Core Insights - The article highlights the successful completion of a Pre-A round financing of several million RMB by ZhiNuo Technology, a rising player in the synthetic biology field, which will enhance its production capacity, pipeline expansion, team growth, and commercialization efforts [2][3]. Company Overview - ZhiNuo Technology, established in 2020, is a national high-tech enterprise focused on synthetic biology technology, headquartered in Beijing, with R&D centers and production bases in Suzhou and Dongying, Shandong [3]. - The core team comprises interdisciplinary talents from top institutions like Oxford University and Peking University, led by Dr. Zhu Tianze, who has over a decade of experience in saccharochemistry and metabolic flow optimization [3]. Key Technological Highlights - Precision design of metabolic pathways: The company has built a microbial library covering model and non-model strains, combined with high-throughput screening and AI data analysis, which is expected to release an additional 70% efficiency potential [6]. - Rapid industrialization capability: The transition from laboratory trials to 60-ton fermentation production can be achieved in just 3-6 months, significantly shortening the cycle compared to traditional chemical processes [6]. - Multi-domain pipeline layout: ZhiNuo Technology has developed product lines worth billions to tens of billions, focusing on areas such as human milk oligosaccharides (HMOs), microbial pigments, and food-grade functional ingredients, covering industries like dyeing, daily chemicals, human health, and modern agriculture [6].

Core Insights - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemicals, new materials, future food, and agriculture [2][30] - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [2][30] Organizational Structure - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by various academic and industry institutions, including Peking University Ningbo Institute of Ocean Medicine and the Zhejiang Synthetic Biology Industry Technology Alliance [3][4] Conference Agenda - The agenda includes a series of forums and discussions, such as the Bio-Manufacturing Industry Leaders Forum and the closed-door seminar for the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [7][19] - Key topics will cover AI applications in bio-manufacturing, green chemistry, and new materials, with specific sessions dedicated to future food and agriculture innovations [9][25] Notable Participants - The conference will feature industry leaders and experts from various organizations, including universities and biotech companies, who will present their research and innovations in synthetic biology and bio-manufacturing [10][11][12] Special Activities - Concurrent activities will include a youth forum on bio-manufacturing, technology showcases, and networking opportunities for industry professionals [2][19]

Core Insights - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemicals, new materials, future food, and agriculture [2][3]. Group 1: Conference Overview - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [2]. - Various activities will be held concurrently, including a Youth Forum on Bio-Manufacturing, a high-level roundtable discussion, and a closed-door seminar on the "2025 Blue Book for AI Empowering Bio-Manufacturing Innovation" [2][3]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by several academic and industry institutions, including Peking University Ningbo Institute of Ocean Medicine and the Zhejiang Synthetic Biology Industry Technology Alliance [3][4]. Group 3: Agenda Highlights - The agenda includes a macro forum on the bio-manufacturing industry, thematic forums on green chemicals and new materials, and AI empowerment in bio-manufacturing [7][9]. - Specific sessions will cover topics such as the application of enzyme molecular engineering, the design of cell factories, and the production of bio-based materials [11][19]. Group 4: Industry Participation - Numerous industry leaders and representatives from over 20 companies will participate in the high-level roundtable discussion, including notable firms like Ningbo Enzyme Science Bioengineering Co., Ltd. and Beijing University Ningbo Institute of Ocean Medicine [10]. - The conference will also feature a showcase of synthetic biology innovations and technology transfer opportunities [2][23]. Group 5: Future Developments - The conference will announce the "China Synthetic Biology Industry Distribution Map (2025 Edition)" and the list of 500+ representative enterprises in the bio-manufacturing sector [34][35].

Core Viewpoint - Lifebio has recently completed a multi-billion B2 round financing led by the listed company Xin Fengming, with participation from GGV Capital and several existing shareholders [2][3]. Group 1: Company Overview - Lifebio is a leading global company in bio-based aromatic materials, having developed a unique "biomass-glucose-HMF-FDCA" process over more than a decade, which allows for the production of furan-based bio-materials without relying on food-sourced fructose [3][10]. - The company has established the world's first FDCA production line with a capacity of 1,000 tons and has initiated the construction of a 10,000-ton production line in Tongling, Anhui, in September 2024 [10][11]. Group 2: Investment and Partnerships - Xin Fengming, the lead investor in the recent financing round, is a major player in the polyester industry, with over 15% of global polyester filament capacity [4][7]. - GGV Capital, another significant investor, is a top-tier venture capital firm with over $9 billion in assets under management and a history of investing in over 500 companies, including Alibaba and Airbnb [7][8]. - Lifebio's previous investors include Lan Chuang Capital, which is associated with the listed company Zhongkong Technology, and Chengkai Fund, linked to Wankai New Materials, which has completed trial production of bio-based furan polyester [7][8]. Group 3: Industry Development - Lifebio has achieved the industry's first large-scale production of 100% bio-based polyester PEF filament through collaboration with leading companies [6][16]. - The company is focusing on non-food biomass sources such as corn cobs and straw to produce bio-based PEF, which can be applied in packaging materials, textiles, and electronics [13][19]. - Lifebio has signed a strategic cooperation agreement with Moutai to accelerate the application of bio-based materials in bottle caps and containers [19][20].

