Core Viewpoint - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on industrial ecological development and the transfer of scientific achievements [1][10]. Group 1: Conference Overview - SynBioCon 2025 is organized by DT New Materials and supported by various organizations, aiming to facilitate over 1,000 connections between research institutions and startup projects [1]. - The conference will feature a special event showcasing 100 innovative achievements in synthetic biology manufacturing, promoting efficient technology transfer [1][9]. Group 2: Featured Project - The project "Synthesis of Selenium Protein from Microalgae" aims to address the issue of selenium deficiency in the Chinese population by using edible microalgae as a source of selenium protein [6]. - The research team has successfully transferred human selenium protein into the edible microalgae Chlorella vulgaris and has significantly increased the yield through optimized cultivation parameters [7]. Group 3: Technical Advantages - Chlorella vulgaris is recognized as a safe and reliable food source, approved by the National Health Commission, and can be cultivated through both photosynthesis and industrial fermentation [7]. - The project is currently in the pilot production stage after successful small-scale trials [7]. Group 4: Intellectual Property and Collaboration - The project is in the process of patent application, with potential collaboration modes including joint development, technology transfer, or intellectual property transfer [8]. Group 5: Industry Focus - The conference will explore the trends in the bio-manufacturing industry, focusing on AI and biological manufacturing, green chemicals, new materials, future food, future agriculture, and beauty raw materials [10].

Core Viewpoint - The era of producing high-value products from CO₂ in the air has arrived, marking significant industrial advancements in the biomanufacturing conversion of carbon-rich gases [1][2]. Group 1: Industrial Challenges and Innovations - The Ministry of Agriculture and Rural Affairs of China has officially approved the use of Debaryomyces hansenii protein as a new feed raw material, representing the first product certificate with independent intellectual property rights derived from CO₂ as the main carbon source [2][4]. - This approval signifies a critical step in the industrial application of this technology, transitioning from laboratory research to practical use [2][4]. - The gas fermentation technology developed by GTLB utilizes inorganic carbon sources (CO₂, CO) to convert them into organic products, overcoming significant industrial challenges [4][6]. Group 2: Production Efficiency and Nutritional Value - The feed protein produced using this gas fermentation technology can achieve production efficiency thousands of times higher than traditional agricultural methods [7]. - A yeast protein factory occupying 150 acres can produce 100,000 tons of high-quality yeast protein annually, equivalent to the output of approximately 600,000 acres of soybean protein [8]. - Yeast protein is recognized for its high and evenly distributed essential amino acid content, rich in trace elements and polysaccharides, making it a safe and high-quality protein source [9]. Group 3: Addressing Resource Shortages - China faces a severe shortage of feed protein resources, with an estimated total consumption of 70 million tons in 2024 and an import dependency exceeding 80%, posing a significant threat to national food security [11]. - The innovative technology aligns with national strategies to develop synthetic biology technologies and explore "artificial protein" as a new food source, aiming to reduce reliance on traditional protein sources like soybean and fishmeal [12]. - The approval of Debaryomyces hansenii protein as a single feed raw material will help create a more sustainable and resource-efficient protein feed supply chain, significantly reducing dependence on land-intensive crops and marine resources [12].

Core Insights - The "14th Five-Year Plan" has concluded, and the "15th Five-Year Plan" is being formulated, highlighting a clear and distinct evolution in China's strategic layout in the field of biomanufacturing [1] Group 1: Development Goals - The "15th Five-Year Plan" is a critical period for the comprehensive rise of China's biomanufacturing industry, with a key goal of achieving an added value of over 4 trillion yuan in advanced biomanufacturing and related services, and a biomanufacturing penetration rate exceeding 8% [3] Group 2: Industry Structure - The plan aims to establish three major systems: innovation, industry, and management services, accelerating the development of a "7+1" biomanufacturing industry system, which includes biopharmaceuticals, bio-based chemicals and materials, bioenergy, fermentation, bioengineering food, animal feed, biotechnology equipment, and bio-services [4] Group 3: Future Opportunities - The upcoming SynBioCon 2025 conference will focus on the intersection of AI and biomanufacturing, exploring trends in green chemicals, new materials, future food, future agriculture, and beauty raw materials, while inviting international leading companies and experts to discuss innovative technologies and products that will sustain the vitality of the biomanufacturing industry [14]

