Core Insights - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the transformation of scientific achievements and the development of the synthetic biology industry [2][13] - The conference aims to facilitate over 1000 connections between research institutions and startups, showcasing 100 innovative synthetic biology manufacturing technologies [2][10] Event Overview - The conference is organized by DT New Materials, with support from various academic and industry organizations, including Peking University and the China Society of Biotechnology [2][13] - Key themes include AI in biological manufacturing, green chemistry, new materials, future food, and agriculture [13] Featured Technology - Hydroxy Rosavin, a derivative of Rosavin, shows promise in anti-fatigue, anti-aging, anti-tumor, and anti-radiation applications, with a production yield of 2.5 g/L and a molar conversion rate of 78% [7][9] - The technology utilizes advanced enzyme screening and directed evolution to create a yeast cell factory for production [7][12] Intellectual Property - The project has several patents related to the production of Hydroxy Rosavin, including recombinant plasmids and gene-engineered strains [8] Collaboration Opportunities - The Hydroxy Rosavin project is supported by the Chongqing Natural Science Foundation and seeks investment from relevant enterprises to accelerate industrialization [9] Conference Activities - The conference will feature a "Technology Achievement Exhibition and Matching" session, inviting 100 innovative projects for display and industry connection [10][14] - Additional activities include a youth forum, high-level discussions, and a closed-door seminar on AI's role in biological manufacturing [13][14]

Core Viewpoint - The joint venture between Evonik (China) Investment Co., Ltd. and Shandong Blue Biological Technology Co., Ltd. has decided to dissolve and liquidate their joint venture, Evonik Blue Biotechnology (Shandong) Co., Ltd., due to unmet operational expectations and changing market conditions [2][3]. Summary by Sections Joint Venture Details - The total investment in the joint venture was 80 million RMB, focusing on GHS products, specifically probiotics for animal gut health [3]. - The joint venture was established on October 16, 2023, with the aim of developing solutions for livestock gut health and probiotic products [2]. Recent Developments - Just half a month prior to the dissolution announcement, the joint venture team presented the first registered feed Bacillus subtilis product in China, named Ecobiol® [4][5]. - This product is noted for its unique mechanism in enhancing poultry growth performance and gut health, effectively reducing pathogen infection risks and significantly improving feed conversion rates [5]. Financial Performance - Evonik's adjusted EBITDA for Q2 2025 was reported at 509 million euros, a 12% decrease compared to the same period last year [5]. - The company anticipates that if the global economy does not worsen, the adjusted EBITDA for the entire year of 2025 will reach the lower end of the forecast range (2 billion to 2.3 billion euros) [7]. - The cash conversion rate is expected to remain around 40%, with capital expenditures reduced by 100 million euros to approximately 750 million euros [7]. Upcoming Events - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI and bio-manufacturing, green chemicals, new materials, future food, and agriculture [9][11]. - The conference will include various forums and discussions aimed at exploring industrial advancements and opportunities in the bio-manufacturing sector [9][11].

Core Insights - The article highlights the strategic development and policy support for the synthetic biology manufacturing industry in the Beijing-Tianjin-Hebei region, emphasizing its collaborative advantages and global competitiveness potential [2][3]. Policy Support and Innovation Mechanisms - Significant policy support has been established, creating a collaborative innovation mechanism among the three regions [4]. - The regions have formed a gradient layout: R&D in Beijing, pilot testing in Tianjin, and industrialization in Hebei [3]. Regional Industrial Layout - Beijing serves as the innovation source, while Tianjin focuses on industrial transformation and manufacturing, particularly in the Binhai New Area, which is developing a "Biomanufacturing Valley" [5]. - Hebei is positioned for low-cost production and supporting industries, with a focus on self-sufficient industrial chains [6]. Financial and Research Support - A joint basic research cooperation project will be established by 2025, with individual project funding up to 600,000 yuan to support synthetic biology manufacturing [8]. - Beijing's action plan aims to accelerate innovation in synthetic biology, with a maximum support of 50 million yuan to cultivate three listed companies by 2026 [8]. Industry Growth Targets - Hebei's Shijiazhuang aims for the biomanufacturing industry revenue to exceed 150 billion yuan by 2025, focusing on gene synthesis and biobased materials [8]. - The industry scale in Yizhuang is expected to surpass 120 billion yuan by 2027, with policies supporting cutting-edge sectors [8]. Upcoming Events and Initiatives - The Fourth Synthetic Biology and Green Biomanufacturing Conference will be held from August 20-22, 2025, in Ningbo, focusing on AI and biomanufacturing, green chemistry, and new materials [17][19]. - The conference will feature various forums and discussions aimed at advancing the industry and showcasing technological achievements [17][19].

