Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the "14th Five-Year Plan" period, discussing innovative technologies and products that can sustain the industry's vitality [1]. Group 2: Organizers and Highlights - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Key highlights include forums on biomanufacturing trends, youth innovation sharing, project roadshows, and participation from leading enterprises, top universities, and investment institutions [4]. Group 3: Agenda and Special Activities - The first day features a closed-door high-level seminar focusing on biomanufacturing development trends and growth points, inviting 30 industry leaders and experts [7]. - The second and third days will include a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. Group 4: Focus Areas in Sub-Forums - Sub-forum topics include the development of bio-based chemicals, green manufacturing technologies for fine chemicals, and the use of non-food raw materials for high-value product development [11]. - AI applications in biomanufacturing will also be discussed, including the use of AI for enzyme discovery and industrial fermentation process control [11].

Core Viewpoint - Vitamin A is essential for human health, supporting vision, immune regulation, and serving as a key ingredient in anti-aging cosmetics. Traditional chemical synthesis methods for Vitamin A are complex and costly, leading to a shift towards green biomanufacturing using synthetic biology techniques [1][6]. Group 1: Research Findings - A recent study by Zhejiang University has engineered yeast to enhance Vitamin A production by modifying transporter systems, energy metabolism, and precursor supply networks, achieving unprecedented yields [1][6]. - The hydrophobic nature of Vitamin A leads to accumulation within cells, increasing metabolic burden and affecting synthesis efficiency. Approximately 17-20% of retinol remains unextracted during high-density fermentation, limiting production [2]. - The research team introduced transporter engineering strategies, identifying key transport proteins that facilitate the synthesis and secretion of retinol, retinal, and retinoic acid [2]. Group 2: Engineering Strategies - The team optimized the yeast's energy metabolism by overexpressing FZO1 and MGM1 to enhance mitochondrial fusion and introducing Vgb to improve oxygen uptake, thereby increasing ATP levels and energy supply [3]. - A multi-faceted engineering approach, combining transporter engineering, energy metabolism enhancement, and precursor supply optimization, led to significant breakthroughs in yeast strains for Vitamin A production [3][4]. Group 3: Production Results - Post-engineering, the yeast strain achieved a retinal yield of 638.12 mg/L with an extracellular ratio of 98.7%, and a retinoic acid yield of 106.75 mg/L, both representing the highest reported shake flask yields to date [4]. - The engineered yeast strain produced 727.30 mg/L of retinol with a carbon conversion rate of 7.62% using 20 g/L glucose, surpassing previous best strains [4]. Group 4: Implications for Industry - This research provides new insights for the efficient biomanufacturing of Vitamin A and serves as a reference for the green production of other high-value lipophilic products [6]. - As synthetic biology technologies advance, microbial cell factories are expected to play a crucial role in future biomanufacturing, contributing to human health and sustainable development [6].

Core Viewpoint - The article highlights the recognition of Professor Xue Chuang from Dalian University of Technology for his significant contributions to bio-manufacturing in the energy and chemical sectors, particularly through the "Min Enze Energy and Chemical Award" [1][5]. Group 1: Award and Recognition - The "Min Enze Energy and Chemical Award" was established in April 2013 by Min Enze, a prominent figure in green chemistry, to honor outstanding researchers in the energy and chemical fields [5]. - This year's award ceremony recognized 12 exceptional scientists, with only 4 receiving the "Outstanding Contribution Award" nationwide [1]. Group 2: Professor Xue Chuang's Contributions - Professor Xue has made notable advancements in the design and construction of industrial strains such as artificial organelles, yeast, and clostridia, focusing on bio-based products like ethanol and butanol [3]. - He developed a self-assembling protein cage artificial organelle that significantly increased the yield of compounds like lycopene [3]. - His work includes optimizing and enhancing the composition and yield of cellulase-producing strains, as well as developing integrated fermentation technologies for bio-manufacturing [3]. Group 3: Future Events and Trends - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and bio-manufacturing, as well as applications in green chemistry, new materials, future food, agriculture, and cosmetics [6]. - The conference aims to explore the development trends in the bio-manufacturing industry and promote the transfer and commercialization of scientific achievements [6].

