Core Viewpoint - The healthcare stocks in mainland China have experienced a significant pullback since early last month, with the Hang Seng Healthcare Index and the CSI 300 Healthcare Index declining by 12% and 9% respectively, compared to a 2% drop in the Hang Seng Index and a 1% increase in the CSI 300 Index [1] Group 1: Market Influences - The decline in healthcare stocks is influenced by multiple factors, including heightened US-China tensions and increased geopolitical risk premiums prompting profit-taking by investors [1] - The inclusion of a milder version of the US "Biosecurity Act" in next year's National Defense Authorization Act has raised uncertainties regarding pharmaceutical outsourcing services [1] - Concerns persist regarding potential increased US regulations that may restrict authorized transactions with China or limit clinical data from Chinese sources, impacting the biotech and pharmaceutical sectors [1] Group 2: Market Sentiment and Valuation - Recent authorized transactions have failed to boost market sentiment, and the lack of strong industry-level positive catalysts for the remainder of the year may limit stock price momentum [1] - The anticipated results of national medical insurance drug price negotiations and the legislative progress of the "Biosecurity Act" are expected to influence market sentiment [1] - Despite the pullback, industry valuations and market expectations for business development transactions are returning to more reasonable levels, with no substantial deterioration in the industry's solid fundamentals observed [1] Group 3: Investment Recommendations - The recent stock price decline is viewed as providing favorable conditions for performance in the upcoming year [1] - Preferred stocks identified by the company include CanSino Biologics (09926), Hansoh Pharmaceutical (03692), and WuXi AppTec (02359), with additional positive outlooks for Innovent Biologics (01801) and Hengrui Medicine (01276) [1]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年10月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 翰森製藥集團有限公司 呈交日期: 2025年11月3日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 03692 | 說明 | - | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 20,000,000,000 | HKD | | 0.00001 | HKD | | 200,000 | | 增加 / 減少 (-) | | | | | | | HKD | | | | 本月底結存 | | | 20,000,000,000 | HKD | | 0.00001 | HKD | | 200,000 | FF30 ...

Core Viewpoint - The Hong Kong Stock Connect Innovative Drug ETF (Southern, 159297) has shown significant market activity, with a recent increase of 3.38% and a trading volume of 170 million yuan, indicating strong investor interest in the innovative drug sector [1] Group 1: Market Performance - The Hong Kong Stock Connect Innovative Drug ETF (Southern, 159297) reached a new high in both scale and shares since its inception as of October 31 [1] - The ETF has experienced net inflows for 4 out of the last 5 trading days, totaling 18.9 million yuan [1] - The index it tracks, the National Certificate Hong Kong Stock Connect Innovative Drug Index, rose by 3.67%, with notable increases in component stocks such as Senhwa Biosciences (up 10.11%) and Kanglongda (up 8.80%) [1] Group 2: Policy and Industry Insights - The ongoing negotiations for the National Medical Insurance drug list are complemented by a new commercial health insurance innovative drug directory, aimed at providing new payment channels for high-value innovative drugs [1] - The CAR-T cell drug, Rukiyou Lunsai injection from WuXi AppTec, is making progress in negotiations to be included in the commercial health insurance innovative drug directory, with a listed price of 1.29 million yuan per injection [1] - Open Source Securities notes that the current innovative drugs included in both medical insurance and commercial insurance are in the early stages of volume growth, with potential for rapid revenue increases as policies continue to support innovative drugs [2] Group 3: Institutional Investment Trends - According to Guotou Securities, the proportion of all funds heavily invested in Biotech innovative drug companies has increased to 27.53%, reflecting a 2.61 percentage point rise, indicating growing institutional interest in the innovative drug sector [2] - The increasing allocation of funds to the innovative drug sector suggests a strong market recognition of its long-term development potential [2]

