Core Insights - The Hong Kong Innovative Drug ETF (159567) closed with a gain of 1.95% on July 24, with a trading volume of 2.504 billion yuan [1] - The fund was established on January 3, 2024, with an annual management fee of 0.50% and a custody fee of 0.10% [1] - As of July 23, 2024, the fund's shares totaled 2.166 billion, with a total size of 3.863 billion yuan, reflecting a year-to-date increase of 447.94% in shares and 922.49% in size [1] Fund Performance - The current fund manager, Ma Jun, has managed the fund since its inception, achieving a return of 78.32% during the management period [2] - The fund's recent trading activity shows a cumulative trading amount of 41.889 billion yuan over the last 20 trading days, with an average daily trading amount of 2.094 billion yuan [1] - Year-to-date, the cumulative trading amount is 125.021 billion yuan, with an average daily trading amount of 0.926 billion yuan [1] Holdings Overview - Major holdings in the fund include: - Innovent Biologics (9.52% holding, 26 million yuan market value) - WuXi Biologics (9.47% holding, 25.8 million yuan market value) - BeiGene (8.73% holding, 23.8 million yuan market value) - CanSino Biologics (7.62% holding, 20.8 million yuan market value) - China National Pharmaceutical Group (7.17% holding, 19.6 million yuan market value) [2] - Other significant holdings include CSPC Pharmaceutical Group (6.34% holding) and Ascletis Pharma (2.86% holding) [2]

Summary of Hansoh Pharmaceutical Conference Call Company Overview - **Company**: Hansoh Pharmaceutical - **Industry**: Pharmaceutical, focusing on oncology and innovative drugs Key Points Industry Impact and Financial Performance - Hansoh Pharmaceutical's revenue from generic drugs has declined from 2021 to 2023 due to centralized procurement policies, but innovative drug revenue has significantly increased since 2023 [2][3] - R&D investment has risen from 1.2 billion CNY in 2020 to an expected 3 billion CNY in 2024, accounting for 22% of revenue [2][3] - Overall revenue decreased from approximately 8.7 billion CNY in 2020 to a low in 2022 but is expected to recover in 2023 [5] Product Development and Pipeline - The oncology segment focuses on lung cancer, gastrointestinal tumors, and gynecological tumors, with Amivantamab (阿美替尼) as a cornerstone product [2][6] - Amivantamab is expected to generate over 6 billion CNY in revenue this year, with peak sales projected at 8 billion CNY [9] - The company has completed four licensing agreements in the past three years, totaling around 2 billion USD, indicating strong external validation of its R&D pipeline [7][19] Innovations and Future Strategies - In the oncology field, Hansoh is developing multiple antibody-drug conjugates (ADCs) and combination therapies to extend the lifecycle of Amivantamab [2][10] - The company is also focusing on non-oncology areas, including metabolic diseases and central nervous system disorders, with key products like CD19 monoclonal antibody and OXRR antagonist for insomnia [4][15][17] - The metabolic segment includes a multi-target dual agonist (GIP GLP-1) and oral GLP-1 agonist, with significant market potential in diabetes and weight loss [18] Clinical Trials and Regulatory Approvals - Amivantamab has received approvals for multiple indications and is undergoing further clinical trials for combination therapies [8][9] - BCH3 ADC and BCH4 ADC are in advanced clinical stages, with promising early data and partnerships with GSK for commercialization [11][13] Market Position and Competitive Landscape - Hansoh's innovative drugs are gaining market share, with Amivantamab's indications expanding and expected to double its revenue from 2021 to 2024 [3][5] - The company is strategically positioned in the ADC space, competing with major players and aiming for significant market penetration [19] Conclusion - Hansoh Pharmaceutical is navigating challenges in the generic drug market while capitalizing on innovative drug development, with a robust pipeline and strategic partnerships that enhance its market position and growth potential [2][3][7][19]

