格隆汇1月9日丨百普赛斯(301080.SZ)在互动平台表示，公司已成功将AI技术应用于蛋白质的改造过程 中，通过结合AI计算和模拟的"干实验"与高通量的"湿实验"，同时引入基于力场的计算机虚拟筛选方 法，形成一套不断闭环迭代的优化流程，最终成功研发出具有特异性的蛋白质。 ...

新指南有哪些变化 作为背景，美国膳食指南自1980年首发，每5年更新一次。这些指南通常用于指导学校的校园餐、医院的病号餐，以及食品券可用来购买的 食品。事实上，该指南在过去40多年里鲜少做出重大改变。 然而，美国卫生部长小肯尼迪一直是这些指南的批评者，他认为这些指南"过时"且被"企业利益裹挟"。因此，在他的治下，这份指南迎来了 历史性的修改。 当地时间周三，美国卫生与公共服务部和美国农业部公布大幅修改后的联邦膳食指南，以展现特朗普政府（特别是卫生部长小肯尼迪）对 于"健康饮食"的理解。 总结来说， 新指南敦促人们更多在家做饭，避免高度加工食品。 该指南也对全脂乳制品、红肉给予支持态度， 并 显著上调蛋白质的建议 摄入量 ，同时建议人们 限制添加糖的摄入 ，减少饮用含糖饮料和能量饮料。 作为新指南背后的主要推手，美国卫生部长小肯尼迪在白宫简报会上说到："我给出的信息很明确： 吃真正的食物（eat real food） "。 在最新指南中，有关理想饮食的主视觉图换成了一个倒置的"食品金字塔"，取代过往的正金字塔和近年来餐盘状的可视化图。 （来源：美国膳食指南） 新指南的最大变化， 是 点名强调应避免超加工食品，并 ...

Core Insights - The article discusses the potential of carbon dioxide (CO2) as a resource for biomanufacturing, highlighting its transformation into biodegradable plastics and other organic materials [1][4][12] - The "14th Five-Year Plan" emphasizes the need for breakthroughs in key technologies across various sectors, including biomanufacturing, with CO2 conversion being a significant focus [1][4] Group 1: CO2 as a Resource - CO2 is not only a greenhouse gas but also a crucial raw material for biomanufacturing, participating actively in the global carbon cycle [4][10] - Through biotechnological processes, CO2 can be converted into starch, proteins, fuels, and biodegradable plastics, showcasing its versatility [4][10][11] Group 2: Advances in CO2 Conversion - Recent advancements include the artificial synthesis of starch from CO2 without relying on photosynthesis, achieving higher efficiency than traditional agricultural methods [10] - The development of new carbon fixation pathways, such as the CETCH and POAP cycles, marks a significant step towards efficient CO2 utilization [9][10] Group 3: Industrial Applications - The industrialization of microbial protein production from CO2 is gaining traction, with companies successfully converting CO2 into feed protein using gas fermentation technology [11] - Research is ongoing to create biodegradable plastics from seawater CO2, indicating a potential solution for marine acidification and sustainable material production [12] Group 4: Future Implications - The exploration of CO2 bioconversion mechanisms is recognized as a major scientific challenge, with implications for achieving carbon neutrality goals [12] - Innovations in this field are expected to reshape material production models and contribute to a more sustainable carbon cycle [12]

Core Viewpoint - The article discusses the potential of carbon dioxide (CO2) as a resource for biomanufacturing, highlighting advancements in converting CO2 into valuable products such as starch, proteins, and biodegradable plastics, which can contribute to sustainable development and carbon neutrality [10][11][12]. Group 1: CO2 as a Resource - CO2 is not only a greenhouse gas but also a crucial raw material for biomanufacturing, participating in the global carbon cycle and supporting the food chain [11][12]. - The international community is increasingly focusing on how to convert CO2 into useful resources, shifting from passive emission reduction to active utilization [11][12]. Group 2: Advances in CO2 Conversion - Researchers have made significant progress in developing new pathways for CO2 conversion, including the design of artificial carbon fixation pathways that outperform natural processes [13][14]. - The first artificial synthesis of starch from CO2, achieved by the Chinese Academy of Sciences, demonstrates a method that does not rely on photosynthesis, utilizing chemical catalysis and enzymatic reactions [15][16]. Group 3: Industrial Applications - Microbial proteins are emerging as a sustainable protein source, with companies successfully converting CO2 or industrial waste gases into microbial protein, thus not competing with food resources [16]. - The development of biodegradable plastics from CO2 captured from seawater showcases the potential for large-scale production and addresses marine acidification [17]. Group 4: Future Implications - The exploration of CO2 bioconversion mechanisms and the development of efficient carbon fixation systems are recognized as significant scientific challenges, with the potential to reshape material production and contribute to carbon neutrality goals [17][18].

