Core Viewpoint - GLP-1 related business is a significant growth driver for the company's life sciences segment, with a focus on market share and collaboration with major clients [1] Group 1: Market Position and Revenue - The company maintains a market share of over 70% for GLP-1 peptide solid-phase synthesis carriers in the domestic clinical pipeline [1] - In the first half of 2025, the company's revenue from the life sciences sector reached 320 million yuan [1] Group 2: Product Range and Client Base - The company offers a diverse range of products in the life sciences field, including solid-phase synthesis carriers for peptides, small nucleic acid synthesis carriers, chromatography fillers, chromatography media, and enzyme carriers [1] - The main downstream customers for the company's peptide solid-phase synthesis carriers are CDMO enterprises, although specific sales revenue and client information for each product type have not been disclosed [1] Group 3: Collaboration with Major Clients - The company is in collaboration with leading clients such as Eli Lilly and Novo Nordisk, focusing on long-term supply agreements and product delivery schedules [1]

Industry Rating - The industry investment rating is maintained as "Outperform" [1] Core Views - The domestic demand for the research service sector is recovering, supported by national policies and increased market activity in innovative drugs, leading to stable revenue and profit growth [2][6] - The overseas business environment is showing steady recovery, with domestic companies making significant progress in international markets, enhancing their profit margins [3][19] - The overall performance of the research service sector is improving, with a notable increase in both domestic and overseas business contributions [6][41] Summary by Sections Financial Performance - For the first three quarters of 2025, the overall revenue of the research service sector increased by 6.61% year-on-year, with net profit rising by 13.30% and non-recurring net profit up by 20.89% [5][6] - In Q3 2025 alone, the sector's revenue grew by 8.53% year-on-year, with net profit increasing by 17.97% and non-recurring net profit by 36.37% [6] - The gross profit margin for the sector was 49.95%, reflecting a 1.64 percentage point increase year-on-year, attributed to improved product quality and effective cost control [6] Market Trends - The demand for innovative drug research is driving growth in the sector, with a significant increase in the number of projects and investments in high-value services [2][14] - The trend of domestic companies replacing imported products is gaining momentum, with leading firms expected to capture a larger market share [2][7] Company Recommendations - Companies to watch include Haoyuan Pharmaceutical, Baiao Saitou-H, Naimi Technology, Aopumai, Yaokang Biological, and Saifen Technology, which are likely to benefit from improved industry demand [4] - New business opportunities are emerging for Haoyuan Pharmaceutical and Baiao Saitou-H, particularly in ADC CDMO services [4][27] Segment Performance - The research service sector consists of 18 listed companies, with stable growth across various segments, including model animals, biological reagents, and chromatography materials [6][7] - Companies like Naimi Technology and Yaokang Biological are experiencing significant growth in their respective fields, driven by strong domestic and international demand [30][36]

Summary of the Conference Call for Sifang Technology Company Overview - **Company**: Sifang Technology - **Industry**: Industrial Purification and Chromatography Key Financial Metrics - **Revenue**: - Q3 2025 revenue reached 3.02 billion CNY, a year-on-year increase of 38.39% [3] - Industrial purification segment revenue was 1.208 billion CNY, up 68.08% year-on-year, accounting for 69% of total revenue [2][3] - Net profit attributable to shareholders was 93.21 million CNY, a 71.07% increase year-on-year [2][3] - **Gross Margin**: - Overall gross margin for Q3 2025 was 72.73% [3] Segment Performance - **Industrial Purification Segment**: - Antibody drugs accounted for 60.62% of revenue, with a total of 1.26 billion CNY [5] - GLP-1 insulin peptide segment revenue grew by 161.44%, contributing 35.41% of the segment [5] - Revenue from recombinant proteins decreased significantly [5] - **Commercialization Stage**: - Revenue from commercialized products was approximately 122.3 million CNY, contributing nearly 60% of purification business revenue [9] - Late-stage clinical and commercialization revenue accounted for about 77% of total industrial purification revenue [9] Project Pipeline and Development - **Project Count**: - As of September 30, 2025, the company had 1,126 projects, with 893 in R&D, 170 in clinical stages, and 60 in commercialization [2][6] - In Q3 2025, 75 new projects were added, with 57 in R&D, 14 in clinical, and 4 in commercialization [6] - **Future Expectations**: - Anticipation of significant orders from clinical phase III projects entering commercialization in 2026, including recombinant proteins and antibodies [4][11] Market Dynamics - **Pricing Trends**: - Domestic chromatography media prices are 40%-50% of imported prices, with expectations of further price reductions in 2026 [7] - The company maintains a gross margin of around 70% for chromatography media [7] - **Customer Demand**: - Increasing number of phase I and II clinical projects, with 137 projects cumulatively [10] - The company has established strong relationships with major clients in the blood products sector, including significant projects in clinical phases [21] International Expansion - **Overseas Market Growth**: - Revenue from overseas markets grew over 300% year-on-year [14] - Plans to establish a factory in Delaware, USA, to support expansion into the North American market [12][13][15] - **Market Strategy**: - Differentiated strategies for the US and "Belt and Road" countries, focusing on technology in the US and competitive pricing in other regions [14] Future Capacity and Revenue Potential - **Capacity Expansion**: - Plans for a 200,000-liter production capacity in Yangzhou and a 50,000-liter facility in the US, with potential annual revenue of approximately 30 billion CNY if fully utilized [23] - **Market Size**: - The global market for related products is estimated to be in the hundreds of billions of CNY, indicating significant growth potential [17] Conclusion - **Overall Outlook**: - The company is positioned for substantial growth with a robust project pipeline, strong market demand, and strategic international expansion plans. The focus on maintaining stable pricing and high-quality products will support long-term profitability and market leadership.

