Core Points - The Hong Kong Innovative Drug ETF (159567) closed down 0.12% with a trading volume of 797 million yuan on October 24, 2024 [1] - The fund was established on January 3, 2024, with a management fee of 0.50% and a custody fee of 0.10% [1] - As of October 23, 2024, the fund's latest share count was 8.225 billion shares, with a total size of 6.801 billion yuan, reflecting a year-to-date increase of 1980.29% in shares and 1700.12% in size [1] Fund Performance - The current fund manager is Ma Jun, who has managed the fund since its inception, achieving a return of 65.38% during the tenure [2] - The fund's performance benchmark is the National Index for Hong Kong Innovative Drugs, adjusted for valuation exchange rates [1] Liquidity and Trading Activity - Over the last 20 trading days, the ETF has accumulated a trading amount of 22.849 billion yuan, with an average daily trading amount of 1.142 billion yuan [1] - Since the beginning of the year, the ETF has recorded a total trading amount of 227.996 billion yuan over 195 trading days, averaging 1.169 billion yuan per day [1] Top Holdings - The ETF's top holdings include: - Innovent Biologics (9.52% holding, 26 million yuan market value) - WuXi Biologics (9.47% holding, 25.8 million yuan market value) - BeiGene (8.73% holding, 23.8 million yuan market value) - CanSino Biologics (7.62% holding, 20.8 million yuan market value) - China National Pharmaceutical Group (7.17% holding, 19.6 million yuan market value) [2]

Core Viewpoint - The pharmaceutical sector is experiencing fluctuations, with a notable increase in the Medical Innovation ETF and several key stocks, indicating a positive trend in the market despite recent adjustments [1][2]. Group 1: Market Performance - As of October 24, the Medical Innovation ETF (516820.SH) rose by 0.26%, with significant gains in constituent stocks such as Kanglong Chemical (300759) up 3.34%, Xingqi Eye Medicine (300573) up 2.35%, and WuXi AppTec (603259) up 1.77% [1]. - Over the past five trading days, there have been net inflows into the Medical Innovation ETF for four days, totaling 14.06 million yuan, with an average daily net inflow of 2.81 million yuan [1]. Group 2: Upcoming Events and Innovations - The European Society for Medical Oncology (ESMO) conference in mid to late October 2025 will showcase research results from several domestic innovative drugs, including clinical trials from Kangfang Bio, Kelun Biotech, and others [1]. - The increasing competitiveness of domestic innovative drugs in global clinical data and progress is strengthening the trend of these drugs entering international markets [1]. Group 3: Industry Trends and Outlook - Historically, the fourth quarter is a peak period for business development (BD) activities, with major deals expected from companies like Kangfang Bio and Kelun Biotech [2]. - Despite recent market adjustments, the outlook for innovative drug companies remains positive, with multiple catalysts expected, including ESMO data and continued performance improvements in quarterly reports [2]. - The long-term trend for innovative drugs is upward, driven by both international expansion and domestic revenue growth, with the potential for significant market opportunities despite short-term disturbances [2].

Group 1 - The Hang Seng Index rebounded, closing up 0.72%, with the internet sector leading the gains, followed by banking, industry, technology, and real estate sectors [1] - The internet sector saw a rise of 1.07%, with Meituan up 4.06%, Alibaba up 1.67%, Tencent Holdings up 1.52%, JD Group up 1.5%, and Baidu Group up 1.22%. However, companies like SenseTime, Bilibili, and Kingdee International experienced declines [3] - The banking sector opened strong and maintained a consolidation above the midline, closing up 0.88%, with Postal Savings Bank rising 4.59% and Minsheng Bank up 2.39% [3] Group 2 - The consumer sector rebounded, closing up 0.35%, with notable gains from companies like Chenzi Biological up 6.68%, Li Ning up 6.55%, and Sands China up 4.4% [3] - The healthcare sector opened low and saw a slight reversal near the end, closing down 1.31%, with CSPC Pharmaceutical down 2.96% and China Biopharmaceutical down 2.78% [3]