Core Viewpoint - Zhejiang Province is accelerating the innovation and development of the synthetic biology industry, aiming for a total industry scale of 150 billion by 2027, with core enterprises achieving a production value of 20 billion [1][2]. Group 1: Industry Development Plan - The "Implementation Plan for Accelerating the Innovation and Development of the Synthetic Biology Industry in Zhejiang Province" outlines six major development directions, eleven regional industrial layouts, key tasks for nine universities and research institutes, and ten core technology breakthroughs [1][2]. - The plan aims to establish an internationally influential synthetic biology industry innovation development hub in Zhejiang [1]. Group 2: Alliance Formation - The Zhejiang Synthetic Biology Industry Technology Alliance, guided by the Zhejiang Provincial Department of Economy and Information Technology, is a non-profit organization initiated by Zhejiang University Hangzhou International Innovation Center, aiming to promote technological innovation and industry cultivation [2]. - The alliance will leverage the advantages of Zhejiang University in talent cultivation, technological innovation, and high-level platforms to support the synthetic biology industry [2]. Group 3: Research and Development Facilities - The Zhejiang University Hangzhou International Innovation Center has established the Bio and Molecular Manufacturing Research Institute and the iBioFoundry, the largest and most integrated automated high-throughput scientific device in the field globally [4]. - This facility enables full-process automation from sample intelligent access to product detection and is now open as a shared research platform for teams and enterprises [4]. Group 4: Upcoming Conference - The 2025 Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, as well as four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials [6][8]. - The conference aims to explore the development trends of the bio-manufacturing industry and promote the transfer and transformation of scientific and technological achievements [6].

【SynBioCon】 获 悉 ，近期， 浙江工业大学郑裕国院士团队柳志强教授课题组 采用模块化途径工程、酶筛选、sRNA 引导的瓶颈识别、微调关键代谢节点、辅因子工程和发酵优化等系统代谢工程策略，开发了一种无质粒、无营养缺陷的 OAH高产菌株OAH37，将OAH发酵产量增产至 94.1 g/L ，创目前报道最高纪录，为OAH的绿色生物制造奠定了坚实基 础。 图1 OAH的代谢途径及其增产策略示意图 主要研究内容及其关键技术突破： 1. 「L-高丝氨酸+MetX」双模块加强，促进OAH初步积累 团队以前期构建的L-高丝氨酸生产菌株HSY6为底盘，通过质粒引入MetX确定该底盘具备OAH合成能力，产量为5.29 g/L。随后，回补了L-赖氨酸和甲硫氨酸途径，以减少菌株的营养缺陷；进一步整合天冬氨酸转氨酶（ aspB cg ）、谷氨 酸合酶（ gltAB bs ）和天冬氨酸激酶（ lysC pa ），以增强L-高丝氨酸模块的代谢通量。通过异源MetX的筛选，发现来 源于海洋环状菌（ Cyclobacterium marinum ）的 metX cm 整合至假基因位点可将产量提升至8.30 g/L，相较于初始菌 株 ...

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing during the 14th Five-Year Plan, exploring new products, technologies, and collaborations [4]. - There will be over 100 financing project roadshows to discover new cooperation opportunities [4]. - Key industry leaders, top universities, and capital from industrial parks will gather to discuss advancements in the biomanufacturing sector [4]. Group 4: Agenda and Special Activities - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [7]. - The second and third days will feature a macro forum on biomanufacturing, covering the development trends and progress of policies related to the industry [10]. Group 5: Specialized Forums - The conference will host specialized forums on various topics, including green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. - Each forum will address specific themes such as the development of bio-based chemicals, green manufacturing technologies, and the application of AI in biomanufacturing processes [11].

