Core Viewpoint - The article discusses the construction project of a collagen production line by Shandong Furida Biotechnology Co., Ltd., highlighting its investment, production capacity, and timeline for completion [2]. Summary by Sections Project Progress - Shandong Furida Biotechnology Co., Ltd. is expanding its collagen production line, located in Linyi City, Shandong Province, with a total investment of 12 million yuan, including 500,000 yuan for environmental protection [2]. - The project will utilize existing facilities and is expected to produce 200 kg of collagen annually upon completion in June 2025 [2]. Existing Project Status - The company has several ongoing projects, including: - Sodium hyaluronate project with an annual output of 50 tons [4]. - Various fermentation projects with different production capacities, including: - Recombinant Type II collagen: 115.2 kg/a - Recombinant Type XVII collagen: 64 kg/a - Recombinant Type III transmembrane collagen: 20.8 kg/a - The total annual production capacity for collagen will reach 200 kg [3][4]. Industry Events - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang Province, focusing on AI and bio-manufacturing, green chemicals, new materials, future food, and agriculture [8][9].

扫码参会报名 SynBioCon 2 025 8月20-22日，浙江·宁波 01 组织机构 SynBioCon 2025 第四届合成生物与绿色生物制造大会 8月20-22日 浙 江 ·宁波东港喜来登酒店 8月20-22日 将于 浙江·宁波 举办 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 。本届大会聚焦 "1+3"：AI+生物制造、绿色化工 与新材料、未来食品、未来农业四大方向 ，邀请行业领先企业、代表性产业化专家、政府、园区、资本、协会和联盟等各方共探"十五五"生物制造产业发 展趋势；AI赋能生物制造产业创新；哪些革新技术和产品将给生物制造产业带来持续的生命力；并致力于促进科技成果转移转化、产品规模化与人才挖掘。 大会将同期举办 生物制造青年论坛 、 生物制造产业高层座谈会（第三期） 、 《2025人工智能赋能生物制造产业创新发展蓝皮书》闭门研讨会 、 合成 生物科技成果展示与对接 等活动 。 主办单位 宁波德泰中研信息科技有限公司（DT新材料） 协办单位 北京大学宁波海洋药物研究院 宁波酶赛生物工程有限公司 支持单位 中国生物工程学会生物基材料专业委员会 浙江省合成生物产 ...

Core Viewpoint - The SynBioCon 2025 conference aims to facilitate the transformation of scientific achievements into industrial applications, focusing on synthetic biology and green manufacturing [2][17]. Group 1: Conference Overview - The fourth Synthetic Biology and Green Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang [2][17]. - The event is organized by DT New Materials and supported by various academic and industrial organizations, emphasizing the development of industry ecosystems and technology transfer [2][17]. - The conference will feature over 100 innovative synthetic biology manufacturing achievements, promoting efficient technology transfer within the industry [2]. Group 2: Featured Projects - A project from Chongqing University focuses on a bio-manufacturing platform for bio-based materials, addressing the shortage of key monomers like hexamethylenediamine, succinic acid, and butanediol in China [7][8]. - The project utilizes advanced metabolic engineering to create a bacterial cell factory capable of producing 1,4-succinic acid with a yield of approximately 145.9 g/L and a sugar-to-acid conversion rate of 0.97 g/g, showcasing world-leading production efficiency [8][9]. Group 3: Technical Advantages - The 1,4-succinic acid production process benefits from optimized bacterial strains, shorter reaction times, lower temperatures, and cost-effective technical routes, leading to higher yields and lower costs [9]. - The 1,4-butanediol production process leverages Pichia pastoris, which is genetically stable and efficient in expressing foreign proteins, with a cost-effective acidic fermentation process [10]. Group 4: Intellectual Property and Collaboration - The project holds patents for the recombinant plasmids and engineered strains used in the production of succinic acid and hexamethylenediamine, indicating a strong intellectual property position [11]. - Collaboration with companies such as Yantai Wanhua Chemical and Guangdong Kingfa Technology is established, inviting further partnerships for technology transfer [13].

Core Viewpoint - The article highlights the approval of the "Regulations on Promoting the Development of Synthetic Biology Manufacturing Industry in Changde City," marking a significant step in the local government's efforts to foster the synthetic biology sector and establish a national-level industrial cluster [2]. Group 1: Legislative Developments - The Changde City government has prioritized the development of the synthetic biology manufacturing industry, creating a multi-faceted industrial landscape across various regions such as Jinshi City, Anxiang County, and Changde Economic Development Zone [2]. - The "Regulations" represent the first local legislation in the synthetic biology manufacturing field in China, consisting of 19 articles covering objectives, scope, government responsibilities, innovation platform construction, and more [2]. Group 2: Upcoming Events - The 4th Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on the intersection of AI and bio-manufacturing, as well as advancements in green chemicals, new materials, future food, and agriculture [4][5]. - The conference will feature various activities, including a youth forum, high-level discussions, and a closed-door seminar on the "2025 Blue Book for AI-Enabled Bio-Manufacturing Industry Innovation Development" [5].

