SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

Project Overview - The project is named "Jinan Baijie High-Performance New Enzyme Preparation R&D and Industrialization Construction Project" [2] - The construction unit is Jinan Baijie Biological Engineering Co., Ltd., located in the Shanghe Chemical Industry Park, Jinan, covering an area of 70,067.81 m² (approximately 105.1 acres) [2] Investment and Construction Details - The total investment for the project is 775.49 million yuan, with phase one investment at 562.24 million yuan and phase two at 213.25 million yuan [3] - Environmental investment for phase one is 41.59 million yuan (7.39% of total investment), and for phase two is 6.21 million yuan (2.91% of total investment), all funded by the company [3] - The construction period for both phases is 21 months each [4] Production Capacity and Facilities - The project includes the construction of a fermentation workshop with a total of 12 fermentation tanks (6 in each phase), and two extraction and blending workshops [4] - The total production capacity for high-performance new enzyme preparations will be 45,000 tons per annum (t/a), with each phase contributing 22,500 t/a [4] Existing Product Situation - The northern fermentation workshop has been out of production for several years, while the southern workshop is operational [6] - The northern workshop has an annual production capacity of 1,500 tons for α-galactosidase, while the southern workshop has capacities of 5,200 t/a for liquid single enzyme products, 3,000 t/a for liquid proteases, and 8,000 t/a for liquid glucose oxidase and liquid fat enzymes, totaling 17,700 t/a for the entire plant [7] Company Background - Jinan Baijie Biological Engineering Co., Ltd. was formerly known as Jinan Nuoneng Biological Engineering Co., Ltd. and is a wholly-owned subsidiary of Kingsoft Bio-Technology (HK01548), established in 2009 [9] - The company specializes in the R&D, production, and sales of biological enzyme preparations, focusing on feed and industrial enzyme preparations, with core products including glucose oxidase, phytase, and compound enzymes [10]

Core Viewpoint - Lignin valorization is crucial for achieving economically viable and sustainable lignocellulosic biorefineries, with a focus on overcoming the challenges posed by expensive cofactors and enzyme activity imbalance [1][3][14] Group 1: Lignin Valorization Challenges - The continuous demand for expensive cofactors like ATP, NADPH, and CoA significantly hinders the sustainable conversion of lignin into valuable products [1] - The production rates of valuable molecules derived from lignin, such as raspberry ketone (RK) and curcumin, are extremely low, highlighting the inefficiencies in current conversion processes [1][3] Group 2: iMECS Strategy Development - The iMECS (in vitro multi-enzyme coordinated expression with cofactor self-circulation) strategy integrates cofactor regeneration and cell-free expression into the lignin upgrading process [3][4] - The iMECS platform demonstrated a 48-fold increase in overall catalytic efficiency without the addition of external cofactors, achieving a curcumin production rate of 0.175 g/L/h and a molar yield of 95.31% [3][6] Group 3: Multi-Enzyme Optimization - The study optimized the production of curcumin by establishing a biocatalytic module and introducing an in situ multi-cofactor recovery module, resulting in a curcumin yield of 126.4 mg/L [5][6] - The iMECS system achieved a curcumin production rate that was over 1455% higher than traditional whole-cell bioconversion methods [6] Group 4: Application to Vanillin Synthesis - The iMECS system was further evaluated for the conversion of ferulic acid to vanillin, achieving a vanillin yield of 94.4 mg/L with a 67% reduction in ATP demand [7][8] - The system's efficiency was enhanced by employing a temperature-guided biocatalytic process, which maintained enzyme activity while inactivating undesirable endogenous enzymes [9] Group 5: RK Biosynthesis - The iMECS strategy was applied to the more complex pathway of converting p-coumaric acid (pCA) to RK, achieving a production rate of 0.15 g/L/h and a conversion rate of 91.56% [10][13] - The integration of upstream and downstream modules within the iMECS system demonstrated significant potential for synthesizing more complex products from lignin-derived substrates [12][13] Group 6: Environmental and Economic Implications - The iMECS strategy promotes the use of lignin-rich agricultural waste as a feedstock, decoupling biomanufacturing from sugar prices and reducing greenhouse gas emissions compared to traditional petroleum-based synthesis [14]