Core Viewpoint - The collaboration between Micro Yuan Synthetic and Cargill aims to promote the application of Allulose in the Chinese market, focusing on healthier, lower-calorie, and flavorful product innovations [2][3]. Group 1: Partnership and Market Expansion - Micro Yuan Synthetic has signed a partnership agreement with Cargill, the largest food and ingredient company globally, to distribute Allulose in China [2]. - Cargill will leverage its extensive B2B platform and diverse customer network to expand the application scenarios of Allulose in the Chinese market [7]. Group 2: Product Innovation and Approval - Allulose has been approved by relevant national authorities as a new food ingredient in China, marking a significant step for its market introduction [3]. - As a natural, low-calorie rare sugar, Allulose offers a taste experience similar to sucrose while demonstrating advantages in blood sugar response and energy intake control [3]. Group 3: Production Capabilities - Micro Yuan Synthetic is the only company globally that produces Allulose using fermentation technology and has obtained the first administrative license for its production in China [4]. - The company has established an efficient production chain from biological fermentation to purification, resulting in high purity, good sensory properties, and wide applicability across various food categories such as functional beverages, dairy, candies, and baked goods [6]. Group 4: Industry Events - The 2025 Synthetic Biology and Green Bio-Manufacturing Conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the industrialization progress and opportunities in synthetic biology and green manufacturing [13]. - The conference will include various activities such as a youth forum, high-level discussions, and a showcase of synthetic biology technology achievements [13].

Core Viewpoint - The article emphasizes that biomanufacturing is becoming a key engine for the transformation and upgrading of the chemical industry, driven by the global green transition and "dual carbon" goals [2]. Group 1: Biomanufacturing and Chemical Industry Transformation - Biobased materials, derived from renewable biomass such as starch, cellulose, and fats, are fundamentally changing the linear economic model of "mass production, mass consumption, and mass waste" through a circular economy approach [2]. - Synthetic biology and biomanufacturing utilize biomass as raw materials, leveraging the metabolic functions of microorganisms, cells, and enzymes to achieve large-scale production of target products [3]. - Key pathways for the green transformation of the chemical industry include the development of non-food biobased synthetic products, green biomanufacturing of plastic monomers like dicarboxylic acids and diols, utilization and conversion of one-carbon resources like CO2, and enzymatic recycling of waste plastics [3]. Group 2: Upcoming Conference and Expert Participation - The Fourth Synthetic Biology and Green Biomanufacturing Conference will be held from August 20-22 in Ningbo, Zhejiang, featuring a session on green chemicals and new materials with participation from prominent experts and representatives from biomanufacturing companies [4]. - Notable speakers include Professor Wang Dan from Chongqing University, Professor Xue Chuang from Dalian University of Technology, and Yang Shihui, founder of Wuhan Ruijia Kang, who will discuss various aspects of biomanufacturing and its applications [6][7]. Group 3: Conference Agenda Highlights - The conference will include discussions on cell factory design, microbial cell factories for plastic monomers, and green separation and purification technologies in synthetic biology [30][35]. - A special focus will be on the application of non-food biomass sugars in synthetic biology and green biomanufacturing, showcasing flexible production platforms [7]. - The agenda also features a series of forums on AI empowerment in biomanufacturing and future food and agriculture innovations [14][43]. Group 4: Industry Collaboration and Research - The conference is organized by DT New Materials in collaboration with various academic and research institutions, highlighting the importance of industry-academia partnerships in advancing biomanufacturing technologies [10][16]. - The event aims to promote the sharing of innovative research and practical applications in the field of biomanufacturing, contributing to the overall growth of the industry [39].

Core Viewpoint - The article emphasizes the importance of synthetic biology technology in enhancing agricultural productivity through innovative solutions such as growth stimulants, biological control, and bio-fertilizers, which contribute to green agriculture efficiency [2][4]. Group 1: Company Overview - Bluepha has established an automated digital black-box laboratory for research and development, focusing on synthetic biology technology to continuously iterate and improve bio-manufacturing strains and processes for agricultural efficiency agents [2]. - The company is set to launch its first multi-strain polyhydroxyalkanoates (PHA) product matrix aimed at the agricultural market in November 2024, designed to effectively activate rhizosphere microorganisms [2]. Group 2: Product Matrix - The product matrix includes BlueDuofeng™ microbial agents, Multi-Element™ organic water-soluble fertilizers, and Rhizosphere Blue™ amino acid water-soluble fertilizers, which are tailored to meet the diverse needs of different crops and agricultural scenarios [4]. Group 3: Industry Event - Bluepha's Chief Scientist, Rao Chitong, will present at the SynBioCon 2025 conference, scheduled for August 20-22 in Ningbo, Zhejiang, discussing innovations in agricultural efficiency agents empowered by synthetic biology [5][17].

