来源：视频滚动新闻 翰森制药(03692.HK)在港交所公告，于二零二五年十二月十六日，本公司全资附属公司江苏豪森药业集 团有限公司与Glenmark Specialty S.A.就阿美替尼订立独家许可、合作及分销协议。阿美替尼是一款用于 治疗非小细胞肺癌的三代表皮生长因子受体-酪氨酸激酶抑制剂。根据许可协议，许可人将授予被许可 人独占许可，允许其在授权区域开发并商业化阿美替尼。 ...

中国能源建设(03996.HK)：投资建设的中能建松原氢能产业园(绿色氢氨醇一体化)项目一期工程正式投产运行。 中煤能源(01898.HK)：前11月商品煤销量为约2.34亿吨，同比减少8.7%。11月煤销量为2174万吨，同比减少15.7%。 中国太保(02601.HK)：前11月，太平洋人寿累计原保险保费收入为人民币2503.22亿元，同比增长9.4%，太平洋财险累计原保险保费收入为人民币1876.82亿 元，同比增长0.3%。 中国铁建(01186.HK)：拟发行不超过40亿元可续期公司债券。 智通财经12月16日讯（编辑 冯轶）智通财经为您带来今日港股重要公告 2）回购动态 1）公司要闻 翰森制药(03692.HK)：与GLENMARK就阿美替尼订立许可协议。 公告称，根据协议将获得首付款和后续可能累计超过十亿美元的监管和商业里程碑付款，以及授权区域内净销售额的分级特许权使用费。 越秀地产(00123.HK)：获授5亿港元的定期贷款融资。 腾讯控股(00700.HK)：斥资约6.36亿港元回购106.7万股，回购价592.5-602.5港元。 小米集团-W(01810.HK)：斥资2.94亿港元回购7 ...

翰森制药(03692)发布公告，于2025年12月16日，公司全资附属公司江苏豪森药业集团有限公司(许可人) 与Glenmark Specialty S.A.(被许可人)就阿美替尼订立独家许可、合作及分销协议(许可协议)。阿美替尼 是一款用于治疗非小细胞肺癌(NSCLC)的三代表皮生长因子受体-酪氨酸激酶抑制剂(EGFR-TKI)。 根据许可协议，许可人将授予被许可人独占许可，允许其在授权区域(中东与非洲、东南亚与南亚、澳 大利亚、新西兰、俄罗斯与其他独联体国家，以及协议覆盖的部分特定加勒比国家)开发并商业化阿美 替尼。许可人将获得首付款和后续可能累计超过十亿美元的监管和商业里程碑付款，以及授权区域内净 销售额的分级特许权使用费。 ...

根据许可协议，许可人将授予被许可人独占许可，允许其在授权区域(中东与非洲、东南亚与南亚、澳 大利亚、新西兰、俄罗斯与其他独联体国家，以及协议覆盖的部分特定加勒比国家)开发并商业化阿美 替尼。许可人将获得首付款和后续可能累计超过十亿美元的监管和商业里程碑付款，以及授权区域内净 销售额的分级特许权使用费。 格隆汇12月16日丨翰森制药(03692.HK)宣布，于2025年12月16日，公司全资附属公司江苏豪森药业集团 有限公司(「许可人」)与Glenmark SpecialtyS.A.(「被许可人」)就阿美替尼订立独家许可、合作及分销 协议(「许可协议」)。阿美替尼是一款用于治疗非小细胞肺癌(「NSCLC」)的三代表皮生长因子受体－ 酪氨酸激酶抑制剂(「EGFR-TKI」)。 ...