Financial Data and Key Metrics Changes - Gross profit increased by $18 million, net income improved by $17 million, and adjusted EBITDA grew by $9 million compared to Q3 2024 [5][17] - Net sales were $241 million, which is $11 million lower than the prior year, reflecting fewer gallons sold (89 million in Q3 2025 compared to 97 million in Q3 2024) [13][17] - Consolidated net income was $13.9 million or $0.19 per share for Q3 2025, improving by $16.6 million compared to Q3 2024 [17] Business Line Data and Key Metrics Changes - In the marketing and distribution segment, gross profit was $23.5 million, an increase of $17.5 million compared to the prior year [13] - Essential ingredients return improved to 53% from 43%, reflecting a strong rebound in corn oil pricing and a shift in production mix [14] - Alto Carbonic contributed nearly $2 million this quarter, bringing the Western production segment's gross profit to $1.5 million, up $3.8 million over Q3 2024 [15] Market Data and Key Metrics Changes - The fuel ethanol export market and related pricing were stronger than the domestic market, leading to increased production and sales in the export market [10] - The newly signed California Assembly Bill 30 authorizing E15 fuel sales year-round in California is expected to unlock significant demand for domestically produced ethanol, potentially adding over 600 million additional gallons per year [10][11] Company Strategy and Development Direction - The company aims to lower its carbon intensity score to capture more benefits from Section 45Z tax regulations and increase CO2 utilization at its facilities [6][20] - The strategy includes prioritizing shorter-term projects based on cost, timing, and projected ROI to pave the way for incremental profitability [5][19] - The company is considering options for other liquid CO2 facilities due to rising demand, particularly in Oregon and neighboring states [9] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the ability to generate Section 45Z tax credits on ethanol production and highlighted the improved intrinsic value of facilities due to recent updates [8][20] - The company remains focused on improving operational efficiency and throughput while targeting growth in high-return market segments [19][20] - Management noted that the fundamentals around the Magic Valley facility have changed positively, allowing for a potential reassessment of its operations [33] Other Important Information - SG&A expenses improved by $1 million to $6.5 million due to right-sizing staffing levels and reduced costs related to the Eagle Alcohol acquisition [17] - The company generated $22.8 million in cash flow from operations during Q3 2025 [18] - The dock outage resulted in $800,000 in business interruption and additional logistical costs, with plans to build a second alcohol loadout dock to mitigate future interruptions [16] Q&A Session Summary Question: Initiatives to increase 45Z capture - Management is assessing low-investment options to improve 45Z capture but is reluctant to share specific details until more certainty is achieved [25][26] Question: Potential for Magic Valley to restart operations - Management is evaluating the highest and best use for the Magic Valley asset, considering the improved demand for CO2 and the potential for it to produce more than the Columbia plant [33][35] Question: Details on locked-in export sales - Management confirmed that they have locked in export volumes, which provides stability during seasonal lows in demand [38][41] Question: European exports and production limitations - The company is selling a combination of high-quality products and essential ingredients to Europe, with potential to pivot to selling more renewable fuel into that market [49][50] Question: Dock repair costs and insurance coverage - Management is working with their insurance carrier to determine coverage for the new dock and repairs to the original dock, with a focus on mitigating business interruption [58] Question: Future SG&A expectations - Management expects the benefits from cost-saving initiatives to continue, indicating that current SG&A levels are sustainable [61]