Group 1: Industry Overview - The pharmaceutical and biotechnology industry is entering a new upward cycle, with accelerated overseas orders and strong upward momentum, particularly for companies with strong overseas capabilities in the upstream biological sector [1] - The early-stage CRO (Contract Research Organization) industry is experiencing a significant development opportunity, driven by the historical chance for innovative drugs to expand internationally [1] Group 2: Early-stage CRO - The early-stage CRO industry is seeing a shift towards domestic advantages in quality, efficiency, and cost, as overseas demand for early-stage research increases [1] - The demand for preclinical and safety evaluation orders is gradually recovering, with a recommendation to focus on leading companies such as Yino Science and Zhaoyan New Drug [1] - The supply-demand mismatch for experimental monkeys is expected to persist, leading to stable prices in the short term [1] Group 3: Upstream Biological Products - The domestic biological sector is recovering quickly, with significant growth expected in biological reagents, including culture media and recombinant proteins, driven by the structural recovery from domestic innovative drug exports [2] - The overseas market presents vast opportunities, and domestic brands are favored for their cost-effectiveness, suggesting a focus on companies with overseas capabilities such as Baipusais and Haoyuan Pharmaceutical [2] Group 4: Clinical CRO - The clinical CRO sector is approaching a turning point, with SMO (Site Management Organization) orders showing early signs of recovery [3] - As innovative drug financing improves, the number of clinical projects is expected to increase, leading to a recovery in overall orders [3] - Leading clinical CRO companies such as Tigermed and Nossger are recommended for investment [3] Group 5: CDMO - The CDMO (Contract Development and Manufacturing Organization) sector is showing strong performance, particularly in the peptide and ADC (Antibody-Drug Conjugate) segments, which are expected to maintain high growth rates [4] - New molecular tracks, including small nucleic acids, also present significant long-term development potential [4] - Recommended CDMO leaders include Kelaiying and WuXi AppTec, which are expected to show performance elasticity due to stable small molecule business and rapid growth in new molecular business [4]

Investment Rating - The report maintains an investment rating of "Outperform the Market - A" for the life sciences upstream sector [6]. Core Insights - The life sciences upstream sector is experiencing simultaneous domestic substitution and accelerated international expansion, with significant room for improvement in the localization rates of research reagents, consumables, and high-end scientific instruments [1][22]. - The demand side is improving due to favorable trends in innovative drug development and supportive national policies, with domestic innovative drug companies' overseas business development (BD) transactions expected to exceed $100 billion in 2025, nearly doubling from 2024 [2][25]. - The supply side is also gradually improving, with domestic life sciences companies achieving technological breakthroughs and expanding their business pipelines through both organic growth and acquisitions [2][29]. - Key companies are showing signs of performance improvement, with notable growth in revenue and net profit for firms like Baipusais and Aopumai [2][34]. Summary by Sections 1. Life Sciences Upstream Overview - The life sciences upstream includes research reagents, experimental consumables, instruments, and comprehensive services, playing a crucial role in various applications such as antibody drugs and gene therapy [9][10]. 1.1 Domestic Substitution and International Expansion - The localization rates for research reagents are around 10%, with high-end scientific instruments having an import rate of approximately 70.6% [22][23]. 1.2 Demand Side Improvement - The innovative drug sector is witnessing a recovery, with significant increases in overseas BD transactions, indicating a robust demand for life sciences products [25][27]. 1.3 Supply Side Enhancements - Domestic companies are making technological advancements, with key players like Aopumai and Baipusais expanding their product lines and market presence through acquisitions and internal development [29][30]. 1.4 Company Performance Trends - Companies such as Baipusais and Aopumai have reported substantial improvements in their financial performance, with Baipusais showing a 31% year-on-year revenue growth and Aopumai achieving a remarkable 402% increase in net profit [34]. 2. Recommended Stocks - Suggested stocks to watch include Baipusais, Aopumai, Aladdin, and others in the research reagent and scientific instrument sectors [2].