Core Viewpoint - The Hu Run Research Institute released the "2025 Hu Run Women Entrepreneurs List," highlighting that Zhong Huijuan and her daughter Sun Yuan topped the list as China's richest women with a wealth of 141 billion yuan, marking an increase of 64 billion yuan or 83% from the previous year. This is the first time a woman from the life and health sector has achieved this status [1][3]. Company Overview - Zhong Huijuan, 64, is from Lianyungang, Jiangsu, and is married to Sun Piaoyang, the founder of Heng Rui Medicine. Together, they are known as "China's most powerful pharmaceutical couple," each leading companies with market values exceeding 100 billion yuan [3]. - Over the past year, Hansoh Pharmaceutical's market value doubled, driven by the launch of innovative drugs and international collaborations. Since 2025, the company's stock price has increased by over 115%, reaching 35.78 HKD per share, with a market capitalization of 216.65 billion HKD [3][4]. Business Transformation - Hansoh Pharmaceutical transitioned from a generic drug manufacturer to a leader in innovative drugs, reflecting the evolution of China's pharmaceutical industry over the past three decades. As of the first half of 2025, innovative drug revenue accounted for 82.7% of total revenue, with frequent overseas licensing deals [3][7]. - The company faced significant challenges due to the implementation of centralized drug procurement policies, which drastically reduced profits from generic drugs. In response, the company shifted its focus to innovative drug development, increasing R&D investments and establishing multiple research centers [7][10]. Financial Performance - In 2024, Hansoh Pharmaceutical reported total revenue of 12.261 billion yuan, a year-on-year increase of 21.3%, with a net profit of 4.372 billion yuan, up 33.4%. Innovative drug and collaboration product sales reached 9.477 billion yuan, a 38.1% increase, making up 77.3% of total revenue [8][10]. - For the first half of 2025, the company achieved revenue of 7.434 billion yuan, a 14.3% increase, and a net profit of 3.135 billion yuan, up 15%. Innovative drug sales further increased to 6.145 billion yuan, representing 82.7% of total revenue [8][10]. R&D Investment - Hansoh Pharmaceutical's commitment to R&D is evident, with R&D expenditures of approximately 2.702 billion yuan in 2024, a 28.8% increase, accounting for over 20% of total revenue. In the first half of 2025, R&D spending was about 1.441 billion yuan, up 20.4% [10]. - The company has over 1,800 R&D professionals and is advancing more than 70 innovative drug clinical trials across various therapeutic areas, including oncology and autoimmune diseases [10][11]. Licensing and Collaborations - International pharmaceutical giants have increasingly sought partnerships with Hansoh Pharmaceutical, leading to significant licensing agreements. Notable deals include a $1.85 billion upfront payment from GSK for ADC drug HS-20093 and a $1.12 billion upfront payment from Merck for GLP-1 receptor agonist HS-10535 [11]. - The company has established a "R&D-licensing-reinvestment" cycle, ensuring stable revenue growth while funding further research initiatives [11][12]. Market Position - The wealth increase of Zhong Huijuan and her daughter is largely attributed to the rise in Hansoh Pharmaceutical's stock price, which has surged over 115% since 2025. However, compared to other major domestic pharmaceutical companies, Hansoh remains relatively under the radar, focusing on R&D rather than media attention [12].

Core Viewpoint - The Hong Kong Innovative Drug ETF (159567) has shown significant growth in both share volume and fund size since its inception, indicating strong investor interest and market performance [1][2]. Group 1: Fund Performance - As of October 31, 2024, the Hong Kong Innovative Drug ETF (159567) closed with a gain of 5.46% and a trading volume of 3.327 billion yuan [1]. - The fund's share volume increased by 1968.65% from 3.95 million shares at the end of 2023 to 81.79 million shares by October 30, 2024 [1]. - The fund's size grew by 1650.00%, from 378 million yuan to 6.612 billion yuan during the same period [1]. Group 2: Liquidity - Over the last 20 trading days, the cumulative trading amount for the fund reached 23.202 billion yuan, with an average daily trading amount of 1.16 billion yuan [1]. - Year-to-date, the cumulative trading amount for the fund is 234.346 billion yuan, averaging 1.172 billion yuan per day over 200 trading days [1]. Group 3: Fund Management - The current fund manager, Ma Jun, has managed the Hong Kong Innovative Drug ETF (159567) since its inception, achieving a return of 64.72% during the management period [2]. - The fund's top holdings include companies such as BeiGene, CanSino Biologics, Innovent Biologics, and others, with significant percentages of the portfolio allocated to these stocks [2].