Investment Rating - The report maintains a "Positive" investment rating for the pharmaceutical and biotechnology industry in China [5]. Core Insights - The ESMO conference showcased significant breakthroughs in both foreign and domestic innovative drugs, highlighting the competitive strength of Chinese pharmaceutical companies on the international stage [3][12]. - The report emphasizes the potential of domestic innovative drugs to redefine standard therapies, particularly in the context of PD-1/VEGF dual antibodies and antibody-drug conjugates (ADCs) [8][29]. Summary by Sections 1. PD-1 plus and Domestic Dual Antibodies - The PD-(L)1/VEGF dual antibody, Ivosidenib, demonstrated strong positive results in a Phase III trial for first-line treatment of advanced squamous non-small cell lung cancer (NSCLC), showing a progression-free survival (PFS) improvement of 4.2 months compared to the PD-1 group [13][16]. - SSGJ-707, a PD-1/VEGF dual antibody, showed promising results in treating microsatellite stable (MSS) colorectal cancer, with an overall response rate (ORR) of 68.7% and a disease control rate (DCR) of 98.5% [18][19]. - HB0025, another PD-L1/VEGF dual antibody, reported an ORR of 83.3% in squamous NSCLC patients, indicating strong anti-tumor efficacy [20][21]. 2. ADCs: Accelerated Breakthroughs - SKB264, an ADC, has shown significant PFS and overall survival (OS) benefits in a Phase III trial for EGFR-mutant NSCLC, with PFS HR of 0.49 and OS HR of 0.60, indicating its potential as a new standard therapy [29][30]. - In the breast cancer domain, SKB264 demonstrated an ORR of 41.5% in CDK4/6i pre-treated HR+/HER2- advanced breast cancer, significantly outperforming chemotherapy [31][32]. - The report highlights the global potential of SKB264, with ongoing studies expected to further validate its efficacy and safety profile [23][29].

Core Viewpoint - The main stock index in South Africa increased by 1% to reach 109,926 points on October 23 [1] Group 1 - The rise in the stock index indicates positive market sentiment in South Africa [1]

Core Viewpoint - The Hong Kong stock market's innovative drug sector is experiencing a decline, with the Hong Kong Stock Connect Innovative Drug ETF (520880) dropping over 3.5% as of the report, indicating a potential buying opportunity for investors despite the downturn [1] Group 1: Market Performance - The Hong Kong Stock Connect Innovative Drug ETF (520880) has seen a trading volume exceeding 200 million yuan, continuing to exhibit high premiums in the market [1] - The innovative drug sector faced a significant drop recently, with the ETF attracting over 75 million yuan in a single day, totaling over 120 million yuan in the last four days [1] Group 2: Recent Developments - The ESMO 2025 conference recently showcased positive data for several core projects of Chinese innovative drugs [1] - On October 22, Innovent Biologics announced a global strategic partnership with Takeda Pharmaceutical worth 11.4 billion USD, setting a record for the value of business development (BD) transactions in China's innovative drug sector, involving three product rights and pipeline development [1] Group 3: Future Outlook - Huafu Securities suggests that the recent adjustments in the Hong Kong innovative drug sector may present a significant opportunity for investment in late October [1] - The long-term outlook remains positive for companies with commercialization capabilities and rich pipelines, particularly in BioPharma, potential BD targets, and cutting-edge technology [1] - The innovative drug industry is expected to benefit from interest rate cuts, with performance anticipated to improve, and the end-of-year BD period may act as a catalyst for growth [1] Group 4: Index Composition - The Hong Kong Stock Connect Innovative Drug ETF (520880) and its linked fund (025220) passively track the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, which includes top ten weighted stocks such as BeiGene, China Biologic Products, Innovent Biologics, and others [1]

Core Insights - The report from Guojin Securities highlights the significant advancements in China's innovative drug research presented at the ESMO conference, indicating a potential boost for the international expansion of these drugs [1] Group 1: Innovative Drug Research - The number of significant research publications from Chinese pharmaceutical companies at ESMO has reached a historical high, making it a focal point of the conference [1] - A total of 35 Chinese studies were included in the regular oral abstracts for the 2025 ESMO conference, with 14 formal oral presentations, a significant increase from 5 in 2024 [1] - The inclusion of 23 Chinese studies in the Late-Breaking Abstracts (LBA) category also set a new record, showcasing the research strength and academic influence of Chinese companies on the international stage [1] Group 2: ADC Developments - Domestic ADCs are demonstrating the potential to redefine existing clinical treatment standards, with notable products like Kelun's SKB264 showing promising Phase III clinical data for NSCLC and HR+/HER2- breast cancer [2] - The mOS data for SKB264 in the second-line EGFRm NSCLC treatment is particularly impressive, with a hazard ratio of 0.60, indicating a significant survival benefit [2] - Bai Li Tian Heng's ADC, iza-bren, has achieved breakthroughs in treating nasopharyngeal carcinoma, marking a critical milestone from concept validation to efficacy verification [2] Group 3: Bispecific and Multi-specific Antibodies - Bispecific and multi-specific antibodies are poised to upgrade existing immunotherapy and targeted therapy, with significant data from Kangfang Biotech's PD-1/VEGF bispecific antibody showing superior results compared to traditional treatments for advanced squamous NSCLC [3] - The mPFS for the combination of the bispecific antibody and chemotherapy was reported at 11.14 months versus 6.90 months for the comparator, with a hazard ratio of 0.60, indicating a strong potential to reshape first-line treatment standards [3] - The HER2 bispecific antibody KN026 from Shiyao Group/Kangning Jierei has shown promising results in III phase trials for gastric cancer, indicating its potential as a global leader in this category [3]

