Core Viewpoint - The bio-manufacturing industry is entering a new phase of accelerated development characterized by clear policies, specific support, and close integration with the real economy [7]. Policy Developments - The National Development and Reform Commission (NDRC) has emphasized the importance of bio-manufacturing as a key part of light industry upgrades, particularly in sectors such as plastic products, textiles, food and beverages, household chemicals, cosmetics, leather, and paper industries [6]. - The recent announcement from the Ministry of Industry and Information Technology highlights support for bio-based, biodegradable materials, and bio-manufacturing industries as part of the "Light Industry Growth Stabilization Work Plan (2025-2026)" [6]. Industry Transformation - Bio-technology is driving a systematic transformation of the light industry from a "resource-consuming" and "cost-competitive" model to a new paradigm focused on green, intelligent, and high-end development through raw material revolution, process innovation, functional upgrades, and supply chain security [6]. Economic Integration - The government is guiding localities to develop new growth engines such as artificial intelligence and bio-manufacturing, focusing on the integration of these technologies into traditional industries to enhance productivity and innovation [4].

Core Viewpoint - The article emphasizes the development of non-grain biomass resources for energy and bio-based materials, highlighting the upcoming NFUCon 2025 forum aimed at discussing commercialization paths, technological challenges, and opportunities in the biomass industry [2]. Group 1: Forum Overview - The NFUCon 2025 forum will be held from November 27-29, 2025, in Hangzhou, Zhejiang, organized by DT New Materials and the National Key Laboratory of Bio-based Transportation Fuels [2][3]. - The forum will gather industry representatives and experts to explore key areas such as biomass green pretreatment, non-grain sugars, bio-based chemicals and materials, and biomass energy [2][4]. Group 2: Forum Agenda - The forum will feature a series of specialized sessions, including: - Session 1: Biomass Green Pretreatment focusing on steam explosion technology and efficient pretreatment methods [6]. - Session 2: Non-grain sugars and their industrial applications [7]. - Session 3: Bio-based chemicals and their production processes [8]. - Session 4: Non-grain bio-based materials and their commercialization [8]. - The second theme of the forum will address biomass energy, including sessions on biomass methanol, fuel ethanol, biogas, and sustainable aviation fuel (SAF) [9]. Group 3: Supporting Activities - The forum will include a special activity for showcasing and connecting technological achievements, aiming to promote innovation and commercialization in the biomass sector [10]. - A total of 50 innovative projects in biomass utilization will be selected for display and networking opportunities during the forum [10]. Group 4: Industry Participation - The forum will attract various stakeholders, including: - Production companies involved in biomass energy and chemicals, cellulose materials, and green composite materials [14]. - Academic and research institutions focusing on biomass chemistry, advanced catalysis, and resource utilization [14]. - Equipment and solution providers for biomass processing and analysis [14].

Core Viewpoint - The article emphasizes the significant policy support for the bio-manufacturing industry in China, highlighting the government's initiatives to promote green, intelligent, and high-end transformations in the light industry sector, particularly focusing on bio-based and biodegradable materials [2][3]. Policy Developments - On September 18, the Ministry of Industry and Information Technology, along with other departments, released the "Light Industry Stabilization Growth Work Plan (2025-2026)", which aims to enhance the quality and efficiency of traditional light industries while supporting emerging fields like bio-manufacturing [2]. - The plan outlines strategies to stabilize growth through consumption, investment, and exports, addressing structural contradictions in supply and demand [2]. Key Initiatives - The plan sets a target to promote 300 upgraded and innovative products and cultivate 10 specialty industrial zones with a scale exceeding 100 billion yuan by 2026 [3]. - It emphasizes optimizing supply, expanding consumption, and enhancing industrial ecology, with specific measures to accelerate technological breakthroughs in bio-manufacturing [3]. Green Development Focus - The plan promotes the establishment of a strict green standard system covering energy consumption, water usage, and pollutant emissions, encouraging the development of green factories in the light industry [4]. - It aims to drive innovation in bio-based materials and biodegradable products, supporting the transition to a circular economy in packaging and other sectors [4]. Recent Government Actions - The Ministry of Industry and Information Technology has issued multiple documents this year to support bio-based and bio-manufacturing initiatives, including the announcement of a list of 36 bio-manufacturing landmark products [5][6]. - The government is also fostering the establishment of pilot platforms for bio-manufacturing to facilitate industrial scale-up by 2027 [6][7]. Industry Events - The article mentions the upcoming "Non-grain Biomass High-Value Utilization Forum" scheduled for November 27-29 in Hangzhou, focusing on non-grain bio-based chemicals and materials [10].