Core Viewpoint - As of July 18, 160 stocks reached their 52-week highs, with notable performances from China New Economy Investment (00080), Aoyuan Group Equity (02905), and Zhong An Holdings Group (08462) showing high growth rates of 288.89%, 55.28%, and 50.00% respectively [1][2]. Summary by Category 52-Week High Performers - China New Economy Investment (00080) closed at 0.440, with a peak price of 0.700, achieving a growth rate of 288.89% [2]. - Aoyuan Group Equity (02905) closed at 0.218, with a peak price of 0.250, achieving a growth rate of 55.28% [2]. - Zhong An Holdings Group (08462) closed at 0.221, with a peak price of 0.228, achieving a growth rate of 50.00% [2]. - Other notable performers include Hualian International (00969) with a growth rate of 40.13% and Zhongke Bio (01237) with a growth rate of 37.25% [2]. Additional High Performers - Wanma Holdings (06928) closed at 0.550 with a growth rate of 30.43% [2]. - Lepu Biopharma-B (02157) closed at 7.940 with a growth rate of 24.54% [2]. - Other stocks with significant growth include ZhiJianYueDong (06860) at 17.14% and China Jindian Group (08281) at 17.12% [2]. 52-Week Low Performers - The document also lists stocks that reached their 52-week lows, with XI Ernan CO-U (09311) showing a decline of 16.10% [6]. - Other notable declines include XI Ernan CO (07311) at -12.62% and Haotian International Construction Investment (01341) at -5.70% [6].

Group 1 - The Hong Kong Innovative Drug ETF (159567) closed with a gain of 0.56% on July 18, with a trading volume of 2.25 billion yuan [1] - The fund was established on January 3, 2024, with a management fee of 0.50% and a custody fee of 0.10% [1] - As of July 17, 2024, the fund's latest share count was 2.025 billion, with a total size of 3.63 billion yuan, reflecting an increase of 412.28% in shares and 860.92% in size since December 31, 2023 [1] Group 2 - The current fund manager is Ma Jun, who has managed the fund since its inception, achieving a return of 79.25% during the management period [2] - The top holdings of the fund include Innovent Biologics, WuXi Biologics, BeiGene, and others, with significant weightings such as 9.52% for Innovent Biologics and 9.47% for WuXi Biologics [2] - The fund's trading liquidity is strong, with a cumulative trading amount of 40.368 billion yuan over the last 20 trading days, averaging 2.018 billion yuan per day [1][2]

Core Insights - The Hong Kong Innovation Drug Index (931787) has shown a strong increase of 5.50% as of July 17, 2025, with significant gains in constituent stocks such as Lepu Biopharma-B (up 20.94%) and CanSino Biologics-B (up 14.50%) [1] - The Hong Kong Innovation Drug ETF (513120) has risen by 4.97%, marking a seven-day consecutive increase, with a trading volume of 9.798 billion HKD and a turnover rate of 67.06% [1] - Over the past year, the Hong Kong Innovation Drug ETF has achieved a net value increase of 109.64%, ranking 1st out of 122 QDII equity funds [2] Market Performance - The Hong Kong Innovation Drug ETF has a current scale of 14.035 billion HKD, making it the largest in the Hong Kong pharmaceutical ETF sector [1] - In the last 22 trading days, there have been net inflows on 12 days, totaling 838 million HKD [1] - The ETF has recorded a maximum monthly return of 23.82% since its inception, with an average monthly return of 7.75% during rising months [2] Index Composition - The index comprises a maximum of 50 listed companies primarily engaged in innovative drug research and development, reflecting the overall performance of the innovative drug sector in the Hong Kong market [2] - The top ten weighted stocks in the index account for 67.94%, with notable companies including Innovent Biologics (01801) and WuXi Biologics (02269) [3] Policy Environment - Recent adjustments to the national medical insurance drug list and commercial health insurance for innovative drugs have established a dual-track payment system, ensuring that innovative drugs are not included in centralized procurement [3] - The regulatory environment is supportive, with the resumption of the fifth set of listing standards for the Sci-Tech Innovation Board and a reduction in clinical trial review periods to 30 days [3] - The combination of favorable policies and significant overseas business development expectations is expected to drive the performance of the innovative drug sector in the coming years [3]

