证券代码：002821 证券简称：凯莱英 公告编号：2025-046 凯莱英医药集团（天津）股份有限公司 独立董事提名人声明与承诺 提名人凯莱英医药集团（天津）股份有限公司董事会现就提名 孙雪娇女士为 凯莱英医药集团（天津）股份有限公司第五届董事会独立董事候选人发表公开声 明。被提名人已书面同意作为凯莱英医药集团（天津）股份有限公司第五届董事 会独立董事候选人。本次提名是在充分了解被提名人职业、学历、职称、详细的 工作经历、全部兼职、有无重大失信等不良记录等情况后作出的，本提名人认为 被提名人符合相关法律、行政法规、部门规章、规范性文件和深圳证券交易所业 务规则对独立董事候选人任职资格及独立性的要求，具体声明并承诺如下事项： 一、被提名人已经通过凯莱英医药集团（天津）股份有限公司第四届董事会 提名委员会或者独立董事专门会议资格审查，提名人与被提名人不存在利害关系 或者其他可能影响独立履职情形的密切关系。 √是 □ 否 二、被提名人不存在《中华人民共和国公司法》第一百四十六条等规定不得 担任公司董事的情形。 √是 □ 否 三、被提名人符合中国证监会《上市公司独立董事管理办法》和深圳证券交 易所业务规则规定的独立 ...

一、监事会会议召开情况 凯莱英医药集团（天津）股份有限公司（以下简称"公司"）第四届监事会 第五十二次会议通知于 2025 年 7 月 11 日以电子邮件及书面报告等形式发送给各 位监事，会议于 2025 年 7 月 18 日以通讯方式召开。公司应到监事 3 名，实到监 事 3 名，会议由公司监事会主席智欣欣女士召集，会议的召集和召开符合《公司 法》及相关法律、法规以及《公司章程》的有关规定。 证券代码：002821 证券简称：凯莱英 公告编号：2025-043 凯莱英医药集团（天津）股份有限公司 第四届监事会第五十二次会议决议公告 本公司及全体监事会成员保证公告内容真实、准确和完整，不存 在虚假记载、误导性陈述或重大遗漏。 本议案尚需提交公司 2025 年第二次临时股东大会审议。 三、备查文件 公司第四届监事会第五十二次会议决议。 二、监事会会议审议情况 会议采用通讯方式进行了表决，经全体监事审议并表决，通过了如下决议： 1、审议通过了《关于取消监事会的议案》 根据《公司法》及中国证监会《关于发布新<公司法>配套制度规则实施相关 过渡期安排》、《上市公司章程指引》（2025年修订）等规定，公司拟对《公司 章 ...

证券代码：002821 证券简称：凯莱英 公告编号：2025-042 凯莱英医药集团（天津）股份有限公司 第四届董事会第六十五次会议决议的公告 本公司及全体董事会成员保证公告内容真实、准确和完整，不存 在虚假记载、误导性陈述或重大遗漏。 一、董事会会议召开情况 凯莱英医药集团（天津）股份有限公司（以下简称"公司"或"凯莱英"） 第四届董事会第六十五次会议通知于 2025 年 7 月 11 日以电子邮件及书面的形式 发送给各位董事、监事及高级管理人员，会议于 2025 年 7 月 18 日以通讯表决方 式召开。公司应到董事 9 名，实到董事 9 名，公司监事及高级管理人员列席了本 次会议。会议由公司董事长 HAO HONG 先生召集和主持，会议的召集和召开符合 《公司法》及相关法律、法规以及《公司章程》的有关规定。 二、董事会议案审议情况 会议采用通讯方式进行了表决，经全体董事审议通过如下决议： 1、逐项审议通过了《关于选举第五届董事会非独立董事的议案》 公司第四届董事会已届满，为进一步完善公司治理结构，符合境内外有关法 律法规的规定以及相关监管要求，在广泛征询公司相关股东意见后，经公司董事 会提名委员会审核， ...