精英计划-人才需求 | 天津工生所 中国科学院天津工业生物技术研究所是由中国科学院与天津市人民政府共建、整建制从事生物制造和 工业生物技术研究的国立科研机构，是我国工业生物领域的战略科技力量，肩负着创新生物产业关键 核心技术、发展生物制造重大颠覆性技术、支撑我国生物经济高质量可持续发展的历史使命，围 绕"以可再生碳资源替代化石资源、以清洁生物加工方式替代传统化学加工方式、以现代生物技术提 升产业水平"三大战略主题，重点开展"工业蛋白质科学与生物催化工程、合成生物学与微生物制造 工程、生物系统与生物工艺工程"三个领域方向的基础研究和应用基础研究。 招 聘部门 简介 01 邓子新大师工作室以活性天然产物的创新与绿色制造为目标，遵循"师从于自然、认知于自然，创新 于自然"的学术思路，运用合成生物学理念，聚焦交叉学科前沿，建立和完善天然药物精准发掘、结 构创新和优产新模式，实现微生物天然药物的高效生产。 团队由 徐敏研究员 与 侯安伟研究员 领衔，重点关注全新作用机制抗生素（糖肽抗生素）与萜类天 然产物的高效精准挖掘、生物合成机制与作用机制解析以及相关新分子的高效创制。 徐敏研究员主要从事微生物天然产物合成生物学以及 ...

【SynBioCon】 获 悉， 6月19日电， 海正药业 公告称其拟与全资子公司瀚晖制药之香港全资子公司 辉正国际合资 设立 合成生物 学独立子公司 ，注册资本 3.5亿元 。新公 司名为 浙江沄生合成生物科 技有限公司 （简称 沄生合成 ）。 海正药业 拟认缴出资2.6亿元，占74.29%，辉正国际拟认缴出资0.9亿元，占注册资本的25.71%。公 告显示，该合资公司将整合资源，结合辉正国际在香港的平台优势，为公司 合成生物 学业务的专业 化、规模化发展提供有力支撑。 资本事件 | 海正药业 海正药业成立于1956年，2000年海正在上海证券交易所上市。公司目前市值超百亿，是国内重要的原 料药生产企业，其产品涵盖多个治疗领域，包括抗肿瘤、心血管系统、抗感染等。 2024年前三季度，公司营收为78.75亿元，归母净利润为5.15亿元。随着肖卫红出任公司董事长，公 司将合成生物视为除人用药、动物药之外的新兴业务。 携手浙工大，加快合成生物项目落地 自2024年11月， 海正药业携手 浙江工业大学 共建 合成生物制造创新研究院 ，双方合作有望加速合 成生物学技术从前端研发到产业化落地的进程。 未来公司将基于合成 ...

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing during the 14th Five-Year Plan, exploring new products, technologies, and collaborations [4]. - There will be over 100 financing project roadshows to discover new cooperation opportunities [4]. - Key industry leaders, top universities, and capital from various sectors will gather to discuss advancements in biomanufacturing [4]. Group 4: Agenda and Special Activities - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [7]. - The second and third days will feature a macro forum on biomanufacturing, covering the development trends and progress of policies related to the industry [10]. Group 5: Specialized Forums - Specialized forums will cover topics such as green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. - The forums will address various key topics, including the development of bio-based chemicals, green manufacturing technologies, and the application of AI in biomanufacturing processes [11].

