Core Insights - The article highlights the recent achievements of Chinese pharmaceutical companies, particularly Heng Rui Medicine and Fosun Pharma, in obtaining Fast Track Designation (FTD) from the FDA for their innovative drugs, indicating a significant step in the internationalization of Chinese pharmaceuticals [1][2]. Group 1: Fast Track Designation - Heng Rui Medicine's SHR-A2009 is the first innovative drug from the company to receive FDA's Fast Track Designation, which is expected to expedite its clinical trials and market registration [2]. - Fosun Pharma's subsidiary, Hanhui, also received FTD for HLX42, a drug targeting advanced non-small cell lung cancer, with a cumulative R&D investment of approximately 6.285 million yuan [2]. - The FTD status allows for increased communication with the FDA during the drug development process, facilitating quicker identification and resolution of issues [3]. Group 2: ADC Market Growth - Both SHR-A2009 and HLX42 are part of the Antibody-Drug Conjugate (ADC) sector, which has seen a surge in interest and investment from Chinese companies [4]. - As of December 2023, over 20 ADC transactions have occurred, with a total value exceeding 35 billion USD, indicating a robust market for these innovative therapies [4]. - The global ADC market is projected to grow from 11.4 billion USD in 2023 to 64.7 billion USD by 2030, with a compound annual growth rate (CAGR) of 28.1% [4]. Group 3: International Expansion of Chinese Pharma - 2023 is marked as a breakthrough year for Chinese innovative drugs entering international markets, with several companies achieving FDA approvals [6]. - Chinese pharmaceutical companies are encouraged to develop competitive products to capture overseas market share while also focusing on domestic and international sales strategies [6]. - The recognition of Chinese innovation in the global pharmaceutical ecosystem is increasing, as evidenced by successful licensing agreements for various innovative therapies [6].

Core Viewpoint - Fosun Pharma (02196.HK) experienced a significant stock price increase following the announcement of a licensing agreement with Expedition for the development and commercialization of the investigational product XH-S004 outside of China and Hong Kong [1] Group 1: Licensing Agreement Details - Fosun Pharma's subsidiary granted Expedition rights to develop, produce, and commercialize XH-S004 in a global scope excluding mainland China and Hong Kong [1] - Expedition will pay up to $120 million in non-refundable upfront payments and milestone payments related to development and regulatory achievements [1] - Additionally, based on annual net sales performance of the licensed product, Expedition may pay up to $525 million in sales milestone payments to Fosun Pharma [1] Group 2: Product Information - XH-S004 is a small molecule oral DPP-1 inhibitor with potential indications including non-cystic fibrosis bronchiectasis and chronic obstructive pulmonary disease (COPD) [1] - The product is currently in Phase II clinical trials for treating non-cystic fibrosis bronchiectasis and in Phase Ib clinical trials for COPD within mainland China [1]

Core Viewpoint - The news highlights the significant developments in the innovative pharmaceutical sector, particularly focusing on Fosun Pharma's recent licensing agreement and the broader trends in AI-driven drug discovery and CAR-T therapies. Group 1: Fosun Pharma's Licensing Agreement - Fosun Pharma signed a licensing agreement with Expedition for the small molecule inhibitor XH-S004, with a potential total value of $645 million (over 4.6 billion RMB) [2][3] - The agreement allows Expedition to develop, produce, and commercialize XH-S004 outside of China, while Fosun retains rights for the Chinese market [2][3] - XH-S004 is currently in Phase II clinical trials for non-cystic fibrosis bronchiectasis and Phase Ib for chronic obstructive pulmonary disease in China, with a cumulative R&D investment of approximately 72 million RMB as of August 11 [2][4] Group 2: Competitive Landscape - The leading competitor in the small molecule inhibitor space is Insmed's Brensocatib, which is under FDA review and may become the first approved treatment for bronchiectasis [4] - Other domestic companies, such as Haikang and Hengrui, are also advancing in this area, with Haikang securing a significant licensing deal worth up to $4.62 million [4] Group 3: AI Drug Discovery - Fosun Pharma is actively involved in AI drug discovery, having partnered with AI pharmaceutical company Insilico Medicine since 2022 to develop AI-targeted drugs [5] - The company has also engaged in strategic collaborations with DeepMind Technology to explore antibody drug development using AI and physical modeling [5] Group 4: CAR-T Therapy Developments - Fosun Pharma is recognized for its CAR-T therapy pipeline, with the CARVYKTI therapy achieving sales of $439 million in Q2 2025, indicating strong market potential [6] - The pricing of CAR-T therapies remains a challenge, with costs exceeding 999,000 to 1,290,000 RMB, which limits access to insurance coverage [6] - The evolving payment landscape for CAR-T therapies is expected to improve as generic technologies mature and more products enter the market, potentially lowering costs [6] Group 5: Market Outlook - The innovative drug sector is anticipated to remain active, with significant upcoming international pharmaceutical conferences and discussions on insurance drug lists expected to drive interest [7] - The domestic innovative drug market is likely to benefit from increased clinical data releases and a rebound in funding for new drug development [7] - Investors are encouraged to consider the innovative drug ETF (159622) for exposure to leading companies in the sector, with a diversified portfolio comprising 40% Hong Kong stocks and 60% A-shares [7]