Core Viewpoint - The AI Fund Zhaoshang Frontier Healthcare Stock A (011373) reported a profit of 41.645 million yuan for Q2 2025, with a fund net value growth rate of 7.89% and a total fund size of 570 million yuan as of the end of Q2 2025 [2][12]. Fund Performance - The fund's weighted average profit per share for the reporting period was 0.0404 yuan [2]. - As of July 17, the unit net value was 0.625 yuan [2]. - The fund's performance over various time frames includes a 32.00% growth rate over the last three months, 43.06% over the last six months, and 42.96% over the last year, ranking 22/54 and 21/53 among comparable funds respectively [2]. Fund Management - The fund is managed by Li Jiasun, who oversees four funds, all of which have shown positive returns over the past year [2]. - The fund focuses on sectors with a comparative advantage in certain growth, particularly in innovative drugs, R&D outsourcing, medical devices, and AI healthcare [2]. Risk Metrics - The fund's three-year Sharpe ratio stands at -0.1027, ranking 28/46 among comparable funds [7]. - The maximum drawdown over the last three years was 48.11%, with the largest single-quarter drawdown occurring in Q3 2022 at 26.38% [8]. Investment Strategy - The fund maintains a high stock position, averaging 90.79% over the last three years, with a peak of 94.27% at the end of Q3 2024 [11]. - The fund has a high concentration in its top ten holdings, which have consistently exceeded 60% over the past two years [15].

Group 1 - The core viewpoint of the news is the performance and holdings of the China Europe Medical Health Mixed Fund C, which has shown positive growth in recent months and has a significant allocation in leading healthcare companies [1][3]. - As of July 15, 2025, the latest net value of the fund is 1.7462 yuan, reflecting a growth of 1.28%. The fund's one-month return is 2.18%, six-month return is 18.43%, and year-to-date return is 14.30% [1]. - The fund's top ten stock holdings account for a total of 55.30%, with significant investments in companies such as Heng Rui Pharmaceutical (10.60%), WuXi AppTec (9.95%), and Mindray Medical (5.21%) [1]. Group 2 - The China Europe Medical Health Mixed Fund C was established on September 29, 2016, and as of March 31, 2025, it has a total scale of 15.566 billion yuan. The fund is managed by Guo Lan and Zhao Lei [1]. - Guo Lan, the fund manager, has a background in biomedical engineering and has held various positions in research and fund management since joining China Europe Fund Management in 2014 [2]. - Zhao Lei, also a fund manager, has experience in the pharmaceutical and biotechnology sectors, having worked as a researcher and analyst before joining China Europe Fund Management in 2021 [2].

Group 1 - The CRO (Contract Research Organization) sector is experiencing a surge in stock prices, with notable increases in companies such as Boteng Co., Ltd. (20% increase), Kailaiying (10% increase), and WuXi AppTec (9.99% increase) [1][2][3] - The Hong Kong CXO concept stocks also saw significant gains, with Kailaiying and WuXi AppTec both rising over 10% [3][4] - WuXi AppTec is projected to achieve approximately RMB 20.8 billion in revenue for the first half of 2025, representing a year-on-year growth of about 20.64%, and an adjusted net profit of approximately RMB 6.315 billion, reflecting a year-on-year increase of about 44.43% [4][5] Group 2 - The growth in performance for WuXi AppTec is attributed to its focus on meeting customer demands, expanding capabilities, and optimizing production processes [5] - The CXO sector is expected to benefit significantly from the current high demand for innovative drugs, with a new upturn in the life sciences and CXO sectors anticipated [5][6] - Analysts predict that the CXO sector will see a recovery in domestic front-end business due to supportive industrial policies and improved investment conditions [6] Group 3 - The current wave of innovation in the pharmaceutical sector is seen as a significant turning point, with a shift from following trends to creating original products, indicating a fundamental change in the industry [7][8] - Large multinational pharmaceutical companies are increasingly purchasing innovative drug patents from China, driven by pressures to lower drug prices and the expiration of patents [8]

Core Viewpoint - The innovative drug concept continues to show strong performance, with significant stock price increases for companies such as Boteng Co. and Changshan Pharmaceutical, which rose over 15% [1] Group 1: Stock Performance - Boteng Co. and Changshan Pharmaceutical saw stock increases of over 15% [1] - WuXi AppTec experienced a nearly 9% rise [1] - Other companies like Kylin Pharmaceutical, Guangsheng Pharmaceutical, and Yifang Bio also saw stock increases of over 5% [1] Group 2: Policy Announcement - On July 10, the National Healthcare Security Administration announced the adjustment plan for the 2025 National Basic Medical Insurance, Maternity Insurance, and Work Injury Insurance Drug Catalogs, as well as the Commercial Health Insurance Innovative Drug Catalog [1] - The plan specifies that the adjustments to the basic medical insurance drug catalog and the establishment of the commercial health insurance innovative drug catalog will occur simultaneously in 2025 [1]