资本事件 | 三井化学 【SynBioCon】 获 悉，6月19日， 三井化学 宣布通 过321FORCE™全球 创新基金（321FORCE）投资了一家总部位于英国伦敦 的 细胞培养替代脂肪 初创Hoxton Farms 。 而就在 今年3月， Hoxton Farms正展开 与 日本住友公司 Sumitomo Corporation达成战略合作，共同推动培育脂肪 Hoxton Fat在 日本及亚太市场 的 应用。 在应用方面 ，双 方将Hoxton Fat整合到多种食品中， 从汤和酱汁到咸味糕点和加工肉类 。 资质方面 ，公司将与日本监管机构合作，在日本细胞农业协会 （JACA）的协助下获得相关的食品安全 批准。 市场方面，亚洲肉类需求增长对健康与食品安全的影响 。 随着收入增长、城市化进程加快及人口增长，亚洲消费者的饮食结构正在发生变化，高热量、高饱和脂肪的食品摄入量不断上升，肥胖问题日益严重。亚太 地区超过40%的成年人超重或肥胖，因肥胖及相关疾病导致的医疗支出占比高达12%。 与此同时， 亚洲的肉类需求预计到2050年将增长78% 。供应链不稳定、气候变化及疾病传播进一步加剧了食品安全危机。在这一背景 ...

Core Viewpoint - Zhiyan Zhaowu (Shaoxing) Biotechnology Co., Ltd. is a high-tech enterprise driven by artificial intelligence and synthetic biology innovation, focusing on the integration of AI technology with biological manufacturing to advance biotechnological progress and commercialization [1][3]. Company Overview - Founded in 2020 in Silicon Valley, Cardinal Biocraft has developed an AI-driven synthetic biology platform, investing over 50 million yuan and establishing a leading research and development platform for synthetic biological strains [1]. - The company has established three major R&D centers in California, Hefei, and Hangzhou, and aims to create a comprehensive R&D, production, and operation center in Shaoxing by 2024 [1]. Core Advantages - The company utilizes AI algorithms to accelerate gene design, metabolic pathway optimization, and strain modification, overcoming traditional R&D efficiency bottlenecks and enabling rapid conversion from laboratory to industrial production [3]. - It focuses on large-scale biological manufacturing needs, developing low-cost and high-stability biological synthesis solutions to empower green biological manufacturing [3]. Talent Acquisition - The company is seeking talented individuals in the fields of synthetic biology and industrial biotechnology, including positions for assistant researchers, fermentation engineers, and research assistants [4][7][12]. - Candidates are expected to have strong professional knowledge and experience in areas such as enzyme and metabolic pathway optimization, high-throughput strain screening, and fermentation process scaling [9][11][13]. Upcoming Events - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, and exploring trends in the bio-manufacturing industry [14][15].

Core Viewpoint - The article highlights the significant advancements in the production of bio-based rubber and its key components, particularly focusing on the initiatives by major companies in Japan, the US, and Europe to transition towards sustainable materials in the rubber industry [1][2][3]. Group 1: Company Initiatives - Zeon Corporation is establishing a research plant to produce butadiene and isoprene directly from plant materials, aligning with its strategic goal of achieving carbon neutrality and a circular economy [1]. - Goodyear has partnered with VISOLIS to produce bio-based isoprene, while Arlanxeo has developed bio-based ethylene from sugarcane waste, achieving a 70% bio-based raw material ratio in their products [3][4]. - Michelin is opening its first industrial-scale bio-based butadiene production demonstration plant, aiming to commercialize the use of plant materials for butadiene production [7]. Group 2: Industry Trends - The global tire industry faces challenges with over 1 billion waste tires, with 6 million tons of tire wear particles contributing to marine plastic pollution [1]. - Developed countries, including the US, Japan, and Europe, are proactively planning the development of bio-based rubber as a substitute for natural rubber due to environmental pressures [2]. - The establishment of a 110,000-ton bio-based degradable polyester rubber project in Jiangsu, China, marks a significant step in the original rubber material sector, with a total investment of 1 billion yuan [10]. Group 3: Technological Developments - Beijing University of Chemical Technology has successfully developed a new generation of high-performance functionalized bio-based polyester-butadiene rubber, showing potential applications in green tire materials and other sectors [5]. - The research team at Beijing University has also created the world's first degradable polyester rubber and the first batch of degradable tires, indicating advancements in sustainable material technology [8].

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