Macro Dynamics - In September, the bond market issued a total of 81,027.8 billion yuan in various bonds, including 14,904.9 billion yuan in government bonds, 8,519.1 billion yuan in local government bonds, 11,741.0 billion yuan in financial bonds, 13,407.3 billion yuan in corporate credit bonds, 365.7 billion yuan in credit asset-backed securities, and 31,627.8 billion yuan in interbank certificates of deposit [2] - In September, China's foreign exchange market had a total transaction volume of 26.87 trillion yuan (approximately 3.78 trillion USD), with the interbank market accounting for 22.44 trillion yuan (approximately 3.16 trillion USD) [3] - In the first three quarters, the revenue of large-scale internet and related service enterprises in China reached 14,420 billion yuan, showing a year-on-year growth of 2.8% [4][5] Financial Institutions - China Taiping announced the sale of minority stakes in four companies for a total consideration of 6.5 billion yuan [8] - Hangzhou Bank received approval to issue capital instruments not exceeding 40 billion yuan [9] Market Data - On October 31, A-shares saw a collective decline, with the Shanghai Composite Index down 0.81%, the Shenzhen Component down 1.14%, and the ChiNext Index down 2.31% [11] - The financing balance in the two markets decreased by 7.392 billion yuan, with the Shanghai Stock Exchange reporting a balance of 12,535.78 billion yuan and the Shenzhen Stock Exchange reporting 12,196.92 billion yuan [12] Company Dynamics - China National Petroleum Corporation announced the resignation of Zhou Song as the chairman of the supervisory board [14] - InSai Group decided to terminate a major asset restructuring plan due to changes in the external environment [15] - Tianqi Co., Ltd. signed a strategic cooperation framework agreement with Foxconn Automotive to deploy at least 2,000 embodied intelligent robots over the next five years [17] - Li Auto announced a recall of 11,411 units of the MEGA 2024 electric vehicle due to potential safety hazards [18] - Qingyue Technology is under investigation by the China Securities Regulatory Commission for suspected false financial reporting [19]

Core Insights - The news highlights that Zhong Huijuan, the founder and CEO of Hansoh Pharmaceutical, has become China's richest woman with a wealth of 141 billion yuan, marking a significant milestone in the 20-year history of the Hurun Women's Entrepreneur List [2][3] Company Overview - Hansoh Pharmaceutical was founded on July 26, 1995, originally as Jiangsu Haosen, a Sino-foreign joint venture [3][4] - The company underwent several restructurings and was listed on the Hong Kong Stock Exchange on June 14, 2019 [4] Business Strategy and Development - The company has focused on a development strategy of "combining imitation and innovation," establishing a foundation with generic drugs while seeking breakthroughs with innovative drugs [5] - Since 2002, Hansoh has been developing Class 1.1 innovative drugs, with its first approved innovative drug, Mylinda, launched in 2014 [5] Financial Performance - In the first half of this year, Hansoh Pharmaceutical achieved revenue of 7.434 billion yuan, a year-on-year increase of 14.3%, and a net profit of 3.135 billion yuan, up 15% [5] - Innovative drugs and cooperative product sales contributed significantly to the revenue, with innovative drugs accounting for approximately 82.7% of total revenue [6] Market Position and Stock Performance - As of October 31, the market capitalization of Hansoh Pharmaceutical reached 212.9 billion yuan, with the stock price doubling this year [6] - Zhong Huijuan and her daughter hold over 60% of the company's shares, indicating strong family control [6] Recent Developments - Hansoh's innovative drug for non-small cell lung cancer, Amelot, was approved for sale in the UK, marking the company's first entry into the overseas market [7] - The company has also licensed overseas rights for its investigational CDH17-targeted antibody-drug conjugate to Roche, receiving an upfront payment of 80 million USD and potential milestone payments of up to 1.45 billion USD [7]