Core Viewpoint - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemistry, new materials, future food, and agriculture [1]. Group 1: Conference Overview - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies that will sustain the vitality of the bio-manufacturing sector [1]. - Various activities will be held concurrently, including a Youth Forum on Bio-Manufacturing, a high-level roundtable discussion, a closed-door seminar on the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book," and a showcase of synthetic biology achievements [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by several institutions, including Peking University Ningbo Institute of Ocean Medicine and Ningbo Enzyme Science Bioengineering Co., Ltd. [2]. - Supporting organizations include the Chinese Society of Biotechnology's Biobased Materials Committee, Zhejiang Synthetic Biology Industry Technology Alliance, and various other academic and research institutions [2]. Group 3: Conference Agenda - The agenda includes registration and sign-in on August 20, followed by a high-level roundtable discussion and a Youth Forum [5][9]. - The opening ceremony and macro forum on bio-manufacturing will take place on August 21, along with specialized forums on green chemistry and new materials, and AI's role in bio-manufacturing [6][19]. - The final day will feature discussions on future food and agriculture, along with a showcase of technological achievements in synthetic biology [28][29]. Group 4: Industry Insights - The conference will release the "China Synthetic Biology Industry Distribution Map (2025 Edition)," which includes a list of over 500 representative companies in the bio-manufacturing sector [31]. - The event will also highlight the achievements of various companies and research institutions in the field of bio-manufacturing, showcasing innovations and applications [31][34].

Core Viewpoint - Anhui Huaheng Biological Technology Co., Ltd. is planning to issue overseas shares (H shares) and list on the Hong Kong Stock Exchange to enhance its global development strategy and brand influence [2][3]. Group 1: Company Overview - Huaheng Biological was listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board on April 22, 2021, with a current market value of approximately 8.35 billion RMB [5]. - The company specializes in the research, production, and sales of bio-based products, focusing on synthetic biology technology [6]. Group 2: Product and Market Position - Huaheng Biological is a leading producer of amino acid products, ranking first globally in the production and sales of alanine and valine [7]. - The company is expanding its product line to include bio-based chemicals such as 1,3-propanediol, succinic acid, and L-malic acid, while also investing in related startups [7]. Group 3: Recent Developments - In June 2023, Huaheng Biological planned to raise no more than 1.689 billion RMB for the construction of production bases for bio-based succinic acid and bio-based apple acid, each with an annual capacity of 50,000 tons [7]. - The company has established partnerships with various institutions, including a joint laboratory with Donghua University to advance the development of bio-based chemical fiber technology [10]. Group 4: Industry Events - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, focusing on AI in bio-manufacturing and green chemistry [17][19]. - The conference will include discussions on the development trends of the bio-manufacturing industry and the role of AI in driving innovation [39].

Core Viewpoint - The Ministry of Industry and Information Technology of China has officially announced the "First Batch of Iconic Products in Biological Manufacturing," which includes 36 products, marking a significant step in technological innovation and industrial upgrading in the biological manufacturing sector [1][3]. Summary by Sections Iconic Products List - The list includes 36 companies such as: - Shoulang Biotechnology - Micro元合成 - KaiLaiYing - Qinhongdao Huaheng Biotechnology - Qilu Pharmaceutical - JinSai Pharmaceutical - And others [3][5]. Product Details - Each product listed has specific applications and innovations: - **Ethanol Clostridium Protein**: Produced from industrial waste gases, beneficial for animal feed [5]. - **Alotose**: A low-calorie sweetener produced through microbial fermentation, enhancing production efficiency [5]. - **Nakiol Injection**: A CAR-T cell therapy for treating acute lymphoblastic leukemia, showing improved safety and efficacy [5]. - **Vitamin B**: Produced via fermentation, offering higher efficiency compared to traditional extraction methods [7]. - **Recombinant Human Serum Albumin**: Produced using rice cell technology, meeting clinical needs effectively [9]. Industry Significance - The announcement reflects the government's strong emphasis on the development of the biological manufacturing industry, showcasing the potential for innovation and growth in this sector [1][3]. Upcoming Events - The "SynBioCon 2025" conference will be held from August 20-22, focusing on AI in biological manufacturing, green chemistry, and future food and agriculture [11][12].

Core Viewpoint - The article highlights the participation of Meikang in the SynBioCon 2025, focusing on its expertise in international new food ingredient compliance and safety assessment services [1][12]. Summary by Sections Service Overview - Meikang's International Regulatory Department specializes in compliance declaration and safety assessment for international new food ingredients, proficient in regulations from authorities like the FDA and EFSA, providing comprehensive services from raw material evaluation to declaration strategy formulation [5]. Advantages - **Bilingual Technical Team**: The team consists of professional food industry scientists who are bilingual, enabling on-site guidance and efficient communication with clients in China [7]. - **Rich North American Expert Resources**: Meikang has access to various experts in the U.S. for different product declarations, including toxicology experts with successful FDA GRAS and NDI application experience [8]. - **Full-Chain Service Capability**: The company offers a complete range of services including dossier writing, feasibility assessment, GMP system establishment, HACCP system establishment, toxicology laboratory collaboration, and communication with the FDA [10]. Customization and Cost Advantages - Services can be customized based on client capabilities and needs, allowing clients to choose between conducting literature searches themselves or outsourcing to Meikang, which provides time and cost advantages compared to overseas institutions [10]. Event Details - The SynBioCon 2025 will take place from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI and bio-manufacturing, green chemicals, new materials, future food, and agriculture [12]. - The event will include various activities such as a youth forum, high-level discussions, and a closed-door seminar on AI-enabled bio-manufacturing innovation [12][14].