特色专场 生物制造青年论坛 8月20日，浙江·宁波 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 SynBioCon 大会 | 生物制造青年论坛 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

DT产业研究院 | 宜可生物 创始人 文 | 陈竞芬 "有关环保的事，我们要第一个先做, 还必须做到最好。Ecopha=Eco+ Alpha=Eco+ PHA。 " 眼前这位头发微白却目光如炬的科学家，二十年间辗转新加坡、马来西亚、澳大利亚，如今回到中 国，创立 宜可生物 ，只为攻克一个难题： 把PHA的成本降到能与石油基材料竞争 。 他将如何做到大幅降低成本？ 近日， DT新材料产业研究院行业分析师陈竞芬 对 宜可生物创始人林理坪博士 进行了独家专访， 他不仅分享了其在海外科研和创业，以及回国创业的初心，更分享了宜可生物将如何降低PHA成 本，为行业提供极具价值的专业洞见。此前，DT新材料第一时间报道了宜可生物的成立。 全球第一家专利！又一企业布局 PHA 生物塑料！ 左：宜可生物创始人 林理坪（Wilson Ling）博士，右：DT新材料行业分析师 陈竞芬 "限塑令"后，PLA、PBAT等可降解材料曾短暂炙手可热，随即陷入产能过剩（2024年PBAT开工率 不足20%）。更深层的问题是性能瓶颈：PLA/PBAT因耐热性差（60-70℃）、降解依赖工业堆肥， 难替代传统石油基塑料，如全球用量最大的塑料PP、 ...

超级智能体驱动AI蛋白设计闭环 在科学研究和产品研发中，AI生成的设计只有通过真实实验验证，才能完成"从想法到发现"的完整闭环。此次平台上线的干湿迭代案例，详细展示了从AI生 成初步设计方案，到实验团队落地执行，再到依据实验反馈进行AI重设计的全过程。整个过程紧密协同，展现出平台强大的任务管理、数据追踪与反馈联动 能力。通过该案例，用户可以清晰理解如何利用科学超智能体进行快速原型验证与多轮优化，也可以参考该流程创建自己的个性化迭代任务。干湿实验的高 效融合，将极大加速科学研究从构想到验证的全过程。 底层技术&AI | 途深智合 【SynBioCon】 获 悉， 6月20日，途深智合自主研发的蛋白质设计平台正式升级为 ProteinNova （www.proteinnova.com） ； 并 上线AI AGENT驱动 的蛋白设计全流程功能 。 途深与镁伽科技、迪赢生物两家产业链企业打通了AI蛋白设计的干实验、 高通量 基因合成和自动化湿实验流程，实现 AI-Driven Closed-Loop Protein Design. 关于途深智合 途深智合致力于通过超智能加速科学突破与产品创新。公司打造了多模态大模型、 ...

Core Viewpoint - The article emphasizes the rapid development and potential of the synthetic biology sector, driven by technological breakthroughs, supportive policies, and increased investment, aiming for the establishment of over 20 pilot platforms for biomanufacturing by 2027 [1][2][12]. Group 1: Policy and Industry Collaboration - The Ministry of Industry and Information Technology and the National Development and Reform Commission have initiated a plan to cultivate biomanufacturing pilot platforms, targeting the establishment of over 20 by 2027 to facilitate industrial scaling [1][2]. - There is a notable synergy between policy and industry, with advancements in biomanufacturing technologies and significant investments from companies like Kasei Biotech and Jinbo Biotech, indicating a robust ecosystem for growth [2][12]. Group 2: Technological Advancements - Synthetic biology is reshaping production models, enabling more efficient and environmentally friendly biomanufacturing processes through breakthroughs in gene editing, enzyme engineering, and metabolic engineering [3][4]. - The CRISPR-Cas9 technology has revolutionized gene editing, making complex genetic operations simpler and more cost-effective, thus laying the groundwork for the synthetic biology industry's expansion [4][15]. Group 3: Company Innovations and Applications - Kasei Biotech focuses on developing bio-based materials, with products that significantly reduce carbon emissions by over 50% compared to traditional petroleum-based counterparts [5][9]. - Fubon Technology has established a comprehensive innovation system in the bio-agriculture sector, developing competitive products that enhance crop nutrient absorption and promote sustainable agricultural practices [5][8]. Group 4: Challenges and Solutions - The transition from laboratory innovations to industrial production is critical, with companies like Huaxi Biotech investing heavily in pilot transformation platforms to enhance China's biomanufacturing competitiveness [7][15]. - Companies face dual technical bottlenecks in synthetic biology, including challenges in microbial cell factory construction and downstream fermentation purification processes [15]. Group 5: Future Trends and Market Dynamics - The synthetic biology sector is expected to experience accelerated technological iterations and expanded application scenarios over the next 3-5 years, driven by AI integration and a focus on quality improvement [14][11]. - The industry is moving towards a more rational investment landscape, with a shift from chasing scale to recognizing the importance of technological capabilities and product validation [14][13].

SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

Project Overview - The project is named "Jinan Baijie High-Performance New Enzyme Preparation R&D and Industrialization Construction Project" [2] - The construction unit is Jinan Baijie Biological Engineering Co., Ltd., located in the Shanghe Chemical Industry Park, Jinan, covering an area of 70,067.81 m² (approximately 105.1 acres) [2] Investment and Construction Details - The total investment for the project is 775.49 million yuan, with phase one investment at 562.24 million yuan and phase two at 213.25 million yuan [3] - Environmental investment for phase one is 41.59 million yuan (7.39% of total investment), and for phase two is 6.21 million yuan (2.91% of total investment), all funded by the company [3] - The construction period for both phases is 21 months each [4] Production Capacity and Facilities - The project includes the construction of a fermentation workshop with a total of 12 fermentation tanks (6 in each phase), and two extraction and blending workshops [4] - The total production capacity for high-performance new enzyme preparations will be 45,000 tons per annum (t/a), with each phase contributing 22,500 t/a [4] Existing Product Situation - The northern fermentation workshop has been out of production for several years, while the southern workshop is operational [6] - The northern workshop has an annual production capacity of 1,500 tons for α-galactosidase, while the southern workshop has capacities of 5,200 t/a for liquid single enzyme products, 3,000 t/a for liquid proteases, and 8,000 t/a for liquid glucose oxidase and liquid fat enzymes, totaling 17,700 t/a for the entire plant [7] Company Background - Jinan Baijie Biological Engineering Co., Ltd. was formerly known as Jinan Nuoneng Biological Engineering Co., Ltd. and is a wholly-owned subsidiary of Kingsoft Bio-Technology (HK01548), established in 2009 [9] - The company specializes in the R&D, production, and sales of biological enzyme preparations, focusing on feed and industrial enzyme preparations, with core products including glucose oxidase, phytase, and compound enzymes [10]

Core Viewpoint - Lignin valorization is crucial for achieving economically viable and sustainable lignocellulosic biorefineries, with a focus on overcoming the challenges posed by expensive cofactors and enzyme activity imbalance [1][3][14] Group 1: Lignin Valorization Challenges - The continuous demand for expensive cofactors like ATP, NADPH, and CoA significantly hinders the sustainable conversion of lignin into valuable products [1] - The production rates of valuable molecules derived from lignin, such as raspberry ketone (RK) and curcumin, are extremely low, highlighting the inefficiencies in current conversion processes [1][3] Group 2: iMECS Strategy Development - The iMECS (in vitro multi-enzyme coordinated expression with cofactor self-circulation) strategy integrates cofactor regeneration and cell-free expression into the lignin upgrading process [3][4] - The iMECS platform demonstrated a 48-fold increase in overall catalytic efficiency without the addition of external cofactors, achieving a curcumin production rate of 0.175 g/L/h and a molar yield of 95.31% [3][6] Group 3: Multi-Enzyme Optimization - The study optimized the production of curcumin by establishing a biocatalytic module and introducing an in situ multi-cofactor recovery module, resulting in a curcumin yield of 126.4 mg/L [5][6] - The iMECS system achieved a curcumin production rate that was over 1455% higher than traditional whole-cell bioconversion methods [6] Group 4: Application to Vanillin Synthesis - The iMECS system was further evaluated for the conversion of ferulic acid to vanillin, achieving a vanillin yield of 94.4 mg/L with a 67% reduction in ATP demand [7][8] - The system's efficiency was enhanced by employing a temperature-guided biocatalytic process, which maintained enzyme activity while inactivating undesirable endogenous enzymes [9] Group 5: RK Biosynthesis - The iMECS strategy was applied to the more complex pathway of converting p-coumaric acid (pCA) to RK, achieving a production rate of 0.15 g/L/h and a conversion rate of 91.56% [10][13] - The integration of upstream and downstream modules within the iMECS system demonstrated significant potential for synthesizing more complex products from lignin-derived substrates [12][13] Group 6: Environmental and Economic Implications - The iMECS strategy promotes the use of lignin-rich agricultural waste as a feedstock, decoupling biomanufacturing from sugar prices and reducing greenhouse gas emissions compared to traditional petroleum-based synthesis [14]