根据许可协议，许可人将授予被许可人独占许可，允许其在授权区域(中东与非洲、东南亚与南亚、澳 大利亚、新西兰、俄罗斯与其他独联体国家，以及协议覆盖的部分特定加勒比国家)开发并商业化阿美 替尼。许可人将获得首付款和后续可能累计超过十亿美元的监管和商业里程碑付款，以及授权区域内净 销售额的分级特许权使用费。 智通财经APP讯，翰森制药(03692)发布公告，于2025年12月16日，公司全资附属公司江苏豪森药业集团 有限公司(许可人)与Glenmark Specialty S.A.(被许可人)就阿美替尼订立独家许可、合作及分销协议(许可 协议)。阿美替尼是一款用于治疗非小细胞肺癌(NSCLC)的三代表皮生长因子受体-酪氨酸激酶抑制剂 (EGFR-TKI)。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 Hansoh Pharmaceutical Group Company Limited 翰森製藥集團有限公司 （於開曼群島註冊成立的有限公司） （股份代號：3692） 自願公告 與GLENMARK訂立許可協議 翰森製藥集團有限公司（「本公司」）董事會（「董事會」）欣然宣佈，於二零二五年十 二月十六日（交易時段後），本公司全資附屬公司江蘇豪森藥業集團有限公司（「許 可人」）與Glenmark Specialty S.A.（「被許可人」）就阿美替尼訂立獨家許可、合作 及分銷協議（「許可協議」）。阿美替尼是一款用於治療非小細胞肺癌（「NSCLC」） 的三代表皮生長因子受體－酪氨酸激酶抑制劑（「EGFR-TKI」）。 根據許可協議，許可人將授予被許可人獨佔許可，允許其在授權區域（中東與非 洲、東南亞與南亞、澳大利亞、新西蘭、俄羅斯與其他獨聯體國家，以及協議覆 蓋的部分特定加勒比國家）開發並商業化阿美替尼。許可人 ...

Core Insights - The Hong Kong Innovative Drug ETF (159567) closed down 1.91% on December 16, with a trading volume of 1.078 billion yuan [1] - The fund was established on January 3, 2024, with an annual management fee of 0.50% and a custody fee of 0.10% [1] - As of December 15, 2024, the fund's total shares reached 10.425 billion, with a total size of 8.174 billion yuan, reflecting a significant increase in shares and size compared to the previous year [1] Fund Performance - The fund manager, Ma Jun, has achieved a return of 64.28% since taking over management on January 3, 2024 [2] - The fund's performance benchmark is the National Index of Hong Kong Innovative Drugs, adjusted for valuation exchange rates [1] Holdings Overview - Major holdings in the fund include: - BeiGene (10.62% holding, market value 817 million yuan) - CanSino Biologics (10.55% holding, market value 812 million yuan) - Innovent Biologics (10.21% holding, market value 786 million yuan) - China National Pharmaceutical Group (9.62% holding, market value 741 million yuan) - CSPC Pharmaceutical Group (7.56% holding, market value 583 million yuan) [2]

Market Overview - The Hong Kong stock market faced downward pressure, with the Hang Seng Index falling by 1.34% to 25,628.88 points, and a total trading volume of HKD 204.29 billion [1] - The Hang Seng China Enterprises Index dropped by 1.78% to 8,917.7 points, while the Hang Seng Tech Index decreased by 2.48% to 5,498.42 points [1] Blue-Chip Stocks Performance - Li Ning (02331) led the blue-chip stocks, rising by 5.43% to HKD 18.64, contributing 3.53 points to the Hang Seng Index [2] - New Oriental-S (09901) increased by 2.81% to HKD 43.2, contributing 1.46 points, while China Ping An (02318) rose by 2.35% to HKD 65.25, contributing 16.07 points [2] - Hansoh Pharmaceutical (03692) fell by 7.58% to HKD 39.74, negatively impacting the index by 7.88 points, and SMIC (00981) dropped by 4.43% to HKD 64.7, contributing a decline of 21.64 points [2] Sector Performance - Major technology stocks generally declined, with Alibaba down by 3.57% and Tencent by 2.11%, amid renewed concerns over an AI bubble following disappointing earnings from leading AI companies [3] - Gold stocks saw significant gains as international gold prices approached historical highs, with Zijin Mining (02259) rising by 7.76% to HKD 158.4 [3] - Dairy stocks also performed well, with Yurun Dairy (09858) increasing by 7.67% to HKD 4.63, supported by favorable policies for childbirth [4] Insurance Sector - The insurance sector showed strong performance, with China Ping An (02318) reaching a four-year high, rising by 2.35% to HKD 65.25 [5] - Other insurers like New China Life (01336) and China Pacific Insurance (02601) also saw gains, attributed to regulatory changes that allow for more long-term investment funds [5][6] Notable Stock Movements - CloudTop New Horizon (01952) rose by 4.55% to HKD 46.88, with significant insider buying reported [7] - Sanhua Intelligent Control (02050) faced pressure, dropping by 7.25% to HKD 33.78, ahead of a significant unlock of cornerstone investor shares [8]