Core Insights - The Australian-Chinese Business Association, led by Li Zhifeng, is investing in the China-Australia International Technology Industrial Park in Hubei, aiming to attract more entrepreneurs back to their hometowns for business development [1][3]. Group 1: Project Overview - The China-Australia International Technology Industrial Park covers an area of 275 acres and focuses on five core industries: health and biomedicine, cultural tourism and venture capital, medical services, agricultural product processing and trade, and cross-border e-commerce and smart logistics [1][3]. - The project is part of Hubei's initiative to promote the return of local entrepreneurs and capital, marking a significant achievement in the "Chuchang Return to Hometown" campaign [3]. Group 2: Investment and Collaboration - Li Zhifeng's company, Zhuo Australia Group, has also signed a cooperation agreement with the China Agricultural Valley (Qujialing) Future Food Innovation Research Institute to focus on protein, peptide raw materials, and health products, with plans for production to begin next year [3][4]. - The strategic location of Hubei, with its comprehensive transportation network and efficient logistics through Huahu International Airport, is seen as a key advantage for businesses [4]. Group 3: Industry Potential - Hubei's health industry has surpassed a trillion yuan, and there is significant potential for collaboration with Australia, especially in areas like elderly care, health management, and smart medical devices due to Australia's aging population [4]. - Plans are underway to establish a "China-Australia Technology Headquarters" in Hubei, focusing on health, artificial intelligence, low-altitude economy, cultural tourism, and agriculture [4]. Group 4: Upcoming Events - The seventh Chuchang Conference will be held in Wuhan at the end of October, where over 1,000 member companies from the Australian-Chinese Business Association will explore new development opportunities and foster cooperation [4].

Core Insights - A breakthrough study by a research team from University College London has successfully demonstrated the chemical connection between RNA and amino acids under prebiotic conditions without enzymes, addressing a long-standing question in the origin of life research [4][5][6] Group 1: Research Findings - The study provides new insights into how proteins are synthesized, which is crucial for understanding the origin of life [5][6] - The research indicates that amino acids can spontaneously connect to RNA in early Earth environments, suggesting a possible pathway for the emergence of life [6][9] - The team utilized a milder method involving thioesters to activate amino acids, allowing for selective connections to RNA, which is essential for functional stability in early life forms [7][8] Group 2: Theoretical Implications - The findings merge the "RNA world" and "thioester world" theories, proposing that life may not have a single origin point but rather a collaborative evolution of metabolic and genetic systems [8][9] - This research narrows the gap between chemical evolution and biological evolution, providing a plausible chemical basis for the transition from non-living to living systems [9][10] Group 3: Future Directions - The research team aims to explore how RNA sequences preferentially bind to specific amino acids, which is vital for understanding the origins of genetic coding [10][11] - The implications of this study extend to potential applications in artificial life systems, in situ protein synthesis, and targeted drug delivery [10][11] - Continued exploration of the chemical microenvironment within cells may offer new strategies for disease prevention and treatment [10][11]

Core Insights - A breakthrough study by a research team from University College London successfully demonstrated the chemical connection between RNA and amino acids under enzyme-free conditions, addressing a long-standing question in the origin of life research [1][3][4] - The research integrates the "RNA world" and "thioester world" theories, suggesting that the origin of life may not have a single starting point but rather a collaborative evolution of metabolic and genetic systems through simple chemical reactions [6][8] Molecular Evolution - The study falls within the realm of molecular evolution, focusing on the self-assembly and functional evolution of biological macromolecules like RNA and proteins, as well as the formation of "primitive cells" [2][6] - The research highlights the importance of understanding how RNA connects with amino acids, which is crucial for comprehending the mechanisms of protein synthesis and the origin of life [3][4] Methodology and Findings - The research team utilized thioesters to activate amino acids, allowing them to connect with RNA in a controlled manner, which was previously unattainable with high-energy molecules that would decompose in water [4][5] - The findings suggest that these reactions likely occurred in early Earth's lakes or small pools rather than in the ocean, providing a more specific direction for scientists searching for the "cradle" of life [5][6] Implications for Future Research - The study opens avenues for further exploration into how RNA sequences preferentially bind to specific amino acids, which is essential for understanding the origin of the genetic code [7][8] - The research may also contribute to the development of artificial life systems, in situ protein synthesis, and targeted drug delivery, highlighting its potential applications in biotechnology and medicine [7][8] Broader Impact - The findings could bridge the gap between chemical evolution and biological evolution, offering a reasonable chemical basis for the transition from non-living chemical substances to living biological systems [6][8] - The research emphasizes the importance of the chemical microenvironment within cells, suggesting that imbalances may lead to molecular interactions abnormalities and metabolic disorders, which could inform new strategies for disease prevention [7][8]

