| 股票简称：华海药业 | 股票代码：600521 | 公告编号：临 | 号 2025-081 | | --- | --- | --- | --- | | 债券简称：华海转债 | 债券代码：110076 | | | 浙江华海药业股份有限公司 关于获得药品注册证书的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 浙江华海药业股份有限公司（以下简称"公司"）于近日收到国家药品监督管 理局（以下简称"国家药监局"）核准签发的琥珀酸美托洛尔缓释片和盐酸尼卡地 平注射液的《药品注册证书》，现将相关情况公告如下： 一、琥珀酸美托洛尔缓释片相关情况 药品名称：琥珀酸美托洛尔缓释片 剂型：片剂 规格：47.5mg（按琥珀酸美托洛尔计） 申请事项：药品注册（境内生产） 注册分类：化学药品 4 类 申请人：浙江华海药业股份有限公司 药品批准文号：国药准字 H20254805 审批结论：根据《中华人民共和国药品管理法》及有关规定，经审查，本品符 合药品注册的有关要求，批准注册，发给药品注册证书。 琥珀酸美托洛尔缓释片用于治疗高血压、心绞 ...

Index Performance - The CSI A500 Index rose by 0.96% this week, closing at 4707.08 points on July 11, marking three consecutive weeks of gains [6] - The average daily trading volume for the week was 4067.87 billion yuan, with a week-on-week increase of 10.89% [6] Component Stocks Performance - The top ten gainers this week included: 1. Zhongyou Capital (000617.SZ) with a gain of 27.78% 2. Quzhou Development (600208.SH) with a gain of 23.67% 3. Northern Rare Earth (600111.SH) with a gain of 21.66% 4. Shenghe Resources (600392.SH) with a gain of 18.99% 5. Harbin Investment (600864.SH) with a gain of 16.36% 6. China Rare Earth (000831.SZ) with a gain of 16.31% 7. Baogang Group (600010.SH) with a gain of 15.47% 8. New Town Holdings (601155.SH) with a gain of 12.98% 9. JA Solar Technology (002459.SZ) with a gain of 12.56% 10. Sungrow Power Supply (300274.SZ) with a gain of 12.50% [4] - The top ten losers included: 1. Huahai Pharmaceutical (600521.SH) with a loss of 9.50% 2. Kelun Pharmaceutical (002422.SZ) with a loss of 8.61% 3. Baillie Gifford (688506.SH) with a loss of 8.43% 4. Junshi Biosciences (688180.SH) with a loss of 7.54% 5. Dongpeng Beverage (605499.SH) with a loss of 6.30% 6. Yingfeng Environment (000967.SZ) with a loss of 5.94% 7. Ziwen Mining (601899.SH) with a loss of 5.79% 8. Juhua Group (600160.SH) with a loss of 5.62% 9. Shandong Gold (600547.SH) with a loss of 5.41% 10. Pudong Development Bank (600000.SH) with a loss of 5.35% [4] Fund Performance - All 38 CSI A500 funds collectively rose this week, with the top performer being the Fortune Fund, which increased by 1.48% [7] - The total scale of these funds reached 1985.44 billion yuan, with the top three being Huatai-PineBridge (189.17 billion yuan), Guotai (178.43 billion yuan), and GF Fund (171.80 billion yuan) [7] Market Insights - Recent reports indicate that the A-share market has broken through key levels, moving away from a "full reduction" mindset, with structural expansion observed [8] - The bond market is experiencing low interest rates and volatility, facing strong resistance both upwards and downwards [8] - The report suggests that the second half of the year will see an influx of incremental capital, driving the market to a new level, with insurance capital leading the way [8] - The technology sector is highlighted as having high probability and return potential due to industry trends and supportive policies [8] - Consumer data shows signs of improvement, with macroeconomic indicators reflecting positive trends, particularly in discretionary consumption [9]