Core Viewpoint - The article highlights the advancements in synthetic biology for the production of functional lipids, showcasing the innovative research led by Professor Huang He from Nanjing Normal University and the Jiangsu Provincial Synthetic Biology Research Center [2][10][14]. Group 1: Importance of Synthetic Biology - Synthetic biology is described as a field that reprograms life, utilizing engineering methods and gene editing to transform microorganisms into efficient production "factories" for useful compounds [11][12]. - The integration of synthetic biology with clean technology offers innovative solutions to global challenges, especially with the advent of CRISPR and other gene editing tools [12]. Group 2: Role of Artificial Intelligence - Artificial intelligence (AI) is crucial in the development of synthetic biology, enabling systematic programming of biological components and significantly reducing the development time of microbial "factories" from years to months [13]. - The combination of machine learning and CRISPR technology optimizes microbial metabolic pathways, revolutionizing industrial biotechnology [13]. Group 3: Focus on Functional Lipids - The shift in dietary patterns, with a decrease in carbohydrate consumption and an increase in fat intake, underscores the importance of lipid metabolism in health and disease, prompting a focus on functional lipids, particularly unsaturated fatty acids [11]. - Traditional extraction methods for functional lipids from fish are limited by high costs and lengthy supply chains, leading to research on engineered lipid production for cost reduction and sustainable practices [11]. Group 4: Achievements and Innovations - The research team has successfully constructed a cell factory using synthetic biology methods, achieving over a twofold increase in fatty acid yield and reducing research and development time significantly [11]. - A high-throughput screening platform was developed, increasing efficiency by over ten times, reducing extraction time from three days to three hours, and cutting costs by 80% [11]. Group 5: Future Plans - Future research will explore the synthesis of functional lipids from purified components, aiming to combine various beneficial ingredients for health management [11]. - The goal includes designing formulations that integrate functional components, such as carotenoids for vision enhancement and other ingredients for brain health [11]. Group 6: Unique Advantages of the Research Center - The Jiangsu Provincial Synthetic Biology Research Center, established in 2023, focuses on industrial biological manufacturing, bridging basic science and applied research [12][14]. - The center promotes interdisciplinary exploration and engineering solutions, providing early-career researchers with autonomy and reducing administrative barriers to collaboration [12]. Group 7: Collaboration and Impact - The center collaborates with major enterprises like the National Development Investment Corporation to connect market demands with scientific breakthroughs and result transformations [14]. - The recent feature in the prestigious journal Nature highlights Professor Huang He's international academic influence in the field [14].

主办单位 宁波德泰中研信息科技有限公司（DT新材料） 协办单位 SynBioCon 2025 第四届合成生物与绿色生物制造大会 8月20-22日 浙 江 ·宁波东港喜来登酒店 8月20-22日 将于 浙江·宁波 举办 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 。本届大会聚焦 "1+3"：AI+生物制造、绿色化工 与新材料、未来食品、未来农业四大方向 ，邀请行业领先企业、代表性产业化专家、政府、园区、资本、协会和联盟等各方共探"十五五"生物制造产业 发展趋势；AI赋能生物制造产业创新；哪些革新技术和产品将给生物制造产业带来持续的生命力；并致力于促进科技成果转移转化、产品规模化与人才挖 掘。 大会将同期举办 生物制造青年论坛 、 生物制造产业高层座谈会（第三期） 、 《2025人工智能赋能生物制造产业创新发展蓝皮书》闭门研讨会 、 合成 生物科技成果展示与对接 等活动 。 扫码参会报名 SynBioCon 2 025 8月20-22日，浙江·宁波 01 组织机构 北京大学宁波海洋药物研究院 宁波酶赛生物工程有限公司 支持单位 中国生物工程学会生物基材料专业委员会 浙江省合成生物 ...

Core Insights - The article discusses the innovative use of synthetic biology to produce sandalwood essential oil sustainably, addressing the scarcity and high cost of natural sandalwood resources [2][3][15] Group 1: Research Breakthroughs - The research team developed a P450 enzyme peroxisome surface display technology, overcoming catalytic bottlenecks and achieving a record production yield of 10.4 g/L of sandalwood alcohol [3][5] - Initial attempts to synthesize sandalwood alcohol resulted in low yields, prompting the team to optimize the supply of acetyl-CoA and reducing power by targeting key enzymes to peroxisomes [5][10] - The innovative strategy of displaying P450 enzymes on the peroxisome surface significantly improved the proximity of the enzyme to the substrate, increasing sandalwood alcohol yield to 1.3 g/L and conversion rate to 36.2% [7][10] Group 2: Production Optimization - The team induced the proliferation of peroxisomes in engineered yeast, which increased the number of "factories" for storing acetyl-CoA and expanded the membrane surface area for enzyme anchoring, leading to a 42.6% increase in sandalwood alcohol yield and a conversion rate of 60.6% [10][12] - The optimized strain was scaled up in a 5L fermentation tank, achieving a record yield of 13.1 g/L of sandalwood olefin and 10.4 g/L of sandalwood alcohol, with a conversion rate of 44.2% [12][14] - The cost of producing sandalwood essential oil using this method is projected to be under $100 per kilogram, significantly lower than the market price of $2500 per kilogram [12][15] Group 3: Implications and Future Prospects - The research demonstrates the potential of peroxisome engineering in synthesizing high-value natural products, particularly those involving complex terpenes catalyzed by P450 enzymes [14][15] - The significant reduction in production costs for sandalwood essential oil could transform the traditional supply chain reliant on scarce plant resources, contributing to the conservation of endangered sandalwood species [15]

