishing a marketing network covering over 70 countries and regions [5][6] - The company has successfully registered 18 products for overseas commercialization and received approvals in multiple countries, including the EU [6] - The introduction of high-end complex formulations, such as albumin paclitaxel, marks a transition to a new phase of international expansion, broadening the product portfolio [6] Strategic Positioning - The company is recognized for its innovative capabilities and has been actively participating in international academic events, enhancing its image as an innovative multinational biopharmaceutical enterprise [4][7] - The strategic focus on both innovation and internationalization is expected to drive sustainable growth and establish a positive image for Chinese enterprises in the global market [5][7]

Core Viewpoint - The company reported significant growth in revenue and net profit for the first half of 2025, indicating strong performance and successful market expansion efforts [1][2]. Financial Performance - The company achieved a revenue of 700 million yuan and a net profit of 80.34 million yuan, representing a year-on-year increase of 576.45% [1]. Research and Development - The company has made notable advancements in R&D, receiving clinical trial approvals for multiple products, including GB18 injection and interferon α1b inhalation solution [1]. - Ongoing clinical trials include Phase I for long-acting growth hormone and Phase III for polyethylene glycol-conjugated granulocyte colony-stimulating factor injection and interferon α1b inhalation solution [1]. Market Expansion - The company is accelerating its overseas market expansion, with its albumin-bound paclitaxel showing a 35.84% quarter-on-quarter revenue increase in the EU market [1]. - Approximately 60 registration applications have been accepted in about 40 countries, with approvals in emerging markets like Indonesia and Peru [1]. Product Portfolio - The company has introduced significant products such as trastuzumab and abicipar injection solution, totaling 19 products with overseas commercialization rights [2]. - The strategy includes extending from emerging markets to regulated markets and upgrading from biosimilars to innovative drugs [2]. Domestic Market Strategy - The company is enhancing regional management and expanding e-commerce channels, with a 90% year-on-year increase in e-commerce revenue [2]. - The production capacity is also ramping up with the launch of the pre-filled production line [2]. Industry Outlook - The pharmaceutical industry is transitioning towards innovation-driven growth, supported by policy and technological advancements [2]. - The company aims to strengthen its core business while focusing on market expansion and management improvement to enhance profitability [2].