Core Viewpoint - The article highlights the recent developments of Inner Mongolia Ruifen Biotechnology Co., Ltd., including the establishment of a new production base for functional sugar alcohols, which signifies a technological breakthrough in the field of functional sweeteners [1][2]. Company Overview - Ruifen Biotechnology, founded in 2007, is a national high-tech enterprise focused on the research and production of natural health food ingredients. The company aims to provide innovative and convenient solutions for the food, beverage, and nutritional supplement industries, emphasizing health, natural ingredients, and high technology [5]. Project Details - The new project involves an investment of 300 million yuan to build a production base with an annual capacity of 30,000 tons of functional sugar alcohols. The project includes the construction of various facilities such as a comprehensive building, R&D center, warehouses, workshops, and energy supply systems [2]. - A cooperation agreement was signed on April 26 between Hohhot Economic and Technological Development Zone and Ruifen Biotechnology for a project with a total investment of approximately 400 million yuan, which will be developed in two phases. The first phase will cover 120 acres and is scheduled to start construction in June 2023, with completion expected by November 2025 and production commencing in March 2026 [4]. Technological Advancements - Ruifen Biotechnology has become the third company in China to obtain approval for D-allohexose-3-epimerase, marking a significant technological advancement in the legal production of allohexose. The company has achieved self-controlled enzyme catalysis technology, which is a critical aspect of its production process [2].

Core Viewpoint - Shougang Longze Technology Co., Ltd. has delayed its global offering and listing plan, returning application funds, originally scheduled for July 9 on the Hong Kong Stock Exchange [1][2]. Company Overview - Shougang Longze focuses on the carbon capture, utilization, and storage (CCUS) industry, producing low-carbon products such as ethanol and microbial protein, and providing comprehensive low-carbon solutions [4]. - The company’s ethanol can be used as fuel and as a raw material for various products, while its microbial protein is the first novel feed protein raw material in China [4]. Financial Performance - In the previous year, Shougang Longze reported revenue of 560 million RMB, a year-on-year decline of 4.9%, with a net loss attributable to shareholders of 140 million RMB, an increase of 1.1 times [6]. - Financial projections indicate a revenue increase to 592.6 million RMB in 2023, followed by a slight decrease to 563.6 million RMB in 2024 [7]. Fund Utilization Plan - The company plans to allocate approximately 37.9% of the net proceeds for the construction and development of SAF production facilities in Baotou, Inner Mongolia, 21.2% for the second phase facility in Hebei, and 11.4% for research and development of strains, production equipment, and smart production management systems [8].

Core Viewpoint - The "15th Five-Year Plan" marks a critical period for the comprehensive rise of China's biomanufacturing industry, aiming for an added value of over 4 trillion yuan and a penetration rate exceeding 8% [3]. Group 1: Strategic Goals - The key objective during the "15th Five-Year Plan" is to achieve an added value of over 4 trillion yuan in advanced biomanufacturing and related services, with a target penetration rate of over 8% [3]. - The industry is expected to transition towards mid-to-high-end development [3]. Group 2: Development Framework - The plan emphasizes the establishment of three major systems: innovation, industry, and management services [4]. - A "7+1" biomanufacturing industry system will be accelerated, which includes biopharmaceuticals, bio-based chemicals and materials, bioenergy, fermentation, bioengineering food, animal feed, biotechnology equipment, and bio-services [4]. Group 3: Industry Events - The 2025 SynBioCon will be held in Ningbo, Zhejiang, focusing on the intersection of AI and biomanufacturing, along with four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials [14]. - The conference aims to explore the development trends of the biomanufacturing industry during the "15th Five-Year Plan" and identify innovative technologies and products that will sustain the industry's vitality [14].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizers and Highlights - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Key highlights include forums on biomanufacturing trends, youth innovation sharing, project roadshows, and participation from leading enterprises, top universities, and investment institutions [4]. Group 3: Agenda and Special Activities - The first day features a closed-door high-level seminar focusing on the development trends and growth points of biomanufacturing, with 30 industry leaders and experts invited [7]. - The second and third days will include a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. Group 4: Focus Areas in Sub-forums - Sub-forum topics include the development of bio-based chemicals, green manufacturing technologies for fine chemicals, and the use of non-food raw materials for high-value product development [11]. - AI applications in biomanufacturing will also be discussed, including enzyme discovery and industrial fermentation process control [11].