Core Viewpoint - The article highlights the rapid growth of metabolic diseases due to modern lifestyle factors and emphasizes the potential of functional sugars as dietary regulators to alleviate gut microbiota imbalance [2]. Group 1: Functional Sugars Market - The global functional sugars market is experiencing rapid growth, but there is significant product homogeneity and challenges in obtaining new functional sugars with specific structures and targeted regulation [2]. - The difficulties stem from unclear mechanisms of action, unknown biosynthetic pathways, and low levels of intelligent manufacturing in large-scale production [2]. Group 2: Research and Development - Professor Wu Jing's team at Jiangnan University has made advancements in the green biomanufacturing of various functional sugars, including allulose, tagatose, lactulose, resistant dextrin, and human milk oligosaccharides [2]. - These developments are crucial for creating health-oriented dietary regulators for the general public and align with the "Healthy China" strategic planning [2]. Group 3: Upcoming Conference - Professor Wu Jing will present at the SynBioCon 2025 conference, scheduled for August 20-22 in Ningbo, focusing on the topic of "Exploration and Green Biomanufacturing of New Functional Sugars" [2][9]. - The conference will cover topics related to AI and biomanufacturing, green chemicals, new materials, future food, and agriculture [9][10].

Core Viewpoint - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemicals, new materials, future food, and agriculture [2]. Group 1: Conference Overview - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies that will sustain the vitality of the bio-manufacturing sector [2]. - Various activities will be held concurrently, including a Youth Forum on Bio-Manufacturing, a high-level roundtable discussion, and a closed-door seminar for the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [2][3]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by several academic and industry institutions, including Peking University Ningbo Institute of Ocean Medicine and the Zhejiang Synthetic Biology Industry Technology Alliance [3]. Group 3: Conference Agenda - The agenda includes a series of forums and discussions on topics such as green chemicals and new materials, AI empowerment in bio-manufacturing, and future food and agriculture [7][9]. - Notable sessions include a high-level roundtable on the development of the synthetic biology industry and various specialized forums focusing on innovative applications and technologies in bio-manufacturing [10][32]. Group 4: Industry Insights - The conference will also feature the release of the "China Synthetic Biology Industry Distribution Map (2025 Edition)" and a list of over 500 representative bio-manufacturing enterprises in China, highlighting significant players in the industry [38].

Core Viewpoint - The article highlights the ongoing development and innovation in the synthetic biology and biomanufacturing sectors in China, particularly focusing on the establishment of industry maps and the upcoming conference in Ningbo, which aims to showcase advancements and opportunities in these fields [2][14]. Group 1: Industry Development - The "China Synthetic Biology Industry Map (2023)" has listed over 300 companies, indicating significant growth and interest in the sector [2]. - Hubei and Hunan provinces are identified as key areas for biomanufacturing, benefiting from national strategies and local government support [3][4]. - Hubei's "Future Industry Development Implementation Plan (2024-2026)" emphasizes biomanufacturing as a priority, with Wuhan's Optics Valley Biotech City as a leading hub [3][4]. Group 2: Key Companies and Innovations - Hubei is home to notable companies such as BGI, Guangji Pharmaceutical, and Wujin Bio, while Hunan has companies like Longping High-Tech and Lier Bio, showcasing a diverse range of biomanufacturing capabilities [4][6]. - The "China Biomanufacturing 500+ Representative Enterprises List" includes 26 companies from Hubei and 14 from Hunan, reflecting the competitive landscape in these provinces [6]. Group 3: Regulatory and Policy Framework - The "Changde City Regulations on Promoting the Development of Synthetic Biology Manufacturing" marks the first local legislation in this field in China, highlighting the regulatory support for industry growth [5]. - Academic institutions such as Central South University and Hunan University are noted for their leading research capabilities in synthetic biology, contributing to the sector's advancement [5]. Group 4: Upcoming Events - The Fourth Synthetic Biology and Green Biomanufacturing Conference will be held from August 20-22, 2025, in Ningbo, focusing on AI and biomanufacturing, green chemistry, and future food and agriculture [14][16]. - The conference will feature various activities, including forums and discussions on industry innovations and challenges, providing a platform for networking and collaboration [14][16].