Core Viewpoint - The article discusses the comprehensive utilization of crop straw in Henan Province, emphasizing the establishment of a robust network for straw collection, storage, transportation, and utilization, aiming for a stable comprehensive utilization rate of over 93% by 2027 [2][3]. Summary by Sections Action Plan Overview - The Henan Provincial Government has issued an action plan for the comprehensive utilization of crop straw from 2025 to 2027, focusing on enhancing the resource value of straw [2]. Key Tasks - **Task 1**: Establish high-standard farmland areas for straw return, focusing on improving soil fertility in major grain-producing regions [3]. - **Task 2**: Develop a straw feed utilization industry, particularly in major cattle-raising cities like Luoyang and Nanyang [3]. - **Task 3**: Build a comprehensive network for straw collection, storage, transportation, and utilization, ensuring land use for storage facilities [3]. Industry Alliance and Innovation - **Task 4**: Form a straw comprehensive utilization industry alliance, collaborating with universities and research institutions to create an information platform for straw utilization [4]. - **Task 5**: Explore new pathways for high-value transformation of straw, including the production of edible fungi substrates and green methanol, while enhancing agricultural machinery for straw utilization [4]. Policy Support - **Task 6**: Increase policy support for straw utilization projects, encouraging financial institutions to innovate credit products and reduce guarantee fees for small enterprises [4].

Core Viewpoint - The article emphasizes the development of non-grain biomass resources for energy and bio-based materials, highlighting the upcoming NFUCon 2025 forum aimed at discussing commercialization paths, technological challenges, and opportunities in the industry [2]. Group 1: Forum Overview - The NFUCon 2025 will be held from November 27-29, 2025, in Hangzhou, Zhejiang, organized by DT New Materials and the National Key Laboratory of Bio-based Transportation Fuels [2][3]. - The forum will gather industry representatives and experts to explore key areas such as green pretreatment of biomass, non-grain sugars, bio-based chemicals and materials, and biomass energy [2][3]. Group 2: Forum Agenda - The forum will feature two main thematic discussions: - The first theme focuses on non-grain bio-based chemicals and materials, including sessions on biomass green pretreatment, non-grain sugars, and bio-based chemicals [6][9]. - The second theme addresses non-grain biomass energy, covering topics like biomass methanol, fuel ethanol, biogas, and sustainable aviation fuel (SAF) [9][10]. Group 3: Special Activities - A special activity titled "Technology Achievement Display and Docking" will be held to promote the development and large-scale application of non-grain biomass industries, showcasing 50 innovative projects with commercial potential [9][10]. Group 4: Participating Entities - The forum will attract a diverse range of participants, including biomass energy and chemical development companies, academic institutions, and solution providers in biomass processing technologies [14].