Core Insights - The pharmaceutical industry is experiencing a surge in innovative products, with clear domestic demand and significant potential for international expansion [4][14][25] - Investment opportunities are concentrated in innovative drugs and their supply chains, with a notable performance from CRO/CMO and chemical pharmaceuticals [9][15][17] - The report emphasizes the importance of innovation as the primary solution to industry challenges, driven by stable demand and supportive policies [26][32][41] Industry Overview - The pharmaceutical sector has faced revenue declines, with a 0.9% year-on-year decrease in revenue for the first three quarters of 2025, and net profit down by 2.2% [15][16] - The innovative drug sector has outperformed, with CRO/CMO and chemical pharmaceuticals showing net profit growth of 31.0% and 16.6% respectively [17][18] - The overall market is characterized by low fund holdings and historical valuation bottoms, indicating high investment value [20][25] Demand and Payment Dynamics - The demand for healthcare services is steadily increasing, with a projected 5% growth in total medical visits and hospital admissions in 2024 [26][28] - The aging population is expected to drive long-term demand, with 220 million people aged 65 and above by 2050 [28][30] - The medical insurance fund's income growth has outpaced expenditure growth, leading to a significant increase in fund reserves [32][36] Financing and Market Trends - The IPO market for healthcare has rebounded, with 28 IPOs in the first three quarters of 2025, a 100% increase from the previous year [42][43] - License-out transactions have surged, with transaction numbers increasing by 41% and total amounts reaching $92 billion, indicating a robust market for innovative drug licensing [48][50] - The number of IND applications and new clinical trials for innovative drugs has been steadily increasing, with a notable rise in NDA approvals [53][57] Technological Advancements - The report highlights the emergence of new technologies such as ADC and small nucleic acids, with domestic companies leading in these areas [60] - The focus on dual antibodies and GLP-1 drugs is expected to drive significant growth, with multiple development directions emerging [9][60] - The report notes that domestic companies are increasingly recognized for their innovative capabilities, particularly in the ADC space [60]

Core Insights - The "2025 Fifth China Health Industry Development and Rehabilitation Service Conference" was successfully held in Beijing, focusing on integrating resources and exploring development paths in the health industry [1] - The conference featured high-level discussions on cutting-edge topics such as innovative drugs, brain-machine interfaces, AI in healthcare, and the transformation of traditional Chinese medicine [1] - A number of innovative case studies were presented, showcasing advancements in various categories including ESG, biotechnology, and mental health services [1] Company Highlights - **Hengrui Medicine**: Invested over 50 billion yuan in R&D, with a focus on patient-centered innovation, resulting in 24 first-class innovative drugs and over 100 products in clinical development [3] - **Hansoh Pharmaceutical**: Reported revenue of 7.434 billion yuan in the first half of 2025, a 14.3% increase, with innovative drugs accounting for 82.7% of total revenue [4] - **China Biologic Products**: Launched "Kumosili," a globally first oral CDK2/4/6 inhibitor for breast cancer, showing significant efficacy and safety in clinical trials [5] - **East China Pharmaceutical**: Focused on endocrine, autoimmune, and oncology fields, with over 90 innovative drug projects and a 35.99% increase in R&D investment [7] - **Changchun High-tech**: Developed over 40 candidate drugs, leveraging advanced drug development platforms and AI technology [8] - **Fuhong Hanlin**: An international biopharmaceutical company with 10 approved products globally, focusing on oncology and autoimmune diseases [9] - **Tonghua Dongbao**: A leader in diabetes treatment, expanding its product line to include various insulin and oral hypoglycemic agents [10] - **Shutai Shen**: Invested 2.3 billion yuan in R&D, significantly above the industry average, focusing on innovative biopharmaceuticals [11] - **Hualing Pharmaceutical**: Developed a novel oral hypoglycemic agent, "Huatangning," with significant sales growth since entering the insurance list [12][13] - **Kangtini Pharmaceutical**: Focused on organ fibrosis treatment, with its lead product F351 showing promise for chronic hepatitis B-related liver fibrosis [14]