Core Viewpoint - Huahai Pharmaceutical has received approval from the National Medical Products Administration for the registration of two new drugs, which are expected to generate significant sales in the domestic market in 2024 [1] Group 1: Product Approvals - The company has obtained the drug registration certificate for Succinic Acid Metoprolol Sustained-Release Tablets, which are used for treating hypertension and angina, with an estimated domestic market sales amount of approximately 3.066 billion yuan in 2024 [1] - The company has also received approval for Nicardipine Hydrochloride Injection, intended for emergency treatment of abnormal hypertension during surgery, with an estimated domestic market sales amount of around 632 million yuan in 2024 [1] Group 2: R&D Investment - The company has invested approximately 17.04 million yuan in the research and development of Succinic Acid Metoprolol Sustained-Release Tablets [1] - The investment in the research and development of Nicardipine Hydrochloride Injection amounts to about 4.98 million yuan [1]

Index Performance - The CSI A500 Index increased by 1.32% this week, closing at 4662.51 points on July 4 [4] - The average daily trading volume for the week was 18341.42 billion yuan, with a week-on-week decrease of 9.22% [4] Top Performing Stocks - The top ten stocks with the highest gains this week included: 1. Tian Shou Pharmaceutical (600521.SH) with a gain of 23.34% 2. Daqian Energy (688303.SH) with a gain of 22.18% 3. Junshi Biosciences (688180.SH) with a gain of 18.93% 4. Lepu Medical (300003.SZ) with a gain of 17.99% 5. Giant Network (002558.SZ) with a gain of 17.42% 6. Tongwei Co., Ltd. (600438.SH) with a gain of 17.32% 7. Hualing Steel (000932.SZ) with a gain of 15.37% 8. Pengding Holdings (002938.SZ) with a gain of 14.57% 9. Shenzhou Taiyue (300002.SZ) with a gain of 13.70% 10. Dongshan Precision (002384.SZ) with a gain of 13.36% [3] Underperforming Stocks - The ten stocks with the largest declines this week included: 1. Hengxuan Technology (688608.SH) with a loss of 33.40% 2. Huazhi Shihua (688120.SH) with a loss of 32.34% 3. Northern Huachuang (002371.SZ) with a loss of 22.87% 4. Weining Health (300253.SZ) with a loss of 8.77% 5. China Eastern Airlines (600115.SH) with a loss of 7.07% 6. Xingyuan Material (300568.SZ) with a loss of 6.99% 7. Cambricon Technologies (688256.SH) with a loss of 6.50% 8. Beiyi Innovation (603986.SH) with a loss of 5.93% 9. Jixiang Airlines (603885.SH) with a loss of 5.84% 10. New Zhou Bang (300037.SZ) with a loss of 5.49% [3] Fund Performance - This week, 38 CSI A500 funds collectively rose, with Pu Yin An Sheng leading at a 1.72% increase [5] - The top three funds by size were Huatai-PB (200.88 billion yuan), Guotai (181.5 billion yuan), and GF Fund (174.22 billion yuan) [5] Market Trends - A new trend has emerged in the Hong Kong stock market where A-share listed technology companies are increasingly pursuing secondary listings in Hong Kong [7] - The secondary listings provide diversified financing channels and enhance international market recognition for the companies [7] - The median discount rate for five companies planning secondary listings in Hong Kong is approximately -17% [7] - The core factors driving asset performance are expected to shift from external to internal influences in the second half of the year [7]

Group 1 - The China Securities Innovation Drug Industry Index (931152) increased by 0.55%, with notable stock performances including Zhenhua Cell (688520) up 16.46%, Rongchang Bio (688331) up 10.65%, and Aosaikang (002755) up 10.00% [1] - The Innovation Drug 50 ETF (159835) has shown a cumulative increase of 33.49% over the past year, indicating significant growth in its market share [1] - The National Healthcare Security Administration and the National Health Commission released measures to support the high-quality development of innovative drugs, marking a pivotal step in the integration of commercial health insurance into the multi-tiered medical security system [1] Group 2 - Multiple policy releases are seen as significant for the development of innovative drugs, with the introduction of a commercial health insurance innovative drug directory expected to expand market opportunities and encourage pharmaceutical companies to enhance R&D efforts [2] - The domestic innovative drug industry is anticipated to reach a turning point by 2025, shifting from capital-driven growth to profit-driven growth, presenting dual opportunities for performance and valuation recovery [2] - The Innovation Drug 50 ETF closely tracks the China Securities Innovation Drug Industry Index, which selects up to 50 representative listed companies involved in innovative drug R&D to reflect the overall performance of the innovative drug sector [2]