Core Viewpoint - The article emphasizes the significance of green bio-manufacturing as a sustainable development frontier, predicting that by the end of this century, bio-manufactured products could cover 70% of chemical manufacturing products, with bio-manufacturing potentially accounting for one-third of global manufacturing by 2050, creating an economic value of $30 trillion [4][5]. Group 1: Green Bio-Manufacturing Potential - The current scale of the bio-manufacturing industry is less than $8 trillion, indicating substantial growth potential in the future [4]. - The third generation of bio-manufacturing, which utilizes carbon dioxide as a raw material, is expected to significantly contribute to carbon neutrality efforts [5]. Group 2: Key Challenges and Innovations - Major scientific challenges include efficiently capturing and activating inert carbon dioxide molecules, requiring the design of new enzyme catalysts and light-enzyme coupling systems [5]. - Engineering challenges involve scaling up efficient but fragile biological systems to create stable, continuous, and low-cost reactors, transitioning from laboratory to industrial scale [5]. Group 3: Interdisciplinary Collaboration - Achieving deep integration across disciplines such as biology, chemistry, materials science, and information technology requires the establishment of project communities, shared platforms, and talent communities [6]. - Educational reforms are necessary to cultivate interdisciplinary talent capable of leading the next industrial revolution, including curriculum changes and new evaluation methods [6]. Group 4: China's Position in Global Green Technology - China is transitioning from a "follower" to a "leader" in the global green technology race, with advantages in applied research, industrialization, and market scale [7]. - The proposed international cooperation model emphasizes open collaboration in basic research, innovation alliances in key technology areas, and self-reliance in core competitive fields [7].

Core Points - The "2025 (5th) Non-Grain Biomass High-Value Utilization Forum (NFUCon 2025)" will be held from November 27-29, 2025, in Hangzhou, Zhejiang, focusing on the theme "Top-notch Intelligence, Industrial Symbiosis" [1][8] - The forum aims to gather representatives from various industries to discuss key areas such as biomass green pretreatment, non-grain sugars, biomass-based chemicals and materials, and biomass energy, contributing to the achievement of carbon neutrality goals [8] Group 1: Event Details - NFUCon 2025 is co-hosted by DT New Materials and the National Key Laboratory of Bio-based Transportation Fuel Technology [1][9] - The forum will feature a series of specialized sessions on topics including biomass green pretreatment, non-grain sugars, and sustainable aviation fuel (SAF) [10] Group 2: Key Personnel - Li Zhenglong, a distinguished professor at Zhejiang University and a national-level high-level talent, serves as one of the conference chairs [5][9] - The National Key Laboratory of Bio-based Transportation Fuel Technology, established in April 2023, focuses on the development of bio-liquid energy applications and the comprehensive utilization of biomass materials [6][9] Group 3: Laboratory Overview - The laboratory has 158 fixed members and aims to become a significant international innovation hub in the field of bio-based transportation fuels [6] - Key tasks include advancing fiber ethanol technology and promoting the industrialization of fiber ethanol, as well as enhancing the quality of by-product utilization [6]

Core Viewpoint - The article discusses the advancements in the production of 1,3-propanediol (1,3-PDO) using engineered strains of Klebsiella pneumoniae, highlighting significant improvements in yield and efficiency through metabolic engineering and strain evolution [2][20][23]. Summary by Sections 1. Production Methodology - 1,3-PDO is a high-value fine chemical used in cosmetics, pharmaceuticals, and plastics, traditionally produced through chemical synthesis, which involves toxic substances and high pressure. Microbial fermentation has emerged as a more economical and environmentally friendly production method [2]. - The research team led by Professor Liu Liming achieved a production yield of 138.6 g/L of 1,3-PDO using the engineered strain FMME-51, with a conversion rate of 0.52 g/g, without the need for additional VB12 [2][20]. 2. Strain Optimization - Initial strain FMME-01 produced 67.2 g/L of 1,3-PDO but generated multiple by-products that reduced yield. Subsequent modifications led to strain FMME-14, which showed improved production performance [6]. - Further optimization of the cell membrane composition in strain FMME-38 resulted in a 62.5% increase in tolerance to high 1,3-PDO concentrations and a 41.2% reduction in cell death [9][10]. 3. Enhancements in Co-Factor Synthesis - The production process relies on VB12 and NADH. The integration of genes responsible for VB12 synthesis into the genome of strain FMME-48 resulted in a VB12 concentration of 50.8 μg/L and a 1,3-PDO yield of 118.3 g/L [14]. - The dynamic regulation of NADH levels was achieved through the construction of a biosensor-based system, enhancing the NADH/NAD⁺ ratio by 31.3% in strain FMME-51, leading to a 12.3% increase in 1,3-PDO yield [18][14]. 4. Process Optimization - The optimization of glycerol feeding rates and pH levels significantly improved the production performance of strain FMME-51, achieving a 1,3-PDO yield of 135.9 g/L at a pH of 6.8 [19]. - The final optimized strain FMME-51 demonstrated a production capacity of 122.7 g/L of 1,3-PDO using low-cost crude glycerol as a substrate, showcasing its industrial potential [20][23]. 5. Industrial Implications - The research indicates a significant advancement in the bioproduction of 1,3-PDO, achieving unprecedented yields and efficiencies while eliminating the need for expensive co-factors, thus reducing production costs [20][23]. - The ability of engineered strain FMME-51 to efficiently utilize crude glycerol highlights its potential for large-scale industrial applications in the production of high-value chemicals [23].