Core Viewpoint - The article highlights the rise of Zhong Huijuan, founder and CEO of Hansoh Pharmaceutical, as the new richest woman in China, with a wealth of 141 billion yuan, marking a significant milestone in the pharmaceutical industry and women's leadership in business [3][4]. Company Overview - Hansoh Pharmaceutical was founded on July 26, 1995, originally as Jiangsu Haosen, a Sino-foreign joint venture [5]. - The company underwent several restructurings and was listed on the Hong Kong Stock Exchange on June 14, 2019 [7]. - The company focuses on the development of innovative drugs, particularly in oncology, anti-infection, central nervous system, metabolism, and autoimmune diseases [8]. Financial Performance - In the first half of the year, Hansoh Pharmaceutical achieved revenue of 7.434 billion yuan, a year-on-year increase of 14.3%, and a net profit of 3.135 billion yuan, up 15% [8]. - Innovative drugs and cooperative product sales accounted for approximately 82.7% of the company's total revenue, with sales from innovative drugs reaching 6.145 billion yuan [8]. Market Position and Growth - The company's stock price has doubled this year, with a market capitalization reaching 212.9 billion yuan as of October 31 [8]. - Zhong Huijuan and her daughter hold over 60% of the company's shares, indicating strong family control and confidence in the company's future [8]. Recent Developments - Hansoh Pharmaceutical's innovative drug for non-small cell lung cancer, Amelot, was approved for sale in the UK, marking the company's first entry into the overseas market [9]. - The company has also licensed overseas rights for its investigational CDH17-targeted antibody-drug conjugate to Roche, which includes an upfront payment of $80 million and potential milestone payments of up to $1.45 billion [9].

Core Viewpoint - The innovative drug sector is experiencing a rise in stock prices despite market conditions, driven by new policies and strong quarterly performances from several pharmaceutical companies [1] Group 1: Stock Performance - Innovent Biologics (01801) saw an increase of 8.12%, reaching HKD 87.25 [1] - Three-Sixty Biopharma (01530) rose by 11.42%, trading at HKD 30.84 [1] - Kelun-Biotech (06990) increased by 6.97%, priced at HKD 451 [1] - Connaissance-B (02162) gained 4.71%, with a price of HKD 60.05 [1] - Hansoh Pharmaceutical (03692) rose by 4.56%, trading at HKD 35.76 [1] Group 2: Policy Changes - The 2025 National Medical Insurance negotiation commenced on October 30, introducing a "commercial insurance innovative drug catalog" mechanism for the first time [1] - This year's negotiations continue the regular adjustment mechanism of the medical insurance catalog [1] Group 3: Market Activity - As of October 21, 2023, there have been 115 licensing agreements for innovative drugs in China, totaling USD 101.24 billion, significantly surpassing the total of USD 51.9 billion for the entire year of 2024 [1] Group 4: Company Performance - Hengrui Medicine reported a net profit of CNY 5.751 billion for the first three quarters, a year-on-year increase of 24.5% [1] - Innovent Biologics achieved total product revenue exceeding CNY 3.3 billion in Q3, maintaining a robust year-on-year growth of approximately 40% [1] Group 5: Industry Outlook - The pharmaceutical industry is showing signs of marginal improvement, with a potential shift in market focus towards high-growth sectors supported by performance [1] - Recommendations include focusing on companies with Q3 performance likely to exceed expectations, as well as sectors such as CXO, upstream life sciences, medical device recovery, and innovative drugs [1]

Core Insights - The news highlights that Zhong Huijuan has become the richest woman in China, with a wealth of 141 billion yuan, according to the 2025 Hurun Women Entrepreneurs List, marking her as the first female billionaire in the life and health sector in the list's history [1] Company Overview - Zhong Huijuan is the founder, chairperson, CEO, and executive director of Hansoh Pharmaceutical, which was established on July 26, 1995, originally as Jiangsu Haosen, a Sino-foreign joint venture [3][4] - The company underwent several transformations and was listed on the Hong Kong Stock Exchange on June 14, 2019 [4] Business Strategy - Hansoh Pharmaceutical has adopted a development strategy of "combining imitation and innovation," focusing on the research and development of innovative drugs since 2002 [4] - The company has successfully developed and launched two innovative drugs, with its first innovative drug, Mai Ling Da, approved in 2014 [4] Financial Performance - In the first half of this year, Hansoh Pharmaceutical achieved a revenue of 7.434 billion yuan, a year-on-year increase of 14.3%, and a net profit of 3.135 billion yuan, up 15% [5] - The sales revenue from innovative drugs and cooperative products accounted for approximately 82.7% of the company's total revenue [5] Market Position - As of October 31, the market capitalization of Hansoh Pharmaceutical reached 212.9 billion yuan, with the stock price doubling this year [5] - The company has made significant strides in its innovative drug business, including the approval of its non-small cell lung cancer drug in the UK and a licensing agreement with Roche for an ADC product, which includes an upfront payment of 80 million USD [5]