Group 1 - The core viewpoint of the news is the significant performance and growth of the Hong Kong Innovative Drug ETF, which has seen a cumulative increase of over 100% in the past year, reflecting strong investor interest in the innovative drug sector [1][2] - As of July 15, 2025, the Hong Kong Innovative Drug ETF has a net asset value increase of 108.39% over the past year, ranking 1st out of 122 QDII equity funds, indicating its strong performance relative to peers [2] - The Hong Kong Innovative Drug ETF closely tracks the CSI Hong Kong Innovative Drug Index, which includes up to 50 listed companies primarily engaged in innovative drug research and development, providing a comprehensive view of the sector's performance [2] Group 2 - Recent measures introduced by the National Healthcare Security Administration and the National Health Commission aim to support the high-quality development of innovative drugs, including increased R&D support and inclusion in insurance directories [3] - The current market rally in Hong Kong's innovative drug sector is driven by a revaluation of value, with expectations for a new commercial insurance directory for innovative drugs to be launched in 2025, potentially creating a more favorable pricing environment [3] - The Hong Kong Innovative Drug ETF supports T+0 trading, enhancing liquidity and allowing investors to conduct multiple transactions within a trading day, thereby improving capital efficiency [3]

Core Insights - The Hong Kong pharmaceutical sector is experiencing a strong rally, with the China Securities Hong Kong Stock Connect Pharmaceutical and Health Comprehensive Index (930965) rising by 1.50% as of July 16, 2025, driven by significant gains in individual stocks such as Lijun Pharmaceutical (01513) up 11.16% and Green Leaf Pharmaceutical (02186) up 8.55% [1][2] - The introduction of a commercial health insurance innovative drug directory by the National Healthcare Security Administration on July 11, 2025, marks a significant development, allowing for the inclusion of high-innovation drugs that exceed basic insurance coverage [1][2] - The first innovative drug directory involving commercial insurance is expected to be launched within 2025, potentially creating a more favorable pricing environment compared to traditional medical insurance negotiations [2] Industry Summary - The Hong Kong Medical ETF (513700) has seen a 1.72% increase, marking its fourth consecutive rise, with the latest price reported at 0.65 yuan [1] - The index reflects the performance of 50 liquid and large-cap healthcare companies within the Hong Kong Stock Connect, with the top ten weighted stocks accounting for 59.44% of the index [2] - The commercial health insurance sector is anticipated to experience significant growth, with potential for premium and innovative drug payment scales to increase by several multiples in the long term [2]

Investment Rating - The investment rating for the pharmaceutical industry is "Positive" (maintained) [4] Core Viewpoints - The pharmaceutical sector is experiencing a transformation with traditional Big Pharma companies increasingly focusing on innovation and BD (business development) transactions, which are expected to become a regular source of income and profit [9][12] - The report highlights that the innovative drug segment is gaining momentum, with companies like 恒瑞医药 (Hengrui Medicine) and 翰森制药 (Hansoh Pharmaceutical) achieving significant growth in their innovative drug revenues [12][21] - The report anticipates that the pharmaceutical industry will benefit from multiple positive factors, including the aging population, steady growth in medical insurance revenue, and advancements in AI technology [45] Summary by Sections Industry Performance - From July 7 to July 11, the pharmaceutical index rose by 1.82%, outperforming the沪深 300 index by 1.00% [5] - The report notes that 350 stocks in the sector increased in value, while 131 stocks decreased [5][25] Business Development (BD) Insights - BD transactions are becoming a crucial strategy for traditional Big Pharma, with a focus on increasing international revenue and opening new growth avenues [9][12] - The report indicates that BD income is expected to contribute significantly to the profit growth of companies like 恒瑞医药 and 翰森制药, with numerous successful licensing agreements [18][21] Investment Recommendations - The report suggests focusing on innovative drugs and related sectors, particularly companies with strong BD capabilities and those positioned for international expansion [45][46] - Specific companies recommended for investment include 恒瑞医药, 科伦药业, and various CXO and supply chain firms [45][46] Market Trends - The report emphasizes the ongoing shift towards innovative drug development, with traditional pharmaceutical companies successfully transitioning to this model [12][21] - The aging population is expected to drive demand for chronic disease treatments, further supporting the growth of the pharmaceutical sector [45] Valuation Insights - As of July 11, 2025, the overall PE valuation for the pharmaceutical sector is 35.79X, indicating that the sector is still at a relatively low historical valuation [33][45]