Core Viewpoint - The article emphasizes the development of non-grain biomass resources for energy and bio-based materials, highlighting the upcoming NFUCon 2025 forum aimed at discussing commercialization paths and technological advancements in this sector [2]. Group 1: Forum Overview - The NFUCon 2025 will be held from November 27-29, 2025, in Hangzhou, Zhejiang, organized by DT New Materials and the National Key Laboratory of Bio-based Transportation Fuels [2][3]. - The forum will gather industry representatives and experts to explore key areas such as green pretreatment of biomass, non-grain sugars, bio-based chemicals and materials, and biomass energy [2][4]. Group 2: Forum Agenda - The forum will feature a series of specialized sessions, including: - Session 1: Green pretreatment technologies and equipment [6]. - Session 2: Development and industrialization of non-grain sugars [10]. - Session 3: Bio-based chemicals and their applications [10]. - Session 4: Non-grain bio-based materials [10]. - Session 5: Biomass energy, including methanol, fuel ethanol, and biogas [10]. Group 3: Supporting Organizations - The forum is supported by various institutions, including Zhejiang University and several key laboratories focused on bio-based materials and chemical engineering [3][4]. - It aims to facilitate collaboration among production enterprises, research institutions, and solution providers in the biomass sector [14]. Group 4: Special Activities - A special activity will be held for showcasing and connecting innovative projects in the biomass utilization field, with a goal to select and display 50 commercially viable innovations [9].

Core Viewpoint - Hefei High-tech Zone aims to become a significant hub for the synthetic biology industry, focusing on innovation in four key areas: biomaterials, biomedicine, bio-agriculture, and bio-foods [2][3]. Group 1: Development Plan - The "Implementation Plan for Synthetic Biology Industry Development" was officially released, emphasizing the importance of resource aggregation and promoting high-end, green development in the industry [2]. - A special fund of no less than 3 billion yuan will be established to support the industrialization of major achievements, alongside collaboration with financial institutions to innovate financial products [2]. Group 2: Industry Foundation - The synthetic biology industry in Hefei High-tech Zone has established a solid foundation, featuring a dual-driven model of "enterprises + platforms" [2]. - Over 30 core enterprises have been cultivated, including Anke Bio, Zhifei Longkema, and Zhaoke Pharmaceutical, covering critical areas such as antibody drugs and new vaccines [2]. Group 3: Future Goals - By 2027, the plan aims to nurture more than 10 enterprises with a production value exceeding 100 million yuan, at least 3 enterprises with over 500 million yuan, and 1 enterprise surpassing 1 billion yuan [3]. - The goal is to gather no less than 50 enterprises in the synthetic biology industry chain, with a total production value exceeding 10 billion yuan [3].