复星医药（02196）早盘高开逾7%，截至发稿，股价上涨6.62%，现报20.62港元，成交额1.38亿港元。 复星医药公布，控股子公司上海复星医药产业发展有限公司（"复星医药产业"）与Expedition Therapeutics， Inc．（"Expedition"）签订《许可协议》，将向Expedition授予小分 根据协议，Expedition将向复星医药产业支付至多1.2亿美元不可退还的首付款、开发里程碑付款，未来还将基于XH-S004于许可区域的年度净销售额的达成情况，由Expedition依约支付至 责任编辑：卢昱君 ...

Group 1: Market Performance - On August 12, A-shares saw a rebound with the three major indices rising, particularly in the medical device and innovative drug sectors [1] - The innovative drug ETF Tianhong (517380) experienced a slight decline of 0.39%, with leading stocks including Fosun Pharma and Renfu Pharmaceutical [1] - The medical device ETF (159873) rose by 1.58%, with significant gains from stocks like Sanxin Medical and Sino Medical [1] Group 2: Fund Flows and ETF Details - The innovative drug ETF Tianhong (517380) has seen continuous net inflows for 12 trading days, accumulating over 186 million yuan [1] - Tianhong is the largest innovative drug ETF in the market, tracking the Hang Seng Shanghai-Shenzhen-Hong Kong Innovative Drug Select 50 Index, which covers both A-shares and Hong Kong stocks [1] - The top ten constituents of the Hang Seng Shanghai-Shenzhen-Hong Kong Innovative Drug 50 Index account for nearly 60% of the index's weight, including high-quality A-share stocks like Innovent Biologics and BeiGene [1] Group 3: Industry Developments - Nudge, a brain-computer interface company, recently completed a $100 million Series A funding round to support its growth and platform expansion [2] - Nudge's platform utilizes non-invasive focused ultrasound technology for precise brain stimulation and imaging, aiming to create an end-to-end brain-computer interface [2] - The National Healthcare Security Administration has introduced pricing guidelines for invasive brain-computer interface procedures, indicating potential growth in the industry [2] Group 4: Insights on Innovative Drug Sector - According to Shenwan Hongyuan, the innovative drug sector has maintained rapid growth in product revenue and external licensing over the past three years [3] - Significant business development transactions have emerged this year, indicating a trend of expanding the innovative drug market [3] - The adjustment of the medical insurance catalog will include commercial insurance for innovative drugs, highlighting potential growth for major innovative drug companies and related CXO companies [3]

Group 1 - The Hang Seng Hong Kong Stock Connect Innovative Drug Selection Index (HSSCPB) increased by 0.02%, with notable stock performances including Jingtai Holdings (02228) up 7.38% and Fosun Pharma (02196) up 6.00% [3] - The Hong Kong Innovative Drug Selection ETF (520690) rose by 0.52%, reaching a latest price of 0.97 yuan, with a trading volume of 240.45 million yuan and a turnover rate of 0.62% [3] - Jingtai Holdings announced an expected comprehensive income of no less than 500 million yuan for the six months ending June 30, 2025, representing an increase of at least 387% compared to the same period in 2024 [3] Group 2 - The Hong Kong Innovative Drug Selection ETF reached a new high in scale at 385 million yuan and a new high in shares at 399 million [4] - The ETF has seen continuous net inflows over the past three days, with a maximum single-day net inflow of 22.93 million yuan, totaling 42.28 million yuan [4] - The ETF's management fee is 0.50% and the custody fee is 0.10%, which are among the lowest in comparable funds [5] Group 3 - The HSSCPB index aims to reflect the performance of Hong Kong-listed companies involved in innovative drug research, development, and production [5] - The top ten weighted stocks in the HSSCPB index account for 78.05% of the total index weight, including companies like BeiGene (06160) and WuXi Biologics (02269) [5]