Core Viewpoint - Summit Therapeutics plans to submit a Biologics License Application (BLA) to the FDA in Q4 2025 for evorpacept in combination with chemotherapy for EGFR mutation non-squamous non-small cell lung cancer (NSCLC) patients who have progressed after third-generation EGFR-TKI treatment, marking a significant step in the drug's overseas commercialization efforts [1][2]. Group 1: Clinical Trial Results - The decision to submit the BLA is based on the positive results from the global Phase III clinical trial HARMONi, which achieved its primary endpoint of progression-free survival (PFS) [1]. - Updated data from the HARMONi study showed an improvement in overall survival (OS) with a hazard ratio (HR) of 0.78 (p=0.0332) for the intention-to-treat (ITT) population, particularly notable in the North American cohort with an HR of 0.70 [2]. - The median overall survival (mOS) for the evorpacept group was reported at 16.8 months compared to 14 months for the control group, with a HR of 0.79 [1]. Group 2: Commercialization and Partnerships - In December 2022, a collaboration agreement worth up to $5 billion was established between Kangfang Biopharma and Summit Therapeutics for the development and commercialization of evorpacept in key markets including the US, Canada, Europe, and Japan [3]. - A supplemental licensing agreement was signed in June 2024, expanding Summit's rights to develop and commercialize evorpacept in additional markets including China, South America, the Middle East, and Africa, with Kangfang receiving a $70 million upfront payment [3]. Group 3: Industry Context and Future Prospects - The development of PD-(L)1/VEGF dual-targeted therapies is seen as a critical advancement in cancer treatment, addressing limitations of existing therapies [7][8]. - The success of evorpacept in clinical trials has sparked renewed interest and investment in the PD-(L)1/VEGF space, with significant cross-border transactions indicating the global market's recognition of the drug's potential [8][9]. - The ongoing clinical exploration of evorpacept is expected to accelerate, with Summit planning to initiate new Phase III trials targeting additional indications [6].

Group 1 - The 2025 European Society for Medical Oncology (ESMO) annual meeting held in Berlin is recognized as one of the most influential oncology conferences globally, showcasing significant breakthroughs in research data from Chinese pharmaceutical companies [1] - The event is seen as a key catalyst for the international expansion of Chinese innovative drugs, with high-quality data disclosure being crucial for international collaboration [1][3] - A total of 2,929 abstracts were presented at the conference, with 448 from Chinese companies, indicating a strong presence and recognition of China's innovation capabilities [2] Group 2 - Chinese pharmaceutical companies showcased their innovative capabilities through clinical data presentations, with 23 studies selected for the latest breakthrough abstracts (LBA), a significant increase from 7 in 2024 [2] - Notable companies like Jiangsu Hengrui Medicine Co., Ltd. presented multiple LBA studies, highlighting their commitment to international research and development strategies [2] - The conference served as a foundation for further international market expansion, with positive clinical data acting as a catalyst for business development (BD) collaborations with major international pharmaceutical companies [3] Group 3 - The total value of overseas BD transactions for Chinese innovative drugs reached $387 billion in the first nine months of the year, nearing the total for the entire previous year [3] - Recent BD agreements, such as the one between Hansoh Pharmaceutical Group and Roche, indicate ongoing interest and activity in the sector [4] - Industry experts predict that while the total transaction value may not reach new highs, the overall number of BD transactions will remain substantial, driven by ongoing innovation and supportive policies [4][5]

Core Insights - The report from CICC highlights that Kangfang Biotech recently presented impressive interim analysis data from the HARMONi-6 trial at The Lancet & ESMO [1] - The company has revised the HARMONi-3 trial protocol to conduct independent statistical analysis based on histological types for the primary endpoint [1] - CICC believes that separate analysis will help the company obtain clinical data earlier and that increasing the enrolled population will contribute to better overall survival (OS) performance [1] Financial Projections - CICC maintains the profit forecasts for Kangfang Biotech at 0.09 CNY for 2025 and 0.59 CNY for 2026 [1] - The firm continues to rate the company as "outperforming the industry" [1] - Due to a downward adjustment in the valuation midpoint for innovative drugs in the Hong Kong stock market, CICC has reduced the target price by 18.2% to 184 HKD [1]