Bio-Techne FY Conference Summary Company Overview - **Company**: Bio-Techne (NasdaqGS: TECH) - **Industry**: Life Science Tools Key Points Company Positioning and Growth Strategy - Bio-Techne is a leader in reagents for life science research, focusing on proteins, antibodies, and assays for diagnostics and therapeutics [4][6] - The company has invested heavily in automation of protein analytics, spatial biology, and cell therapy, which now account for approximately 45% of revenue, up from 30% pre-COVID [6][7] - 90% of Bio-Techne's business is recurring, primarily from consumables, which supports sustainable growth [7] Recent Financial Performance - The company reported a 3% growth in the most recent quarter, with notable performance in China (10% growth) and continued double-digit growth in large pharma [9][10] - Challenges included delays in shipping high-priced instruments due to geopolitical issues [9] Academic Market Exposure - Academic sales account for about 20% of total revenue, with U.S. academia contributing approximately 11-12% [13][14] - Despite funding constraints, consumables have remained flat, indicating resilience in the product portfolio [14][15] Market Dynamics in China - Positive sentiment in China suggests a gradual ramp-up in growth, with expectations of returning to double-digit growth in the long term [18][19] Biopharma Market Insights - Biopharma constitutes roughly 50% of revenue, with large pharma showing strong recovery and growth, while biotech funding has decreased significantly [20][21] - The uncertainty in biotech funding may impact future spending, but recent improvements in funding could signal a recovery [22] Cell Therapy Business - Bio-Techne is well-positioned in the cell therapy market, focusing on GMP proteins, with a significant increase in revenue from this segment [23][24] - The company has built a strong reputation for quality and has a competitive edge in the regen med space, which has greater market potential than CAR-T therapies [25][26] Core Reagents and Instrumentation - The core reagents business remains stable, with healthy competition in the antibody market [30][31] - The ProteinSimple platform has shown resilience, with growth driven by increased usage of consumables despite a downturn in new instrument placements [34][36] Spatial Biology and Competitive Position - Bio-Techne leads in spatial biology with RNAscope reagents and the new COMET instrument, which automates RNA and protein detection [39][41] - The company is positioned to capitalize on the growing demand for translational research tools [40] Strategic Divestiture - The recent divestiture of the Exosome Diagnostics business was driven by a misalignment with Bio-Techne's core capabilities and a lack of a clear path to profitability [43][45] Revenue Outlook and Market Conditions - The company anticipates low single-digit growth, managing costs and investments amid market uncertainties [47][50] - Optimism remains regarding recovery in key markets, with expectations that administrative-induced noise will settle down [51][53] Conclusion Bio-Techne is strategically positioned for growth in the life science tools industry, with a strong focus on automation, spatial biology, and cell therapy. Despite current market challenges, the company maintains a positive outlook for future performance driven by its recurring revenue model and innovative product offerings.

Core Viewpoint - The increasing prevalence of myopia among children is linked to factors such as screen exposure and insufficient outdoor activities, emphasizing the importance of nutrition during critical developmental periods for visual health [1] Group 1: Importance of Outdoor Activities and Nutrition - Children should engage in at least 2 hours of outdoor activities daily to prevent myopia [1] - Nutritional intake is crucial for preventing and improving visual impairments like amblyopia and myopia [1] Group 2: Key Nutritional Components for Eye Health - Protein is essential for visual development and should be sourced from lean meats, fish, dairy, and soy products [2] - Vitamin A is vital for normal growth of corneal and retinal cells, with sources including liver, carrots, and dark vegetables [3] - Vitamins C and E serve as antioxidants, protecting eye tissues from damage, found in citrus fruits, nuts, and leafy greens [4] - B vitamins support metabolic processes in the retina and cornea, primarily sourced from whole grains, meats, and dairy [5] - Calcium is necessary for maintaining the firmness of the eyeball, with dairy, legumes, and leafy greens as primary sources [6] - Trace elements like chromium, manganese, selenium, and zinc are crucial for visual function and development, found in seafood, nuts, and liver [7] Group 3: Dietary Recommendations for Eye Health - Lutein filters harmful blue light and is found in spinach, broccoli, and carrots [9] - DHA, an omega-3 fatty acid, enhances visual sensitivity and is best obtained from deep-sea fish [9] - A balanced diet is essential to prevent nutritional deficiencies that can lead to myopia, with recommendations for whole grains, fresh vegetables, and fruits [10]