Core Viewpoint - Fosun Pharma's stock price increased by 7.55% to HKD 20.8 following the announcement of a licensing agreement with Expedition Therapeutics for the development of a DPP-1 inhibitor [1] Group 1: Licensing Agreement Details - Fosun Pharma's subsidiary, Shanghai Fosun Pharmaceutical Industry Development Co., Ltd., signed a licensing agreement with Expedition Therapeutics for the global development, production, and commercialization rights of the DPP-1 inhibitor XH-S004, excluding mainland China and Hong Kong/Macau [1] - Fosun Pharma retains the development, production, and commercialization rights of XH-S004 within mainland China and Hong Kong/Macau [1] Group 2: Financial Terms of the Agreement - Expedition will pay up to USD 120 million in non-refundable upfront payments and milestone payments for development [1] - Additionally, Expedition may pay up to USD 525 million in sales milestone payments based on the annual net sales performance of XH-S004 in the licensed regions [1] Group 3: Clinical Trial Status - XH-S004 is currently in Phase II clinical trials for the treatment of non-cystic fibrosis bronchiectasis in mainland China and in Phase Ib clinical trials for chronic obstructive pulmonary disease (COPD) [1]

11日，沪指盘中震荡上扬，深证成指、创业板指强势拉升。截至收盘，沪指涨0.34%报3647.55点，深证 成指涨1.46%报11291.43点，创业板指涨1.96%报2379.82点，北证50指数涨1.18%，沪深北三市合计成交 18501亿元，较此前一日增加1135亿元。行业方面，医药、地产、家电、汽车、半导体、券商、酿酒等 板块走强，PEEK材料、锂矿、AI产业链股爆发，消费电子、飞行汽车概念等活跃。 东莞证券表示，当前A股市场内流动性相对充裕，交投情绪仍处于高位，整体运行状态较为健康，短期 震荡或为后续行情积蓄动能。考虑到当前市场呈现一定程度的结构分化，前期热门板块已处于相对高 位，板块轮动节奏或进一步加快，把握结构性机会将成为关键。 今日投资机会解析 锂价有望大幅上涨 宁德时代8月11日在投资者互动平台表示，公司在宜春项目采矿许可证8月9日到期后已暂停了开采作 业，正按相关规定尽快办理采矿证延续申请，待获得批复后将尽早恢复生产，该事项对公司整体经营影 响不大。 据宜春自然资源局，宁德时代该锂矿年采矿产能为3300万吨，配套建设的锂盐冶炼厂年产能为10万吨碳 酸锂，停产一个月将影响约8300吨碳酸锂产量 ...

8月11日， 发布公告，控股子公司上海复星医药产业发展有限公司(「复星医药产业」)与Expedition Therapeutics, Inc.("Expedition")签订《许可协议》，将向 Expedition授予小分子口服二肽基肽酶1(DPP-1)抑制剂XH-S004在全球(不包括中国境内及港澳地区)范围的开发、生产及商业化权利。复星医药产业将保留 XH-S004在中国境内及港澳地区的开发、生产及商业化权利。 受到上述利好消息刺激，8月12日，复星医药港股大幅高开，现涨7.55%，股价报20.8港元。 | 最高 | | | | | 20.800 | | 開市 | | | | | 20.800 | 成交量 | | | | 87.35萬 | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 最低 | | | | | 20.800 | | 前收 | | | | ...

格隆汇8月12日｜复星医药(600196)H股高开7.55%报20.8港元，创2023年5月以来新高；A股高开5.52% 报28.28元。 XH-S004为复星医药拥有自主知识产权的小分子口服DPP-1抑制剂，其通过抑制DPP-1及其激活的中性 粒细胞丝氨酸蛋白酶降低炎症反应，从而阻断感染恶性循环及由此导致的气道结构损伤。 (责任编辑：宋政 HN002) 【免责声明】本文仅代表作者本人观点，与和讯网无关。和讯网站对文中陈述、观点判断保持中立，不对所包含内容 的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考，并请自行承担全部责任。邮箱： news_center@staff.hexun.com 消息面上，8月11日，复星医药宣布其控股子公司复星医药产业与Expedition签订许可协议，授予后者在 除中国境内及港澳地区以外地区开发、生产及商业化XH-S004的权利。 根据约定，Expedition将就本次合作向复星医药产业支付至多1.2亿美元不可退还的首付款、开发及监管 里程碑付款，此外，基于许可产品于许可区域的年度净销售额达成情况，由Expedition向复星医药产业 依约支付至多5.25亿美元 ...