Group 1 - The Hang Seng Index initially expanded its gains to 1%, while the Hang Seng Tech Index rose by 1.06% [1] - The biopharmaceutical, innovative drug, and pharmaceutical outsourcing sectors showed strong performance [1] - Chip stocks have been rising for several consecutive days, and Chinese brokerage stocks continued their upward trend [1] Group 2 - Guotai Junan International (01788.HK) increased by over 7%, while Kelaiying (06821.HK) surged by over 16% [1] - Yesterday's popular stock, Puxing Energy (00090.HK), rose by over 22% [1]

Summary of the Conference Call Records Industry Overview: CRO and CDMO Key Points on CRO Industry - The CRO (Contract Research Organization) industry is facing challenges due to intensified competition and weakened profitability after rapid capacity expansion [1][4] - Orders for CRO companies have decreased due to obstacles in innovative drug financing and changes in pharmaceutical policies, leading to a difficult destocking phase [1][4] - In 2024, the number of drug clinical trials in China is expected to grow by 16%, with Phase III trials increasing by 31%, indicating a push in innovative drug development [1][5] - The proportion of BE (Bioequivalence) trials is close to 50%, while Phase I trials have decreased, suggesting a slowdown in early clinical trials [1][5] - Major CRO companies like Zhaoyan New Drug and Tigermed are still expanding their workforce despite the pressure on profitability, indicating market share growth [1][6] Key Points on CDMO Industry - The CDMO (Contract Development and Manufacturing Organization) industry is significantly driven by large orders, particularly from COVID-19 drug commercialization [2][7] - From 2021 to 2023, major companies like WuXi AppTec, Kelun, and Boteng collectively generated $4.2 billion in revenue from large orders, with profits reaching $1.7 billion [2][7] - The development of the peptide industry is crucial for CDMO companies, with products like Semaglutide driving growth for companies like Nuotai and WuXi AppTec [3][8] - The ADC (Antibody-Drug Conjugate) industry is expected to maintain a compound annual growth rate of over 35% until 2030, reflecting strong demand for outsourcing services [3][8] Future Trends and Opportunities - The CRO industry is undergoing a transformation as companies adjust structures and optimize resource allocation to survive [4][6] - The introduction of new listing standards for unprofitable companies may alleviate financing issues for innovative drug firms, potentially boosting CRO demand [4][6] - The potential of alphablenton, a small molecule drug for chronic disease treatment, is highlighted, with a projected sales figure exceeding $29 billion by 2035 [3][11] - The market for chronic disease treatments is expected to grow significantly, with the global adult obesity population projected to rise from 760 million in 2020 to over 1 billion by 2030 [11][12] Additional Insights - The CRO industry is currently experiencing a downturn, with many small companies facing survival challenges, while leading firms are expanding their market share [4][6] - The complex synthesis routes of products like alphablenton contribute significantly to CDMO value, indicating a shift towards more specialized and high-value offerings [10][11] - The pain management market is projected to exceed $120 billion by 2027, with new drug developments addressing unmet clinical needs [13][14] This summary encapsulates the critical insights from the conference call, focusing on the current state and future outlook of the CRO and CDMO industries, along with emerging opportunities and challenges.

Group 1 - The core point of the news is the performance and holdings of the China Europe Medical Health Mixed Fund C, which has shown a recent net value increase of 0.94% but a one-month return of -0.94% [1] - The fund's three-month return is 16.34%, ranking 306 out of 1238 similar funds, while its year-to-date return is 10.10%, ranking 434 out of 1218 [1] - The top ten stock holdings of the fund account for a total of 55.30%, with significant positions in companies such as Heng Rui Pharmaceutical (10.60%) and WuXi AppTec (9.95%) [1] Group 2 - The China Europe Medical Health Mixed Fund C was established on September 29, 2016, and as of March 31, 2025, it has a total scale of 15.566 billion yuan [1] - The fund is managed by two key managers: Ms. Ge Lan, who has been managing it since its inception, and Ms. Zhao Lei, who took over management on July 4, 2025 [2]