Core Viewpoint - The report highlights the strong financial performance of Sepax Technologies, with significant revenue and profit growth driven by the increasing demand for chromatography materials in the biopharmaceutical sector [1][2]. Financial Performance - In the first three quarters of 2025, Sepax Technologies achieved a revenue of 302 million yuan, representing a year-on-year growth of 38.39% [1][2]. - The net profit attributable to shareholders reached 93.21 million yuan, reflecting a high growth rate of 71.07% compared to the previous year [1][2]. - In Q3 alone, the company reported an explosive growth with revenue and net profit increasing by 81.39% and 141.05% year-on-year, respectively [2]. Business Strategy - The company capitalized on the domestic substitution strategy by actively expanding its customer base and enhancing cooperation with existing clients, leading to further business growth [2][3]. - Sepax Technologies has invested 40.60 million yuan in R&D in the first three quarters of 2025, marking a 20.37% increase year-on-year, which strengthens its technological advantages [2]. Market Position and Global Strategy - The chromatography filler market, previously dominated by international giants, is experiencing a shift towards domestic alternatives, with Sepax Technologies transitioning from imitation to parallel competition and even local leadership [3]. - The company has established a global presence since 2002, with a focus on R&D and innovation in chromatography materials, and has set up a production base in the U.S. to support its dual-circulation strategy [3]. Industry Context - The biopharmaceutical sector in China is entering a commercialization phase, with many R&D projects expected to materialize in the next 3-5 years, creating a robust demand for chromatography materials [3][4]. - Sepax Technologies is positioned as a key player in the high-end biopharmaceutical materials sector, contributing to China's global competitiveness in this field [4].

Core Viewpoint - The company has achieved record-high gross margins, but short-term profits are impacted by foreign exchange losses and tax payments, maintaining a "Buy" rating [1] Group 1: Financial Performance - In the first three quarters of 2025, the company reported revenue of 1.933 billion yuan, a year-on-year increase of 2.2%, and a net profit attributable to shareholders of 652 million yuan, up 9.27% year-on-year [1] - In Q3 2025, the company achieved revenue of 686 million yuan, a year-on-year increase of 14.86% and a quarter-on-quarter increase of 2.29%; net profit attributable to shareholders was 207 million yuan, a year-on-year increase of 7.72% but a quarter-on-quarter decrease of 17.58% [1] - The comprehensive gross margin for Q3 2025 was 55.62%, an increase of 4.42 percentage points year-on-year and 3.96 percentage points quarter-on-quarter [2] Group 2: Business Segments - The life sciences segment saw a revenue increase of 11% year-on-year, while the metal resources segment grew by 30% year-on-year, and the water treatment segment increased by 9% year-on-year; the food processing sector experienced a significant growth of 50% year-on-year [2] - The company is focusing on high-margin businesses, with the polypeptide solid-phase synthesis carrier business continuing to show good growth [2] Group 3: Future Growth Prospects - The company plans to invest 1.15 billion yuan to build a high-end materials industrial park for life sciences, which is expected to support future growth [3] - The company is expanding its life sciences business domestically and establishing a global marketing and technical service network [3] - New product developments in the life sciences sector include antibody IND applications and various types of chromatography fillers, which are anticipated to become new growth points for the company [3]