Core Viewpoint - The article discusses the sustainable production of 1,4-butanediol (BDO) through engineered Escherichia coli, highlighting the potential for antibiotic-free fermentation methods and the optimization of metabolic pathways to enhance yield and efficiency [2][4][20]. Summary by Sections Introduction - 1,4-butanediol (BDO) is a significant non-natural chemical widely used in biodegradable plastics, with a substantial market potential. Traditional production relies on petrochemical methods, while biotechnological approaches face challenges such as low enzyme activity and high production costs [2][4]. Research Content - The study systematically optimized the E. coli chassis by integrating multiple copies of BDO synthesis genes, knocking out byproduct pathways, and engineering key enzymes to enhance metabolic flux. The introduction of a microaerobic fermentation strategy allowed for high BDO yields without antibiotics or inducers [4][5]. Metabolic Engineering Strategies - The research involved various strategies to improve BDO production, including: - Introducing external enzymes and optimizing gene expression to enhance BDO synthesis [7][11]. - Modifying the TCA cycle and enhancing ATP levels to redirect carbon flux towards BDO production [15][18]. - Utilizing the hok/sok system to maintain plasmid stability, achieving a low plasmid loss rate of 5.5% [18][19]. Production Results - In shake flask experiments, BDO production reached 7.88 g/L, the highest reported yield under similar conditions. In a 5-liter bioreactor, BDO production achieved 34.63 g/L with a glucose yield of 0.35 g/g and a production rate of 0.48 g/L/h [20][21]. Conclusion - The study demonstrates a comprehensive metabolic engineering approach for the sustainable industrial production of BDO from glucose, showcasing the potential for antibiotic-free processes and the need for further optimization to address byproduct accumulation [20][22].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemistry, new materials, future food, and agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1][2]. Group 1: Conference Overview - The conference will take place from August 20-22, 2025, at the Sheraton Hotel in Ningbo, Zhejiang [1]. - It will feature various activities including a youth forum, high-level discussions, and a closed-door seminar on the "2025 AI Empowering Biomanufacturing Industry Innovation Development Blue Book" [1][2]. Group 2: Organizing Institutions - The event is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by several academic and industry institutions, including Peking University Ningbo Institute of Ocean Medicine and Ningbo Enzyme Science Biotechnology Co., Ltd. [2]. Group 3: Agenda Highlights - Day 1 will include registration, a high-level discussion on biomanufacturing, and a youth forum focused on innovation [5][9]. - Day 2 will feature an opening ceremony, macro forums on biomanufacturing, and specialized discussions on green chemistry and new materials [6][12]. - Day 3 will focus on AI applications in biomanufacturing and future food and agriculture discussions [27][30]. Group 4: Key Publications - The conference will announce the "China Synthetic Biology Industry Distribution Map (2025 Edition)" which includes a list of over 500 representative companies in the biomanufacturing sector [33].

Core Viewpoint - The article discusses the development of humanized "4D" collagen protein based on natural collagen, aiming to address the immunogenicity and pathogenic risks associated with traditional animal-derived collagen [1]. Group 1: Research and Development - The research team led by Professor Li Shuang from South China University of Technology focuses on biomimetic "honeycomb" porous structures for molecular construction, optimizing collagen triple helix sequences through gene editing [1]. - The team combines computer simulation design with cross-scale self-assembly templates to achieve a synergistic optimization of high specific surface area, strong mechanical strength, and biological activity [1]. - Techniques such as transmission electron microscopy are utilized to analyze the hierarchical structure, and in vitro cell experiments validate the biocompatibility and regenerative efficacy of the developed materials [1]. Group 2: Industry Applications - The innovative collagen material is expected to provide new biological materials for regenerative medicine, promoting upgrades in industries such as medical aesthetics and bone repair [1]. - Professor Li Shuang will present a talk titled "Molecular Design of Humanized '4D' Collagen Protein" at the SynBioCon 2025 conference, which focuses on synthetic biology and green biological manufacturing [1][14]. Group 3: Conference Details - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biological manufacturing, as well as advancements in green chemistry, new materials, future food, and agriculture [14]. - The conference will feature various activities, including a youth forum on biological manufacturing, high-level discussions on the industry, and a closed-door seminar on the "2025 Artificial Intelligence Empowering Biological Manufacturing Industry Innovation Development Blue Book" [14][15].