Core Insights - The article highlights the recent progress of Heilongjiang Xinhecheng in launching multiple fermentation projects, indicating a strategic expansion in biobased energy and materials production [2][3][4]. Group 1: Project Developments - Heilongjiang Xinhecheng is undertaking two major fermentation projects, including the A9, A10, and functional fermentation products project, which aims to establish a production capacity of 5,000 tons/year for A10, 6,000 tons/year for A9, and smaller capacities for other products [3]. - The A18, A20, and isocyanic acid project will utilize existing facilities to produce 1,000 tons/year of A18, 10,000 tons/year of isocyanic acid, and 3,000 tons/year of A20, with an estimated investment of 83.16 million yuan [4]. Group 2: Financial Performance - Heilongjiang Xinhecheng reported impressive financial results, with revenues reaching 21.6 billion yuan and a net profit of 5.869 billion yuan, showcasing significant growth in its operations [5]. Group 3: Industry Events - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, focusing on synthetic biology and green manufacturing, highlighting the industry's trends and opportunities [9][10][11].

Core Viewpoint - DSM-Firmenich, a major player in the chemical industry, has shown significant financial growth in the first half of 2025, with total sales reaching €6.51 billion (approximately ¥53.64 billion), a year-on-year increase of 3% [2]. Group 1: Financial Performance - The adjusted EBITDA for DSM-Firmenich was €1.26 billion, reflecting a 29% increase year-on-year, with the EBITDA margin rising from 15.5% to 19.4% [2]. - The net profit surged from €50 million in the same period last year to €541 million, marking an almost tenfold increase [2]. Group 2: Business Segments - The Animal Nutrition and Health segment reported sales of €1.751 billion, a 14% increase year-on-year, with adjusted EBITDA soaring by 293% due to improved core business and temporary vitamin price effects [3]. - The Fragrance and Beauty segment saw sales of €1.989 billion, a slight decline of 1%, impacted by weak demand for sun care products and customer inventory destocking [3]. - The Taste, Texture, and Health (TTH) segment achieved sales of €1.686 billion, a 3% increase year-on-year [3]. - The Health, Nutrition, and Care (HNC) segment reported sales of €1.072 billion, down 2%, but organic sales grew by 6% [3]. Group 3: Strategic Developments - DSM has undergone significant transformations since its founding in 1902, evolving from a coal mining company to a leader in specialty chemicals and nutrition [4][5]. - The merger with Firmenich in May 2023 has positioned DSM-Firmenich as a global leader in flavor and fragrance manufacturing and the largest vitamin producer [5]. - The company has strategically divested from capital-intensive sectors to focus on high-margin specialty chemicals and nutrition, aligning with market trends [5]. Group 4: Competitor Landscape - Competitors like Wanhua Chemical and New Hope Liuhe are also expanding their nutrition and flavor businesses, indicating a competitive landscape in the sector [6][7]. - New Hope Liuhe reported a record revenue of ¥21.609 billion in 2024, with a 42.95% year-on-year growth, highlighting the robust performance of its nutrition segment [6].

Core Insights - The article emphasizes the importance of strains as the "chip" of biomass refining, highlighting their role in the new bio-manufacturing industry chain and green low-carbon bio-economy [2] - It discusses the challenges faced by strain cells in bio-manufacturing, such as the accumulation of intermediate metabolites and the inhibition of toxic products, which lead to low reaction efficiency and product concentration [2] - The article outlines key research areas, including the construction of strain cell factories and the enhancement of product synthesis processes [2] Research and Development - The research led by Professor Xue Chuang from Dalian University of Technology focuses on creating artificial organelles using multi-enzyme self-assembled protein cages, which enhance the tunability of organelles through chemical and light induction [2] - A rapid strain construction method called "multi-gun-multi-target" has been developed, revealing new mechanisms for the multidimensional cooperative regulation of strains [2] - The team has also prepared carbon nanotube array composite membranes and developed reaction separation coupling technology, providing breakthroughs in enhancing bio-synthesis of bioenergy-based products [2] Conference Participation - Professor Xue Chuang will present at the SynBioCon 2025 conference, focusing on "Cell Factory Design and Product Synthesis Enhancement" [3] - The conference will take place from August 20-22, 2025, in Ningbo, Zhejiang, and will cover topics related to AI and bio-manufacturing, green chemicals, new materials, future food, and agriculture [14][15]