Core Viewpoint - The current valuation of the pharmaceutical sector is at a low level, with public funds (excluding pharmaceutical funds) having low allocation to the sector. Considering the positive recovery of macroeconomic factors such as US Treasury rates and the driving effect of large categories and varieties on the industry, the growth of the pharmaceutical industry is expected to remain optimistic through 2025 [10]. Market Review - The CITIC Pharmaceutical Index rose by 0.56%, underperforming the CSI 300 Index by 2.69 percentage points, ranking 27th among CITIC's 30 primary industries [7]. - The top ten stocks by increase this week included Jianfa Zhixin, Te Yi Pharmaceutical, and Bi De Pharmaceutical, while the top ten stocks by decrease included Tuo Jing Life, Xin Nuo Wei, and Shu Tai Shen [7]. Overall View and Investment Themes - The pharmaceutical sector is expected to see a blooming of investment opportunities, particularly in innovative drugs, medical devices, and the innovative chain (CXO + life science services) [10]. - The innovative drug sector is transitioning from quantity logic to quality logic, emphasizing the importance of products that can ultimately generate profits [10]. - The medical device market is witnessing a recovery in bidding volumes, with a focus on home medical devices and orthopedic procurement [10]. - The innovative chain is expected to see a rebound in domestic financing, with a long-term trend towards high growth in the CXO sector [10]. - The pharmaceutical industry is anticipated to enter a new growth cycle, particularly in the specialty raw materials sector, which is currently at a near ten-year low in valuation [10]. Chromatography Industry Focus - Chromatography technology is crucial for the separation and analysis of components in various fields, especially in biopharmaceuticals, where it plays a key role throughout the drug development process [16][19]. - The global biopharmaceutical market is projected to grow from approximately $503 billion in 2023 to $892 billion by 2028, with a compound annual growth rate (CAGR) of 9.5%-12.5% [24]. - The Chinese biopharmaceutical market is also expanding rapidly, with a projected growth from ¥262.2 billion in 2018 to ¥534.8 billion in 2024, reflecting a CAGR of 12.61% [29]. Market Size and Growth - The global chromatography consumables market is expected to grow from $6.9 billion in 2023 to $9 billion by 2026, with a CAGR of 9.26% [37]. - The Chinese chromatography consumables market is projected to grow from ¥11.2 billion in 2023 to over ¥20.3 billion by 2026, with a CAGR of 21.92% [37]. - The global small molecule liquid chromatography market is expected to increase from $3.6 billion in 2021 to $7.7 billion by 2026, with a CAGR of 16.7% [30]. Domestic Industry Dynamics - Domestic chromatography companies are making significant strides in key areas such as chromatography media and industrial chromatography systems, accelerating the process of domestic substitution [44]. - The domestic chromatography media market is currently dominated by foreign companies, but advancements in domestic technology are enhancing competitiveness [44]. - The demand for chromatography products is driven by the need for cost-effective and reliable purification materials in biopharmaceutical production, where purification processes account for a significant portion of production costs [43].

Core Insights - The report from Zhejiang Securities indicates that the recovery of the upstream life sciences sector in the first half of the year is primarily driven by a stable improvement in the supply-demand balance, with expectations for further profit elasticity and rapid valuation digestion in the fourth quarter and next year [1][2] - The overseas demand recovery has been more pronounced compared to domestic demand, but there is a significant acceleration in domestic business growth for many companies, with improved accounts receivable turnover rates for reagents and consumables [1] - The firm is optimistic about the performance of upstream companies benefiting from a combination of commercial project expansion, accelerated domestic import substitution, and international market expansion [1] Industry Trends - Despite some stocks in the sector returning to their 2022-2023 valuation levels, there is still potential for upward movement based on the recovery of fundamentals and investment opportunities [2] - The industry is entering a new phase characterized by breakthroughs in biotechnology, local innovation, favorable liquidity conditions (with the Federal Reserve's interest rate cuts), and a recovery in the capital cycle, which is expected to enhance the valuation of the innovation chain [2] - The positive trends in the domestic new drug research and development environment, along with successful commercialization pathways, are anticipated to sustain the acceleration of demand for chromatography fillers, culture media, and synthetic reagents [1]

中证报中证网讯（王珞）在近期举行的新加坡ISPE制药会议及展览会（ISPE新加坡展会）上，东富龙 （300171）集中展示了包括生物技术模块化工厂模型、一次性耗材、色谱填料及RTP技术在内的多项前 沿技术与核心解决方案，成为全场焦点。 行业前沿方案国际展会引瞩目 东富龙在国际市场上备受关注的模块化工厂，正悄然改变传统药厂的建设模式。传统药厂建设周期长、 成本高，动辄需2到3年时间，而东富龙的模块化工厂通过"设备+工程"一体化集成，将投产周期压缩至6 个月。 展会期间，东富龙举办的两场Power Talk技术分享会精彩纷呈。东富龙生物技术方案专家Tony Xu分享 了智能生物反应器的一站式解决方案，展示了东富龙如何为生物制药不同阶段提供精准、高效的智能支 持。 凭借硬核的技术实力与系统化的整体解决方案，东富龙吸引了来自新加坡、马来西亚、越南、印尼、澳 大利亚等亚太地区的大量客户驻足深度交流，并引发了与会者的强烈兴趣。 东富龙在新加坡ISPE展会上的成功，是其深化全球化战略的一个缩影。此次参展不仅是东富龙创新成 果的展示，更是其夯实国际市场影响力的关键一步。 东富龙的全球化视野不仅体现在市场拓展上，还体现在其技术 ...