Investment Rating - The report maintains a positive outlook on the innovative drug sector, expecting significant revenue growth and potential profitability for several companies in the first half of 2025 [3][8]. Core Insights - The innovative drug sector is projected to see revenue growth of at least 40% year-on-year for companies such as BeiGene, Innovent Biologics, and others, driven by the commercialization of core products [3][8]. - The Pharma sub-sector is expected to experience a revenue growth rate of 10-15% for companies like Hansoh Pharmaceutical and China Biologic Products, while others may see growth of 5-10% [3][8]. - The medical services sector is anticipated to have a revenue growth of 15-20% for companies like GuoShengTang, with a focus on mergers and acquisitions [3][8]. Summary by Sections Innovative Drugs - Companies expected to achieve over 40% revenue growth in 1H25 include BeiGene, Innovent Biologics, and others, primarily due to the commercialization of key products [3][8]. - Some companies, such as BeiGene and Innovent Biologics, are likely to reach profitability due to increased sales volume [3][8]. - The report highlights that companies like Hutchison China MediTech may see significant profit growth due to asset disposals [3][8]. Pharma - The impact of centralized procurement is gradually diminishing, allowing for continued innovation and transformation within the sector [3][8]. - Companies projected to achieve 10-15% revenue growth include Hansoh Pharmaceutical and China Biologic Products, while others like 3SBio and United Laboratories may see 5-10% growth [3][8]. Medical Services - GuoShengTang is expected to have a revenue growth of 15-20% in 1H25, with ongoing attention to domestic and international acquisition activities [3][8].

Group 1 - Goldman Sachs adjusts target prices for Chinese pharmaceutical stocks, maintaining "Buy" ratings for China Biologic Products (01177) with a target price raised from HKD 3.92 to HKD 6.19, Hansoh Pharmaceutical (03692) from HKD 22.71 to HKD 34.83, and Innovent Biologics with a target price from HKD 74.95 to HKD 96.22, while upgrading the rating for CStone Pharmaceuticals (02616) from "Neutral" to "Buy" with a target price raised from HKD 2.77 to HKD 6.25 [1] - The report highlights a strong performance in the stock prices of Chinese biotech companies, which have risen 78% year-to-date, compared to 41% and 2% for offshore and onshore healthcare stocks respectively, and 18% for the MSCI China Index, indicating a structural shift rather than a temporary rebound [1][2] Group 2 - The potential for upward growth is further supported by product licensing, mergers and acquisitions, and the establishment of new companies, with China accounting for about one-third of the global clinical trial pipeline by mid-2025 and approximately 50% of innovative drug candidates entering human studies in the first half of the year [2] - Chinese companies are leading in new therapies that may define future standard treatments, particularly in areas such as ADCs (antibody-drug conjugates) and BsAb/TCEs, while also emerging as significant players in siRNA and PROTAC fields [2] - The focus on oncology and obesity is expected to grow, with ADC/BsAb representing a key differentiating advantage for China, accounting for one-third of outbound licensing deals, while siRNA and PROTAC pipelines may present future trading opportunities [2] Group 3 - Goldman Sachs introduces a new "Probability of Licensing Success" (PoLS) framework to assess the potential outbound value of Chinese biotech/pharmaceutical pipelines, suggesting that summer presents an opportunity to accumulate high-quality innovative drug stocks [3] - The firm remains optimistic about leading biotech companies such as BeiGene (06160), Innovent Biologics (01801), and Kelun-Biotech (06990), highlighting their significant upside potential by the second half of 2025 [3] - Specific companies like Innovent Biologics, Zai Lab (09688), and Legend Biotech Corporation (LEGN.US) are noted for their promising data releases and sales growth, indicating strong future performance [3]