Market Overview - The Shanghai Composite Index rose by 0.18% on July 3, with 24 out of the 28 sectors in the Shenwan classification experiencing gains. The leading sectors were electronics and electrical equipment, with increases of 1.69% and 1.38% respectively. The pharmaceutical and biological sector ranked third in terms of gains [1] - The coal and transportation sectors saw the largest declines, with decreases of 1.16% and 0.28% respectively [1] Fund Flow Analysis - The main funds in the two markets experienced a net outflow of 4.511 billion yuan throughout the day. Nine sectors saw net inflows, with the electronics sector leading at a net inflow of 7.820 billion yuan, followed by the pharmaceutical and biological sector with a net inflow of 1.382 billion yuan [1] - A total of 22 sectors experienced net outflows, with the machinery equipment sector leading at a net outflow of 2.317 billion yuan, followed by the basic chemicals sector with a net outflow of 1.908 billion yuan [1] Pharmaceutical and Biological Sector Performance - The pharmaceutical and biological sector increased by 1.35% with a net inflow of 1.382 billion yuan. Out of 474 stocks in this sector, 388 stocks rose, and 12 stocks hit the daily limit up. Conversely, 83 stocks declined [2] - Among the stocks with net inflows exceeding 100 million yuan, Huahai Pharmaceutical led with a net inflow of 269 million yuan, followed by Changchun High-tech and Zhongsheng Pharmaceutical with net inflows of 266 million yuan and 178 million yuan respectively [2] - The stocks with the largest net outflows included Dongfang Ocean, Changshan Pharmaceutical, and Mindray Medical, with net outflows of 186 million yuan, 155 million yuan, and 121 million yuan respectively [2][3] Top Gainers in Pharmaceutical Sector - The top gainers in the pharmaceutical sector included: - Huahai Pharmaceutical: +10.01%, turnover rate 4.98%, net inflow 268.63 million yuan - Changchun High-tech: +10.00%, turnover rate 4.06%, net inflow 266.41 million yuan - Zhongsheng Pharmaceutical: +6.22%, turnover rate 13.53%, net inflow 177.88 million yuan [2] Top Losers in Pharmaceutical Sector - The top losers in the pharmaceutical sector included: - Dongfang Ocean: -1.29%, turnover rate 25.09%, net outflow -186.29 million yuan - Changshan Pharmaceutical: +0.41%, turnover rate 2.88%, net outflow -154.59 million yuan - Mindray Medical: -2.13%, turnover rate 0.63%, net outflow -120.66 million yuan [3]

Group 1 - The innovative drug concept sector rose by 2.49%, ranking 7th among concept sectors, with 196 stocks increasing in value [1] - Notable gainers included Guoshentang and Shenzhou Cell, both reaching a 20% limit up, while stocks like Jiuzhitang, Weiming Pharmaceutical, and Huahai Pharmaceutical also hit the limit up [1] - The top gainers in the sector included Shanghai Yizhong, Saiseng Pharmaceutical, and Rejing Biomedical, with increases of 10.82%, 10.45%, and 10.38% respectively [1] Group 2 - The innovative drug sector saw a net inflow of 1.887 billion yuan, with 122 stocks receiving net inflows, and 6 stocks exceeding 100 million yuan in net inflow [2] - Huahai Pharmaceutical led the net inflow with 269 million yuan, followed by Changchun Gaoxin, Zhongsheng Pharmaceutical, and Jiuzhitang with net inflows of 266 million yuan, 178 million yuan, and 172 million yuan respectively [2] - The stocks with the highest net inflow ratios included Jiuzhitang, Weiming Pharmaceutical, and Huahai Pharmaceutical, with net inflow ratios of 33.17%, 24.18%, and 17.37% respectively [3] Group 3 - The innovative drug sector's top stocks by trading volume included Huahai Pharmaceutical, Changchun Gaoxin, and Zhongsheng Pharmaceutical, with trading volumes of 26.863 million yuan, 26.640 million yuan, and 17.787 million yuan respectively [3][4] - Other notable stocks included Guoshentang, which had a trading volume of 13.697 million yuan, and Weiming Pharmaceutical with 8.946 million yuan [4] - The sector's performance was characterized by significant trading activity, with many stocks experiencing high turnover rates [4]

Core Viewpoint - The 中证A500 index represents a balanced selection of leading companies across various industries, reflecting the overall performance of the most representative listed companies in China, with a focus on both traditional and emerging sectors [1][2]. Group 1: Market Performance - As of July 3, 2025, the 中证A500 index rose by 0.60%, with notable increases in constituent stocks such as 蓝思科技 (up 12.14%) and 东山精密 (up 9.29%) [1]. - The 中证A500ETF leading fund (563800) also saw a rise of 0.62%, with a trading volume of 8.54 billion yuan and a turnover rate of 4.9% [1]. Group 2: Industry Insights - The 中证A500 index includes leading companies from various industries, indicating a competitive and stable force within the Chinese economic system, especially as market concentration is expected to increase due to accelerated mergers and acquisitions [2]. - The index is designed to balance traditional and emerging industries, with a significant weight on sectors like pharmaceuticals, new energy, and computing, aiming for a balance between value and growth [1][2]. Group 3: Future Outlook - Analysts predict that the A-share market may exhibit a trend of upward fluctuations in the second half of 2025, supported by the expansion of equity public funds and stable capital inflows [2]. - The 中证A500 index is expected to benefit from improvements in fundamentals, policy catalysts, and institutional optimization, leading to a potential recovery in profitability [2].

Group 1 - The ChiNext index showed strong performance, rising over 1% with active participation from innovative drug and commercial aerospace concepts [1][2][3] - The ChiNext index rose by 1.36% at midday, with notable stocks such as Lens Technology (300433) increasing over 8% and Ningde Times (300750) nearly 4% [2][3] - The innovative drug concept saw significant gains, with multiple stocks hitting the daily limit, including ShenZhou Cell and Jiuzhitang [3][6] Group 2 - The Hong Kong stock market experienced a slight decline, with the Hang Seng Index dropping over 1% at one point [9] - Multi-point Intelligence saw its stock price surge, with an intraday increase nearing 90%, attributed to its plans for a stablecoin license [10][12] - The pharmaceutical sector in the Hong Kong market rose over 2%, with several stocks, including Huahao Zhongtian Pharmaceutical-B, increasing over 10% [12] Group 3 - JiXin Technology (601218) experienced its fourth consecutive trading day of hitting the daily limit, while issuing a risk warning regarding its high rolling P/E ratio of 72.85 compared to the industry average of 22.24 [7][8] - SaiLi Medical also hit the daily limit for the third consecutive day, with the company confirming no undisclosed significant information affecting its stock price [8]

Summary of Key Points Core Viewpoint - The announcement details the conversion results of Zhejiang Huahai Pharmaceutical Co., Ltd.'s convertible bonds, indicating minimal conversion activity and a significant amount of unconverted bonds remaining. Group 1: Convertible Bond Conversion Status - As of June 30, 2025, a total of 182,000 yuan of Huahai convertible bonds have been converted into 5,304 shares, representing 0.00036% of the company's total shares before conversion [1][6] - The amount of unconverted Huahai convertible bonds stands at 1,842,417,000 yuan, accounting for 99.9901% of the total issuance [1][6] - No conversions occurred during the period from April 1, 2025, to June 30, 2025 [5][6] Group 2: Convertible Bond Issuance Overview - Huahai issued 18.426 million convertible bonds on November 2, 2020, with a total value of 184,260,000 yuan and a maturity of six years [2] - The initial conversion price was set at 34.66 yuan per share, which has undergone several adjustments, with the latest adjustment bringing it to 33.31 yuan per share effective June 17, 2025 [2][5] Group 3: Share Capital Changes - The company repurchased and canceled 10,656,753 shares, resulting in a reduction of total share capital [6][7] - The total number of shares after the cancellation is